-
1
-
-
4444339951
-
Thymidylate synthase gene polymorphism predicts toxicity in colorectal cancer patients receiving 5-fluorouracil-based chemotherapy
-
Lecomte T, Ferraz JM, Zinzindohoue F, et al. Thymidylate synthase gene polymorphism predicts toxicity in colorectal cancer patients receiving 5-fluorouracil-based chemotherapy. Clin Cancer Res. 2004;10:5880-5888.
-
(2004)
Clin Cancer Res
, vol.10
, pp. 5880-5888
-
-
Lecomte, T.1
Ferraz, J.M.2
Zinzindohoue, F.3
-
2
-
-
0345596364
-
Toxicity of fluorouracil in patients with advanced colorectal cancer: Effect of administration schedule and prognostic factors. Meta-Analysis Group in Cancer
-
Toxicity of fluorouracil in patients with advanced colorectal cancer: effect of administration schedule and prognostic factors. Meta-Analysis Group in Cancer. J Clin Oncol. 1998;16:3537-3541.
-
(1998)
J Clin Oncol
, vol.16
, pp. 3537-3541
-
-
-
3
-
-
0015962412
-
Mechanism of interaction of thymidylate synthetase with 5-fluorodeoxyuridylate
-
Santi DV, McHenry CS, Sommer H. Mechanism of interaction of thymidylate synthetase with 5-fluorodeoxyuridylate. Biochemistry. 1974;13:471-481.
-
(1974)
Biochemistry
, vol.13
, pp. 471-481
-
-
Santi, D.V.1
McHenry, C.S.2
Sommer, H.3
-
4
-
-
0029122937
-
Functional analysis and DNA polymorphism of the tandemly repeated sequences in the 5′-terminal regulatory region of the human gene for thymidylate synthase
-
Horie N, Aiba H, Oguro K, et al. Functional analysis and DNA polymorphism of the tandemly repeated sequences in the 5′-terminal regulatory region of the human gene for thymidylate synthase. Cell Struct Funct. 1995;20:191-197.
-
(1995)
Cell Struct Funct
, vol.20
, pp. 191-197
-
-
Horie, N.1
Aiba, H.2
Oguro, K.3
-
5
-
-
0035671827
-
Different lengths of a polymorphic repeat sequence in the thymidylate synthase gene affect translational efficiency but not its gene expression
-
Kawakami K, Salonga D, Park JM, et al. Different lengths of a polymorphic repeat sequence in the thymidylate synthase gene affect translational efficiency but not its gene expression. Clin Cancer Res. 2001;7:4096-4101.
-
(2001)
Clin Cancer Res
, vol.7
, pp. 4096-4101
-
-
Kawakami, K.1
Salonga, D.2
Park, J.M.3
-
6
-
-
0005986509
-
A 6 base-pair deletion in the 3′UTR of the thymidylate synthase (TS) gene predicts TS mRNA expression in colorectal tumors. A possible candidate gene for colorectal cancer risk [Abstract]
-
Lenz HJ, Zhang W, Zhahedy S, et al. A 6 base-pair deletion in the 3′UTR of the thymidylate synthase (TS) gene predicts TS mRNA expression in colorectal tumors. A possible candidate gene for colorectal cancer risk [Abstract]. Proc Am Assoc Cancer Res. 2002;43:660.
-
(2002)
Proc Am Assoc Cancer Res
, vol.43
, pp. 660
-
-
Lenz, H.J.1
Zhang, W.2
Zhahedy, S.3
-
7
-
-
0034518362
-
Searching expressed sequence tag databases: Discovery and confirmation of a common polymorphism in the thymidylate synthase gene
-
Ulrich CM, Bigler J, Velicer CM, et al. Searching expressed sequence tag databases: discovery and confirmation of a common polymorphism in the thymidylate synthase gene. Cancer Epidemiol Biomarkers Prev. 2000;9:1381-1385.
-
(2000)
Cancer Epidemiol Biomarkers Prev
, vol.9
, pp. 1381-1385
-
-
Ulrich, C.M.1
Bigler, J.2
Velicer, C.M.3
-
8
-
-
0023187085
-
Clinical pharmacokinetics of 5-fluorouracil and its metabolites in plasma, urine, and bile
-
Heggie GD, Sommadossi JP, Cross DS, et al. Clinical pharmacokinetics of 5-fluorouracil and its metabolites in plasma, urine, and bile. Cancer Res. 1987;47:2203-2206.
