The LIM domain homeobox gene isl-1 is a positive regulator of glycoprotein alpha 2 (GPA2), a subunit of thyrostimulin

Regulatory Peptides

Volumn 142, Issue 1-2, 2007, Pages 60-67

  Suzuki, Chizuko ^a   Nagasaki, Hiroshi ^b   Okajima, Yoshiki ^a   Suga, Hidetaka ^a   Arima, Hiroshi ^a   Iwasaki, Yasumasa ^b   Oiso, Yutaka ^a  

^a NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b KOCHI MEDICAL SCHOOL   (Japan)

Author keywords

GPA2; GPB5; Isl 1; Pituitary; Thyrostimulin; Transcription factor

Indexed keywords

HOMEODOMAIN PROTEIN; HOMEODOMAIN PROTEIN ISL 1; LIM PROTEIN; LIOTHYRONINE; RNA; THYROID HORMONE RECEPTOR BETA; THYROID HORMONE RECEPTOR BETA1; THYROTROPIN; THYROTROPIN BETA SUBUNIT; UNCLASSIFIED DRUG;

ALPHA CHAIN; ANIMAL CELL; ARTICLE; BINDING SITE; CONCENTRATION RESPONSE; CONTROLLED STUDY; GENE ACTIVITY; GENE IDENTIFICATION; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN FUNCTION; REGULATORY MECHANISM; TRANSCRIPTION INITIATION SITE; TRANSCRIPTION REGULATION;

ANIMALS; BASE SEQUENCE; BLOTTING, WESTERN; CELL LINE; CHROMATIN IMMUNOPRECIPITATION; GENE EXPRESSION REGULATION; GLYCOPROTEINS; HOMEODOMAIN PROTEINS; HUMANS; LUCIFERASES; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PLASMIDS; PROMOTER REGIONS (GENETICS); PROTEIN BINDING; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSCRIPTION INITIATION SITE; TRANSCRIPTION, GENETIC; TRANSFECTION; TRIIODOTHYRONINE;

EID: 34248581351     PISSN: 01670115     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.regpep.2007.01.009     Document Type: Article

References (20)

1. Hsu S.Y., Nakabayashi K., and Bhalla A. Evolution of glycoprotein hormone subunit genes in bilateral metazoa: identification of two novel human glycoprotein hormone subunit family genes, GPA2 and GPB5. Mol. Endocrinol. (Baltim. Md.) 16 (2002) 1538-1551
2. Nagasaki H., Wang Z., Jackson V.R., Lin S., Nothacker H.P., and Civelli O. Differential expression of the thyrostimulin subunits, glycoprotein {α}2 and {β}5 in the rat pituitary. J Mol Endocrinol 37 1 (Aug 2006) 39-50
3. Okada S.L., Ellsworth J.L., Durnam D.M., Haugen H.S., Holloway J.L., Kelley M.L., Lewis K.E., Ren H., Sheppard P.O., Storey H.M., Waggie K.S., Wolf A.C., Yao L.Y., and Webster P.J. A glycoprotein hormone expressed in corticotrophs exhibits unique binding properties on thyroid-stimulating hormone receptor. Mol Endocrinol 20 2 (2006) 414-425
4. Nakabayashi K., Matsumi H., Bhalla A., Bae J., Mosselman S., Hsu S.Y., and Hsueh A.J. Thyrostimulin, a heterodimer of two new human glycoprotein hormone subunits, activates the thyroid-stimulating hormone receptor. J Clin Invest 109 (2002) 1445-1452
5. Macdonald L.E., Wortley K.E., Gowen L.C., Anderson K.D., Murray J.D., Poueymirou W.T., Simmons M.V., Barber D., Valenzuela D.M., Economides A.N., Wiegand S.J., Yancopoulos G.D., Sleeman M.W., and Murphy A.J. Resistance to diet-induced obesity in mice globally overexpressing OGH/GPB5. Proc Natl Acad Sci U S A 102 (2005) 2496-2501
6. Nagaya T., Madison L.D., and Jameson J.L. Thyroid hormone receptor mutants that cause resistance to thyroid hormone. J Biol Chem 267 (1992) 13014-13019
7. Aoki Y., Iwasaki Y., Katahira M., Oiso Y., and Saito H. Regulation of the rat proopiomelanocortin gene expression in Att20 cells. Endocrinology 138 (1997) 1923-1929
8. Tomita A., Buchholz D.R., Obata K., and Shi Y.-B. Fusion protein of retinoic acid receptor with promyelocytic leukemia protein or promyelocytic leukemia zinc finger protein recruits N-CoR-TBLR1 corepressor complex to repress transcription in vivo. J Biol Chem 278 33 (2003) 30788-30795
9. Breous E., Wenzel A., and Loos U. Promoter cloning and characterisation of the transcriptional regulation of the human thyrostimulin A2 subunit. Mol Cell Endocrinol 245 (2005) 169-180
10. Wang M., and Drucker D.J. The LIM domain homeobox gene isl-1 is a positive regulator of islet cell-specific proglucagon gene transcription. J Biol Chem 270 (1995) 12646-12652
11. Wang M., and Drucker D.J. Activation of amylin gene transcription by the LIM domain homeobox gene isl-1. Mol Endocrinol 10 3 (1996) 243-251
12. Karlsson O., Thor S., Norberg T., Ohlsson H., and Edlund T. Insulin gene enhancer binding protein Isl-1 is a member of a novel class of proteins containing both a homeo- and a Cys-His domain. Nature 344 6269 (Apr 26 1990) 879-882
13. Thor S., Ericson J., Brännstršm T., and Edlund T. The homeodomain LIM protein Isl-1 is expressed in subsets of neurons and endocrine cells in the adult rat. Neuron 7 (1991) 881-889
14. Dong J., Asa S.L., and Drucker D.J. Islet cell and extrapancreatic expression of the LIM domain homeobox gene Isl-1. Mol Endocrinol 5 (1991) 1633-1641
15. Pfaff S.L., Mendelsohn M., Stewart C.L., Edlund T., and Jessell T.M. Requirement for LIM homeobox gene Isl-1 in motor neuron generation reveals a motor neuron-dependent step in interneuron differentiation. Cell 84 (1996) 309-320
16. Gradwohl G., Dierich A., Lemeur M., and Guillemot F. Neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas. Proc Natl Acad Sci U S A 97 (2000) 1607-1611
17. Ahlgren U., Pfaff S.L., Jessell T.M., Edlund T., and Edlund H. Independent requirement for ISL1 in formation of pancreatic mesenchyme and islet cells. Nature 385 (1997) 257-260
18. Ericson J., Norlin S., Jessell T.M., and Edlund T. Integrated FGF and BMP signaling controls the progression of progenitor cell differentiation and the emergence of pattern in the embryonic anterior pituitary. Development 125 (1998) 1005-1015
19. Davis A.M., Seney M.L., Walker H.J., and Tobet S.A. Differential colocalization of islet-1 and estrogen receptor in the murine preoptic area and hypothalamus during development. Endocrinology 145 1 (2004) 360-366
20. Gay F., Anglade I., Gong Z., and Salbert G. The LIM/homeodomain protein islet-1 modulates estrogen receptor functions. Mol Endocrinol 14 (2000) 1627-1648