Yo Jyo Hen Shi Ko, a novel Chinese herbal, prevents nonalcoholic steatohepatitis in ob/ob mice fed a high fat or methionine-choline-deficient diet

Liver International

Volumn 27, Issue 2, 2007, Pages 227-234

  de Lima, Vicência Mara Rodrigues ^a   de Oliveira, Claudia Pinto Marques Souza ^a   Sawada, Letícia Yumi ^a   Barbeiro, Hermes Vieira ^a   de Mello, Evandro Sobroza ^a   Soriano, Francisco Garcia ^a   Alves, Venâncio Avancini Ferreira ^a   Caldwell, Stephen H ^b   Carrilho, Flair José ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b UNIVERSITY OF VIRGINIA   (United States)

Author keywords

Henshiko; Nonalcoholic steatohepatitis; Oxidative stress; YoJyo Hen Shi Ko

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CHINESE DRUG; CHOLESTEROL; CHOLINE; DEGLYCYRRHIZINATED LIQUORICE; EUCOMMIA ULMOIDES EXTRACT; GINSENG EXTRACT; GLUTATHIONE; LIPID PEROXIDE; MALONALDEHYDE; METHIONINE; POLYGONATUM EXTRACT; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; YO JYO HEN SHI KO; AMINOTRANSFERASE; BIOLOGICAL MARKER; HERBACEOUS AGENT; LIPID;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DRUG MECHANISM; DRUG RESPONSE; HISTOPATHOLOGY; LIPID DIET; MALE; MOUSE; MOUSE STRAIN; NONALCOHOLIC FATTY LIVER; NONHUMAN; OXIDATIVE STRESS; TREATMENT OUTCOME; TRIACYLGLYCEROL BLOOD LEVEL; ANIMAL; BLOOD; BODY WEIGHT; DIET; DOSE RESPONSE; DRUG EFFECT; FAT INTAKE; FATTY LIVER; HEPATITIS; LIVER; METABOLISM; MOUSE MUTANT; PATHOLOGY; VITAMIN DEFICIENCY;

ANIMALS; BIOLOGICAL MARKERS; BODY WEIGHT; CHOLINE DEFICIENCY; DIET; DIETARY FATS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUGS, CHINESE HERBAL; FATTY LIVER; HEPATITIS; LIPIDS; LIVER; MALE; METHIONINE; MICE; MICE, OBESE; OXIDATIVE STRESS; TRANSAMINASES;

EID: 34247620801     PISSN: 14783223     EISSN: 14783231     Source Type: Journal    
DOI: 10.1111/j.1478-3231.2006.01405.x     Document Type: Article

References (36)

