A 3-month, randomized, double-blind, placebo-controlled study to evaluate the safety and efficacy of a highly optimized, capacitively coupled, pulsed electrical stimulator in patients with osteoarthritis of the knee

Osteoarthritis and Cartilage

Volumn 15, Issue 6, 2007, Pages 630-637

  Garland, D ^a   Holt, P ^b   Harrington, J Timothy ^c   Caldwell, J ^d   Zizic, T ^b   Cholewczynski, J ^e  

^a RANCHO LOS AMIGOS NATIONAL REHABILITATION CENTER   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^d BioniCare Medical Technologies Inc   (United States)

^e NONE

Author keywords

Knee osteoarthritis; Pulsed electrical stimulation treatment

Indexed keywords

NARCOTIC ANALGESIC AGENT; NONSTEROID ANTIINFLAMMATORY AGENT;

ADULT; AGED; ARTICLE; CLINICAL EFFECTIVENESS; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEVICE; DISEASE SEVERITY; DOUBLE BLIND PROCEDURE; ELECTRODE; ELECTROSTIMULATION THERAPY; FEMALE; FOLLOW UP; FUNCTIONAL ASSESSMENT; HUMAN; JOINT STIFFNESS; KNEE OSTEOARTHRITIS; KNEE PAIN; MAJOR CLINICAL STUDY; MALE; MONOTHERAPY; OUTPATIENT; PRIORITY JOURNAL; QUESTIONNAIRE; RANDOMIZED CONTROLLED TRIAL; RASH; SAFETY; SYMPTOM; TREATMENT OUTCOME;

AGED; DOUBLE-BLIND METHOD; ELECTRIC STIMULATION THERAPY; FEMALE; HUMANS; MALE; MIDDLE AGED; OSTEOARTHRITIS, KNEE; PAIN MEASUREMENT; TREATMENT OUTCOME;

EID: 34248581862     PISSN: 10634584     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.joca.2007.01.004     Document Type: Article

References (35)

