Toward breast cancer resistance protein (BCRP) inhibitors: design, synthesis of a series of new simplified fumitremorgin C analogues

Tetrahedron

Volumn 63, Issue 25, 2007, Pages 5510-5528

  Wu, Guofeng ^a   Liu, Jiawang ^a   Bi, Lanrong ^b   Zhao, Ming ^b   Wang, Chao ^a   Baudy Floc'h, Michèle ^d   Ju, Jingfang ^c   Peng, Shiqi ^b  

^a PEKING UNIVERSITY   (China)

^b CAPITAL MEDICAL UNIVERSITY   (China)

^c UNIVERSITY OF SOUTH ALABAMA   (United States)

^d UNIVERSITÉ DE RENNES 1   (France)

Author keywords

Breast cancer resistance protein inhibitors; Coupling; Enantioselective synthesis; Fumitremorgin C analogues; Racemization

Indexed keywords

1,2,3,5,5A,6,11,12,14,14A DECAHYDROPYRROLO[1'',2'':4'5']PYRAZINO[1',2':1,6]PYRIDO[3,4 B]INDOLE 1,4 DIONE; 2,3,6,7,12,12A HEXAHYDROPYRAZINO[1',2':1,6]PYRIDO[3,4 B]INDOLE 1,4 DIONE; 3 (1' HYDROXYETH 1' YL) 2,3,6,7,12,12A HEXAHYDROPYRAZINO[1',2':1,6]PYRIDO[3,4 B]INDOLE 1,4 DIONE; 3 (1' METHYLPROPYL) 2,3,6,7,12,12A HEXAHYDROPYRAZINO[1',2':1,6]PYRIDO[3,4 B]INDOLE 1,4 DIONE; 3 (1',3' IMIDAZOL 5' METHYLENE) 2,3,6,7,12,12A HEXAHYDROPYRAZINO[1',2':1,6]PYRIDO[3,4 B]INDOLE 1,4 DIONE; 3 (2' METHYLPROPYL) 2,3,6,7,12,12A HEXAHYDROPYRAZINO[1',2':1,6]PYRIDO[3,4 B]INDOLE 1,4 DIONE; 3 (3' GUANIDINOPROPYL) 2,3,6,7,12,12A HEXAHYDROPYRAZINO[1',2':1,6]PYRIDO[3,4 B]INDOLE 1,4 DIONE; 3 (4 HYDROXYPHENYLMETHYL) 2,3,6,7,12,12A HEXAHYDROPYRAZINO[1',2':1,6]PYRIDO[3,4 B]INDOLE 1,4 DIONE; 3 (ACETYLAMIN 1' YL) 2,3,6,7,12,12A HEXAHYDROPYRAZINO[1',2':1,6]PYRIDO[3,4 B]INDOLE 1,4 DIONE; 3 (PROPIONAMID 2' YL) 2,3,6,7,12,12A HEXAHYDROPYRAZINO[1',2':1,6]PYRIDO[3,4 B]INDOLE 1,4 DIONE; 3 AMINOBUTYL 2,3,6,7,12,12A HEXAHYDROPYRAZINO[1',2':1,6]PYRIDO[3,4 B]INDOLE 1,4 DIONE; 3 BENZYL 2,3,6,7,12,12A HEXAHYDROPYRAZINO[1',2':1,6]PYRIDO[3,4 B]INDOLE 1,4 DIONE; 3 CARBOXYLETHYL 2,3,6,7,12,12A HEXAHYDROPYRAZINO[1',2':1,6]PYRIDO[3,4 B]INDOLE 1,4 DIONE; 3 CARBOXYLMETHYL 2,3,6,7,12,12A HEXAHYDROPYRAZINO[1',2':1,6]PYRIDO[3,4 B]INDOLE 1,4 DIONE; 3 HYDROXYMETHYL 2,3,6,7,12,12A HEXAHYDROPYRAZINO[1',2':1,6]PYRIDO[3,4 B]INDOLE 1,4 DIONE; 3 INDOLYLMETHYL 2,3,6,7,12,12A HEXAHYDROPYRAZINO[1',2':1,6]PYRIDO[3,4 B]INDOLE 1,4 DIONE; 3 ISOPROPYL 2,3,6,7,12,12A HEXAHYDROPYRAZINO[1',2':1,6]PYRIDO[3,4 B]INDOLE 1,4 DIONE; 3 MERCAPTOMETHYL 2,3,6,7,12,12A HEXAHYDROPYRAZINO[1',2':1,6]PYRIDO[3,4 B]INDOLE 1,4 DIONE; 3 METHYL 2,3,6,7,12,12A HEXAHYDROPYRAZINO[1',2':1,6]PYRIDO[3,4 B]INDOLE 1,4 DIONE; 3 METHYLMERCAPTOETHYL 2,3,6,7,12,12A HEXAHYDROPYRAZINO[1',2':1,6]PYRIDO[3,4 B]INDOLE 1,4 DIONE; BREAST CANCER RESISTANCE PROTEIN INHIBITOR; DOXORUBICIN; ELACRIDAR; FUMITREMORGIN C; FUMITREMORGIN C DERIVATIVE; IMATINIB; PROTEIN INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; BREAST CANCER; CONTROLLED STUDY; DRUG DESIGN; DRUG MECHANISM; DRUG SYNTHESIS; HUMAN; HUMAN CELL; PRIORITY JOURNAL;

EID: 34248560759     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tet.2007.04.045     Document Type: Article

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