1. Powell EE, Cooksley WG, Hanson R, Searle J, Halliday JW, Powell LW. The natural history of nonalcoholic steatohepatitis: A follow-up study of forty-two patients for up to 21 years. Hepatology 1990; 11: 74-80.
2. Falck-Ytter Y, Younossi ZM, Marchesini G, McCullough AJ. Clinical features and natural history of nonalcoholic steatosis syndromes. Semin Liver Dis 2001; 21: 17-26.
3. Hui JM, Farrell GC. Clear messages from sonographic shadows? Links between metabolic disorders and liver disease, and what to do about them. J Gastroenterol Hepatol 2003; 18: 1115-7.
4. Day CP, James OFW. Steatohepatiti: A tale of two 'hits'? Gastroenterology 1998; 114: 842-5.
5. Marchesisni G, Brizi M, Morselli-Labate AM, et al. Association of nonalcoholic fatty liver disease with insulin resistance. Am J Med 1999; 107: 450-5.
6. Chitturi S, Farrell G. Ethiopathogenesis of nonalcoholic steatohepatitis. Semin Liver Dis 2001; 21 (1): 27-41.
7. Curzio M, Esterbauer H, Dianzani MU. Chemotactic activity of hydroxyalkenals on rat neutrophils. Int J Tiss Reac 1985; 7: 137-42.
8. Lee KS, Buck M, Houglum K, Chojkier M. Activation of hepatic stellate cells by TGF alpha and collagen type I is mediated by oxidative stress through c-myb expression. J Clin Invest 1995; 96: 2461-8.
9. Marotta F, Rouge A, Harada M, et al. Beneficial effect of a controlled Chinese herbal remedy, K-17-22, in CCl4-induced liver toxicity: An in vivo and vitro study. Biomed Res 2001; 22: 167-74.
10. Marotta F, Bertuccelli J, Albergati F, et al. Ischemia-reperfusion liver injury: Effect of a nutritional approach with K-17-22 on antioxidant defense system. Biomed Res 2001; 22: 221-7.
11. Sha S, Harada M, Yanaihara N. Effect of YHK, a new Chinese herb prescription, on serum ALT and AST levels in patients with hepatic diseases. June 2-7, 2000 IASL-APASL Joint meeting 200, New Insights of Hepatology in the 21 st centuty. Fukuoka, Japan.
12. Chande N, Laidlaw M, Adams P, Marotta P. Yo Jyo Hen Shi Ko (YHK) improves transaminases in nonalcoholic steatohepatitis: A randomized pilot study. Dig Dis Sci 2006; 51: 1183-9.
13. Nanji AA. Animal models of nonalcoholic fatty liver disease and steatohepatitis. Clin Liver Dis 2004; 8: 559-74.
14. Oshima Y, Sato K, Hikino H Isolation and hypoglycemic activity of quinquefolans A, B, and C, glycans of Panax quinquefolius roots. J Nat Prod 1987; 50: 188-90.
15. Sotaniemi EA, Haapakoski E, Rautio A. Ginseng therapy in non-insulin-dependent diabetic patients. Diabetes Care 1995; 18: 1373-5.
16. Lee MK, Kim MJ, Cho SY, et al. Hypoglycemic effect of Du-zhong (Eucommia ulmoides Oliv.) leaves in streptozotocin-induced diabetic rats. Diabetes Res Clin Pract 2005; 67: 22-28.
17. Jeon SM, Lee MK, Park YB, Park HM, Choi MS. Polygonatum rhizoma affects antioxidant defense systems without changing mRNA expression in diet-induced hypercholesterolemic rabbits. J Medicinal Food 2004; 7: 358-65.
18. Choi SB, Park S. A steroidal glycoside from Polygonatum odoratum improves insulin resistance but does not alter insulin secretion in 90% pancreatectomized rats. Biosci, Biotechnol Biochem 2002; 66: 2036-43.
19. Armanini D, Fiore C, Mattarello MJ, Bielenberg J, Palermo M. History of the endocrine effects of licorice. Exp Clin Endocrinol Diab 2002; 110: 257-61.
20. Walker BR, Connacher AA, Lindsay RM, Webb DJ, Edwards CR. Carbenoxolone increases hepatic insulin sensitivity in man: A novel role for 11-oxosteroid reductase in enhancing glucocorticoid receptor activation. J Clin Endocrinol Metab 1995; 80: 3155-9.
21. Kleiner DE, Brunt EM, Van Natta ML, et al. Nonalcoholic Steatohepatitis Clinical Research Network. Design and validation of a histologic scoring system for NAFLD. Hepatology 2005; 41: 1313-21.
22. Koteish A, Diehl AM. Animals models of steatosis. Semin Liv Dis 2001; 21: 89-104.
23. Robertson G, Leclercq I, Farrell GC. Nonalcoholic steatosis and steatohepatitis II. Cytochrome P-450 enzymes and oxidative stress. Am J Physiol Gastrointes Liver Physiol 2001; 281: G1135-9.
24. Yang SQ, Zhu H, Li Y, Gabrielson K, Trush MA, Diehl AM. Mitochondrial adaptations to obesity-related oxidant stress. Arch Biochem Biophysics 2000; 378: 259-68.
25. Oliveira CPMS, Gayotto LCD, Tatai C, et al. Oxidative stress in the pathogenesis of nonalcoholic fatty liver disease, in rats fed with a choline-deficient diet. J Cell Mol Med 2002; 6: 399-406.
26. Grattagliano I, Vendemiale G, Caraceni P, et al. Starvation impairs antioxidant defense in fatty livers of rats fed a choline-deficient diet. J Nutr 2000; 130: 2131-6.
27. Oliveira CPMS, Gayotto LCD, Tatai C, et al. Vitamin C and vitamin E in prevention of nonalcoholic fatty liver disease (NAFLD) in choline deficient diet fed rats. Nut J 2003; 2: 9-11.
28. Ikura Y, Ohsawa M, Suekane T, et al. Localization of oxidized phosphatidylcholine in nonalcoholic fatty liver disease: Impact on disease progression. Hepatology 2006; 43: 506-14.
29. Stefano JT, Oliveira CPM, Lima VMR, et al. Protective effect of Yo Jyo Hen Shi Ko in nonalcoholic steatohepatitis (NASH): Increased PPAR-α gene expression. Gastroenterology 2006; 130: A-826.
30. Hensley K, Kotake Y, Sang H, Pye QN, Wallis GL, Kolker LM. Dietary choline restriction causes complex I dysfunction and increased H(2)O(2) generation in liver mitochondria. Carcinogenesis 2000; 21: 983-9.
31. Rushmore TH, Lim YP, Farber E, Ghoshal AK. Rapid lipid peroxidation in the nuclear fraction of rat liver induced by a diet deficient in choline and methionine. Cancer Lett 1984; 24: 251-5.
32. Lee MK, Kim MJ, Cho SY, et al. Hypoglicemic effect of Do-zhong (Eucommia ulmoides oliv.) leaves in streptozotocin-induced diabetic rats. Diab Reas Clin Pract 2005; 67: 22-28.
33. Chen H, Feng R, Guo Y, Sun L, Jiang J. Hypoglicemic effects of aqueous extract of Rhizoma Polygonati Odorati in mice and rats. J Ethnopharmacoly 2001; 74: 225-9.
34. Nakasa T, Yamaguchi M, Okinaka O, Metori K, Takashi S. Effects of DU-zhong leaf extract on plasma and hepatic lipids in rats feed a high fat plus high cholesterol diet. Nippon Nogeikagaku Kaishi 1995; 69: 1491-8.
35. Fuhrman B, Volkova N, Kaplan M, et al. Antiatherosclerotic effects of licorice extract supllementation on hypercholesterolemic patients: increased resistance of LDL to atherogenic modifications, reduced plasma lipid levels, and decreased systolic blood pressure. Nutrition 2002; 18: 268-73.
36. Nakagawa K, Kishida H, Arai N, Nishiyama T, Mae T. Licorice flavonoids suppress abdominal fat accumulation and increase in blood glucose level in obese diabetic KK-A Mice. Biol Pharm Bull 2004; 27 (11): 1775-8.