Wegener's granulomatosis: Current trends in diagnosis and management

Current Opinion in Otolaryngology and Head and Neck Surgery

Volumn 15, Issue 3, 2007, Pages 170-176

  Erickson, Vanessa R ^a   Hwang, Peter H ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Head and neck; Saddle nose; Subglottic stenosis; Vasculitis; Wegener's granulomatosis

Indexed keywords

15 DEOXYSPERGUALIN; AZATHIOPRINE; COTRIMOXAZOLE; CYCLOPHOSPHAMIDE; ETANERCEPT; GLUCOCORTICOID; LEFLUNOMIDE; METHOTREXATE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PREDNISONE;

ANOSMIA; AUTOIMMUNE DISEASE; CLINICAL FEATURE; COMPUTER ASSISTED TOMOGRAPHY; DIAGNOSTIC PROCEDURE; DISEASE SEVERITY; ENDOSCOPIC SURGERY; EPISCLERITIS; EYE DISEASE; GINGIVA HYPERPLASIA; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; INNER EAR; KERATITIS; LARYNX; MASTOIDECTOMY; MORBIDITY; NOSE CONGESTION; NOSE DISEASE; NOSE INJURY; ORBIT PSEUDOTUMOR; PATHOLOGY; PATHOPHYSIOLOGY; PRIORITY JOURNAL; REVIEW; RHINORRHEA; SALIVARY GLAND; SEPTAL PERFORATION; STRIDOR; SUBGLOTTIC STENOSIS; SURGICAL TECHNIQUE; TRACHEA; TRACHEA STENOSIS; TRACHEOSTOMY; UNSPECIFIED SIDE EFFECT; WEGENER GRANULOMATOSIS;

ADRENAL CORTEX HORMONES; ANTI-BACTERIAL AGENTS; ANTIBODIES, ANTINEUTROPHIL CYTOPLASMIC; HUMANS; IMMUNOSUPPRESSIVE AGENTS; OTORHINOLARYNGOLOGIC SURGICAL PROCEDURES; WEGENER GRANULOMATOSIS;

EID: 34247850921     PISSN: 10689508     EISSN: None     Source Type: Journal    
DOI: 10.1097/MOO.0b013e3281568b96     Document Type: Review

References (30)

