Olfactory bulbectomy increases food intake and hypothalamic neuropeptide Y in obesity-prone but not obesity-resistant rats

Behavioural Brain Research

Volumn 180, Issue 2, 2007, Pages 190-196

  Primeaux, Stefany D ^a   Barnes, Maria J ^a   Bray, George A ^a  

^a PENNINGTON BIOMEDICAL RESEARCH CENTER   (United States)

Author keywords

Amygdala; Depression; Food intake; Hypothalamus; Neuropeptide Y; Obesity prone; Olfactory bulbectomy

Indexed keywords

NEUROPEPTIDE Y;

AMYGDALOID NUCLEUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DEPRESSION; DISEASE ASSOCIATION; FOOD INTAKE; HYPOTHALAMUS; LOCOMOTION; MALE; NONHUMAN; OBESITY; OLFACTORY BULBECTOMY; OPEN FIELD TEST; PRIORITY JOURNAL; RAT; REAL TIME POLYMERASE CHAIN REACTION;

ANIMALS; BODY WEIGHT; DISEASE MODELS, ANIMAL; EATING; EXPLORATORY BEHAVIOR; HYPOTHALAMUS; MALE; NEUROPEPTIDE Y; OBESITY; OLFACTORY BULB; RATS; RATS, INBRED STRAINS; RECEPTORS, NEUROPEPTIDE Y; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TIME FACTORS;

EID: 34248218631     PISSN: 01664328     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbr.2007.03.005     Document Type: Article

References (66)

