Platelet 5-HT2A receptor subresponsivity and lethality of attempted suicide in depressed in-patients

International Journal of Neuropsychopharmacology

Volumn 10, Issue 3, 2007, Pages 335-343

  Malone, Kevin M ^a   Ellis, Steven P ^a,b   Currier, Dianne ^a   John Mann, J ^a,b  

^a Och Spine at New York Presbyterian Hospitals   (United States)

^b NEW YORK STATE PSYCHIATRIC INSTITUTE   (United States)

Author keywords

5 HT2A receptor; Attempted; Depression; Suicide

Indexed keywords

PHOSPHATIDYLINOSITIDE; SEROTONIN; SEROTONIN 2A RECEPTOR; ADRENALIN; ALPHA 2 ADRENERGIC RECEPTOR; ALPHA ADRENERGIC RECEPTOR STIMULATING AGENT; MESSENGER RNA; PHOSPHATIDYLINOSITOL;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DEPRESSION; FEMALE; HOSPITAL PATIENT; HUMAN; HYDROLYSIS; MALE; MENTAL PATIENT; PRIORITY JOURNAL; SEROTONINERGIC SYSTEM; SIGNAL TRANSDUCTION; SUICIDE ATTEMPT; THROMBOCYTE; ADOLESCENT; AGED; AGING; BIOSYNTHESIS; BLOOD; DRUG EFFECT; GENETICS; LONGITUDINAL STUDY; MAJOR DEPRESSION; METABOLISM; MIDDLE AGED; PHYSIOLOGY; PREFRONTAL CORTEX; PSYCHOLOGICAL ASPECT; PSYCHOLOGICAL RATING SCALE; SEASON; SECOND MESSENGER; STATISTICAL ANALYSIS; STATISTICS; SUICIDE;

ADOLESCENT; ADRENERGIC ALPHA-AGONISTS; ADULT; AGED; AGED, 80 AND OVER; AGING; BLOOD PLATELETS; DATA INTERPRETATION, STATISTICAL; DEPRESSIVE DISORDER, MAJOR; EPINEPHRINE; FEMALE; HUMANS; INPATIENTS; LONGITUDINAL STUDIES; MALE; MIDDLE AGED; PHOSPHATIDYLINOSITOLS; PREFRONTAL CORTEX; PSYCHIATRIC STATUS RATING SCALES; RECEPTOR, SEROTONIN, 5-HT2A; RECEPTORS, ADRENERGIC, ALPHA-2; RNA, MESSENGER; SEASONS; SECOND MESSENGER SYSTEMS; SIGNAL TRANSDUCTION; SUICIDE; SUICIDE, ATTEMPTED;

EID: 34247889968     PISSN: 14611457     EISSN: 14695111     Source Type: Journal    
DOI: 10.1017/S1461145706006997     Document Type: Article

References (81)

