Relationship between uremic toxins and oxidative stress in patients with chronic renal failure

Scandinavian Journal of Urology and Nephrology

Volumn 41, Issue 3, 2007, Pages 243-248

  Rutkowski, Przemyslaw ^a   Słomińska, Ewa Maria ^a   Szołkiewicz, Marek ^a   Aleksandrowicz, Ewa ^a   Smoleński, Ryszard Tomasz ^a   Wołyniec, Wojciech ^a   Renke, Marcin ^a   Wisterowicz, Krystyna ^a   Świerczyński, Julian ^a   Rutkowski, Boleslaw ^a  

^a MEDICAL UNIVERSITY OF GDANSK   (Poland)

Author keywords

Kidney failure; Malonyldialdehyde; N methyl 2 pyridone 5 carboxamide; N methyl 4 pyridone 5 carboxamide; Oxidative stress; Uremia; Uremic toxins

Indexed keywords

BIOLOGICAL MARKER; CARBONYL DERIVATIVE; CREATININE; GLUTATHIONE; MALONALDEHYDE; N METHYL 2 PYRIDONE 5 CARBOXAMIDE; N METHYL 4 PYRIDONE 5 CARBOXAMIDE; PYRIDONE DERIVATIVE; UNCLASSIFIED DRUG; UREMIC TOXIN;

ADULT; AGED; ARTICLE; BLOOD LEVEL; CHRONIC KIDNEY FAILURE; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; CREATININE BLOOD LEVEL; DISEASE MARKER; DISEASE SEVERITY; ERYTHROCYTE LEVEL; FEMALE; GLOMERULUS FILTRATION RATE; HUMAN; MALE; MEDICAL PARAMETERS; OXIDATIVE STRESS; PRIORITY JOURNAL; UREMIA;

ADULT; AGED; BIOLOGICAL MARKERS; CREATININE; FEMALE; GLUTATHIONE; HUMANS; KIDNEY FAILURE, CHRONIC; LIPID PEROXIDATION; MALE; MALONDIALDEHYDE; MIDDLE AGED; NIACINAMIDE; OXIDATIVE STRESS;

EID: 34247618254     PISSN: 00365599     EISSN: 16512065     Source Type: Journal    
DOI: 10.1080/00365590601017170     Document Type: Article

References (30)

1. Vanholder R, De Smet R, Glorieux G, Argiles A, Baurmeister U, Brunet P, et al. Review on uremic toxins: classification, concentration, and interindividual variability. Kidney Int 2003;363:1934-43.
2. Slominska EM, Smolenski R, Szolkiewicz M, Leaver N, Rutkowski B, Simmonds H, et al. Accumulation of plasma N-methyl-2-pyridone-5-carboxamide in patients with chronic renal failure. Mol Cell Biochem 2002;231:83-8.
3. Rutkowski B, Swierczynski J, Slominska E, Szolkiewicz M, Smolenski RT, Marlewski M, et al. Disturbances of purine nucleotide metabolism in uremia. Semin Nephrol 2004;24:479-83.
4. Walters CJ, Brown RR, Kaihara M, Price JM. The excretion of N-methyl-2-pyridone-5-carboxamide by man following ingestion of several known or potential precursors. J Biol Chem 1955;217:489-95.
5. Price JM. The determination of N-methyl-2-pyridone-5-carboxamide in human urine. J Biol Chem 1954;211:117-24.
6. Abelson D, Boyle A, Depatie C, Seligson H. N′-methyl-2-pyridone-5- carboxamide in human plasma. Clin Chim Acta 1963;82:603-6.
7. Slominska EM, Rutkowski P, Smolenski RT, Szutowicz A, Rutkowski B, Swierczynski J. The age-related increase in N-methyl-2-pyridone-5-carboxamide (NAD catabolite) in human plasma. Mol Cell Biochem 2004;267:25-30.
8. Oberg BP, McMenamin E, Lucas FL, McMonagle E, Morrow J, Ikizler TA, et al. Increased prevalence of oxidant stress and inflammation in patients with moderate to severe chronic kidney disease. Kidney Int 2004;65:1009-16.
9. Himmelfarb J, McMonagle E. Manifestations of oxidant stress in uremia. Blood Purif 2001;19:200-5.
10. Annuk M, Fellstrom B, Akerblom O, Zilmer K, Vihalemm T, Zilmer M. Oxidative stress markers in pre-uremic patients. Clin Nephrol 2001;56:308-14.
11. Amann K, Tyralla K, Gross ML, Eifert T, Adamczak M, Ritz E. Special characteristics of atherosclerosis in chronic renal failure. Clin Nephrol 2003;60(Suppl 1):S13-21.
12. Ikizler TA. Role of nutrition for cardiovascular risk reduction in chronic kidney disease patients. Adv Chronic Kidney Dis 2004;11:162-71.
13. Zoccali C, Mallamaci F, Tripepi G. Novel cardiovascular risk factors in end-stage renal disease. J Am Soc Nephrol 2004;15(Suppl 1):S77-80.
14. Satoh M, Hayashi H, Watanabe M, Ueda K, Yamato H, Yoshioka T, et al. Uremic toxins overload accelerates renal damage in a rat model of chronic renal failure. Nephron Exp Nephrol 2003;95:e111-8.
15. Cohen G, Rudnicki M, Horl WH. Uremic toxins modulate the spontaneous apoptotic cell death and essential functions of neutrophils. Kidney Int Suppl 2001;78:S48-52.
16. Deppisch RM, Beck W, Goehl H, Ritz E. Complement components as uremic toxins and their potential role as mediators of microinflammation. Kidney Int Suppl 2001;78:S271-7.
17. Rutkowski B, Slominska E, Szolkiewicz M, Smolenski RT, Striley C, Rutkowski P, et al. N-methyl-2-pyridone-5-carboxamide: a novel uremic toxin? Kidney Int Suppl 2003;63:S19-21.
18. Malgorzewicz S, Lichodziejewska-Niemierko M, Rutkowski B, Lysiak-Szydlowska W. Nutritional status and oxidative processes in diabetic and nondiabetic peritoneal dialysis patients