메뉴 건너뛰기




Volumn 9, Issue 3, 2007, Pages 170-176

Pancreatic cancer: An update

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; BEVACIZUMAB; CAPECITABINE; CETUXIMAB; CISPLATIN; DOCETAXEL; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE; ERLOTINIB; EXATECAN; FLUOROPYRIMIDINE; FLUOROURACIL; FOLINIC ACID; GEMCITABINE; GEMCITABINE PLUS OXALIPLATIN; GEMOX; IRINOTECAN; MARIMASTAT; OXALIPLATIN; PEMETREXED; PLACEBO; TANOMASTAT; UNCLASSIFIED DRUG; VASCULOTROPIN;

EID: 34248401996     PISSN: 15233790     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11912-007-0018-z     Document Type: Review
Times cited : (31)

References (35)
  • 1
    • 33645526144 scopus 로고    scopus 로고
    • Cancer statistics, 2006
    • Jemal A, Siegel R, Ward E, et al.: Cancer statistics, 2006. CA J Clin 2006, 56:106-130.
    • (2006) CA J Clin , vol.56 , pp. 106-130
    • Jemal, A.1    Siegel, R.2    Ward, E.3
  • 2
    • 0344742274 scopus 로고    scopus 로고
    • Cancer survival and incidence from the Surveillance, Epidemiology, and End Results (SEER) program
    • Gloeckler Ries LA, Reichman ME, Lewis DR, et al.: Cancer survival and incidence from the Surveillance, Epidemiology, and End Results (SEER) program. Oncologist 2003, 8:541-552.
    • (2003) Oncologist , vol.8 , pp. 541-552
    • Gloeckler Ries, L.A.1    Reichman, M.E.2    Lewis, D.R.3
  • 3
    • 8244254377 scopus 로고    scopus 로고
    • Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: A randomized trial
    • Burris HA III, Moore MJ, Andersen J, et al.: Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial. J Clin Oncol 1997, 15:2403-2413.
    • (1997) J Clin Oncol , vol.15 , pp. 2403-2413
    • Burris III, H.A.1    Moore, M.J.2    Andersen, J.3
  • 4
    • 18744407041 scopus 로고    scopus 로고
    • Chemotherapy for advanced pancreatic cancer: Past, present, and future
    • Friberg G, Kindler HL: Chemotherapy for advanced pancreatic cancer: past, present, and future. Curr Oncol Rep 2005, 7:186-195.
    • (2005) Curr Oncol Rep , vol.7 , pp. 186-195
    • Friberg, G.1    Kindler, H.L.2
  • 5
    • 34248344005 scopus 로고    scopus 로고
    • Moore MJ, Goldstein D, Hamm J, et al.: Erlotinib plus gemcitabine compared to gemcitabine alone in patients with advanced pancreatic cancer. A phase III trial of the National Cancer Institute of Canada Clinical Trials Group [NCIC-CTG] [abstract]. Proc ASCO 2005, 23(16S):1s.
    • Moore MJ, Goldstein D, Hamm J, et al.: Erlotinib plus gemcitabine compared to gemcitabine alone in patients with advanced pancreatic cancer. A phase III trial of the National Cancer Institute of Canada Clinical Trials Group [NCIC-CTG] [abstract]. Proc ASCO 2005, 23(16S):1s.
  • 6
    • 29344476191 scopus 로고    scopus 로고
    • Phase III randomised comparison of gemcitabine (GEM) versus gemcitabine plus capecitabine (GEM-CAP) in patients with advanced pancreatic cancer
    • Cunningham D, Chau I, Stocken C, et al.: Phase III randomised comparison of gemcitabine (GEM) versus gemcitabine plus capecitabine (GEM-CAP) in patients with advanced pancreatic cancer. Eur J Cancer 2005, 3(Suppl):S4.
    • (2005) Eur J Cancer , vol.3 , Issue.SUPPL.
    • Cunningham, D.1    Chau, I.2    Stocken, C.3
  • 7
    • 34248336449 scopus 로고    scopus 로고
    • Poplin E, Levy DE, Berlin J, et al.: Phase III trial of gemcitabine (30-minute infusion) versus gemcitabine (fixed-dose-rate infusion [FDR]) versus gemcitabine + oxaliplatin (GEMOX) in patients with advanced pancreatic cancer (E6201) [abstract]. Proc ASCO 2006, 24:LBA4004.
