Uncoupling metallonuclease metal ion binding sites via nudge mutagenesis

Journal of Biological Inorganic Chemistry

Volumn 12, Issue 4, 2007, Pages 557-569

  Papadakos, Grigorios A ^a   Nastri, Horacio ^b,c   Riggs, Paul ^b   Dupureur, Cynthia M ^a  

^a UNIVERSITY OF MISSOURI ST LOUIS   (United States)

^b NEW ENGLAND BIOLABS   (United States)

^c EMD SERONO INC   (United States)

Author keywords

DNA; Enzyme mechanism; Metal ions; Nuclease

Indexed keywords

ALKALINE EARTH METAL; DNA; HYDROXYL GROUP; METAL ION; METALLONUCLEASE; NITROGEN; NUCLEASE; PROTON; TYROSINE; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CRYSTAL STRUCTURE; DNA BINDING; ENZYME SUBSTRATE; GENE MUTATION; METAL BINDING; MUTAGENESIS; PRIORITY JOURNAL;

BINDING SITES; CALCIUM; CALORIMETRY; CATIONS, DIVALENT; CRYSTALLOGRAPHY, X-RAY; DEOXYRIBONUCLEASES, TYPE II SITE-SPECIFIC; DNA; EUROPIUM; MAGNESIUM; METALLOPROTEINS; MODELS, MOLECULAR; MUTAGENESIS; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEIN STRUCTURE, TERTIARY; SPECTROMETRY, FLUORESCENCE; SUBSTRATE SPECIFICITY; TEMPERATURE; TITRIMETRY; TYROSINE;

EID: 34247643172     PISSN: 09498257     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00775-007-0209-y     Document Type: Article

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