Toxin profiles and resistances to macrolides and newer fluoroquinolones as epidemicity determinants of clinical isolates of Clostridium difficile from Warsaw, Poland

Journal of Clinical Microbiology

Volumn 45, Issue 5, 2007, Pages 1607-1610

  Pituch, Hanna ^a   Van Leeuwen, Willem ^b   Maquelin, Kees ^b   Wultańska, Dorota ^a   Obuch Woszczatyński, Piotr ^a   Nurzyńska, Grayna ^a   Kato, Haru ^c   Reijans, Martin ^d   Meisel Mikołajczyk, Felicja ^a   Łuczak, Mirosław ^a   Van Belkum, Alex ^b  

^a MEDICAL UNIVERSITY OF WARSAW   (Poland)

^b ERASMUS MEDICAL CENTER   (Netherlands)

^c NATIONAL INSTITUTE OF INFECTIOUS DISEASES   (Japan)

^d PathoFinder BV   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL TOXIN; CIPROFLOXACIN; CLINDAMYCIN; ERYTHROMYCIN; GATIFLOXACIN; MACROLIDE; METRONIDAZOLE; MOXIFLOXACIN; QUINOLINE DERIVED ANTIINFECTIVE AGENT; VANCOMYCIN;

ADOLESCENT; ADULT; AMPLIFIED FRAGMENT LENGTH POLYMORPHISM; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL STRAIN; BACTERIUM DETECTION; BACTERIUM ISOLATE; CLOSTRIDIUM DIFFICILE; CONTROLLED STUDY; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; POLAND; PRIORITY JOURNAL; SCHOOL CHILD;

ADOLESCENT; ADULT; ANTI-BACTERIAL AGENTS; BACTERIAL TOXINS; CHILD; CHILD, PRESCHOOL; CLOSTRIDIUM DIFFICILE; CLOSTRIDIUM INFECTIONS; DRUG RESISTANCE, MULTIPLE, BACTERIAL; FECES; FLUOROQUINOLONES; GENOTYPE; HUMANS; MACROLIDES; PHYLOGENY; POLAND;

CLOSTRIDIUM DIFFICILE;

EID: 34248589086     PISSN: 00951137     EISSN: None     Source Type: Journal    
DOI: 10.1128/JCM.00306-07     Document Type: Article

References (21)

