Neutrophil elastase inhibitor prevents endotoxin-induced liver injury following experimental partial hepatectomy

British Journal of Surgery

Volumn 94, Issue 5, 2007, Pages 609-619

  Kwon, A H ^a   Qiu, Z ^a  

^a KANSAI MEDICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BILIRUBIN; CASPASE 3; CASPASE 8; CYTOKINE; ENDOTOXIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LEUKOCYTE ELASTASE INHIBITOR; LIPOPOLYSACCHARIDE; SIVELESTAT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BILIRUBIN BLOOD LEVEL; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG INHIBITION; ENDOTOXEMIA; ENZYME ACTIVATION; ENZYME BLOOD LEVEL; LIVER INJURY; LIVER NECROSIS; MALE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PARTIAL HEPATECTOMY; PRIORITY JOURNAL; RAT; SURVIVAL RATE;

ANIMALS; ENDOTOXINS; GLYCINE; HEPATECTOMY; HUMANS; LEUKOCYTE ELASTASE; LIVER; LIVER DISEASES; MALE; RATS; RATS, SPRAGUE-DAWLEY; SERINE PROTEINASE INHIBITORS; SULFONAMIDES;

EID: 34248384920     PISSN: 00071323     EISSN: 13652168     Source Type: Journal    
DOI: 10.1002/bjs.5625     Document Type: Article

References (39)

