Supplementation with iron and riboflavin enhances dark adaptation response to vitamin A-fortified rice in iron-deficient, pregnant, nightblind Nepali women

American Journal of Clinical Nutrition

Volumn 85, Issue 5, 2007, Pages 1375-1384

  Graham, Joanne M ^a   Haskell, Marjorie J ^a   Pandey, Pooja ^b   Shrestha, Ram K ^b   Brown, Kenneth H ^a   Allen, Lindsay H ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Nepali Technical Assistance Group   (Nepal)

Author keywords

Impaired pupillary threshold; Iron deficiency; Nepal; Nightblindness; Pregnancy; Riboflavin; Women

Indexed keywords

IRON; IRON PLUS RIBOFLAVIN; RETINOL; RIBOFLAVIN; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DARK ADAPTATION; DRUG BLOOD LEVEL; ERYTHROCYTE LEVEL; FEMALE; FERRITIN BLOOD LEVEL; HEMOGLOBIN BLOOD LEVEL; HUMAN; IRON DEFICIENCY; IRON DEFICIENCY ANEMIA; IRON THERAPY; MAJOR CLINICAL STUDY; NEPAL; NIGHT BLINDNESS; NUTRITIONAL STATUS; PREGNANCY; PREVALENCE; PUPIL REFLEX; RANDOMIZED CONTROLLED TRIAL; RETINOL DEFICIENCY; RIBOFLAVIN DEFICIENCY; RICE; VISUAL THRESHOLD;

EID: 34248366517     PISSN: 00029165     EISSN: None     Source Type: Journal    
DOI: 10.1093/ajcn/85.5.1375     Document Type: Article

References (49)

