P53 overexpression is associated with bulky tumor and poor local control in T1 glottic cancer

International Journal of Radiation Oncology Biology Physics

Volumn 46, Issue 1, 2000, Pages 21-26

  Narayana, Ashwatha ^a   Vaughan, Andrew T M ^a   Kathuria, Satinder ^a   Fisher, Susan G ^a   Walter, Scott A ^a   Reddy, Sarada P ^a  

^a LOYOLA UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Immunohistochemistry; Laryngeal cancer; p53; Radiotherapy; Tumor bulk

Indexed keywords

PROTEIN P53;

ARTICLE; BIOPSY; CANCER RECURRENCE; CANCER SURVIVAL; CONTROLLED STUDY; FEMALE; GENE OVEREXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LARYNX CARCINOMA; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; SQUAMOUS CELL CARCINOMA; VOCAL CORD;

AGED; CARCINOMA, SQUAMOUS CELL; FEMALE; GLOTTIS; HUMANS; IMMUNOHISTOCHEMISTRY; LARYNGEAL NEOPLASMS; MALE; MIDDLE AGED; NEOPLASM RECURRENCE, LOCAL; NEOPLASM STAGING; PROGNOSIS; RISK FACTORS; SURVIVAL ANALYSIS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0033972912     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0360-3016(99)00348-X     Document Type: Article

References (24)

1. Borina C.C., Savines T.S., Tong T. Cancer statistics 1994. CA Cancer J Clin. 44:1996;7-26.
2. Rudoltz M.D., Benammar A., Mohiuddin M. Prognostic factors for local control and survival in T1 squamous cell carcinoma of the glottis. Int J Radiat Oncol Biol Phys. 26:1993;762-772.
3. Stevenson J.M., Juillard G.Y., Selch M.T. Stages 1 and 2 epidermoid carcinoma of the glottic larynx Involvement of the anterior commissure . Radiology. 182:1992;797-799.
4. Horiot J.C., Fletcher G.H., Ballantyne A.J., et al. Analysis of failures in early vocal cord cancer. Radiology. 103:1972;663-665.
5. Schwaibold F., Scariato A., Nunno M., et al. The effect of fraction size on control of early glottic cancer. Int J Radiat Oncol Biol Phys. 14:1988;451-454.
6. Horiot J.C., Fletcher G.H., Ballantyne A.J. Analysis of failures in early vocal cord cancer. Radiology. 103:1972;663-665.
7. Mendenhall W.M., Parsons J.T., Stringer S.P., et al. T1-T2 vocal cord carcinoma A basis for comparing the results of radiotherapy and surgery . Head Neck Surg. 10:1988;373-377.
8. Fei D.A., Mendenhall W.M., Parsons J.T. T1-T2 squamous cell carcinoma of the glottic larynx treated with radiotherapy A multivariate analysis of variables potentially influencing local control . Int J Radiat Oncol Biol Phys. 25:1993;605-611.
9. Harwood A.R., Hawkins N.V., Rider W.D. Radiotherapy of early glottic cancer. Int J Radiat Oncol Biol Phys. 5:1979;473-476.
10. Mendenhall W.M., Parsons J.T., Million R.R., et al. T1-T2 squamous cell carcinoma of the glottic larynx treated with radiation therapy Relationship of dose-fractionation factors to local control and complications . Int J Radiat Oncol Biol Phys. 15:1988;1267-1273.
11. Watling D.L., Gowan A.M., Coltrera P. Overexpression of p53 in head and neck cancer. Head Neck. 16:1992;437-444.
12. Awwad S., Jarros E., Jomes J., et al. p53 overexpression in head and neck carcinoma and radiotherapy results. Int J Radiat Oncol Biol Phys. 36:1996;323-332.
13. Dobaski Y., Sakamoto A., Sugimara H., et al. p53 overexpression is an early event in the development of human squamous cell carcinoma of the larynx Genetic and prognostic implications . Int J Cancer. 52:1992;178-182.
14. Field J.K., Malliri A., Butt S.A., et al. p53 overexpression in end-stage squamous cell carcinoma of head and neck prior to chemotherapy treatment Expression correlates with a very poor clinical outcome . Int J Oncol. 3:1993;631-635.
15. Ogden A.R., Kiddne R.A., Lunny D.P. Assessment of p53 protein expression in normal, benign, and malignant oral mucosa. J Pathol. 1166:1992;389-394.
16. Maestro R., Deolcetti R., Gasporotto D. High frequency of p53 gene alteration associated with protein overexpression in human squamous cell carcinoma of the larynx. Oncogene. 7:1992;1159-1166.
17. Raybaud-Diogene H., Fortin A., Morency R. Markers of radioresistance in squamous cell carcinomas of the head and neck A clinocopathologic and immunohistochemical study . J Clin Oncol. 15:1997;1030-1038.
18. Koch W.M., Brennan J.A., Zahurak M., et al. p53 mutation and locoregional treatment failure in head and neck squamous cell carcinoma. J Natl Cancer Inst. 88:1996;1580-1586.
19. Bristow R.G., Benchimol S., Hill R.P. The p53 gene as a modifier of intrinsic radiosensitivity Implications for radiotherapy . Radiother Oncol. 40:1996;197-223.
20. Banks L., Mathlashewski G., Crawford L. Isolation of human p53 specific monoclonal antibodies and their use in the study of human p53 expression. Eur J Biochem. 159:1986;529-534.
21. Finlay C.A., Hinds P.W., Tan T.H., et al. Activating mutations for transformation by p53 produce a gene product that forms an HSC 70-p53 complex with an altered half life. Mol Cell Biol. 8:1988;531-539.
22. Bradford C.R., Zlu S., Poore J., et al. p53 mutation as a prognostic marker in advanced laryngeal carcinoma. Arch Otolaryngol Head Neck Surg. 123:1997;605-609.
23. Hirvikoski P., Kumpulainen E., Virtaniemi J., et al. p53 expression and cell proliferation as prognostic factors in laryngeal squamous cell carcinoma. J Clin Oncol. 15:1997;3111-3120.
24. Dickens W.J., Cassisi N.J., Million R.R., et al. Treatment of early vocal cord carcinoma A comparison of apples and apples . Laryngoscope. 93:1983;216-219.