T-cell recognition of Paracoccidioides brasiliensis gp43-derived peptides in patients with paracoccidioidomycosis and healthy individuals

Clinical and Vaccine Immunology

Volumn 14, Issue 4, 2007, Pages 474-476

  Leo, Kei Iwai ^a,b,c,d   Yoshida, Márcia ^a   Sadahiro, Aya ^a   Da Silva, Washington Robert ^a   Marin, Maria Lucia ^a,b   Goldberg, Anna Carla ^a,b   Juliano, Maria Aparecida ^c   Juliano, Luiz ^c   Shikanai Yasuda, Maria Aparecida ^a   Kalil, Jorge ^a,b   Cunha Neto, Edecio ^a,b   Travassos, Luiz R ^c  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b Millennium Institute   (Brazil)

^c FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^d HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FUNGUS ANTIGEN; GLYCOPROTEIN; GLYCOPROTEIN GP43; UNCLASSIFIED DRUG;

ALGORITHM; ARTICLE; CELL PROLIFERATION; CLINICAL ARTICLE; CONTROLLED STUDY; HUMAN; NUCLEOTIDE SEQUENCE; PARACOCCIDIOIDES BRASILIENSIS; PATHOGENESIS; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; SOUTH AMERICAN BLASTOMYCOSIS; T LYMPHOCYTE ACTIVATION;

ANTIGENS, FUNGAL; CELLS, CULTURED; FUNGAL PROTEINS; GLYCOPROTEINS; HUMANS; PARACOCCIDIOIDES; PARACOCCIDIOIDOMYCOSIS; PEPTIDES; T-LYMPHOCYTES;

EID: 34248384422     PISSN: 15566811     EISSN: None     Source Type: Journal    
DOI: 10.1128/CVI.00458-06     Document Type: Article

References (24)

