The impact of male factor on recurrent pregnancy loss

Current Opinion in Obstetrics and Gynecology

Volumn 19, Issue 3, 2007, Pages 222-228

  Puscheck, Elizabeth E ^a   Jeyendran, Rajasingam S ^b  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Andrology Laboratory Services   (United States)

Author keywords

Infertility; Recurrent abortion; Recurrent pregnancy loss

Indexed keywords

HLA G ANTIGEN; MANNAN BINDING LECTIN;

CHROMOSOME ABERRATION; CHROMOSOME ANALYSIS; CHROMOSOME DELETION; CHROMOSOME NUMBER; CHROMOSOME TRANSLOCATION; CONGENITAL MALFORMATION; EMBRYO DEVELOPMENT; FEMALE; GENE MUTATION; GENETIC POLYMORPHISM; HUMAN; KARYOTYPE; MALE FERTILITY; NIDATION; NONHUMAN; PATERNAL AGE; PRIORITY JOURNAL; RADIATION EXPOSURE; RECURRENT ABORTION; REVIEW; ROBERTSONIAN CHROMOSOME TRANSLOCATION; SPERMATOGENESIS; SPERMATOZOON ABNORMALITY; SPONTANEOUS ABORTION; STRUCTURAL CHROMOSOME ABERRATION; THROMBOPHILIA; Y CHROMOSOME;

ABORTION, HABITUAL; ANIMALS; CHROMOSOME ABERRATIONS; FEMALE; HUMANS; INFERTILITY; MALE; MUTATION; PATERNAL AGE; PREGNANCY; SEX FACTORS; SPERMATOZOA;

EID: 34248375216     PISSN: 1040872X     EISSN: None     Source Type: Journal    
DOI: 10.1097/GCO.0b013e32813e3ff0     Document Type: Review

References (44)

