4′-Acetamidochalcone derivatives as potential antinociceptive agents

Molecules

Volumn 12, Issue 4, 2007, Pages 896-906

  De Campos Buzzi, Fátima ^a,b   Padaratz, Pâmela ^a   Meira, Aleandra Vergilina ^a   Corrêa, Rogério ^a   Nunes, Ricardo José ^b   Cechinel Filho, Valdir ^a  

^a UNIVERSIDADE DO VALE DO ITAJAÍ   (Brazil)

^b FEDERAL UNIVERSITY OF SANTA CATARINA   (Brazil)

Author keywords

Acetamidochalcones; Antinociception; Mice

Indexed keywords

4' ACETAMIDOCHALCONE; 4'-ACETAMIDOCHALCONE; ACETAMIDE DERIVATIVE; ACETYLSALICYLIC ACID; ANALGESIC AGENT; CHALCONE; CHALCONE DERIVATIVE; DRUG DERIVATIVE; FORMALDEHYDE; PARACETAMOL; UNCLASSIFIED DRUG;

ANIMAL; ARTICLE; CHEMICAL MODEL; CHEMISTRY; DRUG DESIGN; DRUG SCREENING; INFLAMMATION; INFUSION; METHODOLOGY; MOUSE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; THIN LAYER CHROMATOGRAPHY;

ACETAMIDES; ACETAMINOPHEN; ANALGESICS; ANIMALS; ASPIRIN; CHALCONE; CHALCONES; CHROMATOGRAPHY, THIN LAYER; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; FORMALDEHYDE; INFLAMMATION; INFUSIONS, PARENTERAL; MAGNETIC RESONANCE SPECTROSCOPY; MICE; MODELS, CHEMICAL;

EID: 34247873076     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/12040896     Document Type: Article

References (20)

1. Ni, L.; Meng, Q. M.; Siroski, J. A. Recent advances in therapeutic chalcones. Expert Opin. Ther. Pat. 2004, 14, 1669 - 1691.
2. Ahmad, S.; Israf., D. A.; Hj. Lajis, N.; Shaari, K.; Mohamed, H.; Wahab, A. A.; Ariffin, K. T.; Hoo, W. Y.; Aziz, N. A.; Kadir, A. A.; Sulaiman, M. R.; Somchit, M. N.. Cardamonin, inhibits pro-inflammatory mediators in activated RAW 264.7 cells and whole blood. Eur. J. Pharmacol. 2006, 538, 188 - 194.
3. Suzuki, K.; Seung, B. H.; Sung, L. S.; Sanghyun, L.; Hoon, J S; Sil, L. Y.; Hyun, S. K.; Ohuchi, K. Synthesis and biological evaluation of new biphenyl ether thiazine derivatives. Ensho Saisei 2005, 25, 130 - 136.
4. Nowakowska, Z. A review of anti-infective and anti-inflammatory chalcones. Eur. J. Med. Chem. 2007, 42, 125 - 137.
5. Corrêa, R.; Pereira, M. A. S.; Buffon, D.; Santos, L.; Cechinel-Filho, V.; Santos, A. R. S.; Nunes, R. J. Antinociceptive properties of chalcones. Structure-activity relationships. Arch. Pharm. 2001, 334, 167 - 172.
6. Campos-Buzzi, F.; Campos, J. P. de; Tonini, P. P.; Corrêa, R.; Yunes; R. A., Boeck, P.; Cechinel-Filho, V. Antinociceptive effects of synthetic chalcones obtained from xanthoxyline. Arch. Pharm. 2006, 339, 361 - 365.
7. Ram, V. J.; Saxena, A. S.; Srivastava, S.; Chandra, S. Bioorg. Oxygenated chalcones and bischalcones as potential antimalarial agents. Med. Chem. Lett. 2000, 10, 2159 - 2161.
8. Hunskaar, S.; Fasmer, O. B.; Hole, K. Formalin test in mice, a useful technique for evaluating mild analgesics. J. Neurosci. Methods 1985, 14, 69 - 76.
9. Shibata, M.; Ohkubo, T.; Takahaschi, H.; Inoki, R. Modified formalin test: characteristic biphasic pain response. Pain 1989, 38, 347 - 352.
10. Abbott, F.V.; Franklin, K.B.J. Noncompetitive antagonism of morphine analgesia by diazepam in the formalin test. Pharmacol. Biochem. Behav. 1986, 24, 319 - 321.
11. Rosesnkranz, H. S.; Mermelstein, R. Mutagenicity and genotoxicity of nitroarenes. All nitro-containing chemicals were not created equal. Mutat. Res. 1983, 114, 217 - 267.
12. Chung, K. T.; Murdock, C. A.; Zhou, Y.; Stevens, S. E. Jr.; Li, Y. S.; Wei, C. I.; Fernando, S. Y. Chou, M. W. Effects of the nitro-group on the mutagenicity and toxicity of some benzamines. Environ. Mol. Mutagen. 1996, 27, 67 - 74.
13. Michaux, C.; Charlier, C.; Julémont, F.; de Leval, X.; Dogné, J. M.; Pirotte, B.; Durant. F. A new potential cyclooxygenase-2 inhibitor, pyridinic analogue of nimesulide. Eur. J. Med. Chem. 2005, 40, 1316 - 1324.
14. Satyanarayana, M.; Tiwari, P.; Tripathi, B. K.; Srivastava, A. K.; Pratap, R. Synthesis and antihyperglycemic activity of chalcone based aryloxypropanolamines. Bioorg. Med. Chem. 2004, 12, 883 - 889.
15. Zimmerman, M. Ethical guidelines for investigations of experimental pain in conscious animals. Pain 1983, 16, 109 - 110.
16. Collier, H. D. J.; Dinnin, L. C.; Johnson, C. A.; Schneider, C. The abdominal constriction response and its suppression by analgesic drugs in the mouse. Br. J. Pharmacol. 1968, 32, 295 - 310.
17. Campos-Buzzi, F.; Corrêa, R.; De Souza, M. M.; Yunes, R. A.; Nunes, R. J.; Cechinel-Filho, V. Studies on new cyclic imides obtained from aminophenazone with analgesic properties. Drug Res. 2002, 52, 455 - 461.
18. Hunskaar, A. T.; Hole, K. The formalin test in mice: dissociation between inflammatory and non-inflammatory pain. Pain 1987, 30, 103 - 104.
19. Sakurada, T.; Katsumata, K.; Tan-No, K.; Sakurada, S.; Kisara, K. The capsaicin test in mice for evaluating tachykinin antagonist in the spinal cord. Neuropharmacol. 1992, 31, 1279 - 1285.
20. Eddy, N. B.; Leimback, D. Synthetic analgesic. II. Dithienylbutenyl and dithienylbutylamines. J. Pharmacol. Exp. Ther. 1953, 107, 385 - 393.