Does endothelin play a role in chemoreception during acute hypoxia in normal men?

Chest

Volumn 131, Issue 5, 2007, Pages 1467-1472

  Gujic, Marko ^a   Houssière, Anne ^a   Xhaët, Olivier ^a   Argacha, Jean François ^a   Denewet, Nathalie ^a   Noseda, André ^a   Jespers, Pascale ^a   Melot, Christian ^a   Naeije, Robert ^a   Van De Borne, Philippe ^a  

^a ERASME HOSPITAL   (Belgium)

Author keywords

Endothelin; Human chemoreceptor; Hypoxia; Sympathetic nervous system

Indexed keywords

BOSENTAN; ENDOTHELIN; ENDOTHELIN RECEPTOR ANTAGONIST; PLACEBO;

ADULT; APNEA; ARTICLE; CHEMORECEPTOR; CHEMORECEPTOR REFLEX; CHEMOSENSITIVITY; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG EFFECT; HEART RATE; HUMAN; HUMAN EXPERIMENT; HYPOXIA; LUNG MINUTE VOLUME; MALE; PRIORITY JOURNAL; PROTEIN FUNCTION; RANDOMIZED CONTROLLED TRIAL; SYMPATHETIC NERVE; SYSTOLIC BLOOD PRESSURE; TREATMENT RESPONSE;

EID: 34248592210     PISSN: 00123692     EISSN: None     Source Type: Journal    
DOI: 10.1378/chest.06-1775     Document Type: Article

References (38)