1. World Health Organization. Micronutrient deficiencies: battling iron deficiency anemia. 2003. Internet: http://www.who.int/nut/ida.htm (accessed 15 November 2005).
2. World Health Organization. Micronutrient Deficiency Information System: database on anemia. 2005. Internet: http://www.who.int/nut/db_mdis.htm, (accessed 15 November 2005).
3. Jang JT, Green JB, Beard JL, Green MH. Kinetic analysis shows that iron deficiency decreases liver vitamin A mobilization in rats. J Nutr 2000;130:1291-6.
4. Rosales FJ, Jang JT, Piñero DJ, Erikson KM, Beard JL, Ross AC. Iron deficiency in young rats alters the distribution of vitamin A between plasma and liver and between hepatic retinol and retinyl esters. J Nutr 1999;129:1223-8.
5. Powers HJ, Bates CJ, Lamb WH. Haematological response to supplements of iron and riboflavin to pregnant and lactating women in rural Gambia. Hum Nutr Clin Nutr 1985;39:117-29.
6. Pongpaew P, Saowakontha S, Schelp FP, et al. Vitamin B1, B2 and B6 during the course of pregnancy of rural and urban women in northeast Thailand. Int J Vitam Nutr Res 1995;65:111-6.
7. Batey DW, Eckhert CD. Identification of FAD, FMN, and riboflavin in the retina by microextraction and high-performance liquid chromatography. Anal Biochem 1990;188:164-7.
8. Batey DW, Eckhert CD. Analysis of flavins in ocular tissues of the rabbit. Invest Ophthalmol Vis Sci 1991;32:1981-5.
9. Batey DW, Daneshgar KK, Eckhert CD. Flavin levels in the rat retina. Exp Eye Res 1992;54:605-9.
10. Miyamoto Y, Sancar A. Vitamin B2-based blue-light photoreceptors in the retinohypothalamic tract as the photoactive pigments for setting the circadian clock in mammals. Proc Natl Acad Sci U S A 1998;95:6097-102.
11. Zaman Z, Verwilghen RL. Effects of riboflavin deficiency on oxidative phosphorylation, flavin enzymes and coenzymes in rat liver. Biochem Biophys Res Commun 1975;67:1192-8.
12. Zaman Z, Verwilghen RL. Effect of riboflavin deficiency on activity of NADH-FMN oxidoreductase (ferriductase) and iron content of rat liver. Biochem Soc Trans 1977;5:306-8.
13. Fairweather-Tait SJ, Powers HJ, Minski MJ, Whitehead J, Downes R. Riboflavin deficiency and iron absorption in adult Gambian men. Ann Nutr Metab 1992;36:34-40.
14. Christian P, West KP Jr, Khatry SK, et al. Vitamin A or beta-carotene supplementation reduces but does not eliminate maternal night blindness in Nepal. J Nutr 1998;128:1458-63.
15. Haskell MJ, Pandey P, Graham JM, Peerson JM, Shresta RK, Brown KH. Recovery from impaired dark adaptation in nightblind pregnant Nepali women who receive small daily doses of vitamin A as amaranth leaves, carrots, goat liver, vitamin A-fortified rice, or retinyl palmitate. Am J Clin Nutr 2005;81:461-71.
16. Christian P, West KP Jr, Khatry SK, et al. Night blindness during pregnancy and subsequent mortality among women in Nepal: effects of vitamin A and beta-carotene supplementation. Am J Epidemiol 2000;152:542-7.
17. Congdon N, Sommer A, Severns M, et al. Pupillary and visual thresholds in young children as an index of population vitamin A status. Am J Clin Nutr 1995;61:1076-82.
18. Congdon NG, Dreyfuss ML, Christian P, et al. Responsiveness of dark-adaptation threshold to vitamin A and β-carotene supplementation in pregnant and lactating women in Nepal. Am J Clin Nutr 2000;72:1004-9.
19. Congdon NG, West KP Jr. Physiologic indicators of vitamin A status. J Nutr 2002;132(suppl):2889S-94S.
20. Graham JM, Peerson JM, Haskell MJ, Shrestha RK, Brown KH, Allen LH. Erythrocyte riboflavin for the detection of riboflavin deficiency in pregnant Nepali women. Clin Chem 2005;51:2162-5.
21. Handelman GJ, Shen B, Krinsky NI. High resolution analysis of carotenoids in human plasma by high-performance liquid chromatography. Methods Enzymol 1992;213:336-46.
22. Olson JA. Serum levels of vitamin A and carotenoids as reflectors of nutritional status. J Natl Cancer Inst 1984;73:1439-44.
23. International Nutritional Anemia Consultative Group. Measurements of iron status. Washington, DC: The Nutrition Foundation, Inc, 1985:1-78.
24. Wieringa FT, Dijkhuizen MA, West CE, Northrop-Clewes CA, Muhilal. Estimation of the effect of the acute phase response on indicators of micronutrient status in Indonesian infants. J Nutr 2002;132:3061-6.
25. Paracha PI, Jamil A, Northrop-Clewes CA, Thurnham DI. Interpretation of vitamin A status in apparently healthy Pakistani children by using markers of subclinical infection. Am J Clin Nutr 2000;72:1164-9.