    • Poplin E, Levy DE, Berlin J, et al.: Phase III trial of gemcitabine (30-minute infusion) versus gemcitabine (fixed-dose-rate infusion [FDR]) versus gemcitabine + oxaliplatin (GEMOX) in patients with advanced pancreatic cancer (E6201) [abstract]. Proc ASCO 2006, 24:LBA4004.
  • 9
    • 0141688333 scopus 로고    scopus 로고
    • Comparison of gemcitabine versus the matrix metalloproteinase inhibitor BAY 12-9566 in patients with advanced or metastatic adenocarcinoma of the pancreas: A phase III trial of the National Cancer Institute of Canada Clinical Trials Group
    • Moore MJ, Hamm J, Dancey J, et al.: Comparison of gemcitabine versus the matrix metalloproteinase inhibitor BAY 12-9566 in patients with advanced or metastatic adenocarcinoma of the pancreas: A phase III trial of the National Cancer Institute of Canada Clinical Trials Group. J Clin Oncol 2003, 21:3296-3302.
    • (2003) J Clin Oncol , vol.21 , pp. 3296-3302
    • Moore, M.J.1    Hamm, J.2    Dancey, J.3
  • 10
    • 0035424135 scopus 로고    scopus 로고
    • Marimastat as first-line therapy for patients with unresectable pancreatic cancer: A randomized trial
    • Bramhall SR, Rosemurgy A, Brown PD, et al.: Marimastat as first-line therapy for patients with unresectable pancreatic cancer: a randomized trial. J Clin Oncol 2001, 19:3447-3455.
    • (2001) J Clin Oncol , vol.19 , pp. 3447-3455
    • Bramhall, S.R.1    Rosemurgy, A.2    Brown, P.D.3
  • 11
    • 18744367197 scopus 로고    scopus 로고
    • Phase III results of exatecan (DX-8951f) versus gemcitabine (Gem) in chemotherapy-naïve patients with advanced pancreatic cancer (APC) [abstract]
    • 314s
    • Cheverton P, Friess H, Andras C, et al.: Phase III results of exatecan (DX-8951f) versus gemcitabine (Gem) in chemotherapy-naïve patients with advanced pancreatic cancer (APC) [abstract]. Proc ASCO 2004, 23:314s.
    • (2004) Proc ASCO , vol.23
    • Cheverton, P.1    Friess, H.2    Andras, C.3
  • 12
    • 0036682041 scopus 로고    scopus 로고
    • Phase III study of gemcitabine in combination with fluorouracil versus gemcitabine alone in patients with advanced pancreatic carcinoma: Eastern Cooperative Oncology Group Trial E2297
    • Berlin JD, Catalano P, Thomas JP, et al.: Phase III study of gemcitabine in combination with fluorouracil versus gemcitabine alone in patients with advanced pancreatic carcinoma: Eastern Cooperative Oncology Group Trial E2297. J Clin Oncol 2002, 20:3270-3275.
    • (2002) J Clin Oncol , vol.20 , pp. 3270-3275
    • Berlin, J.D.1    Catalano, P.2    Thomas, J.P.3
  • 13
    • 28344452125 scopus 로고    scopus 로고
    • A randomised, prospective, multicenter, phase III trial of gemcitabine, 5-fluorouracil (5-FU), folinic acid vs. gemcitabine alone in patients with advanced pancreatic cancer [abstract]
    • 310s
    • Riess H, Helm A, Niedergethmann M, et al.: A randomised, prospective, multicenter, phase III trial of gemcitabine, 5-fluorouracil (5-FU), folinic acid vs. gemcitabine alone in patients with advanced pancreatic cancer [abstract]. Proc ASCO 2005, 23:310s.
    • (2005) Proc ASCO , vol.23
    • Riess, H.1    Helm, A.2    Niedergethmann, M.3
  • 14
    • 34248380701 scopus 로고    scopus 로고
    • Herrmann R, Bodoky G, Ruhstaller T, et al.: Gemcitabine (G) plus Capecitabine (C) versus G alone in locally advanced or metastatic pancreatic cancer. A randomized phase III study of the Swiss Group for Clinical Cancer Research (SAKK) and the Central European Cooperative Oncology Group (CECOG). Proc ASCO 2005, 23(16S):310s.