1. Bai F.L., Yamano M., Shiotani Y., Emson P.C., Smith A.D., Powell J.F., et al. An arcuato-paraventricular and -dorsomedial hypothalamic neuropeptide Y-containing system which lacks noradrenaline in the rat. Brain Res 331 (1985) 172-175
2. Bjorntorp P., and Rosmond R. Obesity and cortisol. Nutrition 16 (2000) 924-936
3. Caberlotto L., Fuxe K., Overstreet D.H., Gerrard P., and Hurd Y.L. Alterations in neuropeptide Y and Y1 receptor mRNA expression in brains from an animal model of depression: region specific adaptation after fluoxetine treatment. Brain Res Mol Brain Res 59 (1998) 58-65
4. Chambliss H.O., Van Hoomissen J.D., Holmes P.V., Bunnell B.N., and Dishman R.K. Effects of chronic activity wheel running and imipramine on masculine copulatory behavior after olfactory bulbectomy. Physiol Behav 82 (2004) 593-600
5. Ebner K., Rupniak N.M., Saria A., and Singewald N. Substance P in the medial amygdala: emotional stress-sensitive release and modulation of anxiety-related behavior in rats. Proc Natl Acad Sci USA 101 (2004) 4280-4285
6. Glass M.J., Cleary J.P., Billington C.J., and Levine A.S. Role of carbohydrate type on diet selection in neuropeptide Y-stimulated rats. Am J Physiol Regul Integ Comp Physiol 273 (1997) 2040-2045
7. Gold P.W., and Chrousos G.P. Organization of the stress system and its dysregulation in melancholic and atypical depression: high vs low CRH/NE states. Mol Psychiatry 7 (2002) 254-275
8. Heilig M., Zachrisson O., Thorsell A., Ehnvall A., Mottagui-Tabar S., Sjogren M., et al. Decreased cerebrospinal fluid neuropeptide Y (NPY) in patients with treatment refractory unipolar major depression: preliminary evidence for association with preproNPY gene polymorphism. J Psychiatr Res 38 (2004) 113-121
9. Henry M., Ghibaudi L., Gao J., and Hwa J.J. Energy metabolic profile of mice after chronic activation of central NPY Y1, Y2, or Y5 receptors. Obes Res 13 (2005) 36-47
10. Holmes P.V., Davis R.C., Masini C.V., and Primeaux S.D. Effects of olfactory bulbectomy on neuropeptide gene expression in the rat olfactory/limbic system. Neurosciences 86 (1998) 587-596
11. Horvath T.L., Bechmann I., Naftolin F., Kalra S.P., and Leranth C. Heterogeneity in the neuropeptide-Y containing neurons of the rat arcuate nucleus: GABAergic and non-GABAergic subpopulations. Brain Res 756 (1997) 283-286
12. Jimenez-Vasquez P.A., Diaz-Cabiale Z., Caberlotto L., Bellido I., Overstreet D., Fuxe K., et al. Electroconvulsive stimuli selectively effect behavior and neuropeptide Y (NPY) and NPY Y(1) receptor gene expressions in hippocampus and hypothalamus of Flinders sensitive line rat model of depression. Behav Brain Res 111 (2000) 115-123
13. Kalra S.P., and Kalra P.S. Neuropeptide Y: a physiological orexigen modulated by the feedback action of ghrelin and leptin. Endocrine 22 (2003) 49-56
14. Kask A., Harro J., von Horsten S., Redrobe J.P., Dumont Y., and Quirion R. The neurocircuitry and receptor subtypes mediating anxiolytic-like effects of neuropeptide Y. Neurosci Biobehav Rev 26 (2002) 259-283
15. Katon W., von Korff M., Ciechanowski P., Russo J., Lin E., Simon G., et al. Behavioral and clinical factors associated with depression among individuals with diabetes. Diabetes Care 27 (2004) 914-920
16. Kelly J.P., Norman T.R., O'Halloran A., and Leonard B.E. Home cage and open-field locomotor activity responses in singly housed olfactory bulbectomised rats. Med Sci Res 24 (1996) 335-337
17. Kelly J.P., Wrynn A.S., and Leonard B.E. The olfactory bulbectomized rat as a model of depression: an update. Pharmacol Ther 74 (1997) 299-316
18. Kendler K.S., Eaves L.J., Walters E.E., Neale M.C., Heath A.C., and Kessler R.C. The identification and validation of distinct depressive syndromes in a population-based sample of female twins. Arch. Gen. Psychiatry 53 (1996) 391-399
19. Kim H., Whang W.W., Kim H.T., Pyun K.H., Cho S.Y., Hahn D.H., et al. Expression of neuropeptide Y and cholecystokinin in the rat brain by chronic mild stress. Brain Res 983 (2003) 201-208
20. Kimbrough T.D., and Weekley L.B. The effect of a high-fat diet on brainstem and duodenal serotonin (5-HT) metabolism in Sprague-Dawley and Osborne-Mendel rats. Int J Obes 8 (1984) 305-310
21. King B.M., Cook J.T., Rossiter K.N., and Rollings B.L. Obesity-inducing amygdala lesions: examination of anterograde degeneration and retrograde transport. Am J Physiol Regul Integ Comp Physiol 284 (2003) R965-R982