-
(1987)
Cancer Res
, vol.47
, pp. 2203-2206
-
-
Heggie, G.D.1
Sommadossi, J.P.2
Cross, D.S.3
-
9
-
-
0023902287
-
Familial deficiency of dihydropyrimidine dehydrogenase. Biochemical basis for familial pyrimidinemia and severe 5-fluorouracil-induced toxicity
-
Diasio RB, Beavers TL, Carpenter JT. Familial deficiency of dihydropyrimidine dehydrogenase. Biochemical basis for familial pyrimidinemia and severe 5-fluorouracil-induced toxicity. J Clin Invest. 1988;81:47-51.
-
(1988)
J Clin Invest
, vol.81
, pp. 47-51
-
-
Diasio, R.B.1
Beavers, T.L.2
Carpenter, J.T.3
-
10
-
-
0026753035
-
Correlation between dihydropyrimidine dehydrogenase activity in peripheral mononuclear cells and systemic clearance of fluorouracil in cancer patients
-
Fleming RA, Milano G, Thyss A, et al. Correlation between dihydropyrimidine dehydrogenase activity in peripheral mononuclear cells and systemic clearance of fluorouracil in cancer patients. Cancer Res. 1992;52:2899-2902.
-
(1992)
Cancer Res
, vol.52
, pp. 2899-2902
-
-
Fleming, R.A.1
Milano, G.2
Thyss, A.3
-
11
-
-
0025990479
-
Severe 5-fluorouracil toxicity secondary to dihydropyrimidine dehydrogenase deficiency. A potentially more common pharmacogenetic syndrome
-
Harris BE, Carpenter JT, Diasio RB. Severe 5-fluorouracil toxicity secondary to dihydropyrimidine dehydrogenase deficiency. A potentially more common pharmacogenetic syndrome. Cancer. 1991;68:499-501.
-
(1991)
Cancer
, vol.68
, pp. 499-501
-
-
Harris, B.E.1
Carpenter, J.T.2
Diasio, R.B.3
-
12
-
-
9044246668
-
Severe neurotoxicity following 5-fluorouracil-based chemotherapy in a patient with dihydropyrimidine dehydrogenase deficiency
-
Takimoto CH, Lu ZH, Zhang R, et al. Severe neurotoxicity following 5-fluorouracil-based chemotherapy in a patient with dihydropyrimidine dehydrogenase deficiency. Clin Cancer Res. 1996;2:477-481.
-
(1996)
Clin Cancer Res
, vol.2
, pp. 477-481
-
-
Takimoto, C.H.1
Lu, Z.H.2
Zhang, R.3
-
13
-
-
0029973215
-
Molecular basis of the human dihydropyrimidine dehydrogenase deficiency and 5-fluorouracil toxicity
-
Wei X, McLeod HL, McMurrough J, et al. Molecular basis of the human dihydropyrimidine dehydrogenase deficiency and 5-fluorouracil toxicity. J Clin Invest. 1996;98:610-615.
-
(1996)
J Clin Invest
, vol.98
, pp. 610-615
-
-
Wei, X.1
McLeod, H.L.2
McMurrough, J.3
-
14
-
-
0031876466
-
Putative role of dihydropyrimidine dehydrogenase in the toxic side effect of 5-fluorouracil in colorectal cancer patients
-
Katona C, Kralovanszky J, Rosta A, et al. Putative role of dihydropyrimidine dehydrogenase in the toxic side effect of 5-fluorouracil in colorectal cancer patients. Oncology. 1998;55:468-474.
-
(1998)
Oncology
, vol.55
, pp. 468-474
-
-
Katona, C.1
Kralovanszky, J.2
Rosta, A.3
-
15
-
-
0034488052
-
Clinical implications of dihydropyrimidine dehydrogenase (DPD) deficiency in patients with severe 5-fluorouracil-associated toxicity: Identification of new mutations in the DPD gene
-
van Kuilenburg AB, Haasjes J, Richel DJ, et al. Clinical implications of dihydropyrimidine dehydrogenase (DPD) deficiency in patients with severe 5-fluorouracil-associated toxicity: identification of new mutations in the DPD gene. Clin Cancer Res. 2000;6:4705-4712.
