S-(1,2,2-trichlorovinyl)-L-cysteine sulfoxide, a reactive metabolite of S-(1,2,2-trichlorovinyl)-L-cysteine formed in rat liver and kidney microsomes, is a potent nephrotoxicant

Journal of Pharmacology and Experimental Therapeutics

Volumn 321, Issue 3, 2007, Pages 1095-1101

  Elfarra, Adnan A ^a   Krause, Renee J ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

(1,2,2 TRICHLOROVINYL)CYSTEINE; (1,2,2 TRICHLOROVINYL)CYSTEINE SULFOXIDE; 1 BENZYLIMIDAZOLE; CATALASE; DEFEROXAMINE; POTASSIUM CYANIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SUPEROXIDE DISMUTASE; TETRACHLOROETHYLENE; THIAMAZOLE; TOXIC SUBSTANCE; UNCLASSIFIED DRUG;

ACUTE KIDNEY TUBULE NECROSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; DRUG INHIBITION; HISTOLOGY; KIDNEY METABOLISM; KIDNEY MICROSOME; LIVER METABOLISM; LIVER MICROSOME; MALE; NEPHROTOXICITY; NONHUMAN; OXIDATION; PRIORITY JOURNAL; RAT; UREA NITROGEN BLOOD LEVEL;

ALANINE TRANSAMINASE; AMINOOXYACETIC ACID; ANIMALS; ASPARTATE AMINOTRANSFERASES; BLOOD GLUCOSE; BLOOD UREA NITROGEN; CYSTEINE; CYTOCHROME P-450 ENZYME SYSTEM; ENZYME INHIBITORS; GAMMA-GLUTAMYLTRANSFERASE; GLYCOSURIA; IMIDAZOLES; KIDNEY; LIVER; MALE; METHIMAZOLE; MICROSOMES; MICROSOMES, LIVER; RATS; RATS, SPRAGUE-DAWLEY; SULFHYDRYL COMPOUNDS; SULFOXIDES;

EID: 34248576155     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.107.120444     Document Type: Article

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