Cytogenetic effects of extremely low frequency magnetic field on Wistar rat bone marrow

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 630, Issue 1-2, 2007, Pages 69-77

  Erdal, Nurten ^a   Gürgül, Serkan ^a   Çelik, Ayla ^a  

^a MERSIN UNIVERSITY   (Turkey)

Author keywords

Chromosomal aberration; Extremely low frequency magnetic fields; Micronucleus formation; Mitotic index; The ratio of polychromatic erythrocytes to normochromatic erythrocytes; Wistar rat

Indexed keywords

MITOMYCIN C;

ACUTE TOXICITY; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BONE MARROW TOXICITY; CHROMOSOME ABERRATION; CHROMOSOME ANALYSIS; CONTROLLED STUDY; CYTOGENETICS; CYTOTOXICITY; DISEASE PREDISPOSITION; ERYTHROCYTE MEMBRANE; FEMALE; GENOTOXICITY; LONG TERM EXPOSURE; MAGNETIC FIELD; MICRONUCLEUS TEST; MITOSIS INDEX; NONHUMAN; PRIORITY JOURNAL; RADIATION MUTAGENESIS; RAT; STATISTICAL SIGNIFICANCE; TIBIA;

ANIMALS; BONE MARROW CELLS; CHROMOSOME ABERRATIONS; ELECTROMAGNETIC FIELDS; ERYTHROCYTES; MICRONUCLEUS TESTS; MITOTIC INDEX; RATS; RATS, WISTAR;

HELIOTHIS ZEA VIRUS 1; MAMMALIA; RATTUS NORVEGICUS;

EID: 34248512090     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mrgentox.2007.03.001     Document Type: Article

References (53)

