Novel nitration of estrone by metal nitrates

Tetrahedron Letters

Volumn 48, Issue 23, 2007, Pages 3945-3947

  Bose, Ashley ^a   Sanjoto, Widyanti P ^a   Villarreal, Samantha ^a   Aguilar, Hector ^a   Banik, Bimal K ^a  

^a UNIVERSITY OF TEXAS PAN AMERICAN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ESTRONE; METAL; NITRIC ACID DERIVATIVE;

ARTICLE; CHEMICAL STRUCTURE; NITRATION; SOLID STATE;

EID: 34247896943     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2007.04.050     Document Type: Article

References (21)

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21. A representative experimental procedure is as follows: Estrone (1 mmol) and montmorillonite KSF (500 mg, Aldrich) were added to a suspension of bismuth nitrate pentahydrate (1 mmol) in THF (10 mL). The solvent was then evaporated under reduced pressure and dried in a vacuum pump for 5 min. The mixture was then repeatedly washed with dichloromethane (25 mL) and concentrated to afford the crude product. The pure product was isolated by crystallization (ethyl acetate/hexanes = 20:80). A number of conditions were examined as can be seen in Table 1.