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Volumn 29, Issue 2, 2007, Pages 190-196

Thymidylate synthase (TYMS) and dihydropyrimidine dehydrogenase (DPYD) polymorphisms in the Korean population for prediction of 5-fluorouracil- associated toxicity

Author keywords

5 fluorouracil (5 FU); Colorectal cancer; DPYD; Korean; TYMS

Indexed keywords

ALANINE; CYSTEINE; DIHYDROPYRIMIDINE DEHYDROGENASE; FLUOROURACIL; GLYCINE; THYMIDYLATE SYNTHASE;

EID: 34248157706     PISSN: 01634356     EISSN: None     Source Type: Journal    
DOI: 10.1097/FTD.0b013e318040b1fe     Document Type: Article
Times cited : (46)

References (37)
  • 1
    • 4444339951 scopus 로고    scopus 로고
    • Thymidylate synthase gene polymorphism predicts toxicity in colorectal cancer patients receiving 5-fluorouracil-based chemotherapy
    • Lecomte T, Ferraz JM, Zinzindohoue F, et al. Thymidylate synthase gene polymorphism predicts toxicity in colorectal cancer patients receiving 5-fluorouracil-based chemotherapy. Clin Cancer Res. 2004;10:5880-5888.
    • (2004) Clin Cancer Res , vol.10 , pp. 5880-5888
    • Lecomte, T.1    Ferraz, J.M.2    Zinzindohoue, F.3
  • 2
    • 0345596364 scopus 로고    scopus 로고
    • Toxicity of fluorouracil in patients with advanced colorectal cancer: Effect of administration schedule and prognostic factors. Meta-Analysis Group in Cancer
    • Toxicity of fluorouracil in patients with advanced colorectal cancer: effect of administration schedule and prognostic factors. Meta-Analysis Group in Cancer. J Clin Oncol. 1998;16:3537-3541.
    • (1998) J Clin Oncol , vol.16 , pp. 3537-3541
  • 3
    • 0015962412 scopus 로고
    • Mechanism of interaction of thymidylate synthetase with 5-fluorodeoxyuridylate
    • Santi DV, McHenry CS, Sommer H. Mechanism of interaction of thymidylate synthetase with 5-fluorodeoxyuridylate. Biochemistry. 1974;13:471-481.
    • (1974) Biochemistry , vol.13 , pp. 471-481
    • Santi, D.V.1    McHenry, C.S.2    Sommer, H.3
  • 4
    • 0029122937 scopus 로고
    • Functional analysis and DNA polymorphism of the tandemly repeated sequences in the 5′-terminal regulatory region of the human gene for thymidylate synthase
    • Horie N, Aiba H, Oguro K, et al. Functional analysis and DNA polymorphism of the tandemly repeated sequences in the 5′-terminal regulatory region of the human gene for thymidylate synthase. Cell Struct Funct. 1995;20:191-197.
    • (1995) Cell Struct Funct , vol.20 , pp. 191-197
    • Horie, N.1    Aiba, H.2    Oguro, K.3
  • 5
    • 0035671827 scopus 로고    scopus 로고
    • Different lengths of a polymorphic repeat sequence in the thymidylate synthase gene affect translational efficiency but not its gene expression
    • Kawakami K, Salonga D, Park JM, et al. Different lengths of a polymorphic repeat sequence in the thymidylate synthase gene affect translational efficiency but not its gene expression. Clin Cancer Res. 2001;7:4096-4101.
    • (2001) Clin Cancer Res , vol.7 , pp. 4096-4101
    • Kawakami, K.1    Salonga, D.2    Park, J.M.3
  • 6
    • 0005986509 scopus 로고    scopus 로고
    • A 6 base-pair deletion in the 3′UTR of the thymidylate synthase (TS) gene predicts TS mRNA expression in colorectal tumors. A possible candidate gene for colorectal cancer risk [Abstract]
    • Lenz HJ, Zhang W, Zhahedy S, et al. A 6 base-pair deletion in the 3′UTR of the thymidylate synthase (TS) gene predicts TS mRNA expression in colorectal tumors. A possible candidate gene for colorectal cancer risk [Abstract]. Proc Am Assoc Cancer Res. 2002;43:660.
    • (2002) Proc Am Assoc Cancer Res , vol.43 , pp. 660
    • Lenz, H.J.1    Zhang, W.2    Zhahedy, S.3
  • 7
    • 0034518362 scopus 로고    scopus 로고
    • Searching expressed sequence tag databases: Discovery and confirmation of a common polymorphism in the thymidylate synthase gene
    • Ulrich CM, Bigler J, Velicer CM, et al. Searching expressed sequence tag databases: discovery and confirmation of a common polymorphism in the thymidylate synthase gene. Cancer Epidemiol Biomarkers Prev. 2000;9:1381-1385.
