Gamma interferon responses of CD4 and CD8 T-cell subsets are quantitatively different and independent of each other during pulmonary Mycobacterium bovis BCG infection

Infection and Immunity

Volumn 75, Issue 5, 2007, Pages 2244-2252

  Ngai, Patricia ^a   McCormick, Sarah ^a   Small, Cherrie ^a   Zhang, Xizhong ^a   Zganiacz, Anna ^a   Aoki, Naoko ^a   Xing, Zhou ^a  

^a MCMASTER UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BCG VACCINE; GAMMA INTERFERON; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN SPECIFICITY; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; CYTOKINE RESPONSIVE ELEMENT; IMMUNITY; IMMUNODETECTION; LUNG INFECTION; LYMPHOCYTE ACTIVATION; MOUSE; MYCOBACTERIOSIS; MYCOBACTERIUM BOVIS; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS;

ANIMALS; ANTIGEN-PRESENTING CELLS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; COCULTURE TECHNIQUES; DISEASE MODELS, ANIMAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; INTERFERON TYPE II; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; MYCOBACTERIUM BOVIS; TUBERCULOSIS, PULMONARY;

EID: 34248376938     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.00024-07     Document Type: Article

References (29)

1. Caruso, A. M., N. Serbina, E. Klein, K. Triebold, B. R. Bloom, and J. L. Flynn. 1999. Mice deficient in CD4 T cells have only transiently diminished levels of IFN-gamma;, yet succumb to tuberculosis. J. Immunol. 162:5407-5416.
2. Cooper, A. M., et al. 1993. Disseminated tuberculosis in interferon γ gene-disrupted mice. J. Exp. Med. 178:2243-2247.
3. Cooper, A. M., C. D'Souza, A. A. Frank, and I. M. Orme. 1997. The course of Mycobacterium tuberculosis infection in the lungs of mice lacking expression of either perforin- or granzyme-mediated cytolytic mechanisms. Infect. Immun. 65:1317-1320.
4. Derrick, S. C., C. Repique, P. Snoy, A. L. Yang, and S. Morris. 2004. Immunization with a DNA vaccine cocktail protects mice lacking CD4 cells against an aerogenic infection with Mycobacterium tuberculosis. Infect. Immun. 72:1685-1692.
5. + T cells mediate adoptive immunity to aerosol infection of Mycobacterium bovis bacillus Calmette-Guérin. J. Infect. Dis. 181:1846-1849.
6. Fruch, D. M., T. Fukao, C. Bogdan, H. Schindler, J. J. O'Shea, and S. Koyasu. 2001. IFN-gamma production by antigen-presenting cells: mechanisms emerge. Trends Immunol. 22:556-560.
7. Fulton, S. A., T. D. Martin, R. W. Redline, and H. W. Boom. 2000. Pulmonary immune responses during primary Mycobacterium bovis Calmette-Guerin bacillus infection in C57BL/6 mice. Am. J. Respir. Cell Mol. Biol. 22:333-343.
8. + T-cell responses. J. Exp. Med. 196:1585-1592.
9. Ladel, C. H., S. Daugelat, and S. H. Kaufmann. 1995. Immune response to Mycobacterium bovis bacillus Calmette-Guerin infection in major histocompatibility complex class I- and II-deficient knockout mice: contribution of CD4 and CD8 T cells to acquired resistance. Eur. J. Immunol. 25:377-384.
10. Laochumroonvorapong, P., J. Wang, C. C. Liu, W. Ye, A. L. Moreira, K. B. Elkon, V. H. Freedman, and G. Kaplan. 1997. Perforin, a cytotoxic molecule which mediates cell necrosis, is not required for the early control of mycobacterial infection in mice. Infect. Immun. 65:127-132.
11. Lazarevic, V., D. Nolt, and J. L. Flynn. 2005. Long-term control of Mycobacterium tuberculosis is mediated by dynamic immune responses. J. Immunol. 175:1107-1117.