    • Herrmann R, Bodoky G, Ruhstaller T, et al.: Gemcitabine (G) plus Capecitabine (C) versus G alone in locally advanced or metastatic pancreatic cancer. A randomized phase III study of the Swiss Group for Clinical Cancer Research (SAKK) and the Central European Cooperative Oncology Group (CECOG). Proc ASCO 2005, 23(16S):310s.
  • 15
    • 27144530079 scopus 로고    scopus 로고
    • A phase III trial of pemetrexed plus gemcitabine versus gemcitabine in patients with unresectable or metastatic pancreatic cancer
    • Oettle H, Richards D, Ramanathan RK, et al.: A phase III trial of pemetrexed plus gemcitabine versus gemcitabine in patients with unresectable or metastatic pancreatic cancer. Ann Oncol 2005, 16:1639-1645.
    • (2005) Ann Oncol , vol.16 , pp. 1639-1645
    • Oettle, H.1    Richards, D.2    Ramanathan, R.K.3
  • 16
    • 4644327989 scopus 로고    scopus 로고
    • Irinotecan plus gemcitabine results in no survival advantage compared with gemcitabine monotherapy in patients with locally advanced or metastatic pancreatic cancer despite increased tumor response rate
    • Rocha Lima CM, Green MR, Rotche R, et al.: Irinotecan plus gemcitabine results in no survival advantage compared with gemcitabine monotherapy in patients with locally advanced or metastatic pancreatic cancer despite increased tumor response rate. J Clin Oncol 2004, 22:3776-3783.
    • (2004) J Clin Oncol , vol.22 , pp. 3776-3783
    • Rocha Lima, C.M.1    Green, M.R.2    Rotche, R.3
  • 17
    • 33749071359 scopus 로고    scopus 로고
    • Randomized phase III study of exatecan and gemcitabine compared with gemcitabine alone in untreated advanced pancreatic cancer
    • Abou-Alfa GK, Letourneau R, Harker G, et al.: Randomized phase III study of exatecan and gemcitabine compared with gemcitabine alone in untreated advanced pancreatic cancer. J Clin Oncol 2006, 24:4441-4447.
    • (2006) J Clin Oncol , vol.24 , pp. 4441-4447
    • Abou-Alfa, G.K.1    Letourneau, R.2    Harker, G.3
  • 18
    • 33748445708 scopus 로고    scopus 로고
    • Randomized phase III trial of gemcitabine plus cisplatin compared with gemcitabine alone in advanced pancreatic cancer
    • Heinemann V, Quietzsch D, Gieseler F, et al.: Randomized phase III trial of gemcitabine plus cisplatin compared with gemcitabine alone in advanced pancreatic cancer. J Clin Oncol 2006, 24:3946-3952.
    • (2006) J Clin Oncol , vol.24 , pp. 3946-3952
    • Heinemann, V.1    Quietzsch, D.2    Gieseler, F.3
  • 19
    • 20644464360 scopus 로고    scopus 로고
    • Gemcitabine in combination with oxaliplatin compared with gemcitabine alone in locally advanced or metastatic pancreatic cancer: Results of a GERCOR and GISCAD phase III trial
    • Louvet C, Labianca R, Hammel P, et al.: Gemcitabine in combination with oxaliplatin compared with gemcitabine alone in locally advanced or metastatic pancreatic cancer: results of a GERCOR and GISCAD phase III trial. J Clin Oncol 2005, 23:3509-3516.
    • (2005) J Clin Oncol , vol.23 , pp. 3509-3516
    • Louvet, C.1    Labianca, R.2    Hammel, P.3
  • 20
    • 4143128359 scopus 로고    scopus 로고
    • Epidermal growth factor receptor expression in human pancreatic cancer: Significance for liver metastasis
    • Tobita K, Kijima H, Dowaki S, et al.: Epidermal growth factor receptor expression in human pancreatic cancer: Significance for liver metastasis. Int J Mol Med 2003, 11:305-309.
    • (2003) Int J Mol Med , vol.11 , pp. 305-309
    • Tobita, K.1    Kijima, H.2    Dowaki, S.3
  • 21
    • 33747066389 scopus 로고    scopus 로고
    • EGF receptor antagonism improves survival in a murine model of pancreatic adenocarcinoma
    • Durkin AJ, Osborne DA, Yeatman TJ, et al.: EGF receptor antagonism improves survival in a murine model of pancreatic adenocarcinoma. J Surg Res 2006, 135:195-201.