1. Li TC, Makris M, Tomsu M, et al. Recurrent miscarriage: aetiology, management and prognosis. Hum Reprod Update 2002; 8:463-481.
2. Morel F, Roux C, Bresson JL. FISH analysis of chromosomal status of spermatozoa from three men with 45,XY,der(13;14)9q10;q10) karyotype. Mol Human Reprod 2001; 7:483-488.
3. Sugiura-Ogasawara M, Ozaki Y, Sato T, et al. Poor prognosis of recurrent aborters with either maternal or paternal reciprocal translocations. Fertil Steril 2004; 81:367-373.
4. Leporrier N, Herrou M, Morello R, Leymarie P. Fetuses with Down's syndrome detected by prenatal screening are more likely to abort spontaneously than fetuses with Down's syndrome not detected by prenatal screening. Br J Obstet Gynecol 2003; 110:18-21.
5. Thompson JS, Thompson MW, editors. Genetics in medicine. Philadelphia, PA: W.B. Saunders Company; 1980.
6. Rubio C, Simon C, Blanco J, et al. Implications of sperm chromosome abnormalities in recurrent miscarriage. J Assist Reprod Genet 1999; 16:253-258.
7. Carrell DT, Wilcox AL, Lowy L, et al. Elevated sperm aneuploidy and apoptosis in patients with unexplained recurrent pregnancy loss. Obstet Gynecol 2003; 101:1229-1235.
8. Evenson DP, Jost LK, Marshall D, et al. Utility of the sperm chromatin structure assay as a diagnostic and prognostic tool in the human fertility clinic. Hum Reprod 1999; 14:1039-1049.
9. Spano M, Bonde JP, Hjollund HI, et al. Sperm chromatin damage impairs human fertility. The Danish First Pregnancy Planner Study Team. Fertil Steril 2000; 73:43-50.
10. Lopes S, Sun JG, Jurisicova A, et al. Sperm deoxyribonucleic acid fragmentation is increased in poor-quality semen samples and correlates with failed fertilization in intracytoplasmic sperm injection. Fertil Steril 1998; 69:528-532.
11. Sakkas D, Urner F, Bizzaro D, et al. Sperm nuclear DNA damage and altered chromatin structure: effect on fertilization and embryo development. Hum Reprod 1998; 13 (Suppl 4):11-19.
12. Aran B, Blanco J, Vidal F, et al. Screening for abnormalities of chromosomes X, Y, and 18 and for diploidy in spermatozoa from infertile men participating in an in vitro fertilization-intracytoplasmic sperm injection program. Fertil Steril 1999; 72:696-701.
13. Syme RM, Martin RH. Meiotic segregation of a 21;22 Robertsonian translocation. Hum Reprod 1992; 7:825-829.
14. Aldrich CL, Stephenson MD, Karrison T, et al. HLA-G genotypes and pregnancy outcome in couples with unexplained recurrent miscarriage. Mol Hum Reprod 2001; 7:1167-1172.
15. Jivraj S, Rai R, Underwood J, Regan L. Genetic thrombophilic mutations among couples with recurrent miscarriage. Hum Reprod 2006; 21:1161-1165. Interesting study comparing the risk of multiple thrombophilic mutations and its effect on pregnancy outcome.
16. Chandley AC. Chromosome anomalies and Y chromosome microdeletions as causal factors in male infertility. Hum Reprod 1998; 13:45-50.
17. Van Assche E, Bonduelle M, Tournaye H, et al. Cytogenetics of infertile men. Hum Reprod 1996; 11:1-26.
18. Dewan S, Puscheck EE, Coulam CB, et al. Y-chromosome microdeletions and recurrent pregnancy loss. Fertil Steril 2006; 85:441-445. This study is the first to evaluate the Y-chromosome microdeletions in couples with recurrent pregnancy loss and find a significant increase in its incidence.
19. Hill JA, Abbott AF, Politch JA. Sperm morphology and recurrent abortion. Fertil Steril 1994; 61:776-778.
20. Hill JA, Anderson DJ, Polgar K, et al. Seminal white blood cells and recurrent abortion. Hum Reprod 1994; 9:1180-1183.
21. Homonnai ZT, Paz GF, Weiss JN, David MP. Relation between semen quality and fate of pregnancy: retrospective study on 534 pregnancies. Int J Androl 1980; 3:574-584.
22. Sbracia S, Cozza G, Grasso JA, et al. Semen parameters and sperm morphology in men in unexplained recurrent spontaneous abortion, before and during a 3 year follow-up period. Hum Reprod 1996; 11:117-120.
23. Buckett WM, Luckas MJ, Aird IA, et al. The hypo-osmotic swelling test in recurrent miscarriage. Fertil Steril 1997; 68:506-509.
24. Gopalkkrishnan K, Padwal V, Meherji PK. Poor quality of sperm as it affects repeated early pregnancy loss. Arch Androl 2000; 45:111-117.
25. Sathananthan AH. Mitosis in the human embryo: the vital role of the sperm centrosome (centriole). Histol Histopathol 1997; 12:827-856.
26. Tesarik J, Greco E, Mendoza C. Late, but not early, paternal effect on human embryo development is related to sperm DNA fragmentation. Hum Reprod 2004; 19:611-615.