22. King B.M., Rossiter K.N., Stines S.G., Zaharan G.M., Cook J.T., Humphries M.D., et al. Amygdaloid-lesion hyperphagia: impaired response to caloric challenges and altered macronutrient selection. Am J Physiol Regul Integ Comp Physiol 275 (1998) R485-R493
23. Kishi T., and Elmquist J.K. Body weight is regulated by the brain: a link between feeding and emotion. Mol Psychiatry 10 (2005) 132-146
24. Kopf D., Westphal S., Luley C.W., Ritter S., Gilles M., Weber-Hamann B., et al. Lipid metabolism and insulin resistance in depressed patients: significance of weight, hypercortisolism, and antidepressant treatment. J Clin Psychopharmacol 24 (2004) 527-531
25. Lin L., York D.A., and Bray G.A. Comparison of Osborne-Mendel and S5B/PL strains of rat: central effects of galanin, NPY, beta-casomorphin and CRH on intake of high-fat and low-fat diets. Obes Res 4 (1996) 117-124
26. Ma S., and Morilak D.A. Induction of FOS expression by acute immobilization stress is reduced in locus coeruleus and medial amygdala of Wistar-Kyoto rats compared to Sprague-Dawley rats. Neurosciences 124 (2004) 963-972
27. Marcilhac A., Maurel D., Anglade G., Ixart G., Mekaouche M., Hery F., et al. Effects of bilateral olfactory bulbectomy on circadian rhythms of ACTH, corticosterone, motor activity and body temperature in male rats. Horm Metab Res 105 (1999) 552-559
28. McElroy S.L., Kotwal R., Malhotra S., Nelson E.B., Keck P.E., and Nemeroff C.B. Are mood disorders and obesity related? A review for the mental health professional. J Clin Psychiatry 65 (2004) 634-651
29. McNish K.A., and Davis M. Olfactory bulbectomy enhances sensitization of the acoustic startle reflex produced by acute or repeated stress. Behav Neurosci 111 (1997) 80-91
30. Meguid M.M., Gleason J.R., and Yang Z.J. Olfactory bulbectomy in rats modulates feeding pattern but not total food intake. Physiol Behav 54 (1993) 471-475
31. Meguid M.M., Koseki M., Yang Z.J., Gleason J.R., and Laviano A. Acute adaptive changes in food intake pattern following olfactory ablation in rats. Neuroreport 8 (1997) 1439-1444
32. Morley J.E., Levine A.S., Gosnell B.A., Kneip J., and Grace M. Effect of neuropeptide Y on ingestive behaviors in the rat. Am J Physiol 252 (1987) R599-R609
33. Nikisch G., Agren H., Eap C.B., Czernik A., Baumann P., and Mathe A.A. Neuropeptide Y and corticotrophin-releasing hormone in CSF mark response to antidepressive treatment with citalopram. Int J Neuropsychopharmacol 8 (2005) 403-410
34. Okada S., York D.A., Bray G.A., Mei J., and Erlanson-Albertsson C. Differential inhibition of fat intake in two strains of rat by the peptide enterostatin. Am J Physiol 262 (1992) R1111-R1116
35. Onyike C.U., Crum R.M., Lee H.B., Lyketsos C.G., and Eaton W.W. Is obesity associated with major depression? Results from the third national health and nutrition examination survey. Am J Epidemiol 158 (2003) 1139-1147
36. Palucha A., Branski P., Szewczyk B., Wieronska J.M., Klak K., and Pilc A. Potential antidepressant-like effect of MTEP, a potent and highly selective mGluR5 antagonist. Pharmacol Biochem Behav 81 (2005) 901-906
37. Papakostas G.I., Petersen T., Iosifescu D.V., Burns A.M., Nierenberg A.A., Alpert J.E., et al. Obesity among outpatients with major depressive disorder. Int. J Neuropsychopharmacol 8 (2005) 59-63
38. Pawlak R., Magarinos A.M., Melchor J., McEwen B., and Strickland S. Tissue plasminogen activator in the amygdala is critical for stress-induced anxiety-like behavior. Nat Neurosci 6 (2003) 168-174
39. Perret M., Aujard F., Seguy M., and Schilling A. Olfactory bulbectomy modifies photic entrainment and circadian rhythms of body temperature and locomotor activity in a nocturnal primate. J Biol Rhythms 18 (2003) 392-401
40. Pine D.S., Goldstein R.B., Wolk S., and Weissman M.M. The association between childhood depression and adulthood body mass index. Pediatrics 107 (2001) 1049-1056
41. Primeaux S.D., and Holmes P.V. Role of aversively motivated behavior in the olfactory bulbectomy syndrome. Physiol Behav 67 (1999) 41-47
42. Primeaux S.D., and Holmes P.V. Olfactory bulbectomy increases met-enkephalin- and neuropeptide-Y-like immunoreactivity in rat limbic structures. Pharmacol Biochem Behav 67 (2000) 331-337
43. Primeaux S.D., Wilson M.A., Wilson S.P., Guth A.N., Lelutiu N.B., and Holmes P.V. Herpes virus-mediated preproenkephalin gene transfer in the ventral striatum mimics behavioral changes produced by olfactory bulbectomy in rats. Brain Res 988 (2003) 43-55
