Stress-ulcer prophylaxis for general medical patients: A review of the evidence

Journal of Hospital Medicine

Volumn 2, Issue 2, 2007, Pages 86-92

  Janicki, Todd ^a,b   Stewart, Scott ^a  

^a UNIVERSITY AT BUFFALO   (United States)

^b NONE   (United States)

Author keywords

Gastrointestinal bleeding; Prophylaxis; Stress ulcer

Indexed keywords

CIMETIDINE; CORTICOSTEROID; HEPARIN; HISTAMINE H2 RECEPTOR ANTAGONIST; MAGALDRATE; NONSTEROID ANTIINFLAMMATORY AGENT; PLACEBO; PREDNISONE; PROTON PUMP INHIBITOR; STOMACH SECRETION INHIBITOR; SUCRALFATE; WARFARIN;

BLOOD TRANSFUSION; CLINICAL TRIAL; COCHRANE LIBRARY; DATA EXTRACTION; DRUG INDICATION; DRUG WITHDRAWAL; EVIDENCE BASED MEDICINE; GASTROINTESTINAL HEMORRHAGE; HUMAN; MEDLINE; PRESCRIPTION; PREVALENCE; PRIMARY PREVENTION; PRIORITY JOURNAL; REVIEW; STRESS ULCER; SYSTEMATIC REVIEW; TREATMENT OUTCOME; UNSPECIFIED SIDE EFFECT;

ALUMINUM HYDROXIDE; ANTACIDS; ANTI-ULCER AGENTS; CIMETIDINE; HUMANS; MAGNESIUM HYDROXIDE; PEPTIC ULCER; PEPTIC ULCER HEMORRHAGE; STRESS;

EID: 34248363243     PISSN: 15535592     EISSN: 15535606     Source Type: Journal    
DOI: 10.1002/jhm.177     Document Type: Review

References (33)

