Association of apolipoprotein A ε2 with white matter disease but not with microbleeds

Stroke

Volumn 38, Issue 4, 2007, Pages 1185-1188

  Lemmens, Robin ^a   Görner, Astrid ^a   Schrooten, Maarten ^a   Thijs, Vincent ^a  

^a UNIVERSITY HOSPITALS LEUVEN   (Belgium)

Author keywords

Apolipoprotein E; Genetics; White matter

Indexed keywords

APOLIPOPROTEIN E; APOLIPOPROTEIN E EPSILON 2; APOLIPOPROTEIN E EPSILON 4; APOLIPOPROTEIN E2; APOLIPOPROTEIN E4; CHOLESTEROL;

AGED; ALLELE; ARTICLE; BRAIN DISEASE; BRAIN HEMORRHAGE; CEREBROVASCULAR ACCIDENT; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; RATING SCALE; TRANSIENT ISCHEMIC ATTACK; VASCULAR AMYLOIDOSIS; WHITE MATTER; BELGIUM; BLOOD; BRAIN; BRAIN ARTERY; COHORT ANALYSIS; GENE FREQUENCY; GENETIC MARKER; GENETIC PREDISPOSITION; GENETIC SCREENING; GENETICS; HETEROZYGOTE; METABOLISM; MIDDLE AGED; MULTIINFARCT DEMENTIA; MYELINATED NERVE; NUCLEOTIDE SEQUENCE; PATHOLOGY; PATHOPHYSIOLOGY; PROSPECTIVE STUDY; RISK FACTOR;

AGED; APOLIPOPROTEIN E2; APOLIPOPROTEIN E4; BELGIUM; BRAIN; CEREBRAL ARTERIES; CEREBRAL HEMORRHAGE; CHOLESTEROL; COHORT STUDIES; DEMENTIA, VASCULAR; DNA MUTATIONAL ANALYSIS; FEMALE; GENE FREQUENCY; GENETIC MARKERS; GENETIC PREDISPOSITION TO DISEASE; GENETIC SCREENING; GENOTYPE; HETEROZYGOTE; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; NERVE FIBERS, MYELINATED; PROSPECTIVE STUDIES; RISK FACTORS;

EID: 34247882890     PISSN: 00392499     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.STR.0000259816.31370.44     Document Type: Article

References (23)