44. Primeaux S.D., Wilson S.P., Bray G.A., York D.A., and Wilson M.A. Overexpression of neuropeptide Y in the central nucleus of the amygdala decreases ethanol self-administration in "anxious" rats. Peptides 30 (2006) 791-801
45. Roberts R.E., Deleger S., Strawbridge W.J., and Kaplan G.A. Prospective association between obesity and depression: evidence from the Alameda County Study. Int. J Obes Relat Metab Disord 27 (2003) 514-521
46. Roberts R.E., Kaplan G.A., Shema S.J., and Strawbridge W.J. Are the obese at greater risk for depression?. Am J Epidemiol 152 (2000) 163-170
47. Roberts R.E., Strawbridge W.J., Deleger S., and Kaplan G.A. Are the fat more jolly?. Ann Behav Med 24 (2002) 169-180
48. Rutkoski N.J., Lerant A.A., Nolte C.M., Westberry J., and Levenson C.W. Regulation of neuropeptide Y in the rat amygdala following unilateral olfactory bulbectomy. Brain Res 951 (2002) 69-76
49. Schaffhauser A.O., Madiehe A.M., Braymer H.D., Bray G.A., and York D.A. Effects of a high-fat diet and strain on hypothalamic gene expression in rats. Obes Res 10 (2002) 1188-1196
50. Schwartz M.W., and Morton G.J. Keep hunger at bay. Nature 418 (2002) 595-597
51. Schwartz M.W., Woods S.C., Porte Jr. D., Seeley R.J., and Baskin D.G. Central nervous system control of food intake. Nature 404 (2000) 661-671
52. Sergeyev V., Fetissov S., Mathe A.A., Jimenez P.A., Bartfai T., Mortas P., et al. Neuropeptide expression in rats exposed to chronic mild stresses. Psychopharmacol 178 (2005) 115-124
53. Shimizu H., Fisler J.S., and Bray G.A. Extracellular hypothalamic monoamines measured by in vivo micro-dialysis in a rat model of dietary obesity. Obes Res 2 (1994) 100-109
54. Sjoberg R.L., Nilsson K.W., and Leppert J. Obesity shame, and depression in school-aged children: a population-based study. Pediatrics 116 (2005) 389-392
55. Smith B.K., Berthoud H.R., York D.A., and Bray G.A. Differential effects of baseline macronutrient preferences on macronutrient selection after galanin, NPY, and an overnight fast. Peptides 18 (1997) 207-211
56. Stanley B.G., Chin A.S., and Leibowitz S.F. Feeding and drinking elicited by central injection of neuropeptide Y: evidence for hypothalamic site(s) of action. Brain Res. Bull. 14 (1985) 521-524
57. Stanley B.G., Daniel D.R., Chin A.S., and Leibowitz S.F. Paraventricular nucleus injections of peptide YY and neuropeptide Y preferentially enhance carbohydrate ingestion. Peptides 6 (1985) 1205-1211
58. Stanley B.G., and Leibowitz S.F. Neuropeptide Y injected in the paraventricular hypothalamus: a powerful stimulant of feeding behaviour. Proc Natl Acad Sci USA 82 (1985) 3940-3943
59. Thorsell A., Slawecki C.J., El Khoury A., Mathe A.A., and Ehlers C.L. The effects of social isolation on neuropeptide Y levels, exploratory and anxiety-related behaviors in rats. Pharmacol Biochem Behav 83 (2006) 28-34
60. Tichomirowa M.A., Keck M.E., Schneider H.J., Paez-Pereda M., Renner U., Holsboer F., et al. Endocrine disturbances in depression. J Endocrinol Invest 28 (2005) 89-99
61. van der Stelt H.M., Breuer M.E., Olivier B., and Westenberg H.G. Permanent deficits in serotonergic functioning of olfactory bulbectomized rats: an in vivo microdialysis study. Biol Psychiatry 57 (2005) 1061-1067
62. Welch C.C., Grace M.K., Billington C.J., and Levine A.S. Preference and diet type affect macronutrient selection after morphine, NPY, norepinephrine, and deprivation. Am J Physiol 266 (1994) R426-R433
63. Werrij M.Q., Mulkens S., Hospers H.J., and Jansen A. Overweight and obesity: the significance of a depressed mood. Patient Educ Couns 62 (2006) 126-131
64. Widdowson P.S., Upton R., Henderson L., Buckingham R., Wilson S., and Williams G. Reciprocal regional changes in brain NPY receptor density during dietary restriction and dietary-induced obesity in the rat. Brain Res 774 (1997) 1-10
65. Wolak M.L., De Joseph M.R., Cator A.D., Mokashi A.S., Brownfield M.S., and Urban J.H. Comparative distribution of neuropeptide Y Y1 and Y5 receptors in the rat brain by using immunohistochemistry. J Comp Neurol 464 (2003) 285-311
66. Wortwein G., Husum H., Anderson W., Bolwig T.G., and Mathe A.A. Effects of maternal separation on neuropeptide Y and calcitonin gene-related peptide in "depressed" Flinders sensitive line rats: a study of gene-environment interactions. Prog Neuropsychopharmacol Biol Psychiatry 30 (2006) 684-693