1. Wertheimer N., and Leeper E. Electrical wiring configurations and childhood cancer. Am. J. Epidemiol. 109 (1979) 273-284
2. Wertheimer N., and Leeper E. Adult cancer related to electrical wires near the home. Int. J. Epidemiol. 11 (1982) 345-355
3. Milham S. Mortality from leukemia in workers exposed to electrical and magnetic fields. N. Engl. J. Med. 307 (1982) 249
4. McDowall M.E. Leukemia mortality in electrical workers in England and Wales. Lancet (1983) 246
5. Coleman M., Bell J., and Skeet R. Leukemia incidence in electrical workers. Lancet (1983) 982-983
6. Fulton J.P., Cobb S., Preble L., Leone L., and Forman E. Electrical wiring configurations and childhood leukemia in Rhode Island. Am. J. Epidemiol. 111 (1980) 292-296
7. Coleman M., Bell C.M., Taylor H.L., and Thornton-Jones J. Leukemia and electromagnetic fields: a case-control study. Proceedings of the International Conference on Electric and Magnetic Fields in Medicine and Biology. London, December 4-5, 1985 (1985) 122-125
8. Myers A., Cartwright R.A., Bonell J.A., Maled C., and Cartwright S.C. Overhead power lines and childhood cancer. Proceedings of the International Conference on Electric and Magnetic Fields in Medicine and Biology. London, December 4-5, 1985 (1985) 126-130
9. Nordenson I., Hansson Mild K., Nordstroém S., Sweins A., and Bikre E. Clastogenic effects in lymphocytes of power frequency electric fields: in vivo and in vitro studies. Radiat. Environ. Biophys. 23 (1984) 191-201
10. D'Ambrosio G., Scaglione A., Di Berardino D., Lioi M.B., Lannuzzi L., Mostacciuolo E., and Scarfi M.R. Chromosomal aberrations induced by ELF electric fields. J. Bioelectricity 4 (1985) 279-284
11. Nordenson I., Hansson Mild K., Ostman U., and Ljungberg H. Chromosomal effects in lymphocytes of 400 kV-substation workers. Radiat. Environ. Biophys. 27 (1988) 39-47
12. Skyberg K., Hansteen I.L., and Vistnes A. Chromosome aberrations in lymphocytes of high voltage laboratory cable slicers exposed to electromagnetic fields. Scand. J. Work Environ. Health 19 (1993) 29-34
13. Valjus J., Norppa H., Jarventaus H., Sorsa M., Nykyri E., Salomaa S., Jarvinen P., and Kajander J. Analysis of chromosomal aberrations, sister chromatid exchanges and micronuclei among power linesmen with long-term exposure to 50-Hz electromagnetic fields. Radiat. Environ. Biophys. 32 (1993) 325-336
14. Jelmert O., Hansteen I.L., and Langerd S. Chromosome damage in lymphocytes of stainless steel welders related to past and current exposure to manual metal arc welding fumes. Mutat. Res. 320 (1994) 223-233
15. I. Nordenson, K. Hansson Mild, A. Berglund, M. Sandström, Chromosomal Aberrations in Lymphocytes of Engine Drivers, National Institute for Working Life, Arbetslivsrapport, 1997, 1 (in Swedish).
16. Schmid W. Chemical mutagen testing on in vivo somatic mammalian cells. Agents Actions 3 (1973) 77-85
17. Heddle J.A. A rapid in vivo test for chromosomal damage. Mutat. Res. 18 (1973) 187-190
18. NRPB, Electromagnetic fields and the risk of cancer, Report of an advisory group on non-ionising radiation, NRPB document 3 (Suppl. 1) (1992) 1-138.
19. Verschaeve L. Can non-ionizing radiation induce cancer?. Cancer J. 5 (1995) 237-249
20. Tenforde T.S. Interaction of ELF magnetic fields with living systems. In: Polk C., and Postow E. (Eds). Biological Effects of Electromagnetic Fields (1996), CRC Press, Boca Raton 185-230
21. Tofani S., Ferrara A., Anglesio L., and Gilli G. Evidence for genotoxic effects of resonant ELF magnetic fields. Bioelectrochem. Bioenerget. 36 Suppl. 5 (1995) 9-13
22. Lai H., and Singh N.P. Acute exposure to a 60 Hz magnetic field increases DNA strand breaks in rat brain cells. Bioelectromagnetics 18 Suppl. 2 (1997) 156-165
23. Cho Y.H., and Chung H.W. The effect of extremely low frequency electromagnetic fields (ELF-EMF) on the frequency of micronuclei and sister chromatid exchange in human lymphocytes induced by benzo(a)pyrene. Toxicol. Lett. 143 1 (2003) 37-44
24. Sert C., Mustafa D., Duz M.Z., Aksen F., and Kaya A. The preventive effect on bone loss of 50-Hz, 1-mT electromagnetic field in ovariectomized rats. J. Bone Miner. Metab. 20 6 (2002) 345-349
25. Hayashi M., Tice R.R., MacGregor J.T., Anderson D., Blakey D.H., Kirsh-Volders M., Oleson Jr. F.B., Pacchierotti F., Romagna F., Shimada H., Sutou S., and Vannier B. In vivo rodent erythrocyte micronucleus assay. Mutat. Res. 312 (1994) 293-304
26. Adler I.D. Cytogenetic tests in mammals. In: Venitt S., and Parry J.M. (Eds). Mutagenicity Testing, A Practical Approach (1984), IRL Press 275-306
27. Schmid W. The micronucleus test for cytogenetic analysis. In: Hollaender A. (Ed). Chemical Mutagens, Principles and Methods for Their Detection vol. 4 (1976), Plenum Press, New York 31-53
28. Agarwal D.K., and Chauhan L.K.S. An improved chemical substitute for fetal calf serum for the micronucleus test. Biotechnol. Histochem. 68 (1993) 187-188
29. Cohen M.M., Kunska A., Astemborski J.A., and McCulloch D. The effect of low-level 60-Hz electromagnetic fields on human lymphoid cells. II. Sister-chromatid exchanges in peripheral lymphocytes and lymphoblastoid cell lines. Mutat. Res. 172 2 (1986) 177-184
30. Cohen M.M., Kunska A., Astemborski J.A., McCulloch D., and Paskewitz D.A. Effect of low-level, 60-Hz electromagnetic fields on human lymphoid cells. I. Mitotic rate and chromosome breakage in human peripheral lymphocytes. Bioelectromagnetics 7 4 (1986) 415-423