1. 2A receptor densities in suicidal and non-suicidal depressives and control subjects. Psychiatry Research 94, 273-277.
2. American Psychiatric Association Task Force (1987). Diagnostic and Statistical Manual of Mental Disorders (DSM-III-R). Washington, DC: APA Press.
3. Arango V, Ernsberger P, Marzuk PM, Chen JS, Tierney H, Stanley M, Reis DJ, Mann JJ (1990). Autoradiographic demonstration of increased serotonin 5-HT2 and beta-adrenergic receptor binding sites in the brain of suicide victims. Archives of General Psychiatry 47, 1038-1047.
4. Arango V, Underwood MD, Gubbi AV, Mann JJ (1995). Localized alterations in pre- and postsynaptic serotonin binding sites in the ventrolateral prefrontal cortex of suicide victims. Brain Research 688, 121-133.
5. Arató M, Tekes K, Palkovits M, Demeter E, Falus A (1987). Serotonergic split brain and suicide. Psychiatry Research 21, 355-356.
6. Arató M, Tekes K, Tóthfalusi L, Magyar K, Palkovits M, Frecska E, Falus A, MacCrimmon DJ (1991). Reversed hemispheric asymmetry of imipramine binding in suicide victims. Biological Psychiatry 29, 699-702.
7. Arora RC, Meltzer HY (1989). Serotonergic measures in the brains of suicide victims: 5-HT2 binding sites in the frontal cortex of suicide victims and control subjects. American Journal of Psychiatry 146, 730-736.
8. Arora RC, Meltzer HY (1993). Serotonin2 receptor binding in blood platelets of schizophrenic patients. Psychiatry Research 47, 111-119.
9. Åsberg M (1986). Biochemical aspects of suicide. Clinical Neuropharmacology 9, 374-376.
10. Audenaert K, Van Laere K, Dumont F, Slegers G, Mertens J, van Heeringen C, Dierckx RA (2001). Decreased frontal serotonin 5-HT2a receptor binding index in deliberate self-harm patients. European Journal of Nuclear Medicine 28, 175-182.
11. Avissar S, Barki-Harrington L, Nechamkin Y, Roitman G, Schreiber G (1996). Reduced β-adrenergic receptor-coupled Gs protein function and Gsa immunoreactivity in mononuclear leukocytes of patients with depression. Biological Psychiatry 39, 755-760.
12. Bakish D, Cavazzoni P, Chudzik J, Ravindran A, Hrdina PD (1997). Effects of selective serotonin reuptake inhibitors on platelet serotonin parameters in major depressive disorder. Biological Psychiatry 41, 184-190.
13. Barratt ES (1965). Factor analysis of some psychometric measures of impulsiveness and anxiety. Psychological Reports 16, 547-554.
14. Beck A, Schuyler D, Herman J (1974a). Development of suicidal intent scales. In: Beck A, Resnick K, Letierri D (Eds.), The Prediction of Suicide (pp. 45-56). Bowie, MD: Charles Press.
15. Beck AT, Beck R, Kovacs M (1975). Classification of suicidal behaviors: I. Quantifying intent and medical lethality. American Journal of Psychiatry 132, 285-287.
16. Beck AT, Kovacs M, Weissman A (1979). Assessment of suicidal intention: the scale for suicide ideation. Journal of Consulting and Clinical Psychology 47, 343-352.
17. Beck AT, Weissman A, Lester D, Trexler L (1974b). The measurement of pessimism: the hopelessness scale. Journal of Consulting and Clinical Psychology 42, 861-865.
18. Berridge MJ, Irvine RF (1989). Inositol phosphates and cell signalling. Nature 341, 197-206.
19. Beskow J, Gottfries CG, Roos BE, Winblad B (1976). Determination of monoamine and monoamine metabolites in the human brain: Post mortem studies in a group of suicides and in a control group. Acta Psychiatrica Scandinavica 53, 7-20.
20. Biegon A, Grinspoon A, Blumenfeld B, Bleich A, Apter A, Mester R (1990). Increased serotonin 5-HT2 receptor binding on blood platelets of suicidal men. Psychopharmacology (Berlin) 100, 165-167.
21. Bourne HR, Bunney Jr. WE, Colburn RW, Davis JM, Shaw DM, Coppen AJ (1968). Noradrenaline, 5-hydroxytryptamine, and 5-hydroxyindoleacetic acid in hindbrains of suicidal patients. Lancet ii, 805-808.
22. Brown GL, Goodwin FK (1986). Human aggression and suicide. Suicide and Life-Threatening Behavior 16, 223-243.
