G-protein-coupled receptor 30 mediates estrogen's nongenomic effects after hemorrhagic shock and trauma

American Journal of Pathology

Volumn 170, Issue 4, 2007, Pages 1148-1151

  Meldrum, Daniel R ^a,b  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Emerson Hall 215 ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE; ESTRADIOL; ESTROGEN; ESTROGEN RECEPTOR; G PROTEIN COUPLED RECEPTOR; PROTEIN BCL 2; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR; BOVINE SERUM ALBUMIN; CONJUGATED ESTROGEN; ESTRADIOL BOVINE SERUM ALBUMIN; ESTRADIOL-BOVINE SERUM ALBUMIN; ESTROGEN RECEPTOR ALPHA; ISOQUINOLINE DERIVATIVE; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; PROTEIN KINASE INHIBITOR; SULFONAMIDE; UNCLASSIFIED DRUG;

BURN; CARDIOVASCULAR DISEASE; DRUG MECHANISM; GENOME; HEMORRHAGIC SHOCK; HUMAN; HYPOVOLEMIC SHOCK; IMMUNE DEFICIENCY; ISCHEMIA; LIVER CELL; MORTALITY; NONHUMAN; NOTE; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROTEIN BINDING; REGULATORY MECHANISM; REPERFUSION INJURY; RESUSCITATION; SEPSIS; SEX DIFFERENCE; ANIMAL; BIOLOGICAL MODEL; BLEEDING; BLOOD; DRUG ANTAGONISM; DRUG EFFECT; GENETIC TRANSFECTION; GENETICS; INJURY; LIVER; METABOLISM; PHYSIOLOGY; RAT; SIGNAL TRANSDUCTION;

ANIMALS; CYCLIC AMP-DEPENDENT PROTEIN KINASES; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; ESTROGENS, CONJUGATED (USP); HEMORRHAGE; HEPATOCYTES; ISOQUINOLINES; LIVER; MODELS, BIOLOGICAL; PROTEIN KINASE INHIBITORS; RATS; RECEPTORS, G-PROTEIN-COUPLED; RNA, SMALL INTERFERING; SERUM ALBUMIN, BOVINE; SIGNAL TRANSDUCTION; SULFONAMIDES; TRANSFECTION; WOUNDS AND INJURIES;

EID: 34247891676     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.2353/ajpath.2007.070025     Document Type: Note

References (26)

