-
1
-
-
0034065822
-
Ubiquitin-mediated proteolysis: Biological regulation via destruction
-
Ciechanover A, Orian A, Schwartz AL: Ubiquitin-mediated proteolysis: biological regulation via destruction. Bioessays 2000, 22:442-451.
-
(2000)
Bioessays
, vol.22
, pp. 442-451
-
-
Ciechanover, A.1
Orian, A.2
Schwartz, A.L.3
-
2
-
-
0033615348
-
The proteasome: A macromolecular assembly designed for controlled proteolysis [review]
-
Zwickl P, Voges D, Baumeister W: The proteasome: a macromolecular assembly designed for controlled proteolysis [review]. Philos Trans R Soc Lond B Biol Sci 1999, 354:1501-1511.
-
(1999)
Philos Trans R Soc Lond B Biol Sci
, vol.354
, pp. 1501-1511
-
-
Zwickl, P.1
Voges, D.2
Baumeister, W.3
-
3
-
-
0034864799
-
Proteasome inhibitors: From research tools to drug candidates
-
Kisselev AF, Goldberg AL: Proteasome inhibitors: from research tools to drug candidates. Chem Biol 2001, 8:739-758.
-
(2001)
Chem Biol
, vol.8
, pp. 739-758
-
-
Kisselev, A.F.1
Goldberg, A.L.2
-
4
-
-
0346333293
-
The proteasome as a target for cancer therapy
-
Voorhees PM, Dees EC, O'Neil B, Orlowski RZ: The proteasome as a target for cancer therapy. Clin Cancer Res 2003, 9:6316-6325.
-
(2003)
Clin Cancer Res
, vol.9
, pp. 6316-6325
-
-
Voorhees, P.M.1
Dees, E.C.2
O'Neil, B.3
Orlowski, R.Z.4
-
5
-
-
0027980321
-
The ubiquitin-proteasome pathway is required for processing the NF-kappa B1 precursor protein and the activation of NF-kappa B
-
Palombella VJ, Rando OJ, Goldberg AL, Maniatis T: The ubiquitin-proteasome pathway is required for processing the NF-kappa B1 precursor protein and the activation of NF-kappa B. Cell 1994, 78:773-785.
-
(1994)
Cell
, vol.78
, pp. 773-785
-
-
Palombella, V.J.1
Rando, O.J.2
Goldberg, A.L.3
Maniatis, T.4
-
6
-
-
0033152760
-
Proteasome inhibitors: A novel class of potent and effective antitumor agents
-
Adams J, Palombella VJ, Sausville EA, et al.: Proteasome inhibitors: a novel class of potent and effective antitumor agents. Cancer Res 1999, 59:2615-2622.
-
(1999)
Cancer Res
, vol.59
, pp. 2615-2622
-
-
Adams, J.1
Palombella, V.J.2
Sausville, E.A.3
-
7
-
-
33746160660
-
Proteasome inhibitor bortezomib for the treatment of multiple myeloma
-
Cavo M: Proteasome inhibitor bortezomib for the treatment of multiple myeloma. Leukemia 2006, 20:1341-1352.
-
(2006)
Leukemia
, vol.20
, pp. 1341-1352
-
-
Cavo, M.1
-
8
-
-
0035300479
-
The proteasome inhibitor PS-341 inhibits growth, induces apoptosis, and overcomes drug resistance in human multiple myeloma cells
-
Hideshima T, Richardson P, Chauhan D, et al.: The proteasome inhibitor PS-341 inhibits growth, induces apoptosis, and overcomes drug resistance in human multiple myeloma cells. Cancer Res 2001, 61:3071-3076.
-
(2001)
Cancer Res
, vol.61
, pp. 3071-3076
-
-
Hideshima, T.1
Richardson, P.2
Chauhan, D.3
-
9
-
-
0037443551
-
The proteasome inhibitor PS-341 potentiates sensitivity of multiple myeloma cells to conventional chemotherapeutic agents: Therapeutic applications
-
Mitsiades CS, Richardson PG, Poulaki V, et al.: The proteasome inhibitor PS-341 potentiates sensitivity of multiple myeloma cells to conventional chemotherapeutic agents: therapeutic applications. Blood 2003, 101:2377-2380.
