P53 expression in squamous cell carcinomas of the supraglottic larynx and its lymph mode metastases: New results for an old question

Cancer

Volumn 109, Issue 9, 2007, Pages 1791-1798

  Cabanillas, Rubén ^a,c   Rodrigo, Juan Pablo ^a   Astudillo, Aurora ^a   Domíngues, Francisco ^b   Suárez, Carlos ^a   Chiara, Maria Dolores ^a  

^a DEPARTAMENTO DE BIOQUÍMICA Y BIOLOGÍA MOLECULAR   (Spain)

^b HOSPITAL VALLE DEL NALÓN   (Spain)

^c HOSPITAL UNIVERSITARIO CENTRAL DE ASTURIAS   (Spain)

Author keywords

Head and neck carcinoma; Immunohistochemistry; Lymph node metastases; p53; Prognosis; Supraglottic

Indexed keywords

PROTEIN P53;

ARTICLE; CANCER RECURRENCE; CANCER SURVIVAL; FOLLOW UP; HEAD AND NECK CANCER; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LARYNX CARCINOMA; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; NECK DISSECTION; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; SQUAMOUS CELL CARCINOMA;

ADULT; AGED; AGED, 80 AND OVER; ALCOHOL DRINKING; CARCINOMA, SQUAMOUS CELL; HUMANS; IMMUNOHISTOCHEMISTRY; KAPLAN-MEIERS ESTIMATE; LARYNGEAL NEOPLASMS; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; NEOPLASM STAGING; PROGNOSIS; SMOKING; TUMOR MARKERS, BIOLOGICAL; TUMOR SUPPRESSOR PROTEIN P53;

EID: 34247626737     PISSN: 0008543X     EISSN: 10970142     Source Type: Journal    
DOI: 10.1002/cncr.22646     Document Type: Article

References (27)

1. Roepman P, Wessels LF, Kettelarij N, et al. An expression profile for diagnosis of lymph node metastases from primary head and neck squamous cell carcinomas. Nat Genet. 2005;37:182-186.
2. Hardisson D. Molecular pathogenesis of head and neck squamous cell carcinoma. Eur Arch Otorhinolaryngol. 2003;260:502-508.
3. Bosch FX, Ritter D, Enders C, et al. Head and neck tumor sites differ in prevalence and spectrum of p53 alterations but these have limited prognostic value. Int J Cancer. 2004;111:530-538.
4. Waitzberg AF, Nonogaki S, Nishimoto IN, et al. Clinical significance of c-myc and p53 expression in head and neck squamous cell carcinomas. Cancer Detect Prev. 2004;28: 178-186.
5. Vlachtsis K, Nikolaou A, Markou K, Fountzilas G, Daniilidis I. Clinical and molecular prognostic factors in operable laryngeal cancer. Eur Arch Otorhinolaryngol. 2005;262:890-898.
6. Freier K, Joos S, Flechtenmacher C, et al. Tissue microarray analysis reveals site-specific prevalence of oncogene amplifications in head and neck squamous cell carcinoma. Head Neck. 2005;27:710-717.
7. Rodrigo JP, Suarez C, Gonzalez MV, et al. Variability of genetic alterations in different sites of head and neck cancer. Laryngoscope. 2001;111:1297-1301.
8. Narayana A, Vaughan AT, Gunaratne S, Kathuria S, Walter SA, Reddy SP. Is p53 an independent prognostic factor in patients with laryngeal carcinoma? Cancer. 1998;82:286-291.
9. Shin DM, Charuruks N, Lippman SM, et al. p53 Protein accumulation and genomic instability in head and neck multistep tumorigenesis. Cancer Epidemiol Biomarkers Prev. 2001;10:603-609.
10. Couture C, Raybaud-Diogene H, Tetu B, et al. p53 and Ki67 as markers of radioresistance in head and neck carcinoma. Cancer. 2002;94:713-722.
11. Blons H, Laurent-Puig P. TP53 and head and neck neoplasms. Hum Mutat. 2003;21:252-257.
12. Dobashi Y, Sakamoto A, Sugimura H, et al. Overexpression of p53 as a possible prognostic factor in human thyroid carcinoma. Am J Surg Pathol. 1993;17:375-381.
13. Field JK, Spandidos DA, Malliri A, Gosney JR, Yiagnisis M, Stell PM. Elevated P53 expression correlates with a history of heavy smoking in squamous cell carcinoma of the head and neck. Br J Cancer. 1991;64:573-577.
14. Dolcetti R, Doglioni C, Maestro R, et al. p53 over-expression is an early event in the development of human squamous-cell carcinoma of the larynx: genetic and prognostic implications. Int J Cancer. 1992;52:178-182.
15. Smith BD, Smith GL, Carter D, et al. Molecular marker expression in oral and oropharyngeal squamous cell carcinoma. Arch Otolaryngol Head Neck Surg. 2001;127:780-785.
16. Hall PA, Lane DP. P53 in tumor pathology: can we trust immunohistochemistry? Revisited! J Pathol. 1994;172:1-4.
17. Hollstein M, Sidransky D, Vogelstein B, Harris CC. P53 mutations in human cancers. Science. 1991;253:49-53.
18. Hagel C, Laking G, Laas R, et al. Demostration of p53 protein and TP53 gene mutations in oligodendrogliomas. Eur J Cancer. 1996;32:2242-2248.
19. Mielcarek-Kuchta D, Olofsson I, Golusinski W. p53, Ki67 and cyclin D1 as prognosticators of lymph node metastases in laryngeal carcinoma. Eur Arch Otorhinolaryngol. 2003;260:549-554.
20. Liu M, Lawson G, Delos M, et al. Prognostic value of cell proliferation markers, tumor suppressor proteins and cell adhesion molecules in primary squamous cell carcinoma of the larynx and hypopharynx. Eur Arch Otorhinolaryngol. 2003;260:28-34.
21. Dai H, van't Veer L, Lamb J, et al. A cell proliferation signature is a marker of extremely poor outcome in a subpopulation of breast cancer patients. Cancer Res. 2005;65:4059-4066.
22. Bernards R, Weinberg RA. Metastasis genes: a progression puzzle. Nature. 2002;418:823.
23. Takes RP, Baatenburg de Jong RJ, Wijffels K, et al. Expression of genetic markers in lymph node metastases compared with their primary tumours in head and neck cancer. J Pathol. 2001;194:298-302.
24. Kropveld A, van Mansfeld AD, Nabben N, Hordijk GJ, Slootweg PJ. Discordance of p53 status in matched primary tumours and metastases in head and neck squamous cell carcinoma patients. Eur J Cancer B Oral Oncol. 1996;32B: 388-393.
25. Yamazaki Y, Chiba I, Hirai A, et al. Clinical value of genetically diagnosed lymph node micrometastasis for patients with oral squamous cell carcinoma. Head Neck. 2005;27: 676-681.
26. Garcia Lozano MC, Orradre Romero JL, Caro Garcia M, Saez del Castillo AI, Piris Pinilla MA. Inmunohistochimic expression of p53 protein and TTS prognostic value in the larynx cancer. Ann Otorhinolaringol Ibero Am. 2004;31:515-529.
27. Narayana A, Vaughan AT, Kathuria S, Fisher SG, Walter SA, Reddy SP. P53 overexpression is associated with bulky tumor and poor local control in T1 glottic cancer. Int J Radiat Oncol Biol Phys. 2000;46:21-26.