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Vitalis T.Z., Keicho N., Itabashi S., Hayashi S., and Hogg J.C. A model of latent adenovirus 5 infection in the guinea pig (Cavia porcellus). Am J Respir Cell Mol Biol 14 (1996) 225-231
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(1996)
Am J Respir Cell Mol Biol
, vol.14
, pp. 225-231
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Vitalis, T.Z.1
Keicho, N.2
Itabashi, S.3
Hayashi, S.4
Hogg, J.C.5
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43
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0031948242
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The effect of latent adenovirus 5 infection on cigarette smoke-induced lung inflammation
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Vitalis T.Z., Kern I., Croome A., Behzad H., Hayashi S., and Hogg J.C. The effect of latent adenovirus 5 infection on cigarette smoke-induced lung inflammation. Eur Respir J 11 (1998) 664-669
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(1998)
Eur Respir J
, vol.11
, pp. 664-669
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Vitalis, T.Z.1
Kern, I.2
Croome, A.3
Behzad, H.4
Hayashi, S.5
Hogg, J.C.6
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44
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0036006795
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Emphysematous lung destruction by cigarette smoke. The effects of latent adenoviral infection on the lung inflammatory response
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Meshi B., Vitalis T.Z., Ionescu D., Elliott W.M., Liu C., Wang X.D., Hayashi S., and Hogg J.C. Emphysematous lung destruction by cigarette smoke. The effects of latent adenoviral infection on the lung inflammatory response. Am J Respir Cell Mol Biol 26 (2002) 52-57
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(2002)
Am J Respir Cell Mol Biol
, vol.26
, pp. 52-57
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Meshi, B.1
Vitalis, T.Z.2
Ionescu, D.3
Elliott, W.M.4
Liu, C.5
Wang, X.D.6
Hayashi, S.7
Hogg, J.C.8
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45
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0030635867
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Adenovirus E1A gene dysregulates ICAM-1 expression in transformed pulmonary epithelial cells
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Keicho N., Elliott W.M., Hogg J.C., and Hayashi S. Adenovirus E1A gene dysregulates ICAM-1 expression in transformed pulmonary epithelial cells. Am J Respir Cell Mol Biol 16 (1997) 23-30
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(1997)
Am J Respir Cell Mol Biol
, vol.16
, pp. 23-30
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Keicho, N.1
Elliott, W.M.2
Hogg, J.C.3
Hayashi, S.4
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46
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0037099249
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Inflammatory mediator mRNA expression by adenovirus E1A-transfected bronchial epithelial cells
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Higashimoto Y., Elliott W.M., Behzad A.R., Sedgwick E.G., Takei T., Hogg J.C., and Hayashi S. Inflammatory mediator mRNA expression by adenovirus E1A-transfected bronchial epithelial cells. Am J Respir Crit Care Med 166 (2002) 200-207
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(2002)
Am J Respir Crit Care Med
, vol.166
, pp. 200-207
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Higashimoto, Y.1
Elliott, W.M.2
Behzad, A.R.3
Sedgwick, E.G.4
Takei, T.5
Hogg, J.C.6
Hayashi, S.7
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47
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0030806360
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Adenovirus E1A upregulates interleukin-8 expression induced by endotoxin in pulmonary epithelial cells
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Keicho N., Elliott W.M., Hogg J.C., and Hayashi S. Adenovirus E1A upregulates interleukin-8 expression induced by endotoxin in pulmonary epithelial cells. Am J Physiol 272 (1997) L1046-L1052
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(1997)
Am J Physiol
, vol.272
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Keicho, N.1
Elliott, W.M.2
Hogg, J.C.3
Hayashi, S.4
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48
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0032886988
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Endotoxin-specific NF-kappaB activation in pulmonary epithelial cells harboring adenovirus E1A
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Keicho N., Higashimoto Y., Bondy G.P., Elliott W.M., Hogg J.C., and Hayashi S. Endotoxin-specific NF-kappaB activation in pulmonary epithelial cells harboring adenovirus E1A. Am J Physiol 277 (1999) L523-L532
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(1999)
