Effects of APOE and CHRNA4 genotypes on retinal nerve fibre layer thickness at the optic disc and on risk for developing exfoliation syndrome

Acta Ophthalmologica Scandinavica

Volumn 85, Issue 3, 2007, Pages 257-261

  Ritland, Jon Ståle ^a,b   Utheim, Tor Paaske ^c   Utheim, Øygunn Aass ^c   Espeseth, Thomas ^c   Lydersen, Stian ^b   Semb, Svein Ove ^c   Rootwelt, Helge ^d   Elsås, Tor ^b  

^a Alesund Hospital   (Norway)

^b NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

^c UNIVERSITY OF OSLO   (Norway)

^d OSLO UNIVERSITY HOSPITAL   (Norway)

Author keywords

APOE; CHRNA4; Exfoliation syndrome; Retinal nerve fibre layer thickness

Indexed keywords

APOLIPOPROTEIN E; NICOTINIC RECEPTOR; PROTEIN CHRNA4; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; EXFOLIATION SYNDROME; EYE PHOTOGRAPHY; EYE REFRACTION; FEMALE; GENETIC POLYMORPHISM; GENETIC RISK; GENOTYPE; HUMAN; INTRAOCULAR PRESSURE; MAJOR CLINICAL STUDY; MALE; OPTIC DISK; OPTICAL COHERENCE TOMOGRAPHY; PRIORITY JOURNAL; RETINA NERVE CELL; SLIT LAMP; STUDENT T TEST; THICKNESS; VISUAL ACUITY;

AGED; APOLIPOPROTEINS E; EXFOLIATION SYNDROME; FEMALE; GENOTYPE; HUMANS; INTRAOCULAR PRESSURE; MALE; MIDDLE AGED; NERVE FIBERS; OPTIC DISK; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; RECEPTORS, NICOTINIC; RETINAL GANGLION CELLS; RISK FACTORS; TOMOGRAPHY, OPTICAL COHERENCE; VISUAL ACUITY;

EID: 34248211807     PISSN: 13953907     EISSN: 16000420     Source Type: Journal    
DOI: 10.1111/j.1600-0420.2006.00824.x     Document Type: Article

References (53)