-
(2003)
Blood
, vol.101
, pp. 2377-2380
-
-
Mitsiades, C.S.1
Richardson, P.G.2
Poulaki, V.3
-
10
-
-
0037342894
-
The proteasome inhibitor PS-341 markedly enhances sensitivity of multiple myeloma tumor cells to chemotherapeutic agents
-
Ma MH, Yang HH, Parker K, et al.: The proteasome inhibitor PS-341 markedly enhances sensitivity of multiple myeloma tumor cells to chemotherapeutic agents. Clin Cancer Res 2003, 9:1136-1144.
-
(2003)
Clin Cancer Res
, vol.9
, pp. 1136-1144
-
-
Ma, M.H.1
Yang, H.H.2
Parker, K.3
-
11
-
-
0037111832
-
Phase I trial of the proteasome inhibitor PS-341 in patients with refractory hematologic malignancies
-
Orlowski RZ, Stinchcombe TE, Mitchell BS, et al.: Phase I trial of the proteasome inhibitor PS-341 in patients with refractory hematologic malignancies. J Clin Oncol 2002, 20:4420-4427.
-
(2002)
J Clin Oncol
, vol.20
, pp. 4420-4427
-
-
Orlowski, R.Z.1
Stinchcombe, T.E.2
Mitchell, B.S.3
-
12
-
-
0037973279
-
A phase 2 study of bortezomib in relapsed, refractory myeloma
-
Richardson PG, Barlogie B, Berenson J, et al.: A phase 2 study of bortezomib in relapsed, refractory myeloma. N Engl J Med 2003, 348:2609-2617.
-
(2003)
N Engl J Med
, vol.348
, pp. 2609-2617
-
-
Richardson, P.G.1
Barlogie, B.2
Berenson, J.3
-
13
-
-
33644844108
-
Extended follow-up of a phase II trial in relapsed, refractory multiple myeloma: Final time to event results from the SUMMIT trial
-
Richardson PG, Barlogie B, Berenson J, et al.: Extended follow-up of a phase II trial in relapsed, refractory multiple myeloma: final time to event results from the SUMMIT trial. Cancer 2006, 106:1316-1319.
-
(2006)
Cancer
, vol.106
, pp. 1316-1319
-
-
Richardson, P.G.1
Barlogie, B.2
Berenson, J.3
-
14
-
-
5644250621
-
A phase 2 study of two doses of bortezomib in relapsed or refractory myeloma
-
Jagannath S, Barlogie B, Berenson J, et al.: A phase 2 study of two doses of bortezomib in relapsed or refractory myeloma. Br J Haematol 2004, 127:165-172.
-
(2004)
Br J Haematol
, vol.127
, pp. 165-172
-
-
Jagannath, S.1
Barlogie, B.2
Berenson, J.3
-
15
-
-
20444433230
-
-
• Richardson Sonneveld P, Schuster MW, et al.: Bortezomib or high-dose dexamethasone for relapsed multiple myeloma. N Engl J Med 2005, 352:2487-2498. In a prospective comparison of bortezomib with dexamethasone as salvage therapy for relapsed multiple myeloma, the superiority of bortezomib in terms of time to progression, response rate, and overall survival was demonstrated.
-
• Richardson PG, Sonneveld P, Schuster MW, et al.: Bortezomib or high-dose dexamethasone for relapsed multiple myeloma. N Engl J Med 2005, 352:2487-2498. In a prospective comparison of bortezomib with dexamethasone as salvage therapy for relapsed multiple myeloma, the superiority of bortezomib in terms of time to progression, response rate, and overall survival was demonstrated.
-
-
-
-
16
-
-
18244428600
-
Criteria for evaluating disease response and progression in patients with multiple myeloma treated by high-dose therapy and haemopoietic stem cell transplantation. Myeloma Subcommittee of the EBMT. European Group for Blood and Marrow Transplant
-
Bladé J, Samson D, Reece D, et al.: Criteria for evaluating disease response and progression in patients with multiple myeloma treated by high-dose therapy and haemopoietic stem cell transplantation. Myeloma Subcommittee of the EBMT. European Group for Blood and Marrow Transplant. Br J Haematol 1998, 102:1115-1123.
-
(1998)
Br J Haematol
, vol.102
, pp. 1115-1123
-
-
Bladé, J.1
Samson, D.2
Reece, D.3
-
17
-
-
33746332717
-
Bortezomib continues demonstrates [sic] superior efficacy compared with high-dose dexamethasone in relapsed multiple myeloma: Updated results of the APEX trail [sic] [abstract]
-
Abstract 2547
-
Richardson PG, Sonneveld P, Schuster M, et al.: Bortezomib continues demonstrates [sic] superior efficacy compared with high-dose dexamethasone in relapsed multiple myeloma: updated results of the APEX trail [sic] [abstract]. Blood (ASH Annual Meeting Abstracts) 2005, 106:Abstract 2547.