1. Boermeester MA, Straatsburg IH, Houdijk AP, Meyer C, Frederiks WM, Wesdorp PJ et al. Endotoxin and interleukin-1 related hepatic inflammatory response promotes liver failure after partial hepatectomy. Hepatology 1995; 22: 1499-1506.
2. Mochida S, Ogata I, Hirata K, Ohta Y, Yamada S, Fujiwara K. Provocation of massive hepatic necrosis by endotoxin after partial hepatectomy in rats. Gastroenterology 1990; 99: 771-777.
3. Deutschman CS, Haber BA, Andrejko K, Cressman DE, Harrison R, Elenko E et al. Increased expression of cytokine-induced neutrophil chemoattractant in septic rat liver. Am J Physiol 1996; 271: R593-R600.
4. Liu SF, Malik AB. NF-κB activation as a pathological mechanism of septic shock and inflammation. Am J Physiol Lung Cell Mol Physiol 2006; 290: L622-L645.
5. Gadjeva M, Tomczak MF, Zhang M, Wang YY, Dull K, Rogers AB et al. A role for NF-κB subunits p50 and p65 in the inhibition of lipopolysaccharide-induced shock. J Immunol 2004; 173: 5786-5793.
6. Vollmar B, Ruttinger D, Wanner GA, Leiderer R, Menger MD. Modulation of Kupffer cell activity by gadolinium chloride in endotoxemic rats. Shock 1996; 6: 434-441.
7. Inoue Y, Tanaka H, Ogura H, Ukai I, Fujita K, Hosotsubo H et al. A neutrophil elastase inhibitor, sivelestat, improves leukocyte deformability in patients with acute lung injury. J Trauma 2006; 60: 936-943.
8. McGowan SE, Murray JJ. Direct effects of neutrophil oxidants on elastase-induced extracellular matrix proteolysis. Am Rev Respir Dis 1987; 135: 1286-1293.
9. Kawabata K, Suzuki M, Sugitani M, Imaki K, Toda M, Miyamoto T. ONO-5046, a novel inhibitor of human neutrophil elastase. Biochem Biophys Res Commun 1991; 177: 814-820.
10. Sakamaki F, Ishizaka A, Urano T, Sayama K, Nakamura H, Terashima T et al. Effect of a specific neutrophil elastase inhibitor, ONO-5046, on endotoxin-induced acute lung injury. Am J Respir Crit Care Med 1996; 153: 391-397.
11. Ishii K, Ito Y, Katagiri H, Matsumoto Y, Kakita A, Majima M. Neutrophil elastase inhibitor attenuates lipopolysaccharide-induced hepatic microvascular dysfunction in mice. Shock 2002; 18: 163-168.
12. Kaneko K, Kudoh I, Hattori S, Yamada H, Ohara M, Wiener-Kronish J et al. Neutrophil elastase inhibitor, ONO-5046, modulates acid-induced lung and systemic injury in rabbits. Anesthesiology 1997; 87: 635-641.
13. Zeiher BG, Matsuoka S, Kawabata K, Repine JE. Neutrophil elastase and acute lung injury: prospects for sivelestat and other neutrophil elastase inhibitors as therapeutics. Crit Care Med 2002; 30(Suppl): S281-S287.
14. Kushimoto S, Okajima K, Okabe H, Binder BR. Role of granulocyte elastase in the formation of hemorrhagic shock-induced gastric mucosal lesions in the rat. Crit Care Med 1996; 24: 1041-1046.
15. Fox-Robichaud A, Kubes P. Molecular mechanisms of tumor necrosis factor α-stimulated leukocyte recruitment into the murine hepatic circulation. Hepatology 2000; 31: 1123-1127.
16. Qiu Z, Kwon AH, Tsuji K, Kamiyama Y, Okumura T, Hirao Y. Fibronectin prevents D-galactosamine/lipopoly saccharide induced lethal hepatic failure in mice. Shock 2006; 25: 80-87.
17. Pullicino EA, Carli F, Poole S, Rafferty B, Malik ST, Elia M. The relationship between the circulating concentrations of interleukin 6 (IL-6), tumor necrosis factor (TNF) and the acute phase response to elective surgery and accidental injury. Lymphokine Res 1990; 9: 231-238.
18. Redmond HP, Chavin KD, Bromberg JS, Daly JM. Inhibition of macrophage-activating cytokines is beneficial in the acute septic response. Ann Surg 1991; 214: 502-509.
19. Biffl WL, Moore EE, Moore FA, Peterson VM. Interleukin-6 in the injured patient. Marker of injury or mediator of inflammation? Ann Surg 1996; 224: 647-664.
20. Arii S, Shibagaki M, Takahashi S, Taki Y, Yokoo N, Jikko A et al. Changes in the reticuloendothelial phagocytic function after partial hepatectomy. J Lab Clin Med 1985; 105: 668-672.
21. Mustafa SB, Flickinger BD, Olson MS. Suppression of lipopolysaccharide- induced nitric oxide synthase expression by platelet-activating factor recepter antagonists in the rat liver and cultured rat Kupffer cells. Hepatology 1999; 30: 1206-1214.
22. Garden D, Xiao F, Moak C, Willis BH, Robinson-Jackson S, Alexander S. Neutrophil elastase promotes lung microvascular injury and proteolysis of endothelial cadherins. Am J Physiol 1998; 275: H385-H392.
23. Smedly LA, Tonnesen MG, Sandhaus RA, Haslett C, Guthrie LA, Johnston RB Jr et al. Neutrophil-mediated injury to endothelial cells. Enhancement by endotoxin and essential role of neutrophil elastase. J Clin Invest 1986; 77: 1233-1243.
24. Guo L, Yamaguchi Y, Ikei S, Sugita H, Ogawa M. Neutrophil elastase inhibitor (ONO-5046) prevents lung hemorrhage induced by lipopolysaccharide in rat model of cerulein pancreatitis. Dig Dis Sci 1995; 40: 2177-2183.
25. Haga Y, Ogawa M. Neutrophil elastase inhibitor (ONO-5046.Na) decreases production of proinflammatory cytokines by lipopolysaccharide-stimulated human monocytes. Res Commun Mol Pathol Pharmacol 1997; 98: 243-248.
26. Nakatani K, Takeshita S, Tsujimoto H, Kawamura Y, Sekine I. Inhibitory effect of serine protease inhibitors on neutrophil-mediated endothelial injury. J Leukoc Biol 2001; 69: 241-247.
27. Chang CK, Gatan M, Schumer W. Efficacy of anti-tumor necrosis factor polyclonal antibody on phosphoenolpyruvate carboxykinase expression in septic and endotoxemic rats. Shock 1996; 6: 57-60.
28. Mawet E, Shiratori Y, Hikiba Y, Takada H, Yoshida H, Okano K et al. Cytokine-induced neutrophil chemoattractant release from hepatocytes is modulated by Kupffer cells. Hepatology 1996; 23: 353-358.
29. Takayashiki T, Yoshidome H, Kimura F, Ohtsuka M, Shimizu Y, Kato A et al. Increased expression of toll-like receptor 4 enhances endotoxin-induced hepatic failure in partially hepatectomized mice. J Hepatol 2004; 41: 621-628.
30. Janeway CA Jr, Medzhitov R. Innate immune recognition. Annu Rev Immunol 2002; 20: 197-216.
31. Beutler B. Tlr4: central component of the sole mammalian LPS sensor. Curr Opin Immunol 2000; 12: 20-26.
32. Su GL, Klein RD, Aminlari A, Zhang HY, Steinstraesser L, Alarcon WH et al. Kupffer cell activation by lipopolysaccharide in rats: role for lipopolysaccharide binding protein and toll-like receptor 4. Hepatology 2000; 31: 932-936.
33. Lentsch AB, Yoshidome H, Cheadle WG, Miller FN, Edwards MJ. Chemokine involvement in hepatic ischemia/reperfusion injury in mice: roles for macrophage inflammatory protein-2 and KC. Hepatology 1998; 27: 1172-1177.
34. Tsujimoto H, Ono S, Majima T, Kawarabayashi N, Takayama E, Kinoshita M et al. Neutrophil elastase, MIP-2, and TLR-4 expression during human and experimental sepsis. Shock 2005; 23: 39-44.
35. Zhou Z, Wang L, Song Z, Saari JT, McClain CJ, Kang YJ. Abrogation of nuclear factor-κB activation is involved in zinc inhibition of lipopolysaccharide-induced tumor necrosis factor-α production and liver injury. Am J Pathol 2004; 164: 1547-1556.
36. Nanji AA, Jokelainen K, Rahemtulla A, Miao L, Fogt F, Matsumoto H et al. Activation of nuclear factor kappa B and cytokine imbalance in experimental alcoholic liver disease in the rat. Hepatology 1999; 30: 934-943.
37. Mignon A, Rouquet N, Fabre M, Martin S, Pages JC, Dhainaut JF et al. LPS challenge in D-galactosamine-sensitized mice accounts for caspase-dependent fulminant hepatitis, not for septic shock. Am J Respir Crit Care Med 1999; 159: 1308-1315.
38. L functions downstream of caspase-8 to inhibit Fas- and tumor necrosis factor receptor 1-induced apoptosis of MCF7 breast carcinoma cells. J Biol Chem 1998; 273: 4523-4529.
39. Kosai K, Matsumoto K, Funakoshi H, Nakamura T. Hepatocyte growth factor prevents endotoxin-induced lethal hepatic failure in mice. Hepatology 1999; 30: 151-159.