23. Buss AH, Durkee A (1957). An inventory for assessing different kinds of hostility. Journal of Consulting Psychology 21, 343-349.
24. 2A receptors: a positron emission tomography study in healthy individuals. Neuroscience Letters 261, 139-142.
25. Coccaro EF, Silverman JM, Klar HM, Horvath TB, Siever LJ (1994). Familial correlates of reduced central serotonergic system function in patients with personality disorders. Archives of General Psychiatry 51, 318-324.
26. Conn PJ, Sanders-Bush E (1984). Selective 5HT-antagonists inhibit serotonin stimulated phosphatidylinositol metabolism in cerebral cortex. Neuropharmacology 23, 993-996.
27. Cowburn RF, Marcusson JO, Eriksson A, Wiehager B, O'Neill C (1994). Adenylyl cyclase activity and G-protein subunit levels in postmortem frontal cortex of suicide victims. Brain Research 633, 297-304.
28. Crow TJ, Cross AJ, Cooper SJ, Deakin JFW, Ferrier IN, Johnson JA, Joseph MH, Owen F, Poulter M, Lofthouse R et al. (1984). Neurotransmitter receptors and monoamine metabolites in the brains of patients with Alzheimer-type dementia and depression, and suicides. Neuropharmacology 23, 1561-1569.
29. Dhaenen H (2001). Imaging the serotonergic system in depression. European Archives of Psychiatry and Clinical Neuroscience 251 (Suppl. 2), II76-II80.
30. Dwivedi Y, Rizavi HS, Conley RR, Roberts RC, Tamminga CA, Pandey GN (2002). mRNA and protein expression of selective alpha subunits of G proteins are abnormal in prefrontal cortex of suicide victims. Neuropsychopharmacology 27, 499-517.
31. Dwivedi Y, Rizavi HS, Shukla PK, Lyons J, Faludi G, Palkovits M, Sarosi A, Conley RR, Roberts RC, Tamminga CA, Pandey GN (2004). Protein kinase A in postmortem brain of depressed suicide victims: altered expression of specific regulatory and catalytic subunits. Biological Psychiatry 55, 234-243.
32. Engstrom G, Alling C, Blennow K, Regnell G, Traskman-Bendz L (1999). Reduced cerebrospinal HVA concentrations and HVA/5-HIAA ratios in suicide attempters. Monoamine metabolites in 120 suicide attempters and 47 controls. European Neuropsychopharmacology 9, 399-405.
33. Hamilton M (1960). A rating scale for depression. Journal of Neurology, Neurosurgery and Psychiatry 23, 56-62.
34. Higley JD, Thompson WW, Champoux M, Goldman D, Hasert MF, Kraemer GW, Scanlan JM, Suomi SJ, Linnoila M (1993). Paternal and maternal genetic and environmental contributions to cerebrospinal fluid monoamine metabolites in Rhesus monkeys (Macaca mulatta). Archives of General Psychiatry 50, 615-623.
35. 2A receptors unchanged by antidepressant treatment. Psychiatry Research 66, 73-85.
36. Hsiung S-C, Adlersberg M, Arango V, Mann JJ, Tamir H, Liu K-P (2003). Attenuated 5-HT1A receptor signaling in brains of suicide victims: involvement of adenylyl cyclase, phosphatidylinositol 3-kinase, Akt and mitogen-activated protein kinase. Journal of Neurochemistry 87, 182-194.
37. Karege F, Bovier P, Rudolph W, Gaillard JM (1996). Platelet phosphoinositide signaling system: an overstimulated pathway in depression. Biological Psychiatry 39, 697-702.
38. Khait VD, Huang YY, Malone KM, Oquendo MA, Brodsky B, Sher L, Mann JJ (2002). Is there circannual variation of human platelet 5-HT(2A) binding in depression? Journal of Affective Disorders 71, 249-258.
39. Laruelle M, Abi-Dargham A, Casanova MF, Toti R, Weinberger DR, Kleinman JE (1993). Selective abnormalities of prefrontal serotonergic receptors in schizophrenia: a postmortem study. Archives of General Psychiatry 50, 810-818.
40. Lloyd KG, Farley IJ, Deck JHN, Hornykiewicz O (1974). Serotonin and 5-hydroxyindoleacetic acid in discrete areas of the brainstem of suicide victims and control patients. Advances in Biochemistry and Psychopharmacology 11, 387-397.
41. Malone KM (1994). Psychobiology of suicidal behavior in major depression (pp. 1-152). M.D. thesis, National University of Ireland.