1. Alexander, J., C. Oseroff, C. Dahlberg, M. Qin, G. Ishioka, M. Beebe, J. Fikes, M. Newman, R. W. Chesnut, P. A. Morton, K. Fok, E. Appella, and A. Sette. 2002. A decaepitope polypeptide primes for multiple CD8+ IFN-gamma and Th lymphocyte responses: evaluation of multiepitope polypeptides as a mode for vaccine delivery. J. Immunol. 168:6189-6198.
2. Bian, H., and J. Hammer. 2004. Discovery of promiscuous HLA-II-restricted T-cell epitopes with TEPITOPE. Methods 34:468-475.
3. Bian, H., J. F. Reidhaar-Olson, and J. Hammer. 2003. The use of bioinformatics for identifying class II-restricted T-cell epitopes. Methods 29:299-309.
4. Brummer, E., E. Castaneda, and A. Restrepo. 1993. Paracoccidioidomycosis: an update. Clin. Microbiol. Rev. 6:89-117.
5. Cisalpino, P. S., R. Puccia, L. M. Yamauchi, M. I. Cano, J. F. da Silveira, and L. R. Travassos. 1996. Cloning, characterization, and epitope expression of the major diagnostic antigen of Paracoccidioides brasiliensis. J. Biol. Chem. 271:4553-4560.
6. De Camargo, Z., C. Unterkircher, S. P. Campoy, and L. R. Travassos. 1988. Production of Paracoccidioides brasiliensis exoantigens for immunodiffusion tests. J. Clin. Microbiol. 26:2147-2151.
7. Dias, M. F., A. C. Pereira, A. Pereira, and M. S. Alves. 2000. The role of HLA antigens in the development of paracoccidioidomycosis. J. Eur. Acad. Dermatol. Venereol. 14:166-171.
8. Goldberg, A. C., M. L. Marin, J. Chiarella, C. Rosales, and J. Kalil. 1997. Brazil normal, p. 330. In D. W. Gjertson and P. E. Terasaki (ed.), HLA 1997. UCLA Tissue Typing Laboratory, American Society for Histocompatibility and Immunonenetics, Los Angeles, CA.
9. Hanna, S. A., J. L. Monteiro da Silva, and M. J. Giannini. 2000. Adherence and intracellular parasitism of Paracoccidioides brasiliensis in Vero cells. Microbes Infect. 2:877-884.
10. Iwai, L. K., M. Yoshida, J. Sidney, M. A. Shikanai-Yasuda, A. C. Goldberg, M. A. Juliano, J. Hammer, L. Juliano, A. Sette, J. Kalil, L. R. Travassos, and E. Cunha-Neto. 2003. In silico prediction of peptides binding to multiple HLA-DR molecules accurately identifies immunodominant epitopes from gp43 of Paracoccidioides brasiliensis frequently recognized in primary peripheral blood mononuclear cell responses from sensitized individuals. Mol. Med. 9:209-219.
11. Mackey, A. J., T. A. Haystead, and W. R. Pearson. 2002. Getting more from less: algorithms for rapid protein identification with multiple short peptide sequences. Mol. Cell Proteomics 1:139-147.
12. Marques da Silva, S. H., A. L. Colombo, M. H. S. L. Blotta, J. D. Lopes, F. Queiroz-Telles, and Z. Pires de Camargo. 2003. Detection of circulating gp43 antigen in serum, cerebrospinal fluid, and bronchoalveolar lavage fluid of patients with paracoccidioidomycosis. J. Clin. Microbiol. 41:3675-3680.
13. Marques, A. F., M. B. da Silva, M. A. Juliano, L. R. Travassos, and C. P. Taborda. 2006. Peptide immunization as an adjuvant to chemotherapy in mice challenged intratracheally with virulent yeast cells of Paracoccidioides brasiliensis. Antimicrob. Agents Chemother. 50:2814-2819.
14. McEwen, J. G., A. M. Garcia, B. L. Ortiz, S. Botero, and A. Restrepo. 1995. In search of the natural habitat of Paracoccidioides brasiliensis. Arch. Med. Res. 26:305-306.
15. Meloen, R. H., J. P. Langeveld, W. M. Schaaper, and J. W. Slootstra. 2001. Synthetic peptide vaccines: unexpected fulfillment of discarded hope? Biologicals 29:233-236.
16. Mendes-Giannini, M. J., J. P. Bueno, M. A. Shikanai-Yasuda, A. W. Ferreira, and A. Masuda. 1989. Detection of the 43,000-molecular-weight glycoprotein in sera of patients with paracoccidioidomycosis. J. Clin. Microbiol. 27:2842-2845.
17. Puccia, R., S. Schenkman, P. A. Gorin, and L. R. Travassos. 1986. Exocellular components of Paracoccidioides brasiliensis: identification of a specific antigen. Infect. Immun. 53:199-206.
18. Puccia, R., and L. R. Travassos. 1991. 43-kilodalton glycoprotein from Paracoccidioides brasiliensis: immunochemical reactions with sera from patients with paracoccidioidomycosis, histoplasmosis, or Jorge Lobo's disease. J. Clin. Microbiol. 29:1610-1615.
19. Restrepo, A., J. G. McEwen, and E. Castaneda. 2001. The habitat of Paracoccidioides brasiliensis: how far from solving the riddle? Med. Mycol. 39: 233-241.
20. Shikanai-Yasuda, M. A. 1996. Paracoccidioidomycosis, p. 814-824. In D. J. Weatherall, J. G. G. Ledinghan, and S. L. Wechsler (ed.), Oxford textbook of medicine. Oxford University Press, New York, NY.
21. Taborda, C. P., and Z. P. Camargo. 1993. Diagnosis of paracoccidioidomycosis by passive haemagglutination assay of antibody using a purified and specific antigen-gp43. J. Med. Vet. Mycol. 31:155-160.
22. Taborda, C. P., M. A. Juliano, R. Puccia, M. Franco, and L. R. Travassos. 1998. Mapping of the T-cell epitope in the major 43-kilodalton glycoprotein of Paracoccidioides brasiliensis which induces a Th-1 response protective against fungal infection in BALB/c mice. Infect. Immun. 66:786-793.
23. Travassos, L. R., C. P. Taborda, L. K. Iwai, E. Cunha-Neto, and R. Puccia. 2004. The gp43 from Paracoccidioides brasiliensis: a major diagnostic antigen and vaccine candidate, p. 279-296. In J. E. Domer and G. S. Kobayashi (ed.), The Mycota XII. Human fungal pathogens. Springer-Verlag, Berlin, Germany.
24. Vicentini, A. P., J. L. Gesztesi, M. F. Franco, S. W. de, J. Z. de Moraes, L. R. Travassos, and J. D. Lopes. 1994. Binding of Paracoccidioides brasiliensis to laminin through surface glycoprotein gp43 leads to enhancement of fungal pathogenesis. Infect. Immun. 62:1465-1469.