1. Greenberg SM, Briggs ME, Hyman BT, Kokoris GJ, Takis C, Kanter DS, Kase CS, Pessin MS. Apolipoprotein e epsilon 4 is associated with the presence and earlier onset of hemorrhage in cerebral amyloid angiopathy. Stroke. 1996;27:1333-1337.
2. Greenberg SM, Vonsattel JP, Segal AZ, Chiu RI, Clatworthy AE, Liao A, Hyman BT, Rebeck GW. Association of apolipoprotein e epsilon2 and vasculopathy in cerebral amyloid angiopathy. Neurology. 1998;50:961-965.
3. Roob G, Schmidt R, Kapeller P, Lechner A, Hartung HP, Fazekas F. MRI evidence of past cerebral microbleeds in a healthy elderly population. Neurology. 1999;52:991-994.
4. Koennecke HC. Cerebral microbleeds on MRI: Prevalence, associations, and potential clinical implications. Neurology. 2006;66:165-171.
5. Fazekas F, Kleinert R, Roob G, Kleinert G, Kapeller P, Schmidt R, Hartung HP. Histopathologic analysis of foci of signal loss on gradient-echo T2*-weighted MR images in patients with spontaneous intracerebral hemorrhage: evidence of microangiopathy-related microbleeds. AJNR Am J Neuroradiol. 1999;20:637-642.
6. Lee SH, Bae HJ, Yoon BW, Kim H, Kim DE, Roh JK. Low concentration of serum total cholesterol is associated with multifocal signal loss lesions on gradient-echo magnetic resonance imaging: analysis of risk factors for multifocal signal loss lesions. Stroke. 2002;33:2845-2849.
7. Yano K, Reed D, MacLean C. Serum cholesterol and hemorrhagic stroke in the Honolulu heart program. Stroke. 1989;20:1460-1465.
8. Sing CF, Davignon J. Role of the apolipoprotein E polymorphism in determining normal plasma lipid and lipoprotein variation. Am J Hum Genet. 1985;37:268-285.
9. Fan YH, Zhang L, Lam WW, Mok VC, Wong KS. Cerebral microbleeds as a risk factor for subsequent intracerebral hemorrhages among patients with acute ischemic stroke. Stroke. 2003;34:2459-2462.
10. Werring DJ, Frazer DW, Coward LJ, Losseff NA, Watt H, Cipolotti L, Brown MM, Jager HR. Cognitive dysfunction in patients with cerebral microbleeds on T2*-weighted gradient-echo MRI. Brain. 2004;127:2265-2275.
11. Fazekas F, Chawluk JB, Alavi A, Hurtig HI, Zimmerman RA. MR signal abnormalities at 1.5 T in Alzheimer's dementia and normal aging. AJR Am J Roentgenol. 1987;149:351-356.
12. Raymond M, Rousset F. Genepop (version-1.2) - population-genetics software for exact tests and ecumenicism. J Heredity. 1995;86:248-249.
13. Schmidt R, Schmidt H, Fazekas F, Schumacher M, Niederkorn K, Kapeller P, Weinrauch V, Kostner GM. Apolipoprotein E polymorphism and silent microangiopathy-related cerebral damage. Results of the Austrian Stroke Prevention study. Stroke. 1997;28:951-956.
14. Kokubo Y, Chowdhury AH, Date C, Yokoyama T, Sobue H, Tanaka H. Age-dependent association of apolipoprotein E genotypes with stroke subtypes in a Japanese rural population. Stroke. 2000;31:1299-1306.
15. Sudlow C, Martinez Gonzalez NA, Kim J, Clark C. Does apolipoprotein E genotype influence the risk of ischemic stroke, intracerebral hemorrhage, or subarachnoid hemorrhage? Systematic review and meta-analyses of 31 studies among 5961 cases and 17,965 controls. Stroke. 2006;37:364-370.
16. Jeerakathil T, Wolf PA, Beiser A, Hald JK, Au R, Kase CS, Massaro JM, DeCarli C. Cerebral microbleeds: prevalence and associations with cardiovascular risk factors in the Framingham study. Stroke. 2004;35:1831-1835.
17. Kim M, Bae HJ, Lee J, Kang L, Lee S, Kim S, Lee JE, Lee KM, Yoon BW, Kwon O, Koo JS, Kim BK. ApoE epsilon2/epsilon4 polymorphism and cerebral microbleeds on gradient-echo MRI. Neurology. 2005;65:1474-1475.
18. Seifert T, Lechner A, Flooh E, Schmidt H, Schmidt R, Fazekas F. Lack of association of lobar intracerebral hemorrhage with apolipoprotein E genotype in an unselected population. Cerebrovasc Dis. 2006;21:266-270.
19. McCarron MO, Nicoll JA, Stewart J, Ironside JW, Mann DM, Love S, Graham DI, Dewar D. The apolipoprotein E epsilon2 allele and the pathological features in cerebral amyloid angiopathy-related hemorrhage. J Neuropathol Exp Neurol. 1999;58:711-718.
20. de Leeuw FE, Richard F, de Groot JC, van Duijn CM, Hofman A, Van Gijn J, Breteler MM. Interaction between hypertension, apoE, and cerebral white matter lesions. Stroke. 2004;35:1057-1060.
21. DeCarli C, Reed T, Miller BL, Wolf PA, Swan GE, Carmelli D. Impact of apolipoprotein E epsilon4 and vascular disease on brain morphology in men from the NHLBI Twin Study. Stroke. 1999;30:1548-1553.
22. Persson J, Lind J, Larsson A, Ingvar M, Cruts M, Van Broeckhoven C, Adolfsson R, Nilsson LG, Nyberg L. Altered brain white matter integrity in healthy carriers of the apoE epsilon4 allele: a risk for AD. Neurology. 2006;66:1029-1033.
23. DeStefano AL, Atwood LD, Massaro JM, Heard-Costa N, Beiser A, Au R, Wolf PA, DeCarli C. Genome-wide scan for white matter hyperintensity: The Framingham heart study. Stroke. 2006;37:77-81.