1. Cook DJ, Fuller HD, Guyatt GH, et al. Risk factors for gastrointestinal bleeding in critically ill patients. Canadian Critical Care Trials Group. N Engl J Med. 1994;330: 377-381.
2. Faisy C, Guerot E, Diehl JL, Iftimovici E, Fagon JY. Clinically significant gastrointestinal bleeding in critically ill patients with and without stress-ulcer prophylaxis. Intensive Care Med. 2003;29:1306-1313.
3. Pimentel M, Roberts DE, Bernstein CN, Hoppensack M, Duerksen DR. Clinically significant gastrointestinal bleeding in critically ill patients in an era of prophylaxis. Am J Gastroenterol. 2000;95:2801-2806.
4. Navab F, Steingrub J. Stress ulcer: is routine prophylaxis necessary? Am J Gastroenterol. 1995;90:708-712.
5. Lasky MR, Metzler MH, Phillips JO. A prospective study of omeprazole suspension to prevent clinically significant gastrointestinal bleeding from stress ulcers in mechanically ventilated trauma patients. J Trauma. 1998;44:527-533.
6. Darlong V, Jayalakhsmi TS, Kaul HL, Tandon R. Stress ulcer prophylaxis in patients on ventilator. Trop Gastroenterol. 2003;24:124-128.
7. Daley RJ, Rebuck JA, Welage LS, Rogers FB. Prevention of stress ulceration: current trends in critical care. Crit Care Med. 2004;32:2008-2013.
8. Terdiman JP, Ostroff JW. Gastrointestinal bleeding in the hospitalized patient: a case-control study to assess risk factors, causes, and outcome. Am J Med. 1998;104:349-354.
9. Zimmerman J, Meroz Y, Siguencia J, Tsvang E, Arnon R. Upper gastrointestinal hemorrhage. Comparison of the causes and prognosis in primary and secondary bleeders. Scand J Gastroenterol. 1994;29:795-798.
10. Davenport RJ, Dennis MS, Warlow CP. Gastrointestinal hemorrhage after acute stroke. Stroke. 1996;27:421-424.
11. Fiaccadori E, Maggiore U, Clima B, Melfa L, Rotelli C, Borghetti A. Incidence, risk factors, and prognosis of gastrointestinal hemorrhage complicating acute renal failure. Kidney Int. 2001;59:1510-1519.
12. Qadeer M, Richter J, Brotman D. Hospital-acquired gastrointestinal bleeding outside the critical care unit. J Hosp Med. 2006:1:13-20.
13. Zimmerman J, Meroz Y, Arnon R, Tsvang E, Siguencia J. Predictors of mortality in hospitalized patients with secondary upper gastrointestinal haemorrhage. J Intern Med. 1995; 237:331-337.
14. Niklasson A, Bajor A, Bergendal L, Simren M, Strid H, Bjornsson E. Overuse of acid suppressive therapy in hospitalised patients with pulmonary diseases. Respir Med. 2003; 97:1143-1150.
15. Kowalsky SF, Hamilton RA, Figge HL. Drug usage evaluation: H2-receptor antagonist use in 30 hospitals. Hosp Formul. 1991;26:725-736.
16. Liberman JD, Whelan CT. Reducing inappropriate usage of stress ulcer prophylaxis among internal medicine residents: A practice-based educational intervention. J Gen Intern Med. 2006:21:498-500.
17. Cook DJ, Mulrow CD, Haynes RB. Systematic reviews: synthesis of best evidence for clinical decisions. Ann Intern Med. 1997;126:376-380.
18. Counsell C. Formulating questions and locating primary studies for inclusion in systematic reviews. Ann Intern Med. 1997;127:380-387.
19. Meade MO, Richardson WS. Selecting and appraising studies for a systematic review. Ann Intern Med. 1997;127:531-537.
20. Begg C, Cho M, Eastwood S, et al. Improving the quality of reporting of randomized controlled trials. The CONSORT statement. JAMA. 1996;276:637-639.
21. Moher D, Schulz KF, Altman D. The CONSORT statement: revised recommendations for improving the quality of reports of parallel-group randomized trials. JAMA. 2001;285: 1987-1991.
22. Nardino RJ, Vender RJ, Herbert PN. Overuse of acid-suppressive therapy in hospitalized patients. Am J Gastroenterol. 2000;95:3118-3122.
23. Parente F, Cucino C, Gallus S, et al. Hospital use of acid-suppressive medications and its fall-out on prescribing in general practice: a 1-month survey. Aliment Pharmacol Ther. 2003;17:1503-1506.
24. Gullota R, Ferraris L, Cortelezzi C. Are we correctly using the inhibitors of gastric acid secretion and cytoprotective drugs? Results of a multicentre study. Ital J Gastroenterol Hepatol. 1997;29:325-329.
25. Estruch R, Pedrol E, Castells A, et al. Prophylaxis of gastrointestinal tract bleeding with magaldrate in patients admitted to a general hospital ward. Scand J Gastroenterol. 1991; 26:819-826.
26. Grau JM, Casademont J, Fernandez-Sola J, Cardellach F, Urbano-Marquez A. Prophylaxis of gastrointestinal tract bleeding in patients admitted to a general hospital ward. Comparative study of sucralfate and cimetidine. Scand J Gastroenterol. 1993;28:244-248.
27. Cook DJ, Reeve BK, Guyatt GH, et al. Stress ulcer prophylaxis in critically ill patients. Resolving discordant meta-analyses. JAMA. 1996;275:308-314.
28. Yologlu S, Durmaz B, Bayindir Y. Nosocomial infections and risk factors in intensive care units. New Microbiol. 2003;26: 299-303.
29. Joshi N, Localio AR, Hamory BH. A predictive risk index for nosocomial pneumonia in the intensive care unit. Am J Med. 1992;93:135-142.
30. Dial S, Alrasadi K, Manoukian C, et. al. Risk of Clostridium difficile diarrhea among hospital inpatients prescribed proton pump inhibitors: cohort and case-control studies. CMAJ. 2004:171:33-38.
31. Dial S, Delaney J, Barkun A, Suissa, S. Use of gastric acid-suppressive agents and the risk of community-acquired clostridium difficile-associated disease. JAMA. 2005:294: 2989-2995.
32. Wade EE, Rebuck JA, Healey MA, Rogers FB. H-2 antagonist-induced thrombocytopenia: is this a real phenomenon? Intensive Care Med. 2002;28:459-465.
33. Levy M, Seelig C, Robinson N, Ranney, J. Comparison of omeprazole and ranitidine for stress ulcer prophylaxis. Dig Dis Sci. 1997:42:1255-1259.