12. Locksley, R. M., S. L. Reiner, F. Hatam, D. R. Littman, and N. Killeen. 1993. Helper T cells without CD4: control of leishmaniasis in CD4-deficient mice. Science 216:1448-1451.
13. Mogues, T., M. E. Goodrich, L. Ryan, R. LaCourse, and R. J. North. 2001. The relative importance of T-cell subsets in immunity and immunopathology of airborne Mycobacterium tuberculosis infection in mice. J. Exp. Med. 193: 271-280.
14. + T-cell responses. Curr. Opin. Immunol. 16:259-263.
15. Saunders, B. M., A. A. Frank, I. M. Orme, and A. M. Cooper. 2002. CD4 is required for the development of a protective granulomatous response to pulmonary tuberculosis. Cell. Immunol. 216:65-72.
16. + T cells participate in the memory immune response to Mycobacterium tuberculosis. Infect. Immun. 69:4320-4328.
17. Serbina, N. V., V. Lazarevic, and J. L. Flynn. 2001. CD4 T cells are required for the development of cytotoxic CD8 T cells during Mycobacterium tuberculosis infection. J. Immunol. 167:6991-7000.
18. Shedlock, D. J., J. K. Whitmire, J. Tan, A. S. MacDonald, R. Ahmed, and H. Shen. 2003. Role of CD4 T-cell help and costimulation in CD8 T-cell responses during Listeria monocytogenes infection. J. Immunol. 170:2053-2063.
19. Smith, S. M., and H. M. Dockrell. 2000. Role of CD8 T cells in mycobacterial infections. Immunol. Cell Biol. 78:325-333.
20. + T cells requires the production of gamma interferon. Infect. Immun. 66:830-834.
21. Turner, J., A. A. Frank, and I. M. Orme. 2002. Old mice express a transient early resistance to pulmonary tuberculosis that is mediated by CD8 T cells. Infect. Immun. 70:4628-4637.
22. Tyznik, A. J., J. C. Sun, and M. J. Bevan. 2004. The CD8 population in CD4-deficient mice is heavily contaminated with MHC class II-restricted T cells. J. Exp. Med. 199:559-565.
23. Wakeham, J., J. Wang, J. Magram, K. Croitoru, R. Harkness, Dunn, A. P. Zganiacz, and Z. Xing. 1998. Lack of both types 1 and 2 cytokines, tissue inflammatory responses, and immune protection during pulmonary infection by Mycobacterium bovis bacillus Calmette-Guérin in IL-12-deficient mice. J. Immunol. 160:6101-6111.
24. Wang, J., J. Wakeham, R. Harkness, and Z. Xing. 1999. Macrophages are a significant source of type 1 cytokines during mycobacterial infection. J. Clin. Investig. 103:1023-1029.
25. Wang, J., P. M. Santosuosso, Ngai, A. Zganiacz, and Z. Xing. 2004. Activation of CD8 T cells by mycobacterial vaccination protects against pulmonary tuberculosis in the absence of CD4 T cells. J. Immunol. 173:4590-4597.
26. Xing, J. Z., Wang, K. Croitoru, and J. Wakeham. 1998. Protection by CD4 or CD8 T cells against pulmonary Mycobacterium bovis bacillus Calmette-Guérin infection. Infect. Immun. 66:5537-5542.
27. Xing, Z., A. Zganiacz, and M. Santosuosso. 2000. Role of IL-12 in macrophage activation during intracellular infection: IL-12 and mycobacteria synergistically release TNF-α and nitric oxide from macrophages via IFN-γ induction. J. Leukoc. Biol. 68:897-902.
28. Xing, Z., A. Zganiacz, J. Wang, and S. K. Sharma. 2001. Enhanced protection against fatal mycobacterial infection in SCID beige mice by reshaping innate immunity with IFN-γ transgene. J. Immunol. 167:375-383.
29. Zganiacz, A., M. Santosuosso, J. Wang, T. Yang, L. Chen, M. Anzulovic, S. Alexander, B. Gicquel, Y. Wan, J. Bramson, M. Inman, and Z. Xing. 2004. TNFα is a critical negative regulator of type I immune activation during intracellular bacterial infection. J. Clin. Investig. 113:401-413.