    • (2000) Cancer Epidemiol Biomarkers Prev , vol.9 , pp. 1381-1385
    • Ulrich, C.M.1    Bigler, J.2    Velicer, C.M.3
  • 8
    • 0023187085 scopus 로고
    • Clinical pharmacokinetics of 5-fluorouracil and its metabolites in plasma, urine, and bile
    • Heggie GD, Sommadossi JP, Cross DS, et al. Clinical pharmacokinetics of 5-fluorouracil and its metabolites in plasma, urine, and bile. Cancer Res. 1987;47:2203-2206.
    • (1987) Cancer Res , vol.47 , pp. 2203-2206
    • Heggie, G.D.1    Sommadossi, J.P.2    Cross, D.S.3
  • 9
    • 0023902287 scopus 로고
    • Familial deficiency of dihydropyrimidine dehydrogenase. Biochemical basis for familial pyrimidinemia and severe 5-fluorouracil-induced toxicity
    • Diasio RB, Beavers TL, Carpenter JT. Familial deficiency of dihydropyrimidine dehydrogenase. Biochemical basis for familial pyrimidinemia and severe 5-fluorouracil-induced toxicity. J Clin Invest. 1988;81:47-51.
    • (1988) J Clin Invest , vol.81 , pp. 47-51
    • Diasio, R.B.1    Beavers, T.L.2    Carpenter, J.T.3
  • 10
    • 0026753035 scopus 로고
    • Correlation between dihydropyrimidine dehydrogenase activity in peripheral mononuclear cells and systemic clearance of fluorouracil in cancer patients
    • Fleming RA, Milano G, Thyss A, et al. Correlation between dihydropyrimidine dehydrogenase activity in peripheral mononuclear cells and systemic clearance of fluorouracil in cancer patients. Cancer Res. 1992;52:2899-2902.
    • (1992) Cancer Res , vol.52 , pp. 2899-2902
    • Fleming, R.A.1    Milano, G.2    Thyss, A.3
  • 11
    • 0025990479 scopus 로고
    • Severe 5-fluorouracil toxicity secondary to dihydropyrimidine dehydrogenase deficiency. A potentially more common pharmacogenetic syndrome
    • Harris BE, Carpenter JT, Diasio RB. Severe 5-fluorouracil toxicity secondary to dihydropyrimidine dehydrogenase deficiency. A potentially more common pharmacogenetic syndrome. Cancer. 1991;68:499-501.
    • (1991) Cancer , vol.68 , pp. 499-501
    • Harris, B.E.1    Carpenter, J.T.2    Diasio, R.B.3
  • 12
    • 9044246668 scopus 로고    scopus 로고
    • Severe neurotoxicity following 5-fluorouracil-based chemotherapy in a patient with dihydropyrimidine dehydrogenase deficiency
    • Takimoto CH, Lu ZH, Zhang R, et al. Severe neurotoxicity following 5-fluorouracil-based chemotherapy in a patient with dihydropyrimidine dehydrogenase deficiency. Clin Cancer Res. 1996;2:477-481.
    • (1996) Clin Cancer Res , vol.2 , pp. 477-481
    • Takimoto, C.H.1    Lu, Z.H.2    Zhang, R.3
  • 13
    • 0029973215 scopus 로고    scopus 로고
    • Molecular basis of the human dihydropyrimidine dehydrogenase deficiency and 5-fluorouracil toxicity
    • Wei X, McLeod HL, McMurrough J, et al. Molecular basis of the human dihydropyrimidine dehydrogenase deficiency and 5-fluorouracil toxicity. J Clin Invest. 1996;98:610-615.
    • (1996) J Clin Invest , vol.98 , pp. 610-615
    • Wei, X.1    McLeod, H.L.2    McMurrough, J.3
  • 14
    • 0031876466 scopus 로고    scopus 로고
    • Putative role of dihydropyrimidine dehydrogenase in the toxic side effect of 5-fluorouracil in colorectal cancer patients
    • Katona C, Kralovanszky J, Rosta A, et al. Putative role of dihydropyrimidine dehydrogenase in the toxic side effect of 5-fluorouracil in colorectal cancer patients. Oncology. 1998;55:468-474.