1. Cotch MF, Hoffman GS, Yerg DE, et al. The epidemiology of Wegener's granulomatosis. Estimates of the five-year period prevalence, annual mortality, and geographic disease distribution from population-based data sources. Arthritis Rheum 1996; 39:87-92.
2. Seo P, Stone JH. The antineutrophil cytoplasmic antibody-associated vasculitides. Am J Med 2004; 117:39-50.
3. Jennette JC, Xiao H, Falk RJ. Pathogenesis of vascular inflammation by antineutrophil cytoplasmic antibodies. J Am Soc Nephrol 2006; 17:1235-1242.
4. Popa ER, Tervaert JW. The relation between Staphylococcus aureus and Wegener's granulomatosis: current knowledge and future directions. Intern Med 2003; 42:771-780.
5. Hoffman GS, Kerr GS, Leavitt RY, et al. Wegener granulomatosis: an analysis of 158 patients. Ann Intern Med 1992; 116:488-498.
6. Takagi D, Nakamaru Y, Maguchi S, et al. Otologic manifestations of Wegener's granulomatosis. Laryngoscope 2002; 112:1684-1690.
7. Rasmussen N. Management of the ear, nose, and throat manifestations of Wegener granulomatosis: an otorhinolaryngologist's perspective. Curr Opin Rheumatol 2001; 13:3-11.
8. Tami TA. Granulomatous diseases and chronic rhinosinusitis. Otolaryngol Clin North Am 2005; 38:1267-1278; x.
9. Kridel RW. Considerations in the etiology, treatment, and repair of septal perforations. Facial Plast Surg Clin North Am 2004; 12:435-450; vi.
10. Heintz H, Ullrich S, Holl-Ulrich K, et al. Parotitis as first presentation of localized (initial phase) and generalized Wegener's granulomatosis. Sarcoidosis Vasc Diffuse Lung Dis 2005; 22:236-237.
11. Jennette JC, Falk RJ, Andrassy K, et al. Nomenclature of systemic vasculitides. Proposal of an international consensus conference. Arthritis Rheum 1994; 37:187-192.
12. Trimarchi M, Gregorini G, Facchetti F, et al. Cocaine-induced midline destructive lesions: clinical, radiographic, histopathologic, and serologic features and their differentiation from Wegener granulomatosis. Medicine (Baltimore) 2001; 80:391-404.
13. Jansen TL, van Houte D, de Vries T, et al. ANCA seropositivity in HIV: a serological pitfall. Neth J Med 2005; 63:270-274.
14. Lohrmann C, Uhl M, Warnatz K, et al. Sinonasal computed tomography in patients with Wegener's granulomatosis. J Comput Assist Tomogr 2006; 30:122-125. This is a descriptive study of the sinonasal computed tomography findings of patients with Wegener's granulomatosis.
15. Benoudiba F, Marsot-Dupuch K, Rabia MH, et al. Sinonasal Wegener's granulomatosis: CT characteristics. Neuroradiology 2003; 45:95-99.
16. Yang C, Talbot JM, Hwang PH. Bony abnormalities of the paranasal sinuses in patients with Wegener's granulomatosis. Am J Rhinol 2001; 15:121-125.
17. Wung PK, Stone JH. Therapeutics of Wegener's granulomatosis. Nat Clin Pract Rheumatol 2006; 2:192-200. An excellent and comprehensive review of the current medical algorithms and options for the treatment of systemic Wegener's granulomatosis as well as new treatments currently under investigation.
18. Haubitz M, Schellong S, Gobel U, et al. Intravenous pulse administration of cyclophosphamide versus daily oral treatment in patients with antineutrophil cytoplasmic antibody-associated vasculitis and renal involvement: a prospective, randomized study. Arthritis Rheum 1998; 41:1835-1844.
19. Guillevin L, Cordier JF, Lhote F, et al. A prospective, multicenter, randomized trial comparing steroids and pulse cyclophosphamide versus steroids and oral cyclophosphamide in the treatment of generalized Wegener's granulomatosis. Arthritis Rheum 1997; 40:2187-2198.
20. De Groot K, Rasmussen N, Bacon PA, et al. Randomized trial of cyclophosphamide versus methotrexate for induction of remission in early systemic antineutrophil cytoplasmic antibody-associated vasculitis. Arthritis Rheum 2005; 52:2461-2469.
21. Langford CA, Talar-Williams C, Barron KS, et al. Use of a cyclophosphamide-induction methotrexate-maintenance regimen for the treatment of Wegener's granulomatosis: extended follow-up and rate of relapse. Am J Med 2003; 114:463-469.
22. Stegeman CA, Tervaert JW, de Jong PE, et al. Trimethoprim- sulfamethoxazole (co-trimoxazole) for the prevention of relapses of Wegener's granulomatosis. Dutch Co-Trimoxazole Wegener Study Group. N Engl J Med 1996;335:16-20.
23. De Groot K, Reinhold-Keller E, Tatsis E, et al. Therapy for the maintenance of remission in sixty-five patients with generalized Wegener's granulomatosis. Methotrexate versus trimethoprim/sulfamethoxazole. Arthritis Rheum 1996; 39:2052-2061.
24. Hellmich B, Lamprecht P, Gross WL. Advances in the therapy of Wegener's granulomatosis. Curr Opin Rheumatol 2006; 18:25-32. A recent, comprehensive review of medical management for the treatment of Wegener's granulomatosis.
25. Metzler C, Fink C, Lamprecht P, et al. Maintenance of remission with leflunomide in Wegener's granulomatosis. Rheumatology (Oxford) 2004; 43:315-320.
26. Schmitt WH, Birck R, Heinzel PA, et al. Prolonged treatment of refractory Wegener's granulomatosis with 15-deoxyspergualin: an open study in seven patients. Nephrol Dial Transplant 2005; 20:1083-1092.
27. Gubbels SP, Barkhuizen A, Hwang PH. Head and neck manifestations of Wegener's granulomatosis. Otolaryngol Clin North Am 2003; 36:685-705.
28. Congdon D, Sherris DA, Specks U, et al. Long-term follow-up of repair of external nasal deformities in patients with Wegener's granulomatosis. Laryngoscope 2002; 112:731-737.
29. Lebovics RS, Hoffman GS, Leavitt RY, et al. The management of subglottic stenosis in patients with Wegener's granulomatosis. Laryngoscope 1992; 102 (12 Pt 1):1341-1345.
30. Hoffman GS, Thomas-Golbanov CK, Chan J, et al. Treatment of subglottic stenosis, due to Wegener's granulomatosis, with intralesional corticosteroids and dilation. J Rheumatol 2003; 30:1017-1021.