31. Paile W., Jokela K., Koivistonen A., and Saloma S. Effects of sinusoidal magnetic fields and spark charges on human lymphocytes in vitro. Bioelectochem. Bioenerget. 36 (1995) 15-22
32. Scarfi M.R., Lioi M.B., Zeni O., Della Noce M., Franceschi C., and Bersani F. Micronucleus frequency and cell proliferation in human lymphocytes exposed to 50 Hz sinusoidal magnetic fields. Health Phys. 76 Suppl. 3 (1999) 244-250
33. Maes A., Collier M., Vandoninck S., Scarpa P., and Verschaeve L. Cytogenetic effects of 50 Hz magnetic fields of different magnetic flux densities. Bioelectromagnetics 21 (2000) 589-596
34. Verheyen G.R., Pauwels G., Verschaeve L., and Schoeters G. Effect of coexposure to 50 Hz magnetic fields and an aneugen on human lymphocytes, determined by the cytokinesis block micronucleus assay. Bioelectromagnetics 24 Suppl. 3 (2003) 160-164
35. McCann J., Dietrich F., Rafferty C., and Martin A.O. A critical review of the genotoxic potential of electric and magnetic fields. Mutat. Res. 297 Suppl. 1 (1993) 61-95
36. Murphy J.C., Kaden D.A., Warren J., and Sivak A. Power frequency electric and magnetic fields: a review of genetic toxicology. Mutat. Res. 296 (1993) 221-240
37. McCann J., Dietrich F., and Rafferty C. The genotoxic potential of electric and magnetic fields: an update. Mutat. Res. 411 Suppl. 1 (1998) 45-86
38. Simko M., Kriehuber R., Weiss D.G., and Luben R.A. Effects of 50 Hz EMF exposure on micronucleus formation and apoptosis in transformed and nontransformed human cell lines. Bioelectromagnetics 19 Suppl. 2 (1998) 85-91
39. Simko M., Kriehuber R., and Lange S. Micronucleus formation in human amnion cells after exposure to 50 Hz MF applied horizontally and vertically. Mutat. Res. 418 Suppl. 2-3 (1998) 101-111
40. Repacholi M.H., and Greenebaum B. Interaction of static and extremely low frequency electric and magnetic fields with living systems: health effects and research needs. Bioelectromagnetics 20 Suppl. 3 (1999) 133-160
41. Walleczek J., Shiu E.C., and Hahn G.M. Increase in radiation-induced HPRT gene mutation frequency after nonthermal exposure to nonionizing 60 Hz electromagnetic fields. Radiat. Res. 151 Suppl. 4 (1999) 489-497
42. Loberg L.I., Luther M.J., Gauger J.R., and McCormick D.L. 60 Hz magnetic fields do not enhance cell killing by genotoxic chemicals in Ataxia telangiectasia and normal lymphoblastoid cells. Radiat. Res. 153 5 Pt 2 (2000) 685-689
43. Heredia-Rojas J.A., Rodriguez-de la Fuente A.O., del Roble Velazco-Campos M., Leal-Garza C.H., Rodriguez-Flores L.E., and de la Fuente-Cortez B. Cytological effects of 60 Hz magnetic fields on human lymphocytes in vitro: sister-chromatid exchanges, cell kinetics and mitotic rate. Bioelectromagnetics 22 (2001) 145-149
44. Stronati L., Testa A., Villani P., Marino C., Lovisolo G.A., Conti D., Russo F., Fresegna A.M., and Cordelli E. Absence of genotoxicity in human blood cells exposed to 50 Hz magnetic fields as assessed by comet assay, chromosome aberration, micronucleus, and sister chromatid exchange analyses. Bioelectromagnetics 25 Suppl. 1 (2004) 41-48
45. Testa A., Cordelli E., Stronati L., Marino C., Lovisolo G.A., Fresegna A.M., Conti D., and Villani P. Evaluation of genotoxic effect of low level 50 Hz magnetic fields on human blood cells using different cytogenetic assays. Bioelectromagnetics 25 (2004) 613-619
46. Fatigoni C., Dominici L., Moretti M., Villarini M., and Monarca S. Genotoxic effects of extremely low frequency (ELF) magnetic fields (MF) evaluated by the tradescantia-micronucleus assay. Environ. Toxicol. 20 (2005) 585-591
47. Winkler R., Ivancsits S., Pilger A., Adlkofer F., and Rüdiger H.W. Chromosomal damage in human diploid fibroblasts by intermittent exposure to extremely low-frequency electromagnetic fields. Mutat. Res. 585 (2005) 43-49
48. Suzuki Y., Nagae Y., Li J., Sabaka H., Mozawa K., Takahashi A., and Shimizu H. The micronucleus test and erythropoiesis: effects of erythropoietin and a mutagen on the ratio of polychromatic to normochromatic erythrocytes (P:N ratio). Mutagenesis 4 (1989) 420-424
49. Scott G. Free radicals provide a mechanism for EMFs to promote cancer. Electromagnetic News 3 (1992) 6-8
50. Grissom C.B. Magnetic field effects in biology: a survey of possible mechanisms with emphasis on radical-pair recombination. Chem. Rev. 95 (1995) 3-24
51. Phillips J.L., Campell-Beachler M., Ishida-Jones T., Haggren W., and Adey W.R. Exposure of PC12 cells to a 1 G sinusoidal magnetic field at 60 Hz: effect on the activity of the DNA repair enzyme poly(ADP-ribose) polymerase. Paper presented at the Annual Review of Research on Biological Effects of Electric and Magnetic Fields from the Generation, Delivery and Use of Electricity. Palm Springs, CA, November 12-16 (1995)
52. Brocklehurst B., and McLauchlin K.A. Free radical mechanism for the effects of environmental electromagnetic fields on biological systems. Int. J. Radiat. Biol. 69 (1996) 3-24
53. Lee B.C., Johng H.M., Lim J.K., Jeong J.H., Baik K.Y., and Sohn U.D. Effects of extremely low frequency magnetic field on the antioxidant defense system in mouse brain: a chemiluminescence study. J. Photochem. Photobiol. B 73 (2004) 43-48