Hyperthermia-enhanced tumor accumulation and antitumor efficacy of a doxorubicin-conjugate with a novel macromolecular carrier system in mice with non-small cell lung cancer

Oncology Reports

Volumn 17, Issue 3, 2007, Pages 653-659

  Oyama, Takahiko ^a   Kawamura, Masafumi ^a   Abiko, Tomohiro ^a   Izumi, Yotaro ^a   Watanabe, Masazumi ^a   Kumazawa, Eiji ^b   Kuga, Hiroshi ^b   Shiose, Yoshinobu ^b   Kobayashi, Koichi ^a  

^a KEIO UNIVERSITY   (Japan)

^b DAIICHI SANKYO CO   (Japan)

Author keywords

Doxorubicin hydrochlorideconjugate; Drug delivery system; Hyperthermia; Macromolecular carrier; Non small cell lung cancer

Indexed keywords

ANTINEOPLASTIC AGENT; CARBOXYMETHYLDEXTRAN; DEXTRAN; DOXORUBICIN; DRUG CARRIER;

ANIMAL; ARTICLE; HYPERTHERMIC THERAPY; LUNG NON SMALL CELL CANCER; LUNG TUMOR; MOUSE; NUDE MOUSE; TISSUE DISTRIBUTION;

ANIMALS; ANTINEOPLASTIC AGENTS; CARCINOMA, NON-SMALL-CELL LUNG; DEXTRANS; DOXORUBICIN; DRUG CARRIERS; HYPERTHERMIA, INDUCED; LUNG NEOPLASMS; MICE; MICE, NUDE; TISSUE DISTRIBUTION;

EID: 34247853331     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.17.3.653     Document Type: Article

References (50)