1. Mankin H.J., Dorfman H.D., Lippiello L., and Zarins A. Biochemical and metabolic abnormalities in articular cartilage from osteoarthritic human hips. II. Correlation of morphology with biochemical and metabolic data. J Bone Joint Surg Am 53A (1971) 523-537
2. Lippiello L., Hall D., and Mankin H.J. Collagen synthesis in normal and osteoarthritic human cartilage. J Clin Invest 59 (1977) 593-600
3. Mankin H.J., and Brandt K.D. Biochemistry and metabolism of articular cartilage in osteoarthritis. In: Moskowitz R.W., Howell D.S., Goldberg V.C., and Mankin H.J. (Eds). Osteoarthritis: Diagnosis and Management. 2nd edn. (1992), WB Saunders, Philadelphia 109
4. Pelletier J.P., Martel-Pelletier J., and Howell D.S. Etiopathogenesis of osteoarthritis. In: Koopman W.J. (Ed). Arthritis and Allied Conditions: a Textbook of Rheumatology. 13th edn. (1997), Williams and Wilkins, Baltimore 1969
5. Holbrook A.M., and for Ontario Musculoskeletal Therapy Review Panel. Ontario Treatment Guidelines for Osteoarthritis, Rheumatoid Arthritis, and Acute Musculoskeletal Injury (2000), Queen's Printer of Ontario, Toronto p. 19
6. Clegg D.O., Reda D.J., Harris C.L., Klein M.A., O'Dell J.R., Hooper M.M., et al. Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis. N Engl J Med 354 (2006) 795-808
7. Zizic T.M., Hoffman K.C., Holt P.A., Hungerford D.S., O'Dell J.R., and Jacobs M.A. The treatment of osteoarthritis of the knee with pulsed electrical stimulation. J Rheumatol 22 (1995) 1757-1761
8. Mont M.A., Hungerford D.S., Caldwell J.R., Hoffman K.C., and Zizic T.M. Electrical stimulation helps delay knee replacement surgery. Biomechanics 5 (2005) 73-78
9. Mont M.A., Hungerford D.S., Caldwell J.R., Ragland P.S., Hoffman K.C., He Y.D., et al. The use of pulsed electrical stimulation to defer total knee arthroplasty in patients with osteoarthritis of the knee. Orthopedics 29 (2006) 887-892
10. Farr J., Mont M.A., Garland D., Caldwell J.R., and Zizic T.M. Pulsed electrical stimulation in patients with osteoarthritis of the knee: follow-up in 288 patients who had failed non-operative therapy. Surg Technol Int IV (2006) 1227-1233
11. Armstrong P.F., Brighton C.T., and Star A.M. Capacitively coupled electrical stimulation of bovine growth plate chondrocytes grown in pellet form. J Orthop Res 6 (1988) 265-271
12. Baker B., Becker R.O., and Spadaro J.A. A study of electrochemical enhancement of articular cartilage repair. Clin Orthop Relat Res 102 (1974) 251-267
13. Baker B., Becker R.O., Spadaro J.A., Marino A., and Becker R.O. Electrical stimulation of articular cartilage regeneration. Ann N Y Acad Sci 238 (1974) 491-499
14. Brighton C.T., Jensen L., Pollack S.R., Tolin B.S., and Clark C.C. Proliferative and synthetic response of bovine growth plate chondrocytes to various capacitively coupled electrical fields. J Orthop Res 7 (1989) 759-765
15. Brighton C.T., Unger A.S., and Stambough J.L. In vitro growth of bovine articular cartilage chondrocytes in various capacitively coupled electrical fields. J Orthop Res 2 (1984) 15-22
16. Rodan G.A., Bourret L.A., and Norton L.A. DNA synthesis in cartilage cells is stimulated by oscillating electrical fields. Science 199 (1978) 690-692
17. Aaron R.K., Ciombor D.M., Keeping H., Wang S., Capuano A., and Polk C. Power frequency fields promote cell differentiation coincident with an increase in transforming growth factor-b (1) expression. Bioelectromagnetics 21 (2000) 73
18. Schmidt-Rohlfing B., Schneider U., Goost H., and Silny J. Mechanically induced electrical potentials of articular cartilage. J Biomech 35 (2002) 475-482
19. Mow V.C., Wang C.C., and Hung C.T. The extracellular matrix, interstitial fluid and ions as a mechanical signal transducer in articular cartilage. Osteoarthritis Cartilage 7 (1999) 41-58
20. Aaron R.K., Wang S., and Ciombor D.M. Upregulation of basal TGFbeta1 levels by EMF coincident with chondrogenesis-implications of skeletal repair and tissue engineering. J Orthop Res 20 (2002) 233-240
21. Ciombor D.M., Aaron R.K., Wang S., and Simon B. Modification of osteoarthritis by pulsed electromagnetic field-a morphological study. Osteoarthritis Cartilage 11 (2003) 455-462
22. Wang W., Wang Z., Zhang G., Clark C.C., and Brighton C.T. Up-regulation of chondrocyte matrix genes and products by electric fields. Clin Orthop Relat Res 427 Suppl (2004) S163-S173
23. Wang Z., Clark C.C., and Brighton C.T. Up-regulation of bone morphogenetic proteins in cultured murine bone cells with use of specific electric fields. J Bone Joint Surg Am 88 5 (2006 May) 1053-1065
24. Kalra A., Urban M.O., and Sluka K.A. Blockade of opioid receptors in rostral ventral medulla prevents antihyperalgesia produced by transcutaneous electrical nerve stimulation (TENS). J Pharmacol Exp Ther 298 1 (2001) 257-263
25. Buckland-Wright J.C., Wolfe F., Ward R.J., Flowers N., and Hayne C. Substantial superiority of semiflexed (MTP) views in knee osteoarthritis: a comparative radiographic study, without fluoroscopy, of standing extended, semiflexed (MTP), and schuss views. J Rheumatol 26 (1999) 2664-2674
26. Kellgren J.H., and Lawrence J.S. Radiological assessment of osteoarthrosis. Ann Rheum Dis 16 (1957) 494-502
27. Trock D.H., Bollet A.J., Dyer Jr. R.H., Fielding L.P., Miner W.K., and Markoll R. A double-blind trial of the clinical effects of pulsed electromagnetic fields in osteoarthritis. J Rheumatol 20 (1993) 456-460
28. Trock D.H., Bollet A.J., and Markoll R. The effect of pulsed electromagnetic fields in the treatment of osteoarthritis of the knee and cervical spine. Report of randomized, double blind, placebo controlled trials. J Rheumatol 21 (1994) 1903-1911
29. Nicolakis P., Kollmitzer J., Crevenna R., Bittner C., Erdogmus C.B., and Nicolakis J. Pulsed magnetic field therapy for osteoarthritis of the knee-a double-blind sham-controlled trial. Wien Klin Wochenschr 114 (2002) 678-684
30. Thamsborg G., Florescu A., Oturai P., Fallentin E., Tritsaris K., and Dissing S. Treatment of knee osteoarthritis with pulsed electromagnetic fields: a randomized, double-blind, placebo-controlled study. Osteoarthritis Cartilage 13 (2005) 575-581
31. White J.A., Blackmore P.F., Schoenbach K.H., and Beebe S.J. Stimulation of capacitative calcium entry in HL-60 cells by nanosecond pulsed electric fields. J Biol Chem 279 (2004) 22964-22972
32. Hartig M., Joos U., and Wiesmann H.P. Capacitively coupled electric fields accelerate proliferation of osteoblast-like primary cells and increase bone extracellular matrix formation in vitro. Eur Biophys J 29 7 (2000) 499-506
33. Bourguignon G.J., Jy W., and Bourguignon L.Y. Electric stimulation of human fibroblasts causes an increase in Ca2+ influx and the exposure of additional insulin receptors. J Cell Physiol 140 2 (1989) 379-385
34. Bourguignon G.J., and Bourguignon L.Y. Electric stimulation of protein and DNA synthesis in human fibroblasts. FASEB J 1 5 (1987 Nov) 398-402
35. Lippiello L., Chakkalakal D., and Connolly J.F. Pulsing direct current-induced repair of articular cartilage in rabbit osteochondral defects. J Orthop Res 8 (1990) 266-275