    • (2006) J Surg Res , vol.135 , pp. 195-201
    • Durkin, A.J.1    Osborne, D.A.2    Yeatman, T.J.3
  • 22
    • 34248360565 scopus 로고    scopus 로고
    • Erlotinib plus gemcitabine in patients with unresectable pancreatic cancer and other solid tumors: Phase IB trial
    • Epub ahead of print
    • Dragovich T, Hubermann M, von Hoff DD, et al.: Erlotinib plus gemcitabine in patients with unresectable pancreatic cancer and other solid tumors: phase IB trial. Cancer Chemother Pharmacol 2006 (Epub ahead of print),
    • (2006) Cancer Chemother Pharmacol
    • Dragovich, T.1    Hubermann, M.2    von Hoff, D.D.3
  • 23
    • 33846220461 scopus 로고    scopus 로고
    • Epidermal growth factor receptor kinase domain mutations in esophageal and pancreatic adenocarcinomas
    • Kwak EL, Jankowski J, Thayer SP, et al.: Epidermal growth factor receptor kinase domain mutations in esophageal and pancreatic adenocarcinomas. Clin Cancer Res 2006, 12:4283-4287.
    • (2006) Clin Cancer Res , vol.12 , pp. 4283-4287
    • Kwak, E.L.1    Jankowski, J.2    Thayer, S.P.3
  • 24
    • 33744725273 scopus 로고    scopus 로고
    • Molecular analysis of the EGFR-RAS-RAF pathway in pancreatic ductal adenocarcinomas: Lack of mutations in the BRAF and EGFR genes
    • Immervol H, Hoem D, Kugarajh K, et al.: Molecular analysis of the EGFR-RAS-RAF pathway in pancreatic ductal adenocarcinomas: lack of mutations in the BRAF and EGFR genes. Virchows Arch 2006, 448:788-796.
    • (2006) Virchows Arch , vol.448 , pp. 788-796
    • Immervol, H.1    Hoem, D.2    Kugarajh, K.3
  • 25
    • 36348999029 scopus 로고    scopus 로고
    • Is it cost-effective to add erlotinib to gemcitabine in advanced pancreatic cancer [abstract]?
    • 313s
    • Grubbs SS, Grusenmeyer PS, Petrelli NJ, et al.: Is it cost-effective to add erlotinib to gemcitabine in advanced pancreatic cancer [abstract]? Proc ASCO 2006, 24:313s.
    • (2006) Proc ASCO , vol.24
    • Grubbs, S.S.1    Grusenmeyer, P.S.2    Petrelli, N.J.3
  • 26
    • 0025978216 scopus 로고
    • A phase I clinical, plasma, and cellular pharmacology study of gemcitabine
    • Abbruzzese JL, Grunewald R, Weeks EA, et al.: A phase I clinical, plasma, and cellular pharmacology study of gemcitabine. J Clin Oncol 1991, 9:491-498.
    • (1991) J Clin Oncol , vol.9 , pp. 491-498
    • Abbruzzese, J.L.1    Grunewald, R.2    Weeks, E.A.3
  • 27
    • 0142121290 scopus 로고    scopus 로고
    • Randomized phase II comparison of dose-intense gemcitabine: Thirty-minute infusion and fixed dose rate infusion in patients with pancreatic adenocarcinoma
    • Tempero M, Plunkett W, Ruiz V, et al.: Randomized phase II comparison of dose-intense gemcitabine: Thirty-minute infusion and fixed dose rate infusion in patients with pancreatic adenocarcinoma. J Clin Oncol 2003, 21:3402-3408.
    • (2003) J Clin Oncol , vol.21 , pp. 3402-3408
    • Tempero, M.1    Plunkett, W.2    Ruiz, V.3
  • 28
    • 0034657029 scopus 로고    scopus 로고
    • High expression of vascular endothelial growth factor is associated with liver metastasis and a poor prognosis for patients with ductal pancreatic adenocarcinoma
    • Seo Y, Baba H, Fukuda T, et al.: High expression of vascular endothelial growth factor is associated with liver metastasis and a poor prognosis for patients with ductal pancreatic adenocarcinoma. Cancer 2000, 88:2239-2245.
    • (2000) Cancer , vol.88 , pp. 2239-2245
    • Seo, Y.1    Baba, H.2    Fukuda, T.3
  • 29
    • 0035217589 scopus 로고    scopus 로고
    • Inhibition of growth and metastasis of human pancreatic cancer growing in nude mice by PTK 787/ ZK222584, an inhibitor of the vascular endothelial growth factor receptor tyrosine kinases
    • Solorzano CC, Baker CH, Bruns CJ, et al.: Inhibition of growth and metastasis of human pancreatic cancer growing in nude mice by PTK 787/ ZK222584, an inhibitor of the vascular endothelial growth factor receptor tyrosine kinases. Cancer Biother Radiopharm 2001, 16:359-370.