26. Milman N, Graudal N, Nielsen OJ, Agger AO. Serum erythropoietin during normal pregnancy: relationship to hemoglobin and iron status markers and impact of iron supplementation in a longitudinal, placebo-controlled study on 118 women. Int J Hematol 1997;66:159-68.
27. Hahn P, Dentchev T, Qian Y, Rouault T, Harris ZL, Dunaief JL. Immunolocalization and regulation of iron handling proteins ferritin and ferroportin in the retina. Mol Vis 2004;10:598-607.
28. Sarici SU, Okutan V, Dundaroz MR, et al. The effect of iron supplementation on visual-evoked potentials in infants with iron-deficiency anemia. J Trop Pediatr 2001;47:132-5.
29. Christian P, West KP Jr, Khatry SK, et al. Night blindness of pregnancy in rural Nepal-nutritional and health risks. Int J Epidemiol 1998;27:231-7.
30. Christian P, West KP Jr, Khatry SK, et al. Vitamin A or beta-carotene supplementation reduces symptoms of illness in pregnant and lactating Nepali women. J Nutr 2000;130:2675- 82.
31. Christian P, Khatry SK, Yamini S, et al. Zinc supplementation might potentiate the effect of vitamin A in restoring night vision in pregnant Nepalese women. Am J Clin Nutr 2001;73:1045-51.
32. Christian P, Jiang T, Khatry SK, LeClerq SC, Shrestha SR, West KP Jr. Antenatal supplementation with micronutrients and biochemical indicators of status and subclinical infection in rural Nepal. Am J Clin Nutr 2006;83:788-94.
33. Carney EA, Russell RM. Correlation of dark adaptation test results with serum vitamin A levels in diseased adults. J Nutr 1980;110:552-7.
34. Wachtmeister L, Björkhem I, Diczfalusy U, Emami A. Attempts to define the minimal serum level of vitamin A required for normal visual function in a patient with severe fat malabsorption. Acta Ophthalmol (Copenh) 1988;66:341-8.
35. Tanumihardjo SA. Vitamin A and iron status are improved by vitamin A and iron supplementation in pregnant Indonesian women. J Nutr 2002;132:1909-12.
36. Furr HC, Green MH, Haskell M, et al. Stable isotope dilution techniques for assessing vitamin A status and bioefficacy of provitamin A carotenoids in humans. Public Health Nutr 2005;8:596-607.
37. Allen LH. Iron-deficiency anemia increases risk of preterm delivery. Nutr Rev 1993;51:49-52.
38. Ramakrishnan U. Functional consequences of nutritional anemia during pregnancy and early childhood. In: Ramakrishnan U, ed. Nutritional anemias. Boca Raton, FL: CRC Press, 2001:43-68.
39. Bondevik GT, Eskeland B, Ulvik RJ, et al. Anaemia in pregnancy: possible causes and risk factors in Nepali women. Eur J Clin Nutr 2000;54:3-8.
40. Dreyfuss ML, Shrestha JB, Khatry SK, et al. The prevalence of anaemia among pregnant and lactating women, and among their infants in Sarlahi District. J Nepali Med Assoc 1997;35:234-40.
41. Nepal Micronutrient Status Survey 1998. Kathmandu, Nepal: Ministry of Health, Child Health Division, HMG/N, New ERA, Micronutrient Initiative, UNICEF Nepal, and WHO, 1998:68-72.
42. Dreyfuss ML, Stoltzfus RJ, Shrestha JB, et al. Hookworms, malaria and vitamin A deficiency contribute to anemia and iron deficiency among pregnant women in the plains of Nepal. J Nutr 2000;130:2527-36.
43. World Health Organization. Iron deficiency anemia: assessment, prevention, and control: a guide for programme managers. 2001. Internet: http://www.who.int/nut/documents/ida_assessment_prevention_control.pdf (accessed 3 August 2003).
44. Charoenlarp P, Pholpothi T, Chatpunyaporn P, Schelp FP. The effect of riboflavin on the hematologic changes in iron supplementation of schoolchildren. Southeast Asian J Trop Med Public Health 1980;11:97-103.
45. Powers HJ, Bates CJ, Prentice AM, Lamb WH, Jepson M, Bowman H. The relative effectiveness of iron and iron with riboflavin in correcting a microcytic anaemia in men and children in rural Gambia. Hum Nutr Clin Nutr 1983;37:413-25.
46. Powers HJ. Experiment to determine the effect of riboflavin deficiency at weaning on iron economy and heme synthesis. Ann Nutr Metab 1985;29:261-6.
47. Christian P, Shrestha J, LeClerq SC, et al. Supplementation with micronutrients in addition to iron and folic acid does not further improve the hematologic status of pregnant women in rural Nepal. J Nutr 2003;133:3492-8.
48. Christian P, Thorne-Lyman AL, West KP Jr, et al. Working after the sun goes down: exploring how night blindness impairs women's work activities in rural Nepal. Eur J Clin Nutr 1998;52:519-24.
49. Christian P, West KP Jr, Khatry SK, et al. Maternal night blindness increases risk of mortality in the first 6 months of life among infants in Nepal. J Nutr 2001;131:1510-2.