-
(2005)
Blood (ASH Annual Meeting Abstracts)
, vol.106
-
-
Richardson, P.G.1
Sonneveld, P.2
Schuster, M.3
-
18
-
-
33644823732
-
Bortezomib at first relapse is superior to high-dose dexamethasone and more effective than when given later in relapsed multiple myeloma [abstract]
-
Abstract PO721
-
Sonneveld P, Richardson PG, Schuster MW, et al.: Bortezomib at first relapse is superior to high-dose dexamethasone and more effective than when given later in relapsed multiple myeloma [abstract]. Haematologica 2005, 90(suppl 1):150: Abstract PO721.
-
(2005)
Haematologica
, vol.90
, Issue.SUPPL. 1
, pp. 150
-
-
Sonneveld, P.1
Richardson, P.G.2
Schuster, M.W.3
-
19
-
-
27644476353
-
Clinical factors predictive of outcome with bortezomib in patients with relapsed, refractory multiple myeloma
-
Richardson PG, Barlogie B, Berenson J, et al.: Clinical factors predictive of outcome with bortezomib in patients with relapsed, refractory multiple myeloma. Blood 2005, 106:2977-2981.
-
(2005)
Blood
, vol.106
, pp. 2977-2981
-
-
Richardson, P.G.1
Barlogie, B.2
Berenson, J.3
-
20
-
-
33845518467
-
Bortezomib appears to overcome the poor prognosis conferred by chromosome 13 deletion in phase 2 and 3 trials
-
Jagannath S, Richardson PG, Sonneveld P, et al.: Bortezomib appears to overcome the poor prognosis conferred by chromosome 13 deletion in phase 2 and 3 trials. Leukemia 2007, 21:151-157.
-
(2007)
Leukemia
, vol.21
, pp. 151-157
-
-
Jagannath, S.1
Richardson, P.G.2
Sonneveld, P.3
-
21
-
-
33845524012
-
Bortezomib in relapsed multiple myeloma: Response rates and duration of response are independent of a chromosome 13q-deletion
-
Sagaster V, Ludwig H, Kaufmann H, et al.: Bortezomib in relapsed multiple myeloma: response rates and duration of response are independent of a chromosome 13q-deletion. Leukemia 2007, 21:164-168.
-
(2007)
Leukemia
, vol.21
, pp. 164-168
-
-
Sagaster, V.1
Ludwig, H.2
Kaufmann, H.3
-
22
-
-
27644510071
-
Safety of prolonged therapy with bortezomib in relapsed or refractory multiple myeloma
-
Berenson JR, Jagannath S, Barlogie B, et al.: Safety of prolonged therapy with bortezomib in relapsed or refractory multiple myeloma. Cancer 2005, 104:2141-2148.
-
(2005)
Cancer
, vol.104
, pp. 2141-2148
-
-
Berenson, J.R.1
Jagannath, S.2
Barlogie, B.3
-
23
-
-
20044381304
-
Bortezomib in recurrent and/or refractory multiple myeloma. Initial clinical experience in patients with impared renal function
-
Jagannath S, Barlogie B, Berenson JR, et al.: Bortezomib in recurrent and/or refractory multiple myeloma. Initial clinical experience in patients with impared renal function. Cancer 2005, 103:1195-1200.
-
(2005)
Cancer
, vol.103
, pp. 1195-1200
-
-
Jagannath, S.1
Barlogie, B.2
Berenson, J.R.3
-
24
-
-
34248390939
-
Activity and safety of bortezomib in multiple myeloma patients with advanced renal failure: A multicenter retrospective study [abstract]
-
Chanan-Khan A, Kaufman JL, Mehta J, et al.: Activity and safety of bortezomib in multiple myeloma patients with advanced renal failure: a multicenter retrospective study [abstract]. Blood (ASH Annual Meeting Abstracts) 2005, 106:716a.
-
(2005)
Blood (ASH Annual Meeting Abstracts)
, vol.106
-
-
Chanan-Khan, A.1
Kaufman, J.L.2
Mehta, J.3
-
25
-
-
28444436266
-
Risk factors and kinetics of thrombocytopenia associated with bortezomib for relapsed, refractory multiple myeloma
-
Lonial S, Waller EK, Richardson PG, et al.: Risk factors and kinetics of thrombocytopenia associated with bortezomib for relapsed, refractory multiple myeloma. Blood 2005, 106:3777-3784.