Am J Physiol
, vol.277
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Keicho, N.1
Higashimoto, Y.2
Bondy, G.P.3
Elliott, W.M.4
Hogg, J.C.5
Hayashi, S.6
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49
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0033330912
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Effect of adenovirus E1A on ICAM-1 promoter activity in human alveolar and bronchial epithelial cells
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Higashimoto Y., Keicho N., Elliott W.M., Hogg J.C., and Hayashi S. Effect of adenovirus E1A on ICAM-1 promoter activity in human alveolar and bronchial epithelial cells. Gene Expr 8 (1999) 287-297
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(1999)
Gene Expr
, vol.8
, pp. 287-297
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Higashimoto, Y.1
Keicho, N.2
Elliott, W.M.3
Hogg, J.C.4
Hayashi, S.5
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50
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0034822044
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Adenoviral E1A primes alveolar epithelial cells to PM(10)-induced transcription of interleukin-8
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Gilmour P.S., Rahman I., Hayashi S., Hogg J.C., Donaldson K., and MacNee W. Adenoviral E1A primes alveolar epithelial cells to PM(10)-induced transcription of interleukin-8. Am J Physiol Lung Cell Mol Physiol 281 (2001) L598-L606
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(2001)
Am J Physiol Lung Cell Mol Physiol
, vol.281
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Gilmour, P.S.1
Rahman, I.2
Hayashi, S.3
Hogg, J.C.4
Donaldson, K.5
MacNee, W.6
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51
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0037310602
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Adenoviral E1A modulates inflammatory mediator expression by lung epithelial cells exposed to PM10
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Fujii T., Hogg J.C., Keicho N., Vincent R., Van Eeden S.F., and Hayashi S. Adenoviral E1A modulates inflammatory mediator expression by lung epithelial cells exposed to PM10. Am J Physiol Lung Cell Mol Physiol 284 (2003) L290-L297
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(2003)
Am J Physiol Lung Cell Mol Physiol
, vol.284
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Fujii, T.1
Hogg, J.C.2
Keicho, N.3
Vincent, R.4
Van Eeden, S.F.5
Hayashi, S.6
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52
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0346727476
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Latent adenoviral infection induces production of growth factors relevant to airway remodeling in COPD
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Ogawa E., Elliott W.M., Hughes F., Eichholtz T.J., Hogg J.C., and Hayashi S. Latent adenoviral infection induces production of growth factors relevant to airway remodeling in COPD. Am J Physiol Lung Cell Mol Physiol 286 (2004) L189-L197
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(2004)
Am J Physiol Lung Cell Mol Physiol
, vol.286
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Ogawa, E.1
Elliott, W.M.2
Hughes, F.3
Eichholtz, T.J.4
Hogg, J.C.5
Hayashi, S.6
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53
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2942720573
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The nature of small-airway obstruction in chronic obstructive pulmonary disease
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Hogg J.C., Chu F., Utokaparch S., Woods R., Elliott W.M., Buzatu L., Cherniack R.M., Rogers R.M., Sciurba F.C., Coxson H.O., et al. The nature of small-airway obstruction in chronic obstructive pulmonary disease. N Engl J Med 350 (2004) 2645-2653
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(2004)
N Engl J Med
, vol.350
, pp. 2645-2653
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Hogg, J.C.1
Chu, F.2
Utokaparch, S.3
Woods, R.4
Elliott, W.M.5
Buzatu, L.6
Cherniack, R.M.7
Rogers, R.M.8
Sciurba, F.C.9
Coxson, H.O.10
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54
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33845354433
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Induction of intermediate phenotypes in lung epithelial cells by adenovirus E1A
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The results from this study demonstrate that adenovirus E1A induces epithelial to mesenchymal transformation in guinea-pig peripheral lung epithelial cells by reducing the expression of epithelial markers and by promoting mesenchymal phenotypes, including vimentin and smooth muscle α-actin expression. These changes might contribute to the remodeling process observed in the peripheral lung in COPD, in which latent adenovirus infection has been studied as a potential risk factor.
