Conformal high dose external radiation therapy, 80.5 Gy, alone for medically inoperable non-small cell lung cancer: A retrospective analysis

Journal of Thoracic Oncology

Volumn 1, Issue 2, 2006, Pages 112-119

  Urbanic, James J ^a   Turrisi III, Andrew T ^b   Sharma, Anand K ^c   Silvestri, Gerard A ^c   Williams, Todd E ^e   Vanek, Kenneth N ^c   Sherman, Carol A ^d  

^a WAKE FOREST BAPTIST HEALTH   (United States)

^b WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^d MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^e Carolina Regional Cancer Center   (United States)

Author keywords

Carcinoma; Dose response relationship; Lung neoplasms; Non small cell lung cancer; Radiation; Radiation oncology; Radiotherapy; Retrospective studies

Indexed keywords

ADULT; AGED; ARTICLE; CANCER GROWTH; CANCER RECURRENCE; CANCER SIZE; CANCER STAGING; CANCER SURGERY; CANCER SURVIVAL; CLINICAL ARTICLE; COMORBIDITY; COMPUTER ASSISTED RADIOTHERAPY; CONFIDENCE INTERVAL; DEATH; DISEASE FREE INTERVAL; EXTERNAL BEAM RADIOTHERAPY; FEMALE; FOLLOW UP; FORCED EXPIRATORY VOLUME; HIGH RISK POPULATION; HUMAN; LOBECTOMY; LUNG FUNCTION; LUNG NON SMALL CELL CANCER; LYMPH NODE; MALE; MORTALITY; ONCOLOGY; PRIORITY JOURNAL; RADIATION DOSE; RADIATION DOSE FRACTIONATION; RETROSPECTIVE STUDY; TIME SERIES ANALYSIS; TREATMENT DURATION; TREATMENT FAILURE; BIOPSY; DISEASE COURSE; LUNG TUMOR; METHODOLOGY; MIDDLE AGED; PATHOLOGY; RADIATION RESPONSE; SURVIVAL RATE; TREATMENT OUTCOME; UNITED STATES;

AGED; AGED, 80 AND OVER; BIOPSY; CARCINOMA, NON-SMALL-CELL LUNG; DISEASE PROGRESSION; DOSE-RESPONSE RELATIONSHIP, RADIATION; FEMALE; FOLLOW-UP STUDIES; HUMANS; LUNG NEOPLASMS; MALE; MIDDLE AGED; NEOPLASM STAGING; RADIOTHERAPY, CONFORMAL; RETROSPECTIVE STUDIES; SOUTH CAROLINA; SURVIVAL RATE; TREATMENT OUTCOME;

EID: 34247867962     PISSN: 15560864     EISSN: 15561380     Source Type: Journal    
DOI: 10.1097/01243894-200602000-00003     Document Type: Article

References (24)