-
(2005)
Blood
, vol.106
, pp. 3777-3784
-
-
Lonial, S.1
Waller, E.K.2
Richardson, P.G.3
-
26
-
-
33746010219
-
Frequency, characteristics, and reversibility of peripheral neuropathy during treatment of advanced multiple myeloma with bortezomib
-
Richardson PG, Briemberg H, Jagannath S, et al.: Frequency, characteristics, and reversibility of peripheral neuropathy during treatment of advanced multiple myeloma with bortezomib. J Clin Oncol 2006, 24:3113-3120.
-
(2006)
J Clin Oncol
, vol.24
, pp. 3113-3120
-
-
Richardson, P.G.1
Briemberg, H.2
Jagannath, S.3
-
27
-
-
33745801771
-
Bortezomib in combination with dexamethasone for the treatment of patients with relapsed and/or refractory multiple myeloma with less than optimal response to bortezomib alone
-
Jagannath S, Richardson PG, Barlogie B, et al.: Bortezomib in combination with dexamethasone for the treatment of patients with relapsed and/or refractory multiple myeloma with less than optimal response to bortezomib alone. Haematologica 2006, 91:929-934.
-
(2006)
Haematologica
, vol.91
, pp. 929-934
-
-
Jagannath, S.1
Richardson, P.G.2
Barlogie, B.3
-
28
-
-
32844455254
-
Bortezomib in combination with melphalan in the treatment of relapse or refractory multiple myeloma: A phase I/II study [abstract]
-
Abstract PO728
-
Berenson JR, Yang HH, Swift R, et al.: Bortezomib in combination with melphalan in the treatment of relapse or refractory multiple myeloma: a phase I/II study [abstract]. Haematologica 2005, 90(suppl 1):150. Abstract PO728.
-
(2005)
Haematologica
, vol.90
, Issue.SUPPL. 1
, pp. 150
-
-
Berenson, J.R.1
Yang, H.H.2
Swift, R.3
-
29
-
-
33645676695
-
A phase I/II study of bortezomib and low dose intravenous melphalan (BM) for relapsed multiple myeloma [abstract]
-
Abstract 2555
-
Popat R, Oakervee HE, Foot N, et al.: A phase I/II study of bortezomib and low dose intravenous melphalan (BM) for relapsed multiple myeloma [abstract]. Blood (ASH Annual Meeting Abstracts) 2005, 106:718a. Abstract 2555.
-
(2005)
Blood (ASH Annual Meeting Abstracts)
, vol.106
-
-
Popat, R.1
Oakervee, H.E.2
Foot, N.3
-
30
-
-
33745883858
-
Velcade plus melphalan, prednisone, and thalidomide (V-MPT) for advanced multiple myeloma [abstract]
-
Abstract 2553
-
Palumbo A, Ambrosini MT, Pregno P, et al.: Velcade plus melphalan, prednisone, and thalidomide (V-MPT) for advanced multiple myeloma [abstract]. Blood (ASH Annual Meeting Abstracts) 2005, 106:717a. Abstract 2553.
-
(2005)
Blood (ASH Annual Meeting Abstracts)
, vol.106
-
-
Palumbo, A.1
Ambrosini, M.T.2
Pregno, P.3
-
31
-
-
33746336016
-
Bortezomib in combination with high-dose dexamethasone and continuous low-dose oral cyclophosphamide for relapsed multiple myeloma [abstract]
-
Abstract 2549
-
Kropff M, Bisping G, Liebisch P, et al.: Bortezomib in combination with high-dose dexamethasone and continuous low-dose oral cyclophosphamide for relapsed multiple myeloma [abstract]. Blood (ASH Annual Meeting Abstracts) 2005, 106:716a. Abstract 2549.
