Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 1

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 11, 2007, Pages 3023-3027

  Ho, Ginny D ^a   Bercovici, Ana ^a   Tulshian, Deen ^a   Greenlee, William J ^a   Fawzi, Ahmad ^a   Smith Torhan, April ^a   Zhang, Hongtao ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

G protein coupled receptor; Nociceptin receptor (NOP); Nociceptin orphin FQ; Opioid receptor like 1 (ORL 1); Opioid receptors (MOP, KOP, DOP)

Indexed keywords

4 HYDROXY 4 PHENYLPIPERIDINE DERIVATIVE; NOCICEPTIN; PIPERIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; DRUG ACTIVITY; DRUG POTENCY; DRUG SYNTHESIS; STRUCTURE ACTIVITY RELATION;

ANIMALS; CHO CELLS; CRICETINAE; CRICETULUS; HUMANS; LIGANDS; MOLECULAR STRUCTURE; PIPERIDINES; RECEPTORS, OPIOID; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 34247866496     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.03.061     Document Type: Article

References (16)

1. Mollereau C., Parmentier M., Mailleux P., Butour J., Moisand C., Chalon P., Caput D., Vassart G., and Meunier J.-C. FEBS Lett. 341 (1994) 33
2. Fukada K., Kato S., Mori K., Nishi M., Takeshima H., Iwabe N., Miyata T., Houtani T., and Sugomoto T. FEBS Lett. 343 (1994) 42
3. Chen Y., Fan Y., Liu J., Mestek A., Tian M., Kozak C.A., and Yu L. FEBS Lett. 347 (1994) 279
4. Wang J.B., Johnson P.S., Imai Y., Persico A.M., Ozenberger B.A., Eppler C.M., and Uhl G.R. FEBS Lett. 348 (1994) 75
5. Meunier J.-C., Mollereau C., Toll L., Suaudeau C., Moisand C., Alvinerie P., Butour J.-L., Guillemot J.-C., Ferrara P., Monsarrat B., Mazarguil H., Vassart G., Parmentier M., and Costentin J. Nature 377 (1995) 532
6. Reinscheid R.K., Nothacker H.P., Bourson A., Ardati A., Henningsen R.A., Bunzow J.R., Grandy D.K., Langen H., Monsma Jr. F.J., and Civelli O. Science 270 (1995) 792
7. Mcleod R.L., Parra L.E., Mutter J.C., Erickson C.H., Carey G.J., Tulshian D.B., Fawzi A.B., Smith-Torhan A., Egan R.W., Cuss F.M., and Hey J. Br. J. Pharmacol. 132 6 (2001) 1175
8. Mcleod R.L., Bolster D.C., Jia Y., Parra L.E., Mutter J.C., Wang X., Tulshian D.B., Egan R.W., and Hey J.A. Pulm. Pharmacol. Therap. 15 (2002) 213
9. Meunier J.-C. Exp. Opin. Ther. Patents 10 (2000) 371 and references cited therein
10. Bignan G.C., Connolly P.J., and Middleton S.A. Exp. Opin. Ther. Patents 15 4 (2005) 357 and references cited therein
11. Calo G., Guerrini R., Rizzi A., Salvadori S., and Regoli D. Br. J. Pharmacol. 129 (2000) 1261 and references cited therein
12. Allen C.N., Jiang Z.-G., Teshima K., Darland T., Ikeda M., Nelson C.S., Quigley D.I., Yoshioka T., Allen R.G., Rea M.A., and Grandy D.K. J. Neurosci. 19 6 (1999) 2152
13. Teshima, K.; Minoguchi, M. World Patent 2003082333, 2003; Chem. Abstr. 2003, 139, 302062.
14. Zaveri N., Jiang F., Olsen C., Polgar W., and Toll L. AAPS J. 7 (2005) E345 and references cited therein
15. Chen Z., Goehring R.R., Valenzano K.J., and Kyle D.J. Bioorg. Med. Chem. Lett. 14 (2004) 1347 and references cited therein
16. Fawzi A.B., Zhang H., Weig B., Hawes B., and Graziano M.P. Eur. J. Pharmacol. 336 (1997) 233