Identification of 3-methoxyzeaxanthin as a novel age-related carotenoid metabolite in the human macula

Investigative Ophthalmology and Visual Science

Volumn 48, Issue 4, 2007, Pages 1435-1440

  Bhosale, Prakash ^a   Zhao, Da You ^a   Serban, Bogdan ^a   Bernstein, Paul S ^a  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 METHOXYZEAXANTHIN; 3' OXOLUTEIN; CAROTENOID; CAROTENOID METABOLITE; MESO ZEAXANTHIN; UNCLASSIFIED DRUG; XANTHOPHYLL; ZEAXANTHIN; 3-METHOXYZEAXANTHIN; EYE PROTEIN;

ABSORPTION SPECTROSCOPY; AGE DISTRIBUTION; ARTICLE; CONTROLLED STUDY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; MASS SPECTROMETRY; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RETINA MACULA LUTEA; ADULT; AGED; AGING; CHEMISTRY; DONOR; ELECTROSPRAY MASS SPECTROMETRY; PHYSIOLOGY; SYNTHESIS;

ADULT; AGED; AGING; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; EYE PROTEINS; HUMANS; LUTEIN; MACULA LUTEA; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TISSUE DONORS; XANTHOPHYLLS;

EID: 34248386515     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: 10.1167/iovs.06-1046     Document Type: Article

References (19)

1. Beatty S, Koh H, Phil M, Henson D, Boulton M. The role of oxidative stress in the pathogenesis of age-related macular degeneration. Surv Ophthalmol. 2000;45:115-134.
2. Hogg R, Chakravarthy U. AMD and micronutrient antioxidants. Curr Eye Res. 2004;29:387-401.
3. Schmidt-Erfurth U. Nutrition and retina. Dev Ophthalmol. 2005; 38:120-147.
4. Krinsky NI, Landrum JT, Bone RA. Biologic mechanisms of the protective role of lutein and zeaxanthin in the eye. Annu Rev Nutr. 2003;23:171-201.
5. Bone RA, Landrum JT, Mayne ST, Gomez CM, Tibor SE, Twaroska EE. Macular pigment in donor eyes with and without AMD: a case-control study. Invest Ophthalmol Vis Sci. 2001;42: 235-240.
6. Bernstein PS, Khachik F, Carvalho LS, Muir GJ, Zhao DY, Katz NB. Identification and quantitation of carotenoids and their metabolites in the tissues of the human eye. Exp Eye Res. 2001;72:215-223.
7. Bone RA, Landrum JT, Friedes LM, et al. Distribution of lutein and zeaxanthin stereoisomers in the human retina. Exp Eye Res. 1997; 64:211-218.
8. Handelman GJ, Dratz EA, Reay CC, van Kuijk FJGM. Carotenoids in the human macula and whole retina. Invest Ophthalmol Vis Sci. 1988;29:850-855.
9. Mares-Perlman JA, Brady WE, Klein R, et al. Serum antioxidants and age-related macular degeneration in a population-based case-control study. Arch Ophthalmol. 1995;113:1518-1523.
10. Gale CR, Hall NF, Phillips DI, Martyn CN. Lutein and zeaxanthin status and risk of age-related macular degeneration. Invest Ophthalmol Vis Sci. 2003;44:2461-2465.
11. Khachik F, Bernstein PS, Garland DL. Identification of lutein and zeaxanthin oxidation products in human and monkey retinas. Invest Ophthalmol Vis Sci. 1997;38:1802-1811.
12. Khachik F, de Moura FF, Zhao DY, Aebischer CP, Bernstein PS. Transformations of selected carotenoids in plasma, liver, and ocular tissues of humans and in nonprimate animal models. Invest Ophthalmol Vis Sci. 2002;43:3383-3392.
13. Bhosale P, Bernstein PS. Quantitative measurement of 3′-oxolutein from human retina by normal-phase high-performance liquid chromatography coupled to atmospheric pressure chemical ionization mass spectrometry. Anal Biochem. 2005;345:296-301.
14. Mueller H, Karrer P. Methyl ethers of carotenoids: configuration of azarine. Helvetica Chimica Acta. 1965;48:291-295.
15. Bhosale P, Zhao DY, Bernstein PS. HPLC measurement of ocular carotenoid levels in human donor eyes in the lutein supplementation era. Invest Ophthalmol Vis Sci. In press.
16. Bone RA, Landrum JT, Fernandez L, Tarsis SL. Analysis of the macular pigment by HPLC: retinal distribution and age study. Invest Ophthalmol Vis Sci. 1988;29:843-849.
17. Rapp LM, Maple SS, Choi JH. Lutein and zeaxanthin concentrations in rod outer segment membranes from perifoveal and peripheral human retina. Invest Ophthalmol Vis Sci. 2000;41: 1200-1209.
18. Brena RM, Huang TH, Plass C. Quantitative assessment of DNA methylation: potential applications for disease diagnosis, classification, and prognosis in clinical settings. J Mol Med. 2006;84:365-377.
19. Badenhop F, Steiger S, Sandmann M, Sandmann G. Expression and biochemical characterization of the 1-HO-carotenoid methylase CrtF from Rhodobacter capsulatus. FEMS Microbiol Lett. 2003; 28:237-242.