Association between KLOTHO gene and hand osteoarthritis in a female Caucasian population

Osteoarthritis and Cartilage

Volumn 15, Issue 6, 2007, Pages 624-629

  Zhang, F ^a   Zhai, G ^a   Kato, B S ^a   Hart, D J ^a   Hunter, D ^b   Spector, T D ^a   Ahmadi, K R ^a  

^a ST THOMAS HOSPITAL   (United Kingdom)

^b BOSTON UNIVERSITY   (United States)

Author keywords

Genetic association; Hand osteoarthritis; KLOTHO gene; Single nucleotide polymorphism

Indexed keywords

GENE PRODUCT; PROTEIN KLOTHO; UNCLASSIFIED DRUG;

ADULT; AGED; ALLELE; ARTICLE; BODY MASS; CAUCASIAN; CHI SQUARE TEST; CHONDROPATHY; CONFIDENCE INTERVAL; CONTROLLED STUDY; COVARIANCE; FEMALE; FISHER EXACT TEST; GENETIC ASSOCIATION; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOTYPE; HAND DISEASE; HAND RADIOGRAPHY; HUMAN; JOINT CAVITY; LOGISTIC REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; OSTEOARTHRITIS; OSTEOPHYTE; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM;

AGED; AGING; DISEASE PROGRESSION; DISEASES IN TWINS; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GLUCURONIDASE; HAND JOINTS; HUMANS; MIDDLE AGED; OSTEOARTHRITIS;

EID: 34248587172     PISSN: 10634584     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.joca.2006.12.002     Document Type: Article

References (29)

1. Carr A.J. Beyond disability: measuring the social and personal consequences of osteoarthritis. Osteoarthritis Cartilage 7 (1999) 230-238
2. Brownson R.C., Remington P.L., and Davis J.R. Chronic Disease Epidemiology and Control. 2nd edn. (1998), American Public Health Association, Washington, DC
3. Spector T.D., Cicuttini F., Baker J., Loughlin J., and Hart D. Genetic influences on osteoarthritis in women: a twin study. BMJ 312 (1996) 940-943
4. MacGregor A.J., Antoniades L., Matson M., Andrew T., and Spector T.D. The genetic contribution to radiographic hip osteoarthritis in women: results of a classic twin study. Arthritis Rheum 43 (2000) 2410-2416
5. Loughlin J. Genome studies and linkage in primary osteoarthritis. Rheum Dis Clin North Am 28 (2002) 95-109
6. Kaprio J., Kujala U.M., Peltonen L., and Koskenvuo M. Genetic liability to osteoarthritis may be greater in women than men. BMJ 313 (1996) 232
7. MacGregor A.J., and Spector T.D. Twins and the genetic architecture of osteoarthritis. Rheumatology (Oxford) 38 (1999) 583-588
8. Spector T.D., and MacGregor A.J. Risk factors for osteoarthritis: genetics. Osteoarthritis Cartilage 12 Suppl A (2004) S39-S44
9. Lawrence J.S., Bremner J.M., and Bier F. Osteo-arthrosis. Prevalence in the population and relationship between symptoms and X-ray changes. Ann Rheum Dis 25 (1966) 1-24
10. Matsumura Y., Aizawa H., Shiraki-Iida T., Nagai R., Kuro-o M., and Nabeshima Y. Identification of the human klotho gene and its two transcripts encoding membrane and secreted klotho protein. Biochem Biophys Res Commun 242 (1998) 626-630
11. Arking D.E., Krebsova A., Macek Sr. M., Macek Jr. M., Arking A., Mian I.S., et al. Association of human aging with a functional variant of klotho. Proc Natl Acad Sci U S A 99 (2002) 856-861
12. Arking D.E., Atzmon G., Arking A., Barzilai N., and Dietz H.C. Association between a functional variant of the KLOTHO gene and high-density lipoprotein cholesterol, blood pressure, stroke, and longevity. Circ Res 96 (2005) 412-418
13. Arking D.E., Becker D.M., Yanek L.R., Fallin D., Judge D.P., Moy T.F., et al. KLOTHO allele status and the risk of early-onset occult coronary artery disease. Am J Hum Genet 72 (2003) 1154-1161
14. Low A.F., O'Donnell C.J., Kathiresan S., Everett B., Chae C.U., Shaw S.Y., et al. Aging syndrome genes and premature coronary artery disease. BMC Med Genet 6 (2005) 38
15. Yamada Y., Ando F., Niino N., and Shimokata H. Association of polymorphisms of the androgen receptor and klotho genes with bone mineral density in Japanese women. J Mol Med 83 (2005) 50-57
16. Kawano K., and Kawaguchi H. Human klotho gene polymorphisms associated with bone density of aged postmenopausal women. Nippon Rinsho 62 Suppl 2 (2004) 190-194
17. Mullin B.H., Wilson S.G., Islam F.M., Calautti M., Dick I.M., Devine A., et al. Klotho gene polymorphisms are associated with osteocalcin levels but not bone density of aged postmenopausal women. Calcif Tissue Int 77 (2005) 145-151
18. Kuro-o M., Matsumura Y., Aizawa H., Kawaguchi H., Suga T., Utsugi T., et al. Mutation of the mouse klotho gene leads to a syndrome resembling ageing. Nature 390 (1997) 45-51
19. Kawaguchi H., Manabe N., Miyaura C., Chikuda H., Nakamura K., and Kuro-o M. Independent impairment of osteoblast and osteoclast differentiation in klotho mouse exhibiting low-turnover osteopenia. J Clin Invest 104 (1999) 229-237
20. Suzuki H., Amizuka N., Oda K., Li M., Yoshie H., Ohshima H., et al. Histological evidence of the altered distribution of osteocytes and bone matrix synthesis in klotho-deficient mice. Arch Histol Cytol 68 (2005) 371-381
21. Kawano K., Ogata N., Chiano M., Molloy H., Kleyn P., Spector T.D., et al. Klotho gene polymorphisms associated with bone density of aged postmenopausal women. J Bone Miner Res 17 (2002) 1744-1751
22. Kellgren J.K. Atlas of Standard Radiographs of Arthritis Volume II (1963), Blackwell Scientific Publications, Oxford
23. Burnett S., Hart D.J., Cooper C., and Spector T.D. A Radiographic Atlas of Osteoarthritis (1994), Springer-Verlag, London
24. Hart D.J., Spector T.D., Brown P., Wilson P., Doyle D.V., and Silman A.J. Clinical signs of early osteoarthritis: reproducibility and relation to X ray changes in 541 women in the general population. Ann Rheum Dis 50 (1991) 467-470
25. Barrett J.C., Fry B., Maller J., and Daly M.J. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 21 (2005) 263-265
26. Lawrence R.C., Helmick C.G., Arnett F.C., Deyo R.A., Felson D.T., Giannini E.H., et al. Estimates of the prevalence of arthritis and selected musculoskeletal disorders in the United States. Arthritis Rheum 41 (1998) 778-799
27. Spector T.D., and Cooper C. Radiographic assessment of osteoarthritis in population studies: whither Kellgren and Lawrence?. Osteoarthritis Cartilage 1 (1993) 203-206
28. Bansal A., van den Boom D., Kammerer S., Honisch C., Adam G., Cantor C.R., et al. Association testing by DNA pooling: an effective initial screen. Proc Natl Acad Sci U S A 99 (2002) 16871-16874
29. Andrew T., Hart D.J., Snieder H., de Lange M., Spector T.D., and MacGregor A.J. Are twins and singletons comparable? A study of disease-related and lifestyle characteristics in adult women. Twin Res 4 (2001) 464-477