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Volumn 7, Issue 3, 2007, Pages 237-243

Adenovirus infections and lung disease

Author keywords

[No Author keywords available]

Indexed keywords

CIDOFOVIR; E1A PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 8; TRANSFORMING GROWTH FACTOR BETA1; VIRUS DNA; VIRUS VACCINE;

EID: 34248572528     PISSN: 14714892     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.coph.2006.11.014     Document Type: Review
Times cited : (69)

References (57)
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    • The results from this study demonstrate that adenovirus E1A induces epithelial to mesenchymal transformation in guinea-pig peripheral lung epithelial cells by reducing the expression of epithelial markers and by promoting mesenchymal phenotypes, including vimentin and smooth muscle α-actin expression. These changes might contribute to the remodeling process observed in the peripheral lung in COPD, in which latent adenovirus infection has been studied as a potential risk factor.
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    • Assessment of adenovirus infection in adult lung transplant recipients using molecular surveillance
    • This study shows that not all adenovirus infections in lung transplant patients are associated with the severe consequences reported previously. The authors attribute the source of this discrepancy to (i) the limitation of their patient population to adults rather than the more susceptible pediatric patients, (ii) the greater sensitivity of detection of virus by PCR, and (iii) detection of virus in the plasma as opposed to lung tissue, as well as other technical issues.
    • Humar A., Doucette K., Kumar D., Pang X.L., Lien D., Jackson K., and Preiksaitis J. Assessment of adenovirus infection in adult lung transplant recipients using molecular surveillance. J Heart Lung Transplant 25 (2006) 1441-1446. This study shows that not all adenovirus infections in lung transplant patients are associated with the severe consequences reported previously. The authors attribute the source of this discrepancy to (i) the limitation of their patient population to adults rather than the more susceptible pediatric patients, (ii) the greater sensitivity of detection of virus by PCR, and (iii) detection of virus in the plasma as opposed to lung tissue, as well as other technical issues.
    • (2006) J Heart Lung Transplant , vol.25 , pp. 1441-1446
    • Humar, A.1    Doucette, K.2    Kumar, D.3    Pang, X.L.4    Lien, D.5    Jackson, K.6    Preiksaitis, J.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.