1. Pairolero P, Williams D, Bergstralh E, et al. Postsurgical stage I bronchogenic carcinoma: Morbid implications of recurrent disease. Ann Thorac Surg 1984;38:331-338.
2. Thomas P, Rubinstein L. Cancer recurrence after resection: T1 N0 non-small cell lung cancer. Lung Cancer Study Group. Ann Thorac Surg 1990;49:242-246.
3. Zhang H, Yin W, Yang Z. Curative radiotherapy of early operable non-small -cell lung cancer. Radiother Oncol 1989;14:89-94.
4. Talton B, Constable W, Kersh C. Curative radiotherapy in non-small cell carcinoma of the lung. Int J Radiat Oncol Biol Phys 1990;19:15-21.
5. Sandler H, Curran W, Turrisi A. The influence of tumor size and pre-treatment staging on outcome following radiation therapy alone for Stage I non-small cell lung cancer. Int J Radiat Oncol Biol Phys. 1991;19:9-13.
6. Morita K, Fuwa N, Suzuli Y, et al. Radical radiotherapy for medically inoperable nonsmall cell lung cancer in clinical stage I: A retrospective analysis of 149 patients. Radiother Oncol 1997;42:31-36.
7. Sibley G, Jamieson T, Marks L, et al. Radiotherapy alone for medically inoperable stage I non-small-cell lung cancer: The Duke experience. Int J Radiat Oncol Biol Phys 1998;40:149-154.
8. Sibley GS. Radiotherapy for patients with medically inoperable stage I nonsmall cell lung carcinoma: Smaller volumes and higher doses - A review. Cancer 1998;82:433-438.
9. Ghosh S, Sujendran V, Alexiou C, et al. Long term results of surgery versus continuous hyperfractionated accelerated radiotherapy (CHART) in patients >70 years with stage I non-small cell lung cancer. Eur J Cardio-Thoracic Surg 2003;24:1002-1007.
10. McGarry RC, Papiez L, Williams M, et al. Stereotactic body radiation therapy of early-stage non-small-cell lung carcinoma: Phase I study. Int J Radiat Oncol Biol Phys 2006;63:1010-1015.
11. Timmerman R, McGarry R, Papiez L, et al. Initial report of a prospective phase II trial of stereotactic body radiation therapy for patients with medically inoperable stage I non-small cell lung cancer (Abstract). Int J Radiat Oncol Biol Phys 2006;63:S99.
12. Hayman JA, Martel MK, Ten Haken RK, et al. Dose escalation in non-small-cell lung cancer using three-dimensional conformal radiation therapy: Update of a phase I trial. J Clin Oncol 2001;19:127-136.
13. Kaplan EL, Meier P. Nonparametric estimation from incomplete observations. J Am Stat Assoc 1958;53:457-481.
14. McGarry RC, Song G, des Rosiers P, Timmerman R. Observation-only management of early stage, medically inoperable lung cancer: Poor outcome. Chest 2002;121:1155-1158.
15. Dosoretz D, Katin M, Blitzer P, et al. Radiation therapy in the management of medically inoperable carcinoma of the lung: results and implications for future treatment strategies. Int J Radiat Oncol Biol Phys 1992;24:3-9.
16. Bradley JD, Wahab S, Lockett MA, et al. Elective nodal failures are uncommon in medically inoperable patients with stage I non-small lung carcinoma treated with limited radiotherapy fields. Int J Radiat Oncol Biol Phys 2003;56:342-347.
17. Krol ADG, Aussems P, Noorduk EM, et al. Local irradiation alone for peripheral stage I lung cancer: Could we omit the elective nodal irradiation? Int J Radiat Oncol Biol Phys 1996;34:297-302.
18. Nagata Y, Negoro Y, Aoki T, et al. Clinical outcomes of 3D conformal hypofractionated single high-dose radiotherapy for one or two lung tumors using a stereotactic body frame. Int J Radiat Oncol Biol Phys 2002;52:1041-1046.
19. Onimaru R, Shirato H, Shimizu S, et al. Tolerance of organs at risk in small-volume, hypofractionated, image-guided radiotherapy for primary and metastatic lung cancers. Int J Radiat Oncol Biol Phys 2003;56:126-135.
20. Hall EJ. Radiobiology for the radiologist, 5th Ed. Philadelphia: Lippincott, 2000. Pp. 314-336.
21. Bradley JD, Graham MV, Winter KW, et al. Toxicity and outcome results of RTOG 93-11: A phase I-II dose escalation study using three-dimensional conformal radiotherapy in patients with inoperable non-small cell lung carcinoma. Int J Radiat Oncol Biol Phys 2006;61:318-328.
22. Hayman JA, Martel MK, Ten Haken RK, et al. Dose escalation in non-small-cell lung cancer using three-dimensional conformal radiation therapy: Update of a phase I trial. J Clin Oncol 2001;19:127-136.
23. Jeremic B, Classen J, Bamberg M. Radiotherapy alone in technically operable, medically inoperable, early-stage (I/II) non-small-cell lung cancer. Int J Radiat Oncol Biol Phys 2002;54:119-130.
24. Simon C, Dupuy D, Mayo-Smith W. Microwave ablation: principles and applications. Radiographics. 2005;25:S69-S83.