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Behzad A.R., Morimoto K., Gosselink J., Green J., Hogg J.C., and Hayashi S. Induction of intermediate phenotypes in lung epithelial cells by adenovirus E1A. Eur Respir J 28 (2006) 1106-1116. The results from this study demonstrate that adenovirus E1A induces epithelial to mesenchymal transformation in guinea-pig peripheral lung epithelial cells by reducing the expression of epithelial markers and by promoting mesenchymal phenotypes, including vimentin and smooth muscle α-actin expression. These changes might contribute to the remodeling process observed in the peripheral lung in COPD, in which latent adenovirus infection has been studied as a potential risk factor.
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(2006)
Eur Respir J
, vol.28
, pp. 1106-1116
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Behzad, A.R.1
Morimoto, K.2
Gosselink, J.3
Green, J.4
Hogg, J.C.5
Hayashi, S.6
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55
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0033709831
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Latent adenoviral infection modifies the steroid response in allergic lung inflammation
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Yamada K., Elliott W.M., Hayashi S., Brattsand R., Roberts C., Vitalis T.Z., and Hogg J.C. Latent adenoviral infection modifies the steroid response in allergic lung inflammation. J Allergy Clin Immunol 106 (2000) 844-851
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(2000)
J Allergy Clin Immunol
, vol.106
, pp. 844-851
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Yamada, K.1
Elliott, W.M.2
Hayashi, S.3
Brattsand, R.4
Roberts, C.5
Vitalis, T.Z.6
Hogg, J.C.7
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56
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0036152623
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Molecular mechanisms of decreased steroid responsiveness induced by latent adenoviral infection in allergic lung inflammation
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Yamada K., Elliott W.M., Brattsand R., Valeur A., Hogg J.C., and Hayashi S. Molecular mechanisms of decreased steroid responsiveness induced by latent adenoviral infection in allergic lung inflammation. J Allergy Clin Immunol 109 (2002) 35-42
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(2002)
J Allergy Clin Immunol
, vol.109
, pp. 35-42
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Yamada, K.1
Elliott, W.M.2
Brattsand, R.3
Valeur, A.4
Hogg, J.C.5
Hayashi, S.6
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57
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33845467039
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Assessment of adenovirus infection in adult lung transplant recipients using molecular surveillance
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This study shows that not all adenovirus infections in lung transplant patients are associated with the severe consequences reported previously. The authors attribute the source of this discrepancy to (i) the limitation of their patient population to adults rather than the more susceptible pediatric patients, (ii) the greater sensitivity of detection of virus by PCR, and (iii) detection of virus in the plasma as opposed to lung tissue, as well as other technical issues.
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Humar A., Doucette K., Kumar D., Pang X.L., Lien D., Jackson K., and Preiksaitis J. Assessment of adenovirus infection in adult lung transplant recipients using molecular surveillance. J Heart Lung Transplant 25 (2006) 1441-1446. This study shows that not all adenovirus infections in lung transplant patients are associated with the severe consequences reported previously. The authors attribute the source of this discrepancy to (i) the limitation of their patient population to adults rather than the more susceptible pediatric patients, (ii) the greater sensitivity of detection of virus by PCR, and (iii) detection of virus in the plasma as opposed to lung tissue, as well as other technical issues.
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(2006)
J Heart Lung Transplant
, vol.25
, pp. 1441-1446
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Humar, A.1
Doucette, K.2
Kumar, D.3
Pang, X.L.4
Lien, D.5
Jackson, K.6
Preiksaitis, J.7
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