    • (1998) Oncology , vol.55 , pp. 468-474
    • Katona, C.1    Kralovanszky, J.2    Rosta, A.3
  • 15
    • 0034488052 scopus 로고    scopus 로고
    • Clinical implications of dihydropyrimidine dehydrogenase (DPD) deficiency in patients with severe 5-fluorouracil-associated toxicity: Identification of new mutations in the DPD gene
    • van Kuilenburg AB, Haasjes J, Richel DJ, et al. Clinical implications of dihydropyrimidine dehydrogenase (DPD) deficiency in patients with severe 5-fluorouracil-associated toxicity: identification of new mutations in the DPD gene. Clin Cancer Res. 2000;6:4705-4712.
    • (2000) Clin Cancer Res , vol.6 , pp. 4705-4712
    • van Kuilenburg, A.B.1    Haasjes, J.2    Richel, D.J.3
  • 16
    • 0027426408 scopus 로고
    • Dihydropyrimidine dehydrogenase activity in human peripheral blood mononuclear cells and liver: Population characteristics, newly identified deficient patients, and clinical implication in 5-fluorouracil chemotherapy
    • Lu Z, Zhang R, Diasio RB. Dihydropyrimidine dehydrogenase activity in human peripheral blood mononuclear cells and liver: population characteristics, newly identified deficient patients, and clinical implication in 5-fluorouracil chemotherapy. Cancer Res. 1993;53:5433-5438.
    • (1993) Cancer Res , vol.53 , pp. 5433-5438
    • Lu, Z.1    Zhang, R.2    Diasio, R.B.3
  • 17
    • 0028813120 scopus 로고
    • Human polymorphism in drug metabolism: Mutation in the dihydropyrimidine dehydrogenase gene results in exon skipping and thymine uracilurea
    • Meinsma R, Fernandez-Salguero P, Van Kuilenburg AB, et al. Human polymorphism in drug metabolism: mutation in the dihydropyrimidine dehydrogenase gene results in exon skipping and thymine uracilurea. DNA Cell Biol. 1995;14:1-6.
    • (1995) DNA Cell Biol , vol.14 , pp. 1-6
    • Meinsma, R.1    Fernandez-Salguero, P.2    Van Kuilenburg, A.B.3
  • 18
    • 15144351973 scopus 로고    scopus 로고
    • Dihydropyrimidine dehydrogenase pharmacogenetics in patients with colorectal cancer
    • Ridge SA, Sludden J, Wei X, et al. Dihydropyrimidine dehydrogenase pharmacogenetics in patients with colorectal cancer. Br J Cancer. 1998;77:497-500.
    • (1998) Br J Cancer , vol.77 , pp. 497-500
    • Ridge, S.A.1    Sludden, J.2    Wei, X.3
  • 19
    • 0032974922 scopus 로고    scopus 로고
    • Genotype and phenotype in patients with dihydropyrimidine dehydrogenase deficiency
    • Van Kuilenburg AB, Vreken P, Abeling NG, et al. Genotype and phenotype in patients with dihydropyrimidine dehydrogenase deficiency. Hum Genet. 1999;104:1-9.
    • (1999) Hum Genet , vol.104 , pp. 1-9
    • Van Kuilenburg, A.B.1    Vreken, P.2    Abeling, N.G.3
  • 20
    • 0034050905 scopus 로고    scopus 로고
    • Known variant DPYD alleles do not explain DPD deficiency in cancer patients
    • Collie-Duguid ES, Etienne MC, Milano G, et al. Known variant DPYD alleles do not explain DPD deficiency in cancer patients. Pharmacogenetics. 2000;10:217-223.
    • (2000) Pharmacogenetics , vol.10 , pp. 217-223
    • Collie-Duguid, E.S.1    Etienne, M.C.2    Milano, G.3
  • 21
    • 34248176139 scopus 로고    scopus 로고
    • National Cancer Institute. Common Toxicity Criteria version 2.0 CTC, 1999. Available at
    • National Cancer Institute. Common Toxicity Criteria version 2.0 (CTC). 1999. Available at: http://ctep.cancer.gov/reporting/CTC-3.html.
  • 22
    • 0037567591 scopus 로고    scopus 로고
    • A novel single nucleotide polymorphism within the 5′ tandem repeat polymorphism of the thymidylate synthase gene abolishes USF-1 binding and alters transcriptional activity
    • Mandola MV, Stoehlmacher J, Muller-Weeks S, et al. A novel single nucleotide polymorphism within the 5′ tandem repeat polymorphism of the thymidylate synthase gene abolishes USF-1 binding and alters transcriptional activity. Cancer Res. 2003;63:2898-2904.