-
(2005)
Blood (ASH Annual Meeting Abstracts)
, vol.106
-
-
Kropff, M.1
Bisping, G.2
Liebisch, P.3
-
32
-
-
33746340326
-
Velcade (V)-thalidomide (T)-dexamethasone (D) for advanced and refractory multiple myeloma (MM): Long-term follow-up of phase I-II trial UARK 2001-37: superior outcome in patients with normal cytogenetics and no prior T [abstract]
-
Abstract 2552
-
Zangari M, Barlogie B, Burns MJ, et al.: Velcade (V)-thalidomide (T)-dexamethasone (D) for advanced and refractory multiple myeloma (MM): long-term follow-up of phase I-II trial UARK 2001-37: superior outcome in patients with normal cytogenetics and no prior T [abstract]. Blood (ASH Annual Meeting Abstracts) 2005, 106:717a. Abstract 2552.
-
(2005)
Blood (ASH Annual Meeting Abstracts)
, vol.106
-
-
Zangari, M.1
Barlogie, B.2
Burns, M.J.3
-
33
-
-
0037097595
-
Apoptotic signaling induced by immunomodulatory thalidomide analogs in human multiple myeloma cells: Therapeutic implications
-
Mitsiades N, Mitsiades CS, Poulaki V, et al.: Apoptotic signaling induced by immunomodulatory thalidomide analogs in human multiple myeloma cells: therapeutic implications. Blood 2002, 99:4525-4530.
-
(2002)
Blood
, vol.99
, pp. 4525-4530
-
-
Mitsiades, N.1
Mitsiades, C.S.2
Poulaki, V.3
-
34
-
-
33744803947
-
A phase 1 trial of lenalidomide (REVLIMID) with bortezomib (VELCADE) in relapsed and refractory multiple myeloma [abstract]
-
Abstract 365
-
Richardson P, Schlossman R, Munshi N, et al.: A phase 1 trial of lenalidomide (REVLIMID) with bortezomib (VELCADE) in relapsed and refractory multiple myeloma [abstract]. Blood (ASH Annual Meeting Abstracts) 2005, 106:110a. Abstract 365.
-
(2005)
Blood (ASH Annual Meeting Abstracts)
, vol.106
-
-
Richardson, P.1
Schlossman, R.2
Munshi, N.3
-
35
-
-
27244442582
-
Addition of bortezomib (Velcade) to high dose melphalan (vel-mel) as an effective conditioning regimen with autologous stem cell support in multiple myeloma (MM) [abstract]
-
Abstract 929
-
Hollmig K, Stover J, Talamo G, et al.: Addition of bortezomib (Velcade) to high dose melphalan (vel-mel) as an effective conditioning regimen with autologous stem cell support in multiple myeloma (MM) [abstract]. Blood (ASH Annual Meeting Abstracts) 2004, 104:266a. Abstract 929.
-
(2004)
Blood (ASH Annual Meeting Abstracts)
, vol.104
-
-
Hollmig, K.1
Stover, J.2
Talamo, G.3
-
36
-
-
27244436459
-
Results of bortezomib (BTZ) therapy for myeloma (MM) patients relapsing after an allogeneic transplant. Preliminary results show efficacy without induction of GVHD [abstract]
-
Abstract
-
Giralt S, Aleman A, Lei X, et al.: Results of bortezomib (BTZ) therapy for myeloma (MM) patients relapsing after an allogeneic transplant. Preliminary results show efficacy without induction of GVHD [abstract]. Blood (ASH Annual Meeting Abstracts) 2004, 104:459a. Abstract 1651.
-
(1651)
Blood (ASH Annual Meeting Abstracts)
, vol.104
-
-
Giralt, S.1
Aleman, A.2
Lei, X.3
-
37
-
-
34248327490
-
-
Anderson K, Richardson P, Chanan-Khan A, et al.: Single-agent bortezomib in previously untreated multiple myeloma (MM): results of a phase II multicenter study [abstract]. J Clin Oncol 2006, 24(18S): Abstract 7504.
-
Anderson K, Richardson P, Chanan-Khan A, et al.: Single-agent bortezomib in previously untreated multiple myeloma (MM): results of a phase II multicenter study [abstract]. J Clin Oncol 2006, 24(18S): Abstract 7504.
-
-
-
-
38
-
-
33744826216
-
Bortezomib therapy alone and in combination with dexamethasone for patients with previously untreated multiple myeloma
-
Abstract 783
-
Jagannath S, Durie B, Wolf J, et al.: Bortezomib therapy alone and in combination with dexamethasone for patients with previously untreated multiple myeloma. Blood (ASH Annual Meeting Abstracts) 2005, 106:231a. Abstract 783.