-
(2000)
Clin Cancer Res
, vol.6
, pp. 4705-4712
-
-
van Kuilenburg, A.B.1
Haasjes, J.2
Richel, D.J.3
-
16
-
-
0027426408
-
Dihydropyrimidine dehydrogenase activity in human peripheral blood mononuclear cells and liver: Population characteristics, newly identified deficient patients, and clinical implication in 5-fluorouracil chemotherapy
-
Lu Z, Zhang R, Diasio RB. Dihydropyrimidine dehydrogenase activity in human peripheral blood mononuclear cells and liver: population characteristics, newly identified deficient patients, and clinical implication in 5-fluorouracil chemotherapy. Cancer Res. 1993;53:5433-5438.
-
(1993)
Cancer Res
, vol.53
, pp. 5433-5438
-
-
Lu, Z.1
Zhang, R.2
Diasio, R.B.3
-
17
-
-
0028813120
-
Human polymorphism in drug metabolism: Mutation in the dihydropyrimidine dehydrogenase gene results in exon skipping and thymine uracilurea
-
Meinsma R, Fernandez-Salguero P, Van Kuilenburg AB, et al. Human polymorphism in drug metabolism: mutation in the dihydropyrimidine dehydrogenase gene results in exon skipping and thymine uracilurea. DNA Cell Biol. 1995;14:1-6.
-
(1995)
DNA Cell Biol
, vol.14
, pp. 1-6
-
-
Meinsma, R.1
Fernandez-Salguero, P.2
Van Kuilenburg, A.B.3
-
18
-
-
15144351973
-
Dihydropyrimidine dehydrogenase pharmacogenetics in patients with colorectal cancer
-
Ridge SA, Sludden J, Wei X, et al. Dihydropyrimidine dehydrogenase pharmacogenetics in patients with colorectal cancer. Br J Cancer. 1998;77:497-500.
-
(1998)
Br J Cancer
, vol.77
, pp. 497-500
-
-
Ridge, S.A.1
Sludden, J.2
Wei, X.3
-
19
-
-
0032974922
-
Genotype and phenotype in patients with dihydropyrimidine dehydrogenase deficiency
-
Van Kuilenburg AB, Vreken P, Abeling NG, et al. Genotype and phenotype in patients with dihydropyrimidine dehydrogenase deficiency. Hum Genet. 1999;104:1-9.
-
(1999)
Hum Genet
, vol.104
, pp. 1-9
-
-
Van Kuilenburg, A.B.1
Vreken, P.2
Abeling, N.G.3
-
20
-
-
0034050905
-
Known variant DPYD alleles do not explain DPD deficiency in cancer patients
-
Collie-Duguid ES, Etienne MC, Milano G, et al. Known variant DPYD alleles do not explain DPD deficiency in cancer patients. Pharmacogenetics. 2000;10:217-223.
-
(2000)
Pharmacogenetics
, vol.10
, pp. 217-223
-
-
Collie-Duguid, E.S.1
Etienne, M.C.2
Milano, G.3
-
21
-
-
34248176139
-
-
National Cancer Institute. Common Toxicity Criteria version 2.0 CTC, 1999. Available at
-
National Cancer Institute. Common Toxicity Criteria version 2.0 (CTC). 1999. Available at: http://ctep.cancer.gov/reporting/CTC-3.html.
-
-
-
-
22
-
-
0037567591
-
A novel single nucleotide polymorphism within the 5′ tandem repeat polymorphism of the thymidylate synthase gene abolishes USF-1 binding and alters transcriptional activity
-
Mandola MV, Stoehlmacher J, Muller-Weeks S, et al. A novel single nucleotide polymorphism within the 5′ tandem repeat polymorphism of the thymidylate synthase gene abolishes USF-1 binding and alters transcriptional activity. Cancer Res. 2003;63:2898-2904.
