Involvement of the potassium-dependent sodium/calcium exchanger gene product NCKX2 in the brain insult induced by permanent focal cerebral ischemia

Annals of the New York Academy of Sciences

Volumn 1099, Issue , 2007, Pages 486-489

  Cuomo, Ornella ^a   Pignataro, Giuseppe ^a   Gala, Rosaria ^a   Boscia, Francesca ^a   Tortiglione, Anna ^a   Molinaro, Pasquale ^a   Di Renzo, Gianfranco ^a   Lytton, Jonathan ^b   Annunziato, Lucio ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b UNIVERSITY OF CALGARY   (Canada)

Author keywords

Antisense oligodeoxynucleotides; Cerebral ischemia; Na+ Ca2+ exchanger; NCKX2

Indexed keywords

ANTISENSE OLIGODEOXYNUCLEOTIDE; GENE PRODUCT; POTASSIUM; SODIUM CALCIUM EXCHANGE PROTEIN; SODIUM CALCIUM EXCHANGE PROTEIN 2; UNCLASSIFIED DRUG; ANTISENSE OLIGONUCLEOTIDE; POTASSIUM DEPENDENT SODIUM CALCIUM EXCHANGER; POTASSIUM-DEPENDENT SODIUM-CALCIUM EXCHANGER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; BRAIN ISCHEMIA; BRAIN PROTECTION; CONFERENCE PAPER; CONTROLLED STUDY; EXPERIMENTAL MODEL; GENE EXPRESSION; GENE FUNCTION; IN VIVO STUDY; MIDDLE CEREBRAL ARTERY OCCLUSION; NONHUMAN; OSMOTIC MINIPUMP; RAT; ARTICLE; BRAIN; HUMAN; METABOLISM; NUCLEOTIDE SEQUENCE;

BASE SEQUENCE; BRAIN; BRAIN ISCHEMIA; HUMANS; OLIGONUCLEOTIDES, ANTISENSE; POTASSIUM; SODIUM-CALCIUM EXCHANGER;

EID: 34248579027     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1196/annals.1387.051     Document Type: Conference Paper

References (11)

1. 2+ exchanger: from molecular biology to therapeutic perspectives. Pharmacol. Rev. 56: 633-654.
2. BLAUSTEIN M.P. & W.J. LEDERER. 1999. Sodium/calcium exchange: its physiological implications. Physiol. Rev. 79: 763-840
3. REILANDER H., A. ACHILLES, U. FRIEDEL, et al. 1992. Primary structure and functional expression of the Na/Ca,K-exchanger from bovine rod photoreceptors. EMBO J. 11: 1689-1695.
4. TSOI M., K.H. RHEE & D. BUNGARD. 1998. Chromosomal localization and genomic organization of the human retinal rod Na-Ca+K exchanger. Hum. Genet. 103: 411-414.
5. KRAEV A., B.D. QUEDNAU, S. LEACH, et al. 2001. Molecular cloning of a third member of the potassium-dependent sodium-calcium exchanger gene family, NCKX3. J. Biol. Chem. 276: 23161-23172.
6. LI X.F., A.S. KRAEV & J. LYTTON. 2002. Molecular cloning of a fourth member of the potassium-dependent sodium-calcium exchanger gene family, NCKX4. J. Biol. Chem. 277: 48410-48417.
7. 2+ exchanger in cerebral ischemia induced by middle cerebral artery occlusion in male rats. Neuropharmacology 46: 439-448.
8. PIGNATARO G., R. GALA, O. CUOMO, et al. 2004b. Two sodium/calcium exchanger gene products, NCX1 and NCX3, play a major role in the development of permanent focal cerebral ischemia. Stroke 35: 2566-2570.
9. KIEDROWSKI L., A. CZYZ, G. BARANAUSKAS, et al. 2004. Differential contribution of plasmalemmal Na/Ca exchange isoforms to sodium-dependent calcium influx and NMDA excitotoxicity in depolarized neurons. J. Neurochem. 90: 117-128.
10. KRISTIAN T. & B.K. SIESJO. 1998. Calcium in ischemic cell death. Stroke 29: 705-718.
11. YU S.P., C.H. YEH & S.L. SENSI. 1997. Mediation if neuronal apoptosis by enhancement of outward potassium current. Science 278: 114-117.