Highly sensitive assay of HMG-CoA reductase activity by LC-ESI-MS/MS

Journal of Lipid Research

Volumn 48, Issue 5, 2007, Pages 1212-1220

  Honda, Akira ^a,b   Mizokami, Yuji ^a   Matsuzaki, Yasushi ^a   Ikegami, Tadashi ^a   Doy, Mikio ^b   Miyazaki, Hiroshi ^c  

^a TOKYO MEDICAL UNIVERSITY   (Japan)

^b Ibaraki Prefectural Institute of Public Health   (Japan)

^c Pharmax Institute   (Japan)

Author keywords

3 hydroxy 3 methylglutaryl coenzyme A reductase; Cholesterol biosynthesis; Liquid chromatography electrospray ionizationtandem mass spectrometry; Mevalonic acid; Mevalonolactone

Indexed keywords

HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; MEVALONIC ACID; MEVALONOLACTONE; MEVALONYL (2 DIMENTHYLAMINO ETHYL)AMIDE; MEVALONYL (2 MORPHOLIN 4 YL ETHYL)AMIDE; MEVALONYL (2 PIPERAZIN 1 YL ETHYL)AMIDE; MEVALONYL (2 PIPERIDIN 1 YL ETHYL)AMIDE; MEVALONYL (2 PYRIDYL 4 YL ETHYL)AMIDE; MEVALONYL (2 PYRROLIDIN 1 YL ETHYL)AMIDE; MEVALONYL DIMENTHYLAMINO BENZYLAMIDE; SILICON DIOXIDE; STABLE ISOTOPE; UNCLASSIFIED DRUG;

ACCURACY; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DILUTION; ELECTROSPRAY MASS SPECTROMETRY; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME KINETICS; ENZYME STRUCTURE; INTERMETHOD COMPARISON; ISOTOPE DILUTION ASSAY; ISOTOPE TRACING; LIQUID CHROMATOGRAPHY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RELIABILITY; REPRODUCIBILITY; SENSITIVITY ANALYSIS; SIGNAL NOISE RATIO; TANDEM MASS SPECTROMETRY;

ANIMALS; CALIBRATION; CHROMATOGRAPHY, LIQUID; HYDROXYMETHYLGLUTARYL COA REDUCTASES; MALE; MEVALONIC ACID; MOLECULAR STRUCTURE; RATS; RATS, SPRAGUE-DAWLEY; SENSITIVITY AND SPECIFICITY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SUBSTRATE SPECIFICITY; TANDEM MASS SPECTROMETRY;

EID: 34248164367     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.D600049-JLR200     Document Type: Article

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