-
(2003)
Cancer Res
, vol.63
, pp. 2898-2904
-
-
Mandola, M.V.1
Stoehlmacher, J.2
Muller-Weeks, S.3
-
23
-
-
0033564283
-
Ethnic variation in the thymidylate synthase enhancer region polymorphism among Caucasian and Asian populations
-
Marsh S, Collie-Duguid ES, Li T, et al. Ethnic variation in the thymidylate synthase enhancer region polymorphism among Caucasian and Asian populations. Genomics. 1999;58:310-312.
-
(1999)
Genomics
, vol.58
, pp. 310-312
-
-
Marsh, S.1
Collie-Duguid, E.S.2
Li, T.3
-
24
-
-
27144478904
-
Polymorphisms of thymidylate synthase in the 5′- and 3′-untranslated regions associated with risk of gastric cancer in South China: A case-control analysis
-
Zhang Z, Xu Y, Zhou J, et al. Polymorphisms of thymidylate synthase in the 5′- and 3′-untranslated regions associated with risk of gastric cancer in South China: a case-control analysis. Carcinogenesis. 2005;26:1764-1769.
-
(2005)
Carcinogenesis
, vol.26
, pp. 1764-1769
-
-
Zhang, Z.1
Xu, Y.2
Zhou, J.3
-
25
-
-
1642539113
-
Heterozygote deficiency in thymidylate synthase enhancer region polymorphism genotype distribution in Hungarian colorectal cancer patients
-
Adleff V, Hitre E, Koves I, et al. Heterozygote deficiency in thymidylate synthase enhancer region polymorphism genotype distribution in Hungarian colorectal cancer patients. Int J Cancer. 2004;108:852-856.
-
(2004)
Int J Cancer
, vol.108
, pp. 852-856
-
-
Adleff, V.1
Hitre, E.2
Koves, I.3
-
26
-
-
0037096858
-
Thymidylate synthase promotor polymorphism, interaction with folate intake, and risk of colorectal adenomas
-
Ulrich CM, Bigler J, Bostick R, et al. Thymidylate synthase promotor polymorphism, interaction with folate intake, and risk of colorectal adenomas. Cancer Res. 2002;62:3361-3364.
-
(2002)
Cancer Res
, vol.62
, pp. 3361-3364
-
-
Ulrich, C.M.1
Bigler, J.2
Bostick, R.3
-
27
-
-
27944455699
-
One-carbon metabolism related gene polymorphisms interact with alcohol drinking to influence the risk of colorectal cancer in Japan
-
Keitaro M, Hidemi I, Kenji W, et al. One-carbon metabolism related gene polymorphisms interact with alcohol drinking to influence the risk of colorectal cancer in Japan. Carcinogenesis. 2005;26:2164-2171.
-
(2005)
Carcinogenesis
, vol.26
, pp. 2164-2171
-
-
Keitaro, M.1
Hidemi, I.2
Kenji, W.3
-
28
-
-
11144221690
-
Polymorphism in thymidylate synthase promotor enhancer region and risk of colorectal adenomas
-
Chen J, Kite C, Chan W, et al. Polymorphism in thymidylate synthase promotor enhancer region and risk of colorectal adenomas. Cancer Epidemiol Biomarkers Prev. 2004;13:2247-2250.
-
(2004)
Cancer Epidemiol Biomarkers Prev
, vol.13
, pp. 2247-2250
-
-
Chen, J.1
Kite, C.2
Chan, W.3
-
29
-
-
33750331660
-
Thymidylate synthase, dihydropyrimidine dehydrogenase and thymidine phosphorylase expression in colorectal cancer and normal mucosa in patients
-
Amatori F, Di Paolo A, Del Tacca M, et al. Thymidylate synthase, dihydropyrimidine dehydrogenase and thymidine phosphorylase expression in colorectal cancer and normal mucosa in patients. Pharmacogenet Genomics. 2006;16:809-816.
-
(2006)
Pharmacogenet Genomics
, vol.16
, pp. 809-816
-
-
Amatori, F.1
Di Paolo, A.2
Del Tacca, M.3
-
30
-
-
0032929295
-
Clinical and biochemical abnormalities in a patient with dihydropyrimidine dehydrogenase deficiency due to homozygosity for the C29R mutation
-
Van Kuilenburg AB, Vreken P, Riva D, et al. Clinical and biochemical abnormalities in a patient with dihydropyrimidine dehydrogenase deficiency due to homozygosity for the C29R mutation. J Inherit Metab Dis. 1999;22:191-192.
