Reactions of [4-[bis(2-chloroethyl)amino]phenyl}acetic acid (phenylacetic acid mustard) with d′-deoxyribonucleosides

Chemistry and Biodiversity

Volumn 4, Issue 3, 2007, Pages 406-423

  Florea Wang, Diana ^a   Ijä, Inna ^a   Hakala, Kristo ^a   Mattinen, Jorma ^b   Vilpo, Juhani ^c   Hovinen, Jari ^a,d  

^a UNIVERSITY OF TURKU   (Finland)

^b ÅBO AKADEMI UNIVERSITY   (Finland)

^c TAMPERE UNIVERSITY HOSPITAL   (Finland)

^d PerkinElmer Finland Oy   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

4 [BIS(2 CHLOROETHYL)AMINO]PHENOL; ANTINEOPLASTIC AGENT; CHLORAMBUCIL; CHLORAMBUCIL DERIVATIVE; CYTIDINE DERIVATIVE; DEOXYADENOSINE; DEOXYCYTIDINE; DEOXYGUANOSINE; DEOXYRIBONUCLEOSIDE; NUCLEOSIDE DERIVATIVE; PYRIMIDINE NUCLEOSIDE DERIVATIVE; THYMIDINE; UNCLASSIFIED DRUG; MUSTARD GAS DERIVATIVE; PHENYLACETIC ACID; PHENYLACETIC ACID DERIVATIVE;

ARTICLE; CHEMICAL ANALYSIS; CHEMICAL REACTION; CHEMICAL STRUCTURE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOTOXICITY; DRUG STABILITY; DRUG STRUCTURE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROLYSIS; MASS SPECTROMETRY; PH; PROTON NUCLEAR MAGNETIC RESONANCE; ULTRAVIOLET SPECTROSCOPY; CHEMISTRY; METABOLISM;

CHLORAMBUCIL; DEOXYRIBONUCLEOSIDES; MUSTARD COMPOUNDS; PHENYLACETATES;

EID: 34248524650     PISSN: 16121872     EISSN: 16121880     Source Type: Journal    
DOI: 10.1002/cbdv.200790033     Document Type: Article

References (27)

1. C. B. Faguet, J. Clin. Oncol. 1994, 12, 1974.
2. B. D. Cheson, 'Chronic Lymphocytic Leukemia - Scientific Advances and Clinical Developments', Marcel Dekker, New York, 1993.
3. M. J. Lind, C. Ardiet, Cancer Surv. 1993, 17, 157.
4. B. Singer, J. T. Kusmierek, Annu. Rev. Biochem. 1982, 52, 655.
5. J. E. F. Reynolds, 'Martindale: The Extra Pharmacopoeia', 31st edn., Royal Pharmaceutical Society, London, 1996, p. 550.
6. W. B. Pratt, R. W. Ruddon, W. D Ensminger, J. Maybaum, 'The Anticancer Drugs', 2nd edn., Oxford University Press, New York, 1994, Chapt. 6.
7. A. McLean, D. Newell, G. Baker, T. Connors, Biochem. Pharmacol. 1980, 29, 2039.
8. L. Bastholt, C. J. Johansson, P. Pfeiffer, L. Svensson, P. O. Johansson, P. O. Gunnarsson, Cancer Chemother. Pharmacol. 1991, 28, 205.
9. N. H. Greig, E. M. Daly, D. J. Sweeney, S. I. Rapoport, Cancer Chemother. Pharmacol. 1990, 25, 320.
10. M. M. Oppitz, E. Musch, M. Malek, H. P. Rub, G. E. von Unruh, U. Loos, B. Mühlenbruch, Cancer Chemother. Pharmacol. 1989, 23, 208.
11. E. Haapala, K. Hakala, E. Jokipelto, J. Vilpo, J. Hovinen, Chem. Res. Toxicol. 2001, 14, 988.
12. D. Florea-Wang, E. Haapala, J. Mattinen, K. Hakala, J. Vilpo, J. Hovinen, Chem. Res. Toxicol. 2003, 16, 403.
13. D. Florea-Wang, E. Haapala, J. Mattinen, K. Hakala, J. Vilpo, J. Hovinen, Chem. Res. Toxicol. 2004, 17, 383.
14. T. Fujii, T. Itaya, Heterocycles 1998, 48, 359.
15. B. Singer, L. Sun, H. Fraenkel-Conrat, Biochemistry 1974, 13, 1913.
16. B. Singer, D. Grunberger, 'Molecular Biology of Mutagens and Carcinogens', Plenum Press, New York, 1983.
17. K. Hemminki, 'DNA Adducts: Identification and Biological Significance', IACR Scientific Publications, Lyon, 1994, p. 313.
18. T. Pettersson-Fernholm, J. Vilpo, M. Kosonen, K. Hakala, J. Hovinen, J. Chem. Soc., Perkin Trans. 2 1999, 2183.
19. J. Kusmierek, R. Käppi, K. Neuvonen, D. Shugar, H. Lönnberg, Acta Chem. Scand. 1989, 43, 196.
20. F. Y. Lee, P. Coe, P. Workman, Cancer Chemother. Pharmacol. 1986, 17, 21.
21. P. E. Mirkes, J. C. Greenaway, Teratology 1982, 26, 135.
22. F. Drablos, A. Feyzi, P. A. Aas, C. B. Vaagbo, B. Kavli, M. S. Bratlie, J. Pena-Diaz, M. Otterlei, G. Slupphaug, H. E. Krokan, DNA Repair 2004, 2, 1389.
23. L. Panasci, J.-P. Paiement, G. Christodoulopoulos, A. Belenkov, A. Malapetsa, R. Aloyz, Clin. Cancer Res. 2001, 7, 424.
24. C. Salmelin, J. Hovinen, J. Vilpo, Mutation Res. 2000, 467, 129.
25. B. Sedgwick, P. A. Bates, J. Paik, S. C. Jacobs, T. Lindahl, DNA Repair 2007, in press.
26. E. C. Friedberg, G. C. Walker, W. Siede, R. D. Wood, R. A. Schultz, T. Ellenberger, 'DNA Repair and Mutagenesis', 2nd edn., ASM Press, Wahington, D.C., 2006, Chapt. 17.
27. J. Hovinen, Acta Chem. Scand. 1996, 50, 1174.