    • (2001) Cancer Biother Radiopharm , vol.16 , pp. 359-370
    • Solorzano, C.C.1    Baker, C.H.2    Bruns, C.J.3
  • 30
    • 0037058302 scopus 로고    scopus 로고
    • Effect of the vascular endothelial growth factor receptor-2 antibody DC101 plus gemcitabine on growth, metastasis and angiogenesis of human pancreatic cancer growing orthotopically in nude mice
    • Bruns CJ, Shrader M, Harbison MT, et al.: Effect of the vascular endothelial growth factor receptor-2 antibody DC101 plus gemcitabine on growth, metastasis and angiogenesis of human pancreatic cancer growing orthotopically in nude mice. Int J Cancer 2002, 102:101-108.
    • (2002) Int J Cancer , vol.102 , pp. 101-108
    • Bruns, C.J.1    Shrader, M.2    Harbison, M.T.3
  • 31
    • 32944478346 scopus 로고    scopus 로고
    • Phase II trial of bevacizumab plus gemcitabine in patients with advanced pancreatic cancer
    • Kindler HL, Friberg G, Singh DA, et al.: Phase II trial of bevacizumab plus gemcitabine in patients with advanced pancreatic cancer. J Clin Oncol 2005, 23:8033-8040.
    • (2005) J Clin Oncol , vol.23 , pp. 8033-8040
    • Kindler, H.L.1    Friberg, G.2    Singh, D.A.3
  • 32
    • 30544446419 scopus 로고    scopus 로고
    • Clinical trials broadcast: CALGB 80303, A randomized phase III trial of gemcitabine plus bevacizumab versus gemcitabine plus placebo in patients with advanced pancreatic cancer
    • Kindler HL: Clinical trials broadcast: CALGB 80303, A randomized phase III trial of gemcitabine plus bevacizumab versus gemcitabine plus placebo in patients with advanced pancreatic cancer. Clin Adv Hematol Oncol 2005, 3:420-422.
    • (2005) Clin Adv Hematol Oncol , vol.3 , pp. 420-422
    • Kindler, H.L.1
  • 33
    • 4344590997 scopus 로고    scopus 로고
    • Cetuximab, a monoclonal antibody targeting the epidermal growth factor receptor, in combination with gemcitabine for advanced pancreatic cancer: A multi-center phase II trial
    • Xiong HQ, Rosenberg A, LoBuglio A, et al.: Cetuximab, a monoclonal antibody targeting the epidermal growth factor receptor, in combination with gemcitabine for advanced pancreatic cancer: A multi-center phase II trial. J Clin Oncol 2004, 22:2610-2616.
    • (2004) J Clin Oncol , vol.22 , pp. 2610-2616
    • Xiong, H.Q.1    Rosenberg, A.2    LoBuglio, A.3
  • 34
    • 33646227448 scopus 로고    scopus 로고
    • Synergistic antitumor effects of combined epidermal growth factor receptor and vascular endothelial growth factor receptor-2 targeted therapy
    • Tonra JR, Deevi DS, Corcoran E, et al.: Synergistic antitumor effects of combined epidermal growth factor receptor and vascular endothelial growth factor receptor-2 targeted therapy. Clin Cancer Res 2006, 12:2197-2207.
    • (2006) Clin Cancer Res , vol.12 , pp. 2197-2207
    • Tonra, J.R.1    Deevi, D.S.2    Corcoran, E.3
  • 35
    • 33750903161 scopus 로고    scopus 로고
    • A randomized phase II study of bevacizumab and gemcitabine plus cetuximab or erlotinib in patients with advanced pancreatic cancer: A preliminary analysis [abstract]
    • 188s
    • Kindler HL, Bylow KA, Hochster H, et al.: A randomized phase II study of bevacizumab and gemcitabine plus cetuximab or erlotinib in patients with advanced pancreatic cancer: A preliminary analysis [abstract]. Proc ASCO 2006, 24:188s.
    • (2006) Proc ASCO , vol.24
    • Kindler, H.L.1    Bylow, K.A.2    Hochster, H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.