42. Malone KM, Corbitt EM, Li S, Mann JJ (1996). Prolactin response to fenfluramine and suicide attempt lethality in major depression. British Journal of Psychiatry 168, 324-329.
43. Mann JJ, Arango V (1992). Integration of neurobiology and psychopathology in a unified model of suicidal behavior. Journal of Clinical Psychopharmacology 12 (2 Suppl.), 2S-7S.
44. Mann JJ, Huang YY, Underwood MD, Kassir SA, Oppenheim S, Kelly TM, Dwork AJ, Arango V (2000). A serotonin transporter gene promoter polymorphism (5-HTTLPR) and prefrontal cortical binding in major depression and suicide. Archives of General Psychiatry 57, 729-738.
45. Mann JJ, Malone KM (1997). Cerebrospinal fluid amines and higher-lethality suicide attempts in depressed inpatients. Biological Psychiatry 41, 162-171.
46. Mann JJ, Malone KM, Sweeney JA, Brown RP, Linnoila M, Stanley B, Stanley M (1996a). Attempted suicide characteristics and cerebrospinal fluid amine metabolites in depressed inpatients. Neuropsychopharmacology 15, 576-586.
47. Mann JJ, McBride PA, Brown RP, Linnoila M, Leon AC, DeMeo MD, Mieczkowski TA, Myers JE, Stanley M (1992). Relationship between central and peripheral serotonin indexes in depressed and suicidal psychiatric inpatients. Archives of General Psychiatry 49, 442-446.
48. Mann JJ, Petito C, Stanley M, McBride PA, Chin J, Philogene A (1985). Amine receptor binding and monoamine oxidase activity in postmortem human brain tissue: effect of age, gender and postmortem delay. In: Burrows GD, Norman TR, Dennerstein L (Eds.), Clinical and Pharmacological Studies in Psychiatric Disorders (pp. 37-39). London: John Libbey & Co. Ltd.
49. 2 and β-adrenergic receptor binding in the frontal cortices of suicide victims. Archives of General Psychiatry 43, 954-959.
50. Mann JJ, Underwood MD, Arango V (1996b). Postmortem studies of suicide victims. In: Watson SJ (Ed.), Biology of Schizophrenia and Affective Disease (pp. 197-220). Washington, DC: American Psychiatric Press, Inc.
51. 2 receptor indices to major depressive disorder, personality traits, and suicidal behavior. Biological Psychiatry 35, 295-308.
52. McBride PA, Mann JJ, McEwen B, Biegon A (1983). Characterization of serotonin binding sites on human platelets. Life Sciences 33, 2033-2041.
53. McBride PA, Tierney H, DeMeo M, Chen J-S, Mann JJ (1990). Effects of age and gender on CNS serotonergic responsivity in normal adults. Biological Psychiatry 27, 1143-1455.
54. Mieczkowski TA, Sweeney JA, Haas GL, Mann JJ, Brown RP, Junker B (1993). Factor composition of the suicide intent scale. Suicide and Life-Threatening Behavior 23, 37-45.
55. Mori H, Koyama T, Yamashita I (1991). Platelet alpha-2 adrenergic receptor-mediated phosphoinositide responses in endogenous depression. Life Sciences 48, 741-748.
56. Mori H, Mikuni M, Koyama T, Yamashita I (1989). Epinephrine stimulates inositol phospholipid metabolism by activating alpha-2 adrenergic receptors in human platelets. Life Sciences 44, 741-747.
57. Oquendo MA, Placidi GP, Malone KM, Campbell C, Keilp J, Brodsky B, Kegeles LS, Cooper TB, Parsey RV, Van Heertum RL, Mann JJ (2003). Positron emission tomography of regional brain metabolic responses to a serotonergic challenge and lethality of suicide attempts in major depression. Archives of General Psychiatry 60, 14-22.
58. Ostroff RB, Giller E, Harkness L, Mason J (1985). The norepinephrine-to-epinephrine ratio in patients with a history of suicide attempts. American Journal of Psychiatry 142, 224-227.
59. 2 receptors and suicide. Lancet ii, 1256.
60. Oxenstierna G, Edman G, Iselius L, Oreland L, Ross SB, Sedvall G (1986). Concentrations of monoamine metabolites in the cerebrospinal fluid of twins and unrelated individuals. A genetic study. Journal of Psychiatric Research 20, 19-29.