1. Hsieh YC, Yu HP, Frink M, Suzuki T, Choudhry MA, Schwacha MG, Chaudry IH: G protein-coupled receptor 30-dependent protein kinase A pathway is critical in nongenomic effects of estrogen in attenuating liver injury following trauma-hemorrhage. Am J Pathol 2007, 170:1210-1218
2. Crisostomo PR, Wang M, Herring CM, Markel TA, Meldrum KK, Lillemoe KD, Meldrum DR: Gender differences in injury induced mesenchymal stem cell apoptosis and VEGF, TNF, IL-6 expression: role of the 55 kDa TNF receptor (TNFR1). J Mol Cell Cardiol 2007, 42:142-149
3. Crisostomo PR, Wang M, Herring CM, Morrell ED, Seshadri P, Meldrum KK, Meldrum DR: Sex dimorphisms in activated mesenchymal stem cell function. Shock 2006, 26:571-574
4. George RL, McGwin Jr G, Schwacha MG, Metzger J, Cross JM, Chaudry IH, Rue III LW: The association between sex and mortality among burn patients as modified by age. J Burn Care Rehabil 2005, 26:416-421
5. Hildebrand F, Hubbard WJ, Choudhry MA, Frink M, Pape HC, Kunkel SL, Chaudry IH: Kupffer cells and their mediators: the culprits in producing distant organ damage after trauma-hemorrhage. Am J Pathol 2006, 169:784-794
6. Hsieh YC, Choudhry MA, Yu HP, Shimizu T, Yang S, Suzuki T, Chen J, Bland KI, Chaudry IH: Inhibition of cardiac PGC-1alpha expression abolishes ERbeta agonist-mediated cardioprotection following trauma-hemorrhage. FASEB J 2006, 20:1109-1117
7. Hubbard WJ, Choudhry M, Schwacha MG, Kerby JD, Rue III LW, Bland KI, Chaudry IH: Cecal ligation and puncture. Shock 2005, 24(Suppl 1):52-57
8. Jarrar D, Kuebler JF, Wang P, Bland KI, Chaudry IH: DHEA: a novel adjunct for the treatment of male trauma patients. Trends Mol Med 2001, 7:81-85
9. Kher A, Meldrum KK, Wang M, Tsai BM, Pitcher JM, Meldrum DR: Cellular and molecular mechanisms of sex differences in renal ischemia-reperfusion injury. Cardiovasc Res 2005, 67:594-603
10. Kher A, Wang M, Tsai BM, Pitcher JM, Greenbaum ES, Nagy RD, Patel KM, Wairiuko GM, Markel TA, Meldrum DR: Sex differences in the myocardial inflammatory response to acute injury. Shock 2005, 23:1-10
11. Lorenzo J: A new hypothesis for how sex steroid hormones regulate bone mass. J Clin Invest 2003, 111:1641-1643
12. Manavathi B, Kumar R: Steering estrogen signals from the plasma membrane to the nucleus: two sides of the coin. J Cell Physiol 2006, 207:594-604
13. Choudhry MA, Bland KI, Chaudry IH: Gender and susceptibility to sepsis following trauma. Endocr Metab Immune Disord Drug Targets 2006, 6:127-135
14. Choudhry MA, Schwacha MG, Hubbard WJ, Kerby JD, Rue LW, Bland KI, Chaudry IH: Gender differences in acute response to trauma-hemorrhage. Shock 2005, 24(Suppl 1):101-106
15. Meldrum DR: Estrogen increases protective proteins following trauma and hemorrhage. Am J Physiol 2006, 290:R809-R811
16. Meldrum DR, Wang M, Tsai BM, Kher A, Pitcher JM, Brown JW, Meldrum KK: Intracellular signaling mechanisms of sex hormones in acute myocardial inflammation and injury. Front Biosci 2005, 10:1835-1867
17. Schneider CP, Schwacha MG, Chaudry IH: Impact of gender and age on bone marrow immune responses in a murine model of trauma-hemorrhage. J Appl Physiol 2007, 102:113-121
18. Chaudry IH, Samy TS, Schwacha MG, Wang P, Rue III LW, Bland KI: Endocrine targets in experimental shock. J Trauma 2003, 54:S118-S125
19. Mendelsohn ME, Karas RH: Molecular and cellular basis of cardiovascular gender differences. Science 2005, 308:1583-1587
20. Napolitano LM, Greco ME, Rodriguez A, Kufera JA, West RS, Scalea TM: Gender differences in adverse outcomes after blunt trauma. J Trauma 2001, 50:274-280
21. Oberholzer A, Keel M, Zellweger R, Steckholzer U, Trentz O, Ertel W: Incidence of septic complications and multiple organ failure in severely injured patients is sex specific. J Trauma 2000, 48:932-937
22. Gannon CJ, Napolitano LM, Pasquale M, Tracy JK, McCarter RJ: A statewide population-based study of gender differences in trauma: validation of a prior single-institution study. J Am Coll Surg 2002, 195:11-18
23. Zellweger R, Ayala A, Stein S, DeMaso CM, Chaudry IH: Females in proestrus state tolerate sepsis better than males. Surg Forum 1995, 46:65-67
24. Wichmann MW, Zellweger R, DeMaso CM, Ayala A, Chaudry IH: Enhanced immune responses in females, as opposed to decreased responses in males following haemorrhagic shock and resuscitation. Cytokine 1996, 8:853-863
25. Zellweger R, Wichmann MW, Ayala A, Stein S, DeMaso CM, Chaudry IH: Females in proestrus state maintain splenic immune functions and tolerate sepsis better than males. Crit Care Med 1997, 25:106-110
26. Chaudry IH, Wichterman KA, Baue AE: Effect of sepsis on tissue adenine nucleotide levels. Surgery 1979, 85:205-211