    • (2003) Cancer Res , vol.63 , pp. 2898-2904
    • Mandola, M.V.1    Stoehlmacher, J.2    Muller-Weeks, S.3
  • 23
    • 0033564283 scopus 로고    scopus 로고
    • Ethnic variation in the thymidylate synthase enhancer region polymorphism among Caucasian and Asian populations
    • Marsh S, Collie-Duguid ES, Li T, et al. Ethnic variation in the thymidylate synthase enhancer region polymorphism among Caucasian and Asian populations. Genomics. 1999;58:310-312.
    • (1999) Genomics , vol.58 , pp. 310-312
    • Marsh, S.1    Collie-Duguid, E.S.2    Li, T.3
  • 24
    • 27144478904 scopus 로고    scopus 로고
    • Polymorphisms of thymidylate synthase in the 5′- and 3′-untranslated regions associated with risk of gastric cancer in South China: A case-control analysis
    • Zhang Z, Xu Y, Zhou J, et al. Polymorphisms of thymidylate synthase in the 5′- and 3′-untranslated regions associated with risk of gastric cancer in South China: a case-control analysis. Carcinogenesis. 2005;26:1764-1769.
    • (2005) Carcinogenesis , vol.26 , pp. 1764-1769
    • Zhang, Z.1    Xu, Y.2    Zhou, J.3
  • 25
    • 1642539113 scopus 로고    scopus 로고
    • Heterozygote deficiency in thymidylate synthase enhancer region polymorphism genotype distribution in Hungarian colorectal cancer patients
    • Adleff V, Hitre E, Koves I, et al. Heterozygote deficiency in thymidylate synthase enhancer region polymorphism genotype distribution in Hungarian colorectal cancer patients. Int J Cancer. 2004;108:852-856.
    • (2004) Int J Cancer , vol.108 , pp. 852-856
    • Adleff, V.1    Hitre, E.2    Koves, I.3
  • 26
    • 0037096858 scopus 로고    scopus 로고
    • Thymidylate synthase promotor polymorphism, interaction with folate intake, and risk of colorectal adenomas
    • Ulrich CM, Bigler J, Bostick R, et al. Thymidylate synthase promotor polymorphism, interaction with folate intake, and risk of colorectal adenomas. Cancer Res. 2002;62:3361-3364.
    • (2002) Cancer Res , vol.62 , pp. 3361-3364
    • Ulrich, C.M.1    Bigler, J.2    Bostick, R.3
  • 27
    • 27944455699 scopus 로고    scopus 로고
    • One-carbon metabolism related gene polymorphisms interact with alcohol drinking to influence the risk of colorectal cancer in Japan
    • Keitaro M, Hidemi I, Kenji W, et al. One-carbon metabolism related gene polymorphisms interact with alcohol drinking to influence the risk of colorectal cancer in Japan. Carcinogenesis. 2005;26:2164-2171.
    • (2005) Carcinogenesis , vol.26 , pp. 2164-2171
    • Keitaro, M.1    Hidemi, I.2    Kenji, W.3
  • 28
    • 11144221690 scopus 로고    scopus 로고
    • Polymorphism in thymidylate synthase promotor enhancer region and risk of colorectal adenomas
    • Chen J, Kite C, Chan W, et al. Polymorphism in thymidylate synthase promotor enhancer region and risk of colorectal adenomas. Cancer Epidemiol Biomarkers Prev. 2004;13:2247-2250.
    • (2004) Cancer Epidemiol Biomarkers Prev , vol.13 , pp. 2247-2250
    • Chen, J.1    Kite, C.2    Chan, W.3
  • 29
    • 33750331660 scopus 로고    scopus 로고
    • Thymidylate synthase, dihydropyrimidine dehydrogenase and thymidine phosphorylase expression in colorectal cancer and normal mucosa in patients
    • Amatori F, Di Paolo A, Del Tacca M, et al. Thymidylate synthase, dihydropyrimidine dehydrogenase and thymidine phosphorylase expression in colorectal cancer and normal mucosa in patients. Pharmacogenet Genomics. 2006;16:809-816.
    • (2006) Pharmacogenet Genomics , vol.16 , pp. 809-816
    • Amatori, F.1    Di Paolo, A.2    Del Tacca, M.3
  • 30
    • 0032929295 scopus 로고    scopus 로고
    • Clinical and biochemical abnormalities in a patient with dihydropyrimidine dehydrogenase deficiency due to homozygosity for the C29R mutation
    • Van Kuilenburg AB, Vreken P, Riva D, et al. Clinical and biochemical abnormalities in a patient with dihydropyrimidine dehydrogenase deficiency due to homozygosity for the C29R mutation. J Inherit Metab Dis. 1999;22:191-192.