61. Pandey GN, Dwivedi Y, Pandey SC, Teas SS, Conley RR, Roberts RC, Tamminga CA (1999). Low phosphoinositide-specific phospholipase C activity and expression of phospholipase C beta1 protein in the prefrontal cortex of teenage suicide subjects. American Journal of Psychiatry 156, 1895-1901.
62. Pandey GN, Dwivedi Y, Rizavi HS, Ren X, Conley RR (2004). Decreased catalytic activity and expression of protein kinase C isozymes in teenage suicide victims: a postmortem brain study. Archives of General Psychiatry 61, 685-693.
63. Pandey GN, Dwivedi Y, Rizavi HS, Ren X, Pandey SC, Pesold C, Roberts RC, Conley RR, Tamminga CA (2002). Higher expression of serotonin 5-HT(2A) receptors in the postmortem brains of teenage suicide victims. American Journal of Psychiatry 159, 419-429.
64. Pandey GN, Pandey SC, Dwivedi Y, Sharma RP, Janicak PG, Davis JM (1995). Platelet serotonin-2A receptors: a potential biological marker for suicidal behavior. American Journal of Psychiatry 152, 850-855.
65. Pandey GN, Pandey SC, Janicak PG, Marks RC, Davis JM (1990). Platelet serotonin-2 receptor binding sites in depression and suicide. Biological Psychiatry 28, 215-222.
66. Pare CMB, Yeung DPH, Price K, Stacey RS (1969). 5-Hydroxytryptamine, noradrenaline, and dopamine in brainstem, hypothalamus, and caudate nucleus of controls and of patients committing suicide by coal-gas poisoning. Lancet ii, 133-135.
67. Pine DS, Trautman PD, Shaffer D, Cohen L, Davies M, Stanley M, Parsons B (1995). Seasonal rhythm of platelet [3H]imipramine binding in adolescents who attempted suicide. American Journal of Psychiatry 152, 923-925.
68. 2A receptor and low blood serotonin in suicidal psychiatric patients. Neuropsychobiology 38, 84-89.
69. 2-adrenergic receptor populations on phosphoinositide hydrolysis. Life Sciences 50, 169-180.
70. 125I]-DOI. European Psychiatry 14, 451-457.
71. Shaw DM, Camps FE, Eccleston EG (1967). 5-Hydroxytryptamine in the hind-brain of depressive suicides. British Journal of Psychiatry 113, 1407-1411.
72. Spitzer RL, Williams JBW, Gibbon M, First MB (1989). Instruction Manual for the Structured Clinical Interview for DSM-III-R (SCID, 5/1/89 Revision). New York: Biometrics Research Department, New York State Psychiatric Institute.
73. Stahl SM (1977). The human platelet. Diagnostic and research tool for the study of biogenic amines in psychiatric and neurologic disorders. Archives of General Psychiatry 34, 509-516.
74. Stanley M, Mann JJ (1983). Increased serotonin-2 binding sites in frontal cortex of suicide victims. Lancet i, 214-216.
75. Stanley M, Virgilio J, Gershon S (1982). Tritiated imipramine binding sites are decreased in the frontal cortex of suicides. Science 216, 1337-1339.
76. Stoff DM, Goldman W, Bridger WH, Jain AK, Pylypiw A (1990). No correlation between platelet imipramine binding and CSF 5HIAA in neurosurgical patients. Psychiatry Research 33, 323-326.
77. Träskman L, Åsberg M, Bertilsson L, Sjöstrand L (1981). Monoamine metabolites in CSF and suicidal behavior. Archives of General Psychiatry 38, 631-636.
78. Tuomisto J, Tukiainen E, Ahlfors UG (1979). Decreased uptake of 5-hydroxytryptamine in blood platelets from patients with endogenous depression. Psychopharmacology (Berlin) 65, 141-147.
79. Uchitomi Y, Kugaya A, Akechi T, Nakano T, Inagaki M, Matsuoka Y, Kagaya A, Yamawaki S (2002). Lack of association between suicidal ideation and enhanced platelet 5-HT2A receptor-mediated calcium mobilization in cancer patients with depression. Biological Psychiatry 52, 1159-1165.
80. van Heeringen C, Audenaert K, Van Laere K, Dumont F, Slegers G, Mertens J, Dierckx RA (2003). Prefrontal 5-HT2a receptor binding index, hopelessness and personality characteristics in attempted suicide. Journal of Affective Disorders 74, 149-158.
81. Yatham LN, Steiner M, Liddle PF, Shiah IS, Lam RW, Zis AP, Coote M (2000). A PET study of brain 5-HT2 receptors and their correlation with platelet 5-HT2 receptors in healthy humans. Psychopharmacology (Berlin) 151, 424-427.