Part-human chimeras: Worrying the facts, probing the ethics

American Journal of Bioethics

Volumn 7, Issue 5, 2007, Pages 41-45

  Baylis, Franoise ^a   Robert, Jason Scott ^b  

^a DALHOUSIE UNIVERSITY   (Canada)

^b ARIZONA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL; CANADA; CHIMERA; HISTOCOMPATIBILITY; HUMAN; LEGAL ASPECT; MOUSE; NERVE CELL; NOMENCLATURE; PRACTICE GUIDELINE; RESEARCH; RESEARCH ETHICS; REVIEW; STANDARD; TRANSPLANTATION;

ANIMALS; CANADA; CHIMERA; ETHICS, RESEARCH; GUIDELINES; HUMANS; MICE; NEURONS; RESEARCH; TERMINOLOGY; TRANSPLANTATION CHIMERA;

EID: 34248526195     PISSN: 15265161     EISSN: 15360075     Source Type: Journal    
DOI: 10.1080/15265160701290397     Document Type: Review

References (26)

1. Almeida-Porada, G., C. Porada, and E. D. Zanjani. 2004. The fetal sheep: A unique model system for assessing the full differentiative potential of human stem cells. Yonsei Medical Journal 45: 7-14.
2. Almeida-Porada, G., K. Crapnell, C. Porada, et al. 2005. In vivo haematopoietic potential of human neural stem cells. British Journal of Haemotology. 130(2): 276-283.
3. Appel, J. M. 2006. The monster's laws: A legal history of chimera research. Genewatch 19(2): 12-16.
4. Assisted Human Reproduction Act, Canada. 2004. c. 2 (assented to March 29, 2004). Available at http://www2.parl.gc.ca/HousePublications/ Publication.aspx?DocId=2331612&Language=e&Mode=1 (accessed February 15, 2007).
5. Baylis, F., and J.S. Robert. 2006a. Human embryonic stem cell research: an argument for national research review. Accountability in Research 13(3): 207-224.
6. Baylis, F., and J.S. Robert. 2006b. Primer on ethics and crossing species boundaries. Actionbioscience.org. Available at http://www. actionbioscience.org/biotech/baylis_robert.html (accessed February 15, 2007).
7. Baylis, F., and A. Fenton. 2007. Chimera research and stem cell therapies for human neurodegenerative disorders. Cambridge Quarterly of Healthcare Ethics 16(2): 195-208.
8. Canadian Institutes of Health Research. 2002. Human pluripotent stem cell research: Guidelines for CIHR-funded research (March 4). Available at http://www.cihr-irsc.gc.ca/e/1487.html (accessed February 15, 2007).
9. Canadian Institutes of Health Research. 2005. Guidelines for human pluripotent stem cell research (June 7). Available from http://www.irsc.gc. ca/e/28216.html (accessed February 15, 2007).
10. Canadian Institutes of Health Research. 2006. Updated guidelines for human pluripotent stem cell research (June 28). Available from http://www.irsc.gc.ca/e/31488.html (accessed February 15, 2007).
11. Greely, H. T., M. K. Cho, L. F. Hogle, and D. M. Satz. 2007. Thinking about the human neuron mouse. American Journal of Bioethics (AJOB-Neuroscience) 7(5): 27-40.
12. Greene, M., K. Schill, S. Takahashi, et al. 2005. Ethics: Moral issues of human-non-human primate neural grafting. Science 309(5733): 385-386.
13. Karpowicz, P., C.B. Cohen, and D. van der Kooy. 2004. It is ethical to transplant human stem cells into nonhuman embryos. Nature Medicine 10(4): 331-335.
14. Karpowicz, P., C. B. Cohen, and D. van der Kooy. 2005. Developing human-nonhuman chimeras in human stem cell research: Ethical issues and boundaries. Kennedy Institute of Ethics Journal 15(2): 107-134.
15. Kopinski, N. 2004. Human-nonhuman chimeras: A regulatory proposal on the blurring of species lines. Boston College Law Review 45(3): 619-666.
16. Lill, W. 2007. Chimera. World Premiere at the Tarragon Theatre, Toronto (January 1-February 11, 2007).
17. Magnus, D. 2006. Ask the bioethicist: Watching the chimeras. Stanford Medicine (Summer). Available at http://mednews.stanford.edu/stanmed/ 2006summer/bioethicist.html (accessed February 15, 2007).
18. Medical Research Council of Canada, Natural Sciences and Engineering Research Council of Canada, and Social Sciences and Humanities Research Council of Canada. 1998. Tri-council policy statement ethical conduct for research involving humans. Ottawa, ONT: Medical Research Council of Canada. Available at http://www.pre.ethics.gc.ca/english/pdf/TCPS%20June2003_E.pdf (accessed February 15, 2007).
19. Muotri, A. R., K. Nakashima, N. Toni, V. M. Sandler, and F. H. Gage. 2005. Development of functional human embryonic stem cell-derived neurons in mouse brain. Proceedings of the National Academy of Sciences USA 102(51): 18644-18648.
20. National Research Council (U.S.), Committee on Guidelines for Human Embryonic Stem Cell Research, Institute of Medicine, and Board on Health Sciences Policy. 2005. Guidelines for human embryonic stem cell research. Washington, DC: National Academies Press.
21. Robert, J. S. 2002. Regulating the creation of novel beings. Health Law Review 11(1): 14-19.
22. Robert, J. S. 2004. Model systems in stem cell biology. Bioessays 26(9): 1005-1012.
23. Robert, J. S. 2006. The science and ethics of making part-human animals in stem cell biology. FASEB Journal 20(7): 838-845.
24. Robert, J. S., and F. Baylis. 2003. Crossing species boundaries. American Journal of Bioethics 3(3): 1-13.
25. Robert, J. S., and F. Baylis. 2005. Stem cell politics: The NAS prohibitions pack more bark than bite. Hastings Center Report 35(6): 15-16.
26. Streiffer, R. 2005. At the edge of humanity: Human stem cells, chimeras, and moral status. Kennedy Institute of Ethics Journal 15(4): 347-370.