    • (1999) J Inherit Metab Dis , vol.22 , pp. 191-192
    • Van Kuilenburg, A.B.1    Vreken, P.2    Riva, D.3
  • 31
    • 0031948047 scopus 로고    scopus 로고
    • Dihydropyrimidine dehydrogenase deficiency: A novel mutation and expression of missense mutations in E. coli
    • Vreken P, van Kuilenburg AB, Meinsma R, et al. Dihydropyrimidine dehydrogenase deficiency: a novel mutation and expression of missense mutations in E. coli. J Inherit Metab Dis. 1998;21:276-279.
    • (1998) J Inherit Metab Dis , vol.21 , pp. 276-279
    • Vreken, P.1    van Kuilenburg, A.B.2    Meinsma, R.3
  • 32
    • 0030753062 scopus 로고    scopus 로고
    • Identification of a fourbase deletion (delTCAT296-299) in the dihydropyrimidine dehydrogenase gene with variable clinical expression
    • Vreken P, Van Kuilenburg AB, Meinsma R, et al. Identification of a fourbase deletion (delTCAT296-299) in the dihydropyrimidine dehydrogenase gene with variable clinical expression. Hum Genet. 1997;100:263-265.
    • (1997) Hum Genet , vol.100 , pp. 263-265
    • Vreken, P.1    Van Kuilenburg, A.B.2    Meinsma, R.3
  • 33
    • 7344249042 scopus 로고    scopus 로고
    • Dihydropyrimidine dehydrogenase pharmacogenetics in Caucasian subjects
    • Ridge SA, Sludden J, Brown O, et al. Dihydropyrimidine dehydrogenase pharmacogenetics in Caucasian subjects. Br J Clin Pharmacol. 1998;46:151-156.
    • (1998) Br J Clin Pharmacol , vol.46 , pp. 151-156
    • Ridge, S.A.1    Sludden, J.2    Brown, O.3
  • 34
    • 0035074119 scopus 로고    scopus 로고
    • Germline mutation of dihydropyrimidine dehydrogenese gene among a Japanese population in relation to toxicity to 5-fluorouracil
    • Yamaguchi K, Arai Y, Kanda Y, et al. Germline mutation of dihydropyrimidine dehydrogenese gene among a Japanese population in relation to toxicity to 5-fluorouracil. Jpn J Cancer Res. 2001;92:337-342.
    • (2001) Jpn J Cancer Res , vol.92 , pp. 337-342
    • Yamaguchi, K.1    Arai, Y.2    Kanda, Y.3
  • 35
    • 0344923828 scopus 로고    scopus 로고
    • Dihydropyrimidine dehydrogenase activity in a Korean population
    • Sohn DR, Cho MS, Chung PJ. Dihydropyrimidine dehydrogenase activity in a Korean population. Ther Drug Monit. 1999;21:152-154.
    • (1999) Ther Drug Monit , vol.21 , pp. 152-154
    • Sohn, D.R.1    Cho, M.S.2    Chung, P.J.3
  • 36
    • 28444436251 scopus 로고    scopus 로고
    • Advances and challenges in fluoropyrimidine pharmacogenomics and pharmacogenetics
    • Soong R, Diasio RB. Advances and challenges in fluoropyrimidine pharmacogenomics and pharmacogenetics. Pharmacogenomics. 2005;6:835-847.
    • (2005) Pharmacogenomics , vol.6 , pp. 835-847
    • Soong, R.1    Diasio, R.B.2
  • 37
    • 0035987174 scopus 로고    scopus 로고
    • Allele and genotype frequencies of polymorphic cytochromes P450 (CYP2C9, CYP2C19, CYP2E1) and dihydropyrimidine dehydrogenase (DPYD) in the Egyptian population
    • Hamdy SI, Hiratsuka M, Narahara K, et al. Allele and genotype frequencies of polymorphic cytochromes P450 (CYP2C9, CYP2C19, CYP2E1) and dihydropyrimidine dehydrogenase (DPYD) in the Egyptian population. Br J Clin Pharmacol. 2002;53:596-603.
    • (2002) Br J Clin Pharmacol , vol.53 , pp. 596-603
    • Hamdy, S.I.1    Hiratsuka, M.2    Narahara, K.3


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