1. Amaratunga A, Abraham CR, Edwards RB, Sandell JH, Schreiber BM & Fine RE (1996): Apolipoprotein E is synthesized in the retina by Müller glial cells, secreted into the vitreous, and rapidly transported into the optic nerve by retinal ganglion cells. J Biol Chem 271: 5628-5632.
2. Bartus RT, Dean RL III, Beer B & Lippa AS (1982): The cholinergic hypothesis of geriatric memory dysfunction. Science 217: 408-414.
3. Bayer AU, Ferrari F & Erb C (2002): High occurrence rate of glaucoma among patients with Alzheimer's disease. Eur Neurol 47: 165-168.
4. Benjamin R, Leake A, Edwardson JA, McKeith IG, Ince PG, Perry RH & Morris CM (1994): Apolipoprotein E genes in Lewy body and Parkinson's syndrome. Lancet 343: 1565.
5. Castano E, Prelli F, Pras M & Frangione B (1995): Apolipoprotein E carboxyl-terminal fragments are complexed to amyloids A and L. Implications for amyloidogenesis and Alzheimer's disease. J Biol Chem 270: 1-6.
6. Cohen RM, Podruchny TA, Bokde AL, Carson RE, Herscovitch P, Kiesewetter DO, Eckelman WC & Sunderland T (2003): Higher in vivo muscarinic-2 receptor distribution volumes in ageing subjects with an apolipoprotein E €4 allele. Synapse 49: 150-156.
7. Cook LJ, Ho LW, Taylor AE et al. (2004): Candidate gene association studies of the α4 (CHRNA4) and β2 (CHRNB2) neuronal nicotinic acetylcholine receptor subunit genes in Alzheimer's disease. Neurosci Lett 358: 142-146.
8. Copin B, Brezin AP, Valtot F, Dascotte JC, Bechetoille A & Garchon HJ (2002): Apolipoprotein E-promoter single-nucleotide polymorphisms affect the phenotype of primary open-angle glaucoma and demonstrate interaction with the myocilin gene. Am J Hum Genet 70: 1575-1581.
9. Corder EH, Saunders AM, Strittmatter WJ et al. (1993): Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late-onset families. Science 261: 921-923.
10. Dark AJ, Streeten BW & Cornwall CC (1977): Pseudoexfoliative disease of the lens: A study in electron microscopy and histochemistry. Br J Ophthalmol 61: 462-472.
11. Davanger M & Pedersen OO (1975): Pseudoexfoliation on the anterior lens surface. Demonstration and examination of an interfibrillar ground substance. Acta Ophthalmol 53: 3-18.
12. Dubelaar EJ, Verwer RW, Hofman MA, Van Heerikuize JJ, Ravid R & Swaab DE (2004): APOE €4 genotype is accompanied by lower metabolic activity in nucleus basalis of Meynert neurons in Alzheimer patients and controls as indicated by the size of the Golgi apparatus. J Neuropathol Exp Neurol 63: 159-169.
13. Eagle RC Jr, Font RL & Fine BS (1979): The basement membrane syndrome. Arch Ophthalmol 97: 510-515.
14. Espeseth T, Greenwood PM, Reinvang I et al. (2006): Interactive effects of APOE and CHRNA4 on attention and white matter volume in healthy middle-aged and older adults. Cognit Affect Behav Neuroscience 6: 31-43.
15. Fan BJ, Wang DY, Fan DSP et al. (2005): SNPs and interaction analyses of myocilin, optineurin and apolipoprotein E in primary open-angle glaucoma patients. Mol Vis 11: 625-631.
16. Hagadus RJ, Wandel T, Ritch R, Scharf B & Kasten S (1989): Pseudoexfoliation in patients with Alzheimer's disease. Invest Ophthalmol Vis Sci 30: 27.
17. Harnisch J-P (1977): Exfoliation material in different sections of the eye. Graefes Arch Clin Exp Ophthalmol 203: 181-190.
18. Hutchins JB & Hollyfield JG (1985): Acetylcholine receptors in the human retina. Invest Ophthalmol Vis Sci 26: 1550-1557.
19. Janciauskiene SA& Krakau T (2001): Alzheimer's peptide: a possible link between glaucoma, exfoliation syndrome and Alzheimer's disease. Acta Ophthalmol Scand 79: 238-239.
20. Jünemann A, Bleich S, Reulbach U et al. (2004): Prospective case control study on genetic association of apolipoprotein €2 with intraocular pressure. Br J Ophthalmol 88: 581-582. [Erratum: Br J Ophthalmol 2005; 89: 393]
21. Kawamata J & Shimohama S (2002): Association of novel and established polymorphisms in neuronal nicotinic acetylcholine receptors with sporadic Alzheimer's disease. J Alzheimers Dis 4: 71-76.
22. Khalil AK, Kubota T, Tawara A & Inomata H (1998): Early changes in iris blood vessels in exfoliation syndrome. Curr Eye Res 17: 1124-1134.
23. Klein RC & Yakel JL (2004): Inhibition of nicotinic acetylcholine receptors by apolipoprotein E-derived peptides in rat hippocampal slices. Neuroscience 127: 563-567.
24. Lake S, Liverani E, Desai M, Casson R, James B, Clark A & Salmon JF (2004): Normal-tension glaucoma is not associated with the common apolipoprotein E gene polymorphisms. Br J Ophthalmol 88: 491-493.
25. Layden WE & Shaffer RN (1974): Exfoliation syndrome. Am J Ophthalmol 78: 835-841.
