Investigation of the 'fines' hypothesis of primary open-angle glaucoma: The possible role of alpha-crystallin

Ophthalmic Research

Volumn 30, Issue 3, 1998, Pages 142-156

  Doss, Ellen W ^a   Ward, K A ^a   Koretz, J F ^a  

^a RENSSELAER POLYTECHNIC INSTITUTE   (United States)

Author keywords

crystallin; Cross linking with glutaraldehyde; Fast performance liquid chromatography; Gel filtration; Micelles; Primary open angle glaucoma; Serum albumin; Sodium dodecyl sulfate polyacrylamide gel electrophoresis

Indexed keywords

ALPHA CRYSTALLIN;

ANIMAL EXPERIMENT; AQUEOUS HUMOR; ARTICLE; LENS FIBER; NONHUMAN; OPEN ANGLE GLAUCOMA; PRIMARY GLAUCOMA; PRIORITY JOURNAL; TRABECULAR MESHWORK;

ANIMALS; CATTLE; CHROMATOGRAPHY, GEL; CHROMATOGRAPHY, LIQUID; CRYSTALLINS; DIMERIZATION; ELECTROPHORESIS, POLYACRYLAMIDE GEL; GLAUCOMA, OPEN-ANGLE; LENS, CRYSTALLINE; MACROMOLECULAR SUBSTANCES; PHILOSOPHY; PROTEIN BINDING; SERUM ALBUMIN;

EID: 0031777266     PISSN: 00303747     EISSN: None     Source Type: Journal    
DOI: 10.1159/000055468     Document Type: Article

References (27)

1. Russell P, Koretz JF, Epstein DL: Is primary open angle glaucoma caused by small proteins? Med Hypotheses 1993;41:455-458.
2. Epstein DL, Jedziniak JA, Grant WM: Obstruction of aqueous outflow by lens particles and by heavy molecular weight soluble proteins. Invest Ophthalmol Vis Sci 1978;17: 272-277.
3. Epstein DL: Chandler and Grant's Glaucoma. Philadelphia. Lea & Febiger, 1986.
4. Gaasterland DE, Pederson JE, MacLellan HM, Reddy VN: Rhesus monkey aqueous humor composition and a primate ocular perfusate. Invest Ophthalmol Vis Sci 1979;18: 1139-1150.
5. Tripathi RC, Millard CB, Tripathi BJ: Protein composition of human aqueous humor: SDS-PAGE analysis of surgical and post-mortem samples. Exp Eye Res 1989;48:117-130.
6. Jampel HD, Brown A, Roberts A, Koya P, Quigley H: Effect of paracentesis upon the blood-aqueous barrier of cynomolgus monkeys. Invest Ophthalmol Vis Sci 1992;33: 165-171.
7. Raviola G: The structural basis of the blood-ocular barriers. Exp Eye Res 1977;25(suppl):27-63.
8. Freddo TF: Intercellular junctions of the ins epithelia in Macaca mulatta. Invest Ophthalmol Vis Sci 1984;25:109-112.
9. Richardson TM: Distribution of glycosammoglycans in the aqueous outflow of the cat. Invest Ophthalmol Vis Sci 1982;22:319-329.
10. Johnson M, Ethier CR, Kamm RD, Grant WM, Epstein DL, Gaasterland D: The flow of the aqueous humor through microporous filters. Invest Ophthalmol Vis Sci 1986;27: 92-97.
11. Sandberg HO, CLoss O: The alpha and gamma crystallin concentration in aqueous humor of eyes with clear lenses and with cataracts. Exp Eye Res 1979;28:601-610.
12. Augusteyn RC, Koretz JF: A possible model for α-crystallin. FEBS Lett 1987;22:1-5.
13. Walsh MT, Sen AC, Chakrabarti B: Micellar subunit assembly in a three-layer model of oligomeric alpha-crystallin. J Biol Chem 1991; 266:20079-20084.
14. Radlick LW, Koretz JF: Biophysical characterization of α-crystallin aggregates: Validation of the micelle hypothesis. Biochim Biophys Acta 1992;1120:193-200.
15. Carver JA, Aquilina JA, Cooper PG, Williams GA, Truscott R: α-Crystallin: Molecular chaperone and protein surfactant. Biochim Biophys Acta 1994;1204:195-206.
16. Doss EW, Ward KA, Koretz JF: Preliminary studies on the aggregation process of alpha-crystallin. Exp Eye Res 1997;65:255-266.
17. Thompson JA, Augusteyn RC: αm-Crystallin: The native form of the protein? Exp Eye Res 1983;37:367-377.
18. Laemmli UK: Cleavage of structural proteins during the assembly of the head of bacterophage T4. Nature 1970,227:680-685.
19. Erickson KA, Kaufman PL: Comparative effects of three ocular perfusates on the outflow facility in the cynomolgus monkey. Curr Eye Res 1981;1:211-216.
20. Yan DB, Trope GE, Ethier CR, Menon IA, Wakeham A: Effects of hydrogen peroxide-induced damage on the outflow facility and washout in pig eyes. Invest Ophthalmol Vis Sci 1991;32:2515-2524.
21. Milton CE, Deville WB: Perfusion studies on eyes of four species. Am J Ophthalmol 1960;50:302-308.
22. Clough G. The relationship of hyaluronidase to aqueous outflow resistance. Prog Biophys Mol Biol 1991; 55:47-69.
23. Johnson M, Gong H, Freddo T, Ritter N, Kamm R: Serum protein and aqueous outflow resistance in bovine eyes. Invest Ophthalmol Vis Sci 1993,34:3549-3557.
24. Erickson-Lamy K, Schroder AM, Bassett-Chu S, Epstein DL: Absence of time-dependent facility increase ('wash-out') in the perfused enucleated human eye. Invest Ophthalmol Vis Sci 1990;31:2384-2394.
25. Davson H: Davson's Physiology of the Eye, ed 5. New York, Pergamon Press, 1990.
26. Freddo TF, Bartels SP, Barsotti MF, Kamm RD: The source of proteins in the aqueous humor of the normal rabbit. Invest Ophthalmol Vis Sci 1990;31:125-137.
27. Barsotti MF, Bartels SP, Freddo TF, Kamm RD: The source of proteins in the aqueous humor of the normal monkey eye. Invest Ophthalmol Vis Sci 1992;33:581-595.