Demonstration, of an anterior diflusional pathway for solutes in the normal human eye with high spatial resolution contrast-enhanced dynamic MR imaging

Investigative Ophthalmology and Visual Science

Volumn 47, Issue 12, 2006, Pages 5153-5162

  Bert, Robert J ^a   Caruthers, Shelton D ^b   Jara, Hernan ^c   Krejza, Jaroslaw ^d,e   Melhem, Elias R ^d   Kolodny, Nancy H ^f   Patz, Samuel ^g   Freddo, Thomas F ^c  

^a UNIVERSITY OF COLORADO   (United States)

^b PHILIPS HEALTHCARE   (United States)

^c BOSTON MEDICAL CENTER   (United States)

^d HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

^e MEDICAL UNIVERSITY OF GDANSK   (Poland)

^f WELLESLEY COLLEGE   (United States)

^g TUFTS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GADOLINIUM; CONTRAST MEDIUM; GADOLINIUM PENTETATE;

ADULT; ANTERIOR EYE CHAMBER; ARTICLE; BLOOD EYE BARRIER; CILIARY BODY; CONTRAST ENHANCEMENT; CONTROLLED STUDY; DIFFUSION; DIFFUSION WEIGHTED IMAGING; FEMALE; HUMAN; HYPOTHESIS; MALE; MONKEY; NONHUMAN; NORMAL HUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; RABBIT; VISUAL SYSTEM; AQUEOUS HUMOR; ECHO PLANAR IMAGING; METABOLISM; MIDDLE AGED; TRANSPORT AT THE CELLULAR LEVEL;

ADULT; ANTERIOR CHAMBER; AQUEOUS HUMOR; BIOLOGICAL TRANSPORT; BLOOD-AQUEOUS BARRIER; CILIARY BODY; CONTRAST MEDIA; DIFFUSION; ECHO-PLANAR IMAGING; FEMALE; GADOLINIUM DTPA; HUMANS; MALE; MIDDLE AGED;

EID: 34248188131     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: 10.1167/iovs.05-0372     Document Type: Article

References (17)

1. Raviola. G. The structural basis of the blood-ocular barriers. Exp Eye Res. 1977;(suppl)25:27-64.
2. Freddo TF, Battels SP, Barsotti MF, Kamm RD. The source of proteins in the aqueous humor of the normal rabbit. Invest Ophthalmol Vis Sci. 1990;31:125-137.
3. Barsotti MF, Battels SP, Freddo TF, Kamm RD. The source of protein in the aqueous humor of the normal monkey eye. Invest Ophthalmol Vis Sci. 1992;33:581-595.
4. Freddo T. Aqueous humor proteins: a key for unlocking glaucoma? The 1992 Glenn Fry Award Lecture. Optom Vis Sci. 1993;70:263-270.
5. Kolodny N, Freddo T, Lawrence B, Suarez C, Battels SP. Contrast-enhanced MRI confirmation of an anterior protein pathway in the normal rabbit eye. Invest Ophthalmol Vis Sci. 1996;37:1602-1607.
6. Erickson-Lamy K, Schroeder AM, Bassett-Chu S, Epstein DL. Absence of time-dependent facility increase ("washout") in the perfused, enucleated human eye. Invest Ophthalmol Vis Sci. 1990; 31:2384-2388.
7. Bert RJ, Patz S, Ossiani M, et al. High resolution MR imaging of the human eye. AJNR Am J Neuroradiol Supplement. 2006;13;368-378.
8. Haacke ME, Brown RW, Thompson MR, Venkatesan R. Magnetic Resonance Imaging: Physical Principles and Sequence Design. New York: Wiley-Liss; 1999:340.
9. Freddo, T. Intercellular junctions of the iris epithelia in Macaca mulatta. Invest Ophthalmol Vis Sci. 1984;25-1094-1104.
10. Johnson M, Gong H, Freddo TF, Ritter N, Kamm RD. Serum proteins and aqueous outflow resistance in bovine eyes. Invest Ophthalmol Vis Sci. 1993;34:3549-3557.
11. Sit AJ, Gong H, Ritter N, Freddo TF, Kamm RD, Johnson M. The role of soluble proteins in generating aqueous outflow resistance in the bovine and human eye. Exp Eye Res. 1997;64:813-821.
12. Russell P, Koretz J, Epstein DL. Is primary open angle glaucoma caused by small proteins? Med Hypotheses. 1993;41:455-458.
13. Doss EW, Ward KA, Koretz JF. Investigation of the "fines" hypothesis of primary open-angle glaucoma: the possible role of alpha-crystallin. Ophthalmic Res. 1998;30:142-156.
14. Stur M, Brabner G, Huber-Spitzy V, Schreiner J, Haddad R. Effect of Timolol on aqueous humor protein concentration in the human eye. Arch Ophthalmol. 1986;104:899-900.
15. Diestelhorst M, Roters S, Krieglstein GK. The effect of latanoprost 0.005% once daily versus 0.0015% twice daily on intraocular pressure and aqueous humour protein concentration in glaucoma subjects: a randomized, double-masked comparison with timolol 0.5%. Graefes Arch Clin Exp Ophthalmol. 1997; 235:20-26.
16. Haacke ME, Brown RW, Thompson MR, Venkatesan R. Magnetic Resonance Imaging: Physical Principles and Sequence Design. New York: Wiley-Liss; 1999:876.
17. Gudbjartsson H, Patz S. The Rician distribution of noisy MRI data. Magn Reson Med. 1995;34:910-914.