-
(2005)
Blood (ASH Annual Meeting Abstracts)
, vol.106
-
-
Jagannath, S.1
Durie, B.2
Wolf, J.3
-
39
-
-
33750953054
-
Bortezomib plus dexamethasone as induction treatment prior to autologous stem cell transplantation in patients with newly diagnosed multiple myeloma: Results of an IFM phase II study
-
Harousseau JL, Attal M, Leleu X, et al.: Bortezomib plus dexamethasone as induction treatment prior to autologous stem cell transplantation in patients with newly diagnosed multiple myeloma: results of an IFM phase II study. Haematologica 2006, 91:1498-1505.
-
(2006)
Haematologica
, vol.91
, pp. 1498-1505
-
-
Harousseau, J.L.1
Attal, M.2
Leleu, X.3
-
40
-
-
21344435052
-
-
• Oakervee HE, Popat R, Curry N, et al.: PAD combination therapy (PS-341/bortezomib, doxorubicin and dexamethasone) for previously untreated patients with multiple myeloma. Br J Haematol 2005, 129:755-762. Front-line therapy with bortezomib in combination with doxorubicin and dexamethasone in preparation for subsequent autologous transplantation yielded complete or near-complete response rate in the 30% range, which increased to more than 55% following a single autologous transplantation.
-
• Oakervee HE, Popat R, Curry N, et al.: PAD combination therapy (PS-341/bortezomib, doxorubicin and dexamethasone) for previously untreated patients with multiple myeloma. Br J Haematol 2005, 129:755-762. Front-line therapy with bortezomib in combination with doxorubicin and dexamethasone in preparation for subsequent autologous transplantation yielded complete or near-complete response rate in the 30% range, which increased to more than 55% following a single autologous transplantation.
-
-
-
-
41
-
-
33745765108
-
Reduced dose PAD combination therapy (PS-341/bortezomib, Adriamycin and dexamethasone) for previously untreated patients with multiple myeloma [abstract]
-
Abstract 2554
-
Popat R, Oakervee HE, Curry N, et al.: Reduced dose PAD combination therapy (PS-341/bortezomib, Adriamycin and dexamethasone) for previously untreated patients with multiple myeloma [abstract]. Blood (ASH Annual Meeting Abstracts) 2005, 106:717a. Abstract 2554.
-
(2005)
Blood (ASH Annual Meeting Abstracts)
, vol.106
-
-
Popat, R.1
Oakervee, H.E.2
Curry, N.3
-
42
-
-
33645662389
-
Rapid control of previously untreated multiple myeloma with bortezomibthalidomide-dexamethasone followed by early intensive therapy [abstract]
-
Abstract 784
-
Wang M, Delasalle K, Giralt S, Alexanian R: Rapid control of previously untreated multiple myeloma with bortezomibthalidomide-dexamethasone followed by early intensive therapy [abstract]. Blood (ASH Annual Meeting Abstracts) 2005, 106:231a. Abstract 784.
-
(2005)
Blood (ASH Annual Meeting Abstracts)
, vol.106
-
-
Wang, M.1
Delasalle, K.2
Giralt, S.3
Alexanian, R.4
-
43
-
-
33746352833
-
Total Therapy 3 (TT3) incorporating Velcade (V) intro upfront management of multiple myeloma (MM): Comparison with TT2 + thalidomide (T) [abstract]
-
Abstract 1154
-
Barlogie B, Tricot G, Rasmussen E, ct al.: Total Therapy 3 (TT3) incorporating Velcade (V) intro upfront management of multiple myeloma (MM): comparison with TT2 + thalidomide (T) [abstract]. Blood (ASH Annual Meeting Abstracts) 2005, 106:337a. Abstract 1154.
-
(2005)
Blood (ASH Annual Meeting Abstracts)
, vol.106
-
-
Barlogie, B.1
Tricot, G.2
Rasmussen, E.3
ct al4
-
44
-
-
33748287079
-
-
• Mateos MV, Hernandez JM, Hernandez MT, et al.: Bortezomib plus melphalan and prednisone in elderly untreated patients with multiple myeloma: results of a multicenter phase 1/2 study. Blood 2006, 108:2165-2172. In elderly myeloma patients who arc not candidates for autologous transplantation, addition of bortezomib to standard melphalan-prednisone effected an impressive overall response rate in the 90% range, including 43% of complete or near-complete response.