1. Ackermann, G., A. Degner, S. H. Cohen, J. Silva, Jr., and A. C. Rodloff. 2003. Prevalence and association of macrolide-lincosamide- streptogratnin B (MLS(B)) resistance with resistance to moxifloxacin in Clostridium difficile. J. Anntimicrob. Chemother. 51:599-603.
2. Ackermann, G., Y. J. Tang-Feldman, R. Schaumann, J. P. Henderson, A. C. Rodloff, J. Silva, and S. H. Cohen. 2003. Antecedent use of fluoroquinolones is associated with resistance to moxifloxacin in Clostridium difficile. Clin. Microbiol. Infect. 9:526-530.
3. Borriello, S. P. 1998. Pathogenesis of Clostridium difficile infection. J. Antimocrob. Chemother. 41:13-19.
4. Braun, V., T. Hundsberger, P. Leukel, M. Sauerborn, and C. von Eichel-Streiber. 1996. Definition of a single integration site of the pathogenicity locus in Clostridium difficile. Gene 181:29-38.
5. Clinical and Laboratory Standards Institute. 2006. Methods for antimicrobial susceptibility testing of anaerobic bacteria, 6th ed. Approved standard M11-A6. CLSI, Wayne, PA.
6. Drudy, D., T. Quinn, R. O'Mahony, L. Kyne, P. O'Gaora, and S. Fanning. 2006. High-level resistance to moxifloxacin and gatifloxacin associated with a novel mutation in gyrB in toxin-A-negative, toxin-B-positive Clostridium difficile, J. Antimocrob. Chemother. 58:1264-1267.
7. Hundsberger, T., V. Braun, M. Weidmann, P. Leukel, M. Sauerborn, and C. Eichel-Streiber. 1997. Transcription analysis of the genes tcdA-E of the pathogenicity locus of Clostridium difficile. Eur. J. Biochem. 244:735-742.
8. Kato, H., N. Kato, S. Katow, T. Maegawa, S. Nakamura, and D. M. Lyerly. 1999. Deletions in the repeating sequences of the toxin A gene of toxin A-negative, toxin B-positive Clostridium difficile strains. FEMS Microbiol. Lett. 175:197-203.
9. Klaassen, C. H. W., H. A. Van Haren, and A. M. Horrevorts. 2002. Molecular fingerprinting of Clostridium difficile isolates: pulsed-field gel electrophoresis versus amplified fragment length polymorphism. J. Clin. Microbiol. 40:101-104.
10. Lemee, L., A. Dhalluin, M. Pestel-Caron, J. F. Lemeland, and J. L. Pons. 2004. Multilocus sequence typing analysis of human and animal Clostridium difficile isolates of various toxigenic types. J. Clin. Microbiol. 42:2609-2617.
11. Loo, V. G., L. Poirier, M. A. Miller, M. Oughton, M. D. Libman, S. Michaud, A. M. Bourgault, T. Nguyen, C. Frenette, M. Kelly, A. Vibien, P. Brassard, S. Fenn, K. Dewar, T. J. Hudson, R. Horn, P. Rene, Y. Monczak, and A. Dascal. 2005. A predominantly clonal multi-institutional outbreak of Clostridium difficile-associated diarrhea with high morbidity and mortality. N. Engl. J. Med. 353:2442-2449.
12. McDonald, L. C., M. Owings, and J. B. Jernigan. 2006. Clostridium difficile infection in patients discharged from US short-stay hospitals, 1996-2003. Emerg. Infect. Dis. 12:409-415.
13. Melles, D. C., R. F. J. Gorkink, A. M. Boelens, S. V. Snijders, G. Simons, W. B. Van Leeuwen, H. A. Verbrugh, and A. Van Belkum. 2004. Natural population dynamics and expansion of pathogenic clones of Staphylococcus aureus. J. Clin. Investig. 114:1732-1740.
14. Perelle, S., M. Gibert, P. Boulioux, G. Corthier, and M. R. Popoff. 1997. Production of a complete binary toxin (actin-specific ADP-ribosyltransferase) by Clostridium difficile CD196. Infect. Immun. 65:1402-1407.
15. Pituch, H., A. Van Belkum, N. Van den Braak, P. Obuch- Woszczatyński, H. A. Verbrugh, F. Meisel-Mikołajczyk, and M. ℒczak. 2003. Recent emergence of an epidemic clindamycin-resistant clone of Clostridium difficile among Polish patients with C. difficile-associated diarrhea. J. Clin. Microbiol. 41:4184-4187.
16. Pituch, H., D. Kreft, P. Obuch-Woszczatynski, D. Wultańska, F. Meisel-Mikołajczyk, M. Luczak, and A. Van Belkum. 2005. Clonal spread of a Clostridium difficile strain with a complete set of toxin A, toxin B, and binary toxin genes among Polish patients with Clostridium difficile-associated diarrhea. J. Clin. Microbiol. 43:472-475.
17. Riley, T. V. 2004. Nosocomial diarrhoea due to Clostridium difficile. Curr. Opin. Infect. Dis. 17:323-327.
18. Samore, M., G. Killgore, S. Johnson, R. Goodman, J. Shim, L. Venkataraman, S. Sambol, P. DeGirolami, F. C. Tenover, R. Arbeit, and D. Gerding. 1997. Multicenter typing comparison of sporadic and outbreak Clostridium difficile isolates from geographically diverse hospitals. J. Infect. Dis. 176: 1233-1238.
19. Stubbs, S., M. Rupnik, M. Gilbert, J. Brazier, B. Duerden, and M. Popoff. 2000. Production of actin specific ADP-ribosyltransferase (binary toxin) by strains of Clostridium difficile. FEMS Microbiol. Lett. 15:307-312.
20. Van den Berg, R. J., E. C. J. Claas, D. H. Oyib, C. H. W. Klaassen, L. Dijkshoorn, J. S. Brazier, and E. J. Kuijper. 2004. Characterization of toxin A-negative, toxin B-positive Clostridium difficile isolates from outbreaks in different countries by amplified fragment length polymorphism and PCR ribotyping. J. Clin. Microbiol. 42:1035-1041.
21. Von Eichel-Streiber, C., R. Laufenberg-Feldmann, S. Sartingen, and J. Schultze. 1992. Comparative sequence analysis of Clostridium difficile toxins A and B. Mol. Gen. Genet. 233:260-268.