1. Berger AJ, Mitchell RA, Severinghaus JW. Regulation of respiration (third of three parts). N Engl J Med 1977; 297:194-201
2. SaprU HN. Carotid chemoreflex: neural pathways and transmitters. Adv Exp Med Biol 1996; 410:357-364
3. Gonzalez C, Almaraz L, Obeso A, et al. Carotid body chemoreceptors: from natural stimuli to sensory discharges. Physiol Rev 1994; 74:829-898
4. Lugliani R, Whipp BJ, Seard C, et al. Effect of bilateral carotid-body resection on ventilatory control at rest and during exercise in man. N Engl J Med 1971; 285:1105-1111
5. Wade JG, Larson CP Jr, Ehrenfeld WK. Effect of carotid endarterectomy on carotid chemoreceptor and baroreceptor function. Surg Forum 1968; 19:144-145
6. Kara T, Narkiewicz K, Somers VK. Chemoreflexes: physiology and clinical implications. Acta Physiol Scand 2003; 177: 377-384
7. Benigni A, Remuzzi G. Endothelin antagonists. Lancet 1999; 353:133-138
8. Channick RN, Sitbon O, Barst RJ, et al. Endothelin receptor antagonists in pulmonary arterial hypertension. J Am Coll Cardiol 2004; 43(suppl):62S-67S
9. Chen J, He L, Dinger B, et al. Cellular mechanisms involved in rabbit carotid body excitation elicited by endothelin peptides. Respir Physiol 2000; 121:13-23
10. Chen J, He L, Dinger B, et al. Pharmacological effects of endothelin in rat carotid body, activation of second messenger pathways and potentiation of chemoreceptor activity. Adv Exp Med Biol 2000; 475:517-525
11. Kuwaki T, Ling GY, Onodera M, et al. Endothelin in the central control of cardiovascular and respiratory functions. Clin Exp Pharmacol Physiol 1999; 26:989-994
12. McQueen DS, Dashwood MR, Cobb VJ, et al. Effects of endofhelins on respiration and arterial chemoreceptor activity in anaesthetised rats. Adv Exp Med Biol 1994; 360:289-291
13. McQueen DS, Dashwood MR, Cobb VJ, et al. Endothelins and rat carotid body: autoradiographic and functional pharmacological studies. J Auton Nerv Syst 1995; 53:115-125
14. Rey S, Del Rio R, Alcayaga J, et al. Endothelins in the cat petrosal ganglion and carotid body: effects and immunolocalization. Brain Res 2006; 1069:154-158
15. Spyer KM, McQueen DS, Dashwood MR, et al. Localization of [125I]endothelin binding sites in the region of the carotid bifurcation and brainstem of fhe cat: possible baro- and chemoreceptor involvement. J Cardiovasc Pharmacol 1991; 17(suppl):S385-S389
16. Narkiewicz K, van de Borne PJ, Pesek CA, et al. Selective potentiation of peripheral chemoreflex sensitivity in obstructive sleep apnea. Circulation 1999; 99:1183-1189
17. Somers VK, Mark AL, Abboud FM. Potentiation of sympathetic nerve responses to hypoxia in borderline hypertensive subjects. Hypertension 1988; 11:608-612
18. Chua TP, Ponikowski P, Webb-Peploe K, et al. Clinical characteristics of chronic heart failure patients with an augmented peripheral chemoreflex. Eur Heart J 1997; 18:480-486
19. Narkiewicz K, Pesek CA, van de Borne PJ, et al. Enhanced sympathetic and ventilatory responses to central chemoreflex activation in heart failure. Circulation 1999; 100:262-267
20. Ponikowski P, Chua TP, Piepoli M, et al. Augmented peripheral chemosensitivity as a potential input to baroreflex impairment and autonomic imbalance in chronic heart failure. Circulation 1997; 96:2586-2594
21. Phillips BG, Narkiewicz K, Pesek CA, et al. Effects of obstructive sleep apnea on endothelin-1 and blood pressure. J Hypertens 1999; 17:61-66
22. Zamarron-Sanz C, Ricoy-Galbaldon J, Gude-Sampedro F, et al. Plasma levels of vascular endothelial markers in obstructive sleep apnea. Arch Med Res 2006; 37:552-555
23. Grimpen F, Kanne P, Schulz E, et al. Endothelin-1 plasma levels are not elevated in patients with obstructive sleep apnoea. Eur Respir J 2000; 15:320-325
24. Jordan W, Reinbacher A, Cohrs S, et al. Obstructive sleep apnea: plasma endothelin-1 precursor but not endothelin-1 levels are elevated and decline with nasal continuous positive airway pressure. Peptides 2005; 26:1654-1660
25. Lerman A, Kubo SH, Tschumperlin LK, et al. Plasma endothelin concentrations in humans with end-stage heart failure and after heart transplantation. J Am Coll Cardiol 1992; 20:849-853
26. McMurray JJ, Ray SG, Abdullah I, et al. Plasma endothelin in chronic heart failure. Circulation 1992; 85:1374-1379
27. Seals DR, Suwarno NO, Dempsey JA. Influence of lung volume on sympathetic nerve discharge in normal humans. Circ Res 1990; 67:130-141
28. van de BP, Oren R, Somers VK. Dopamine depresses minute ventilation in patients with heart failure. Circulation 1998; 98:126-131
29. Velez-Roa S, Kojonazarov B, Ciarka A, et al. Dobutamine potentiates arterial chemoreflex sensitivity in healthy normal humans. Am J Physiol Heart Circ Physiol 2003; 285:H1356-H1361
30. Delius W, Hagbarth KE, Hongell A, et al. General characteristics of sympathetic activity in human muscle nerves. Acta Physiol Scand 1972; 84:65-81
31. van de BP, Montano N, Zimmerman B, et al. Relationship between repeated measures of hemodynamics, muscle sympathetic nerve activity, and tiheir spectral oscillations. Circulation 1997; 96:4326-4332
32. Jones B, Kenward MG. Design and analysis of cross-over trials. Norwell, MA: Chapman and Hall, 1989; 60-67
33. Weber C, Schmitt R, Birnboeck H, et al. Multiple-dose pharmacokinetics, safety, and tolerability of bosentan, an endothelin receptor antagonist, in healthy male volunteers. J Clin Pharmacol 1999; 39:703-714
34. Heistad D, Abboud FM, Mark AL, et al. Effect of baroreceptor activity on ventilatory response to chemoreceptor stimulation. J Appl Physiol 1975; 39:411-416
35. Weber C, Schmitt R, Birnboeck H, et al. Pharmacokinetics and pharmacodynamics of the endothelin-receptor antagonist bosentan in healthy human subjects. Clin Pharmacol Ther 1996; 60:124-137
36. Chen J, He L, Dinger B, et al. Role of endothelin and endothelin A-type receptor in adaptation of the carotid body to chronic hypoxia. Am J Physiol Lung Cell Mol Physiol 2002; 282:L1314-L1323
37. Rey S, Del Rio R, Iturriaga R. Contribution of endothelin-1 to fhe enhanced carotid body chemosensory responses induced by chronic intermittent hypoxia. Brain Res 2006; 1086:152-159
38. Chen Y, Tipoe GL, Liong E, et al. Chronic hypoxia enhances endothelin-1-induced intracellular calcium elevation in rat carotid body chemoreceptors and up-regulates ETA receptor expression. Pflugers Arch 2002; 443:565-573