-
• Mateos MV, Hernandez JM, Hernandez MT, et al.: Bortezomib plus melphalan and prednisone in elderly untreated patients with multiple myeloma: results of a multicenter phase 1/2 study. Blood 2006, 108:2165-2172. In elderly myeloma patients who arc not candidates for autologous transplantation, addition of bortezomib to standard melphalan-prednisone effected an impressive overall response rate in the 90% range, including 43% of complete or near-complete response.
-
-
-
-
45
-
-
22044452126
-
Superiority of thalidomide and dexamethasone over vincristine-doxorubicin-dexamethasone (VAD) as primary therapy in preparation for autologous transplantation for multiple myeloma
-
Cavo M, Zamagni E, Tosi P, et al.: Superiority of thalidomide and dexamethasone over vincristine-doxorubicin-dexamethasone (VAD) as primary therapy in preparation for autologous transplantation for multiple myeloma. Blood 2005, 106:35-39.
-
(2005)
Blood
, vol.106
, pp. 35-39
-
-
Cavo, M.1
Zamagni, E.2
Tosi, P.3
-
46
-
-
33644831033
-
Phase III clinical trial of thalidomide plus dexamethasone compared with dexamethasone alone in newly diagnosed multiple myeloma: A clinical trial coordinated by the Eastern Cooperative Oncology Group
-
Rajkumar SV, Blood E, Vesole D, et al.: Phase III clinical trial of thalidomide plus dexamethasone compared with dexamethasone alone in newly diagnosed multiple myeloma: a clinical trial coordinated by the Eastern Cooperative Oncology Group. J Clin Oncol 2006, 24:431-436.
-
(2006)
J Clin Oncol
, vol.24
, pp. 431-436
-
-
Rajkumar, S.V.1
Blood, E.2
Vesole, D.3
-
47
-
-
27744492561
-
Combination therapy with lenalidomide plus dexamethasone (Rev/Dex) for newly diagnosed myeloma
-
Rajkumar SV, Hayman SR, Lacy MQ, et al.: Combination therapy with lenalidomide plus dexamethasone (Rev/Dex) for newly diagnosed myeloma. Blood 2005, 106:4050-4053.
-
(2005)
Blood
, vol.106
, pp. 4050-4053
-
-
Rajkumar, S.V.1
Hayman, S.R.2
Lacy, M.Q.3
-
48
-
-
20144387627
-
Phase 1 trial of the proteasome inhibitor bortezomib and pegylated liposomal doxorubicin in patients with advanced hematologic malignancies
-
Orlowski RZ, Voorhees PM, Garcia RA, et al.: Phase 1 trial of the proteasome inhibitor bortezomib and pegylated liposomal doxorubicin in patients with advanced hematologic malignancies. Blood 2005, 105:3058-3065.
-
(2005)
Blood
, vol.105
, pp. 3058-3065
-
-
Orlowski, R.Z.1
Voorhees, P.M.2
Garcia, R.A.3
-
49
-
-
23944486566
-
A phase II study of Velcade (V), Doxil (D) in combination with low-dose thalidomide (T) as salvage therapy for patients with relapsed or refractory multiple myeloma (MM) and Waldenstrom's macroglobulinemia: Encouraging preliminary results [abstract]
-
Abstract 2421
-
Chanan-Khan A, Miller KC, McCarthy P: A phase II study of Velcade (V), Doxil (D) in combination with low-dose thalidomide (T) as salvage therapy for patients with relapsed or refractory multiple myeloma (MM) and Waldenstrom's macroglobulinemia: encouraging preliminary results [abstract]. Blood (ASH Annual Meeting Abstracts) 2004, 104:665a. Abstract 2421.
-
(2004)
Blood (ASH Annual Meeting Abstracts)
, vol.104
-
-
Chanan-Khan, A.1
Miller, K.C.2
McCarthy, P.3
-
50
-
-
34147216614
-
Bortezomib (Velcade) when given pretransplant and once weekly as consolidation therapy following high dose chemotherapy (HDCT) leads to high rates of reactivation of varicella zoster virus (VZV) [abstract]
-
Abstract 3237
-
Peles S, Fisher NM, Devine SM, et al.: Bortezomib (Velcade) when given pretransplant and once weekly as consolidation therapy following high dose chemotherapy (HDCT) leads to high rates of reactivation of varicella zoster virus (VZV) [abstract]. Blood (ASH Annual Meeting Abstracts) 2005, 106:Abstract 3237.
-
(2005)
Blood (ASH Annual Meeting Abstracts)
, vol.106
-
-
Peles, S.1
Fisher, N.M.2
Devine, S.M.3
|