A new potential cyclooxygenase-2 inhibitor, pyridinic analogue of nimesulide

European Journal of Medicinal Chemistry

Volumn 40, Issue 12, 2005, Pages 1316-1324

  Michaux, Catherine ^a   Charlier, Caroline ^a   Julémont, Fabien ^b   De Leval, Xavier ^b   Dogné, Jean Michel ^b   Pirotte, Bernard ^b   Durant, François ^a  

^a UNIVERSITY OF NAMUR   (Belgium)

^b UNIVERSITY OF LIÈGE   (Belgium)

Author keywords

COX 2 selective inhibitor; Interactions model; Molecular modeling studies; Pyridinic compounds

Indexed keywords

CYCLOOXYGENASE 1; CYCLOOXYGENASE 2 INHIBITOR; DRUG ANALOG; NIMESULIDE; PYRIDINE DERIVATIVE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG ACTIVITY; DRUG SELECTIVITY; DRUG STRUCTURE; ENZYME INHIBITION; MOLECULAR MODEL; NONHUMAN; STRUCTURE ACTIVITY RELATION;

CRYSTALLOGRAPHY, X-RAY; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PYRIDINES; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

EID: 27744496853     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2005.08.003     Document Type: Article

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