1. Lowenthal RM and Eaton K: Toxicity of chemotherapy. Hematol Oncol Clin North Am 10: 967-990, 1996. (Pubitemid 26241018)
2. Matsumura Y and Maeda H: A new concept for macromolecular therapeutic in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and antitumor agent smancs. Cancer Res 46: 6387-6392, 1975.
3. Maeda H, Wu J, Sawa T, Matsumura Y and Hori K: Tumor vascular permeability and EPR effect in macromolecular theraputics: a review. J Control Release 65: 271-284, 2000. (Pubitemid 30122932)
4. Maeda H: The enhanced permeability and retention (EPR) effect in tumor vascular: the key role of tumor-selective macromolecular dug targeting. Adv Enzyme Regul 41: 189-207, 2001.
5. Dvorak H: Identification and characterization of the blood vessels of solid tumors that are leaky to circulating macromolecules. Am J Pathol 133: 95-109, 1998.
6. Jain R: Extravascular transport in normal and tumor tissue. Crit Rev Oncol Hematol 5: 115-170, 1986.
7. Inoue K: Glyco-technology and DDS. Farumashia 29: 1256-1260, 1993.
8. Nogusa H: Synthesis of carboxymethylpulluan-peptidedoxorubicin conjugates and their properties. Chem Pharm Bull 43: 1931-1938, 1995.
9. Sugawara S: Characteristics of tissue distribution of various polysaccharides as drug carriers: influences of molecular weight and anionic charge on tumor targeting. Biol Pharm Bull 24: 535-543, 2001.
10. Kumazawa E and Ochi Y: DE-310, a novel macromolecular carrier system for the camptotecin analog DX-8951f: potent antitumor activities in various murine tumor models. Cancer Sci 95: 168-175, 2004. (Pubitemid 38404319)
11. Masubuchi N: Pharmacokinetics of DE-310, a novel macromolecular carrier system for the camptothescin analog DX- 8951f, in tumor-bearing mice. Pharmazie 59: 374-377, 2004.
12. Engin K: Thermoradiotherapy in the management of superficial malignant tumors. Clin Cancer Res 1: 1139-1145, 1995.
13. Field SB: An Introduction to the Practical Aspects of Clinical Hyperthermia. Taylor and Francis: London, 1990.
14. Dewhirst M, Prosnitz L, Tharll D, et al: Hyperthermic treatment of malignant diseases: current status and a view toward the future. Semin Oncol 24: 616-625, 1997. (Pubitemid 28035878)
15. Karino T, Koga S and Maeta M: Experimental studies of the effects of local hyperthermia on blood flow, oxygen pressure and pH in tumors. Jpn J Surg 18: 276-283, 1988.
16. Song CW: Effect of local hyperthermia on blood flow and microenvironment (Review). Cancer Res 44 (suppl l): S4721-S4730, 1984.
17. Engin K: Biological rationale and clinical experience with hyperthermia. Control Clin Trials 17: 316-342, 1996.
18. Feyerabend T: Rationale and clinical status of local hyperthermia, radiation and chemotherapy in locally advanced malignancies. Anticancer Res 17: 2895-2897, 1997.
19. Issels R: Hyperthermia combined with chemotherapy: biological rationale, clinical application and treatment results. Oncology 22: 374-381, 1999.
20. Matthew CB: Hyperthermia-induced changes in the vascular permeability of rats: a model system to examine therapeutic interventions. J Thermal Biol 25: 381-386, 2000.
21. Inaba M: Evaluation of antitumor activity in a human breast tumor/nude mouse model with a special emphasis on treatment dose. Cancer 64: 1577-1582, 1989.
22. Tashiro T: Responsiveness of human lung cancer/nude mouse to antitumor agents in a model using clinically equivalent doses. Cancer Chemother Pharmacol 24: 187-192, 1989.
23. Hori K, Suzuki M, Tanda S, Saito S and Zhang QH: Functional characterization of developing tumor vascular system and drug delivery (Review). Int J Oncol 2: 289-296, 1993. (Pubitemid 23043357)
24. Ringsdorf H: Structure and properties of pharmacologically active polymers. J Polym Sci Polym Symp 20: 135-153, 1975.
25. Allen TM: Liposomal drug formulations: rationale for development and what we can expect in the future. Drugs 56: 747-756, 1998.
26. Duncan R: Drug-polymer conjugates: potential for improved chemotherapy. Anticancer Drugs 3: 175-210, 1992.
27. Jones M and Leroux J: Polymer micelles - a new generation of colloidal drug carriers. Eur J Pharm Biopharm 48: 101-111, 1999. (Pubitemid 29401986)
28. Langer R: Drug delivery and targeting. Nature 392 (suppl l): S5-S10, 1998.
29. Massing U: Cancer therapy with liposomal formations of anticancer drugs. Int J Clin Pharm Ther 35: 87-90, 1997.
30. Torchilin VP: Polymer-coated long-circulating microparticulate pharmaceuticals. J Microencapsul 15: 1-19, 1998.
31. Huang SK, Stauffer PR, Hong K, et al: Liposomes and hyperthermia in mice: increased tumor uptake and therapeutic efficacy of doxorubicin in sterically stabilized liposomes. Cancer Res 54: 2186-2191, 1994. (Pubitemid 24138693)
32. Kong G and Dewhirst MW: Hyperthermia and liposomes. Int J Hyperthermia 15: 345-370, 1999. (Pubitemid 29425711)
33. Maruyama K, Unezaki S, Takahashi N and Iwastsuru M: Enhanced delivery of doxorubicin to tumor by long-circulating thermosensitive liposomes and local hyperthermia. Biochim Biophys Acta 1149: 209-216, 1993. (Pubitemid 23197677)
34. Unezaki S, Maruyama K, Takahashi N, et al: Enhanced delivery and antitumor activity of doxorubicin using long-circulating thermosensitive liposomes containing amphipathic polyethylene glycol in combination with local hyperthermia. Pharm Res 11: 1180-1185, 1994. (Pubitemid 24259860)
35. Fujiwara K and Watanabe T: Effects of hyperthermia radiotherapy and thermoradiotherapy on tumor microvascular permeability. Acta Pathol Jpn 40: 79-84, 1990. (Pubitemid 20283071)
36. Gaber MH, Wu NZ, Hong K, Huang SK, Dewhirst MW and Papahadjopoulos D: Thermosensitive liposomes: extravasation and release of contents in tumor microvascular networks. Int J Radiat Oncol Biol Phys 36: 1177-1187, 1996. (Pubitemid 27014505)
37. Hauck M, Coffin D, Dodge R, Dewhirst MW, Mitchell J and Zalutsky M: A local hyperthermia treatment which enhances antibody uptake in a glioma xenograft model does not affect tumor interstitial fluid pressure. Int J Hyperthermia 13: 307-316, 1997. (Pubitemid 27296609)
38. Kong G, Braun RD and Dewhirst MW: Characterization of the effect of hyperthermia on nanoparticle extravasation from tumor vasculature. Cancer Res 61: 3027-3032, 2001. (Pubitemid 32691950)
39. Lefor A, Makohon S and Ackerman N: The effects of hyperthermia on vascular permeability in experimental liver metastasis. J Surg Oncol 28: 297-300, 1985. (Pubitemid 15087024)
40. Dudar T and Jain R: Differential response of normal and tumor microcirculation to hyperthermia. Cancer Res 44: 605-612, 1984. (Pubitemid 14187461)
41. Eddy HA: Alterations in tumor microvasculature during hyperthermia. Radiology 137: 515-521, 1980.
42. Moriyama E: Cerebral blood flow changes during localized hyperthermia. Neurol Med Chir 30: 923-929, 1990.
43. Nishimura Y, Hiraoka MJS, Akuta K, et al: Microangiographic and histologic analysis of the effects of hyperthermia on murine tumor microvasculature. Int J Radiat Oncol Biol Phys 15: 411-420, 1988.
44. Bree VC, Krooshoop JJ, Rietbroek RC, Kipp JBA and Bakker PJM: Hyperthermia enhanced tumor uptake and anti-tumor efficacy of thermostable liposomes daunorubicin in a rat solid tumor. Cancer Res 56: 563-568, 1996. (Pubitemid 26043654)
45. Clark A, Robins H, Vorpahl J and Yatvin M: Structural changes in murine cancer associated with hyperthermia and lidocaine. Cancer Res 43: 1716-1723, 1983. (Pubitemid 13122577)
46. Yuan F: Transvascular drug delivery in solid tumors. Radiation Oncol 8: 164-175, 1998.
47. Lin PS, Ho KC, Sung SJ and Gladding J: Effect of tumor necrosis factor, heat and radiation on the viability and microfilament organization in cultured endothelial cells. Int J Hyperthermia 8: 667-677, 1992.
48. Ketis NV and Lawler J: Effects of thorobospondin antibody on the recovery of endothelial cells from hyperthermia. J Cell Sci 96: 263-270, 1990.
49. - exchanger on adriamycin accumulation. Anticancer Res 15: 71-79, 1995.
50. Asaumi J, Kawasaki S, Nishikawa K, Kuroda M and Hiraki Y: Effects of hyperthermia and cepharanthin on adriamycin accumulation with changes in extracelluar pH. Int J Hyperthermia 11: 27-35, 1995.