-
(1999)
J Inherit Metab Dis
, vol.22
, pp. 191-192
-
-
Van Kuilenburg, A.B.1
Vreken, P.2
Riva, D.3
-
31
-
-
0031948047
-
Dihydropyrimidine dehydrogenase deficiency: A novel mutation and expression of missense mutations in E. coli
-
Vreken P, van Kuilenburg AB, Meinsma R, et al. Dihydropyrimidine dehydrogenase deficiency: a novel mutation and expression of missense mutations in E. coli. J Inherit Metab Dis. 1998;21:276-279.
-
(1998)
J Inherit Metab Dis
, vol.21
, pp. 276-279
-
-
Vreken, P.1
van Kuilenburg, A.B.2
Meinsma, R.3
-
32
-
-
0030753062
-
Identification of a fourbase deletion (delTCAT296-299) in the dihydropyrimidine dehydrogenase gene with variable clinical expression
-
Vreken P, Van Kuilenburg AB, Meinsma R, et al. Identification of a fourbase deletion (delTCAT296-299) in the dihydropyrimidine dehydrogenase gene with variable clinical expression. Hum Genet. 1997;100:263-265.
-
(1997)
Hum Genet
, vol.100
, pp. 263-265
-
-
Vreken, P.1
Van Kuilenburg, A.B.2
Meinsma, R.3
-
33
-
-
7344249042
-
Dihydropyrimidine dehydrogenase pharmacogenetics in Caucasian subjects
-
Ridge SA, Sludden J, Brown O, et al. Dihydropyrimidine dehydrogenase pharmacogenetics in Caucasian subjects. Br J Clin Pharmacol. 1998;46:151-156.
-
(1998)
Br J Clin Pharmacol
, vol.46
, pp. 151-156
-
-
Ridge, S.A.1
Sludden, J.2
Brown, O.3
-
34
-
-
0035074119
-
Germline mutation of dihydropyrimidine dehydrogenese gene among a Japanese population in relation to toxicity to 5-fluorouracil
-
Yamaguchi K, Arai Y, Kanda Y, et al. Germline mutation of dihydropyrimidine dehydrogenese gene among a Japanese population in relation to toxicity to 5-fluorouracil. Jpn J Cancer Res. 2001;92:337-342.
-
(2001)
Jpn J Cancer Res
, vol.92
, pp. 337-342
-
-
Yamaguchi, K.1
Arai, Y.2
Kanda, Y.3
-
35
-
-
0344923828
-
Dihydropyrimidine dehydrogenase activity in a Korean population
-
Sohn DR, Cho MS, Chung PJ. Dihydropyrimidine dehydrogenase activity in a Korean population. Ther Drug Monit. 1999;21:152-154.
-
(1999)
Ther Drug Monit
, vol.21
, pp. 152-154
-
-
Sohn, D.R.1
Cho, M.S.2
Chung, P.J.3
-
36
-
-
28444436251
-
Advances and challenges in fluoropyrimidine pharmacogenomics and pharmacogenetics
-
Soong R, Diasio RB. Advances and challenges in fluoropyrimidine pharmacogenomics and pharmacogenetics. Pharmacogenomics. 2005;6:835-847.
-
(2005)
Pharmacogenomics
, vol.6
, pp. 835-847
-
-
Soong, R.1
Diasio, R.B.2
-
37
-
-
0035987174
-
Allele and genotype frequencies of polymorphic cytochromes P450 (CYP2C9, CYP2C19, CYP2E1) and dihydropyrimidine dehydrogenase (DPYD) in the Egyptian population
-
Hamdy SI, Hiratsuka M, Narahara K, et al. Allele and genotype frequencies of polymorphic cytochromes P450 (CYP2C9, CYP2C19, CYP2E1) and dihydropyrimidine dehydrogenase (DPYD) in the Egyptian population. Br J Clin Pharmacol. 2002;53:596-603.
-
(2002)
Br J Clin Pharmacol
, vol.53
, pp. 596-603
-
-
Hamdy, S.I.1
Hiratsuka, M.2
Narahara, K.3
|