27. Spindle A, Sturm KS, Flannery M, et al. Defective chorioallantoic fusion in mid-gestation lethality of parthenogenone↔tetraploid chimeras. Dev Biol 1996; 173:447-458.
28. Kleinhaus K, Perrin M, Friedlander Y, et al. Paternal age and spontaneous abortion. Obstet Gynecol 2006; 108:369-377. A case-controlled study of 13 865 women from a population-based cohort of 92 408 births demonstrating a significant impact of paternal age (>40 years) on spontaneous loss rates by almost three-fold. An excellent large study using a religiously conservative population.
29. Slama R, Bouyer J, Windham G, et al. Influence of paternal age on the risk of spontaneous abortion. Am J Epid 2005; 161:816-823. A prospective study of 5121 pregnant Californian women from the Kaiser Permanente Medical Care Program studied from time of their first obstetric appointment; subjects must present before 13 weeks' gestation for inclusion. The participants showed an independent risk factor for paternal age on spontaneous abortion. A well done study.
30. De La Rochebrochard E, McElreavey K, Thonneau P. Paternal age over 40 years: the 'amber light' in the reproductive life of men? J Androl 2003; 24:459-465.
31. De La Rochebrochard E, de Mouzon J, Thepot F, Thonneau P, and the French National IVF Registry (FIVNAT) association. Fathers over 40 and increased failure to conceive: the lessons of invitro fertilization in France. Fertil Steril 2006; 85:1420-1424.
32. Wyrobek AJ, Eskenazi B, Young S, et al. Advancing age has differential effects on DNA damage, chromatin integrity, gene mutations and aneuploidies in sperm. PNAS 2006; 103:9601-9606. An excellent smaller study of 97 healthy, nonsmoking men - all from a government research laboratory (a nonclinical population) - that studied sperm chromatin, sperm aneuploidy and certain sperm mutations thoroughly and showed a relationship with paternal age.
33. Crow JF. Development. There's something curious about paternal-age effects. Science 2003; 301:606-607.
34. Kilpatrick DC, Bevan BH, Liston WA. Association between mannan binding protein deficiency and recurrent miscarriage. Hum Reprod 1995; 10:2501-2505.
35. Christiansen OB, Kilpatrick DC, Souter V, et al. Mannan-binding lectin deficiency is associated with unexplained recurrent miscarriage. Scand J Immunol 1999; 49:193-196.
36. Kilpatrick DC, Starrs L, Moore S, et al. Mannan binding lectin concentration and risk of miscarriage. Hum Reprod 1999; 14:2379-2380.
37. Puscheck EE, Philip PA, Jeyendran RS. Male fertility preservation and cancer treatment. Cancer Treat Rev 2004; 30:173-180.
38. Sergerie M, Martinet S, Kiffer N, et al. Impact of reverse transcriptase inhibitors on sperm mitochondrial and genomic DNA in assisted reproduction techniques. Gynecol Obstet Fertil 2004; 32:841-849.
39. Dixon ME, Chien EK, Osol G, et al. Failure of decidual arteriolar remodeling in the CBA/J x DBA/2 murine model of recurrent pregnancy loss is linked to increased expression of tissue inhibitor of metalloproteinase 2 (TIMP-2). Am J Obstet Gynecol 2006; 194:113-119. A well designed animal study showing the impact of vascular remodeling of decidual vessels on recurrent pregnancy loss, which has implications for future human studies.
40. Chaouat G, Assal Meliani A, Martal J, et al. IL-10 prevents naturally occurring fetal loss in the CBA x DBA/2 mating combination, and local defect in IL-10 production in this abortion-prone combination is corrected by in vivo injection of IFN-tau. J Immunol 1995; 154:4261-4268.
41. Greco E, Iacobelli M, Rienzi L, et al. Reduction of the incidence of sperm DNA fragmentation by oral antioxidant treatment. J Androl 2005; 26:349-353. A prospectively randomized trial using oral vitamin C and E reduced sperm DNA fragmentation that did not affect basic semen analysis parameters. A well done study.
42. Vidal F, Rubio C, Simon C, et al. Is there a place for preimplantation genetic diagnosis screening in recurrent miscarriage patients? J Reprod Fertil Suppl 2000; 55:143-146.
43. Aran B, Veiga A, Vidal F, et al. Preimplantation genetic diagnosis in patients with male meiotic abnormalities. Reprod Biomed Online 2004; 8:470-476.
44. Hazout A, Dumont-Hassan M, Junca AM, et al. High-magnification ICSI overcomes paternal effect resistant to conventional ICSI. Reprod Biomed Online 2006; 12:19-25. An interesting study to overcome the paternal effect by selecting sperm using a high-magnification optical system for use in ICSI in a study of 125 couples who had two or more conventional ICSI failures and showed improved clinical outcome.