26. Libby RT, Gould DB, Anderson MG & John SWM (2005): Complex genetics of glaucoma susceptibility. Annu Rev Genomics Human Genet 6: 15-44.
27. Linner E, Popovic V, Gottfries C-G, Johnsson M, Sjögren M & Wallin A (2001): The exfoliation syndrome in cognitive impairment of cerebrovascular or Alzheimer's type. Acta Ophthalmol Scand 79: 283-285.
28. Mabuchi F, Tang S, Ando D et al. (2005): The apolipoprotein E gene polymorphism is associated with open-angle glaucoma in the Japanese population. Mol Vis 11: 609-612.
29. Mahley RW (1C88): Apolipoprotein E: cholesterol transport protein with expanding role in cell biology. Science 240: 622-630.
30. McKiOnon SJ (2003): Glaucoma: ocular Alzheimer's disease? Front Biosci 8: 1140-1156.
31. Mehrotra DV, Chan ISF & Berger RL (2003): A cautionary note on exact unconditional inference for a difference between two independent binomial proportions. Biometrics 59: 441-450.
32. Meretoja J & Tarkkanen A (1977): Occurrence of amyloid in eyes with pseudoexfoliation. Ophthalmic Res 7: 194-203.
33. Pilar G, Nunez R, McLennan IS & Meriney SD (1987): Muscarinic and nicotinic synaptic activation of the developing chicken iris. J Neurosci 7: 3813-3826.
34. Poirier J (2000): Apolipoprotein E aAd Alzheimer's disease: a role in amyloid catabolism. Ann N Y Acad Sci 924: 81-90.
35. Reniewska B, Mulak M, Misiuk-Hojlo M & Kostus E (2004): Coexistence of Alzheimer's disease with pseudoexfoliation syndrome PEX. Klin Oczna 106: 107-109.
36. Ressiniotis T, Griffiths PG, Birch M, Keers S & Chinnery P (2004): The role of apolipoprotein E gene polymorphisms in primary open-angle glaucoma. Arch Ophthalmol 122: 258-261.
37. Ringvold A (1972): Electron microscopy of the limbal conjunctiva in eyes with pseudoexfoliation syndrome (PE syndrome). Virchows Arch Path Anat 355: 275-283.
38. Ringvold A (1973): On the occurrence of pseudoexfoliation material in extrabulbar tissue from patients with pseudoexfoliation syndrome of the eye. Acta Ophthalmol (Copenh) 51: 411-418.
39. Ringvold A & Husby G (1973): Pseudoexfoliation material - an amyloid-like substance. Exp Eye Res 17: 289-299.
40. Sarter M & Bruno JP (2004): Developmental origins of the age-related decline in cortical cholinergic function and associated cognitive abilities. Neurobiol Aging 25: 1127-1139.
41. Sato A, Sato Y & Uchida S (2002): Regulation of cerebral cortical blood flow by the basal forebrain cholinergic fibres and ageing. Auton Neurosci 96: 13-19.
42. Schlötzer-Schrehardt U, Koca MR, Naumann GOH & Volkholz H (1992): Pseudoexfoliation syndrome. Ocular manifestation of a systemic disorder? Arch Ophthalmol 110: 1752-1759.
43. Schlötzer-Schrehardt U, Küchle M & Naumann GOH (1991): Electron-microscopic identification of pseudoexfoliation material in extrabulbar tissue. Arch Ophthalmol 109: 565-570.
44. Steinlein OK, Deckert J, Nothen MM, Franke P, Maier W, Beckmann H & Propping P (1997): Neuronal nicotinic acetylcholine receptor α4 subunit (CHRNA4) and panic disorder: An association study. Am J Med Gen 74: 199-201.
45. Streeten BW, Bookman L, Ritch R, Prince AM & Dark AJ (1987): Pseudoexfoliative fibrillopathy in the conjunctiva: A relation to elastic fibres and elastosis. Ophthalmology 94: 1439-1449.
46. Streeten BW, Dark JA, Wallace RN, Li BSZ-Y & Hoepner JA (1990): Pseudoexfoliative fibrillopathy in the skin of patients with ocular pseudoexfoliation. Am J Ophthalmol 110: 490-499.
47. Streeten BW, Gibson SA & Dark AJ (1986): Pseudoexfoliative material contains an elastic microfibrilla-associated glycoprotein. Trans Am Ophthalmol Soc 84: 304-320.
48. Streeten BW, Li Z-Y, Wallace RN, Eagle RC Jr & Keshgegian AA (1992): Pseudoexfoliative fibrillopathy in visceral organs of a patient with pseudoexfoliation syndrome. Arch Ophthalmol 110: 1757-1762.
49. Strittmatter WJ, Saunders AM, Schmechel D, Pericak-Vance MA, Enghild J, Salvesen GS Hamp; Roses AD (1993): Apolipoprotein E: high avidity binding to β-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease. Proc Natl Acad Sci U S A 90: 1977-1981.
50. Sugino T (1990): Exfoliative materials in the skin of patients with exfoliation syndrome. Acta Soc Ophthalmol Jpn 94: 856-869.
51. Tamura H, Kawakami H, Kanamoto T et al. (2006): High frequency of open-angle glaucoma in Japanese patients with Alzheimer's disease. J Neurol Sci 246: 79-83.
52. Vickers JC, Craig JE, Stankovich J et al. (2002): The apolipoprotein €4 gene is associated with elevated risk of normal-tension glaucoma. Mol Vis 8: 389-393.
53. Yilmaz A, Tamer L, Ates NA, Camdeviren H & Degirmeci U (2005): Effects of apolipoprotein E genotypes on the development of exfoliation syndrome. Exp Eye Res 80: 871-875.