ProCMD: A database and 3D web resource for protein C mutants

BMC Bioinformatics

Volumn 8, Issue SUPPL. 1, 2007, Pages

  D'Ursi, Pasqualina ^a   Marino, Francesca ^b   Caprera, Andrea ^b   Milanesi, Luciano ^b   Faioni, Elena M ^a   Rovida, Ermanna ^b  

^a UNIVERSITY OF MILAN   (Italy)

^b CNR   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATED PROTEIN C; COMPUTATIONAL ANALYSIS; COMPUTATIONAL APPROACH; MOLECULAR DEFECTS; MULTIPLE ALIGNMENT; RELATIONAL DATABASE; STRUCTURE PREDICTION; VENOUS THROMBOSIS;

AMINO ACIDS; CELL PROLIFERATION; COMPUTATIONAL METHODS; DATABASE SYSTEMS; MOLECULAR BIOLOGY; SEARCH ENGINES; TOOLS;

GLYCOPROTEINS;

PROTEIN C;

ARTICLE; COMPUTER PROGRAM; HUMAN COMPUTER INTERACTION; INFORMATION RETRIEVAL; MISSENSE MUTATION; MOLECULAR MODEL; MUTANT; PHENOTYPE; PROCMD DATABASE; PROTEIN DATABASE; SEARCH ENGINE; AMINO ACID SEQUENCE; CHEMISTRY; COMPUTER GRAPHICS; COMPUTER INTERFACE; DATA BASE; GENETICS; INTERNET; METHODOLOGY; MOLECULAR GENETICS; MUTATION; THREE DIMENSIONAL IMAGING;

AMINO ACID SEQUENCE; COMPUTER GRAPHICS; DATABASE MANAGEMENT SYSTEMS; DATABASES, PROTEIN; IMAGING, THREE-DIMENSIONAL; INFORMATION STORAGE AND RETRIEVAL; INTERNET; MOLECULAR SEQUENCE DATA; MUTATION; PROTEIN C; USER-COMPUTER INTERFACE;

EID: 34248155630     PISSN: None     EISSN: 14712105     Source Type: Journal    
DOI: 10.1186/1471-2105-8-S1-S11     Document Type: Article

References (25)

1. Van De Wouwer M Collen D Conway EM Thrombomodulin-protein C-EPCR system. Integrated to regulate coagulation and inflammation Arterioscler Thromb Vasc Biol 2004, 24:1374-1383. 10.1161/01.ATV.0000112102.28859.39 15178554
2. Bernard GR Vincent JL Laterre PF LaRosa SP Dhainaut JF Lopez-Rodriguez A Steingrub JS Garber GE Helterbrand JD Ely EW Fisher CJ Efficacy and safety of recombinant human activated protein C for severe sepsis N Engl J Med 2001, 344:699-709. 10.1056/NEJM200103083441001 11236773
3. Stenflo J Structure and function of protein C Semin Thromb Hemost 1984, 10:109-112. 6429858
4. Esmon CT The regulation of natural anticoagulant pathways Science 1987, 235:1348-1352. 10.1126/science.3029867 3029867
5. Fukudome K Ye X Tsuneyoshi N Tokunaga O Sugawara K Mizokami H Kimoto M Activation mechanism of anticoagulant protein C in large blood vessels involving the endothelial cell protein C receptor J Exp Med 1998, 187:1029-1035. 10.1084/jem.187.7.1029 9529319
6. Mather T Oganessyan V Hof P Huber R Foundling S Esmon C Bode W The 2.8 Å crystal structure of Gla-domainless activated protein C The EMBO Journal 1996, 15:6822-6831. 452507 9003757
7. Oganesyan V Oganesyan N Terzyan N Qu D Dauter Z Esmon NL Esmon CT The crystal structure of the endothelial protein C receptor and a bound phospholipid J Biol Chem 2002, 277:24851-24854. 10.1074/jbc.C200163200 12034704
8. Aiach M Borgel D Gaussem P Emmerich J Alhenc-Gelas M Gandrille S Protein C and protein S deficiencies Semin Hematol 1997, 34:205-216. 9241706
9. Dahlback B The protein C anticoagulant system: Inherited defects as basis for venous thrombosis Thromb Res 1995, 77:1-43. 10.1016/ 0049-3848(94)00138-4 7701473
10. Reitsma PH Bernardi F Doig RG Gandrille S Greengard JS Ireland H Krawczak M Lind B Long GL Bertina RM Protein C deficiency: A database of mutations, 1995 update. On behalf of the subcommittee on plasma coagulation inhibitors of the scientific and standardization committee of the ISTH Thromb Haemost 1995, 73:876-889. 7482420
11. Database of mutations - Protein C http://www.xs4all.nl/~reitsma/ Prot_c_intro.html
12. Human Gene Mutation Database, HGMD http://www.hgmd.cf.ac.uk/.
13. Stenson PD Ball EV Mort M Phillips AD Shiel JA Thomas NS Abeysinghe S Krawczak M Cooper DN Human Gene Mutation Database (HGMD®): 2003 Update Hum Mutat 2003, 21:577-581. 10.1002/humu.10212 12754702
14. Yip YL Scheib H Diemand AV Gattiker A Famiglietti LM Gasteiger E Bairoch A The Swiss-Prot Variant Page and the ModSNP Database: A Resource for Sequence and Structure information on Human Protein Variants Hum Mutat 2004, 23:464-470. 10.1002/humu.20021 15108278
15. Swiss-Prot http://www.expasy.org/sprot/
16. Faioni EM Hermida J Rovida E Razzari C Asti D Zeinali S Mannucci PM Type II protein C deficiency: Identification and molecular modelling of two natural mutants with low anticoagulant and normal amidolytic activity Br J Haematol 2000, 108:265-271. 10.1046/j.1365-2141.2000.01848.x 10691853
17. Rovida E Merati G D'Ursi P Zanardelli S Marino F Fontana G Castaman G Faioni EM Identification and computationally based structural interpretation of naturally occurring variants of human protein C Hum Mutat 2006. 17152060
18. Higgins DG Sharp PM CLUSTAL: A package for performing multiple sequence alignments on a microcomputer Gene 1988, 73:237-244. 10.1016/ 0378-1119(88)90330-7 3243435
19. Sali A Blundell TL Comparative protein modelling by satisfaction of spatial restraint J Mol Biol 1993, 234:779-815. 10.1006/jmbi.1993.1626 8254673
20. Kraulis J MOLSCRIPT: A Program to Produce Both Detailed and Schematic Plots of Protein Structures J Appl Cryst 1991, 24:946-950. 10.1107/ S0021889891004399
21. Cortona VRML Client http://www.parallelgraphics.com/products/cortona
22. MySQL http://www.mysql.com/
23. PHP http://www.php.net/
24. Apache Web Server http://www.apache.org/
25. Foster DC Yoshitake S Davie EW The nucleotide sequence of the gene for human protein C Proc Natl Acad Sci USA 1985, 82:4673-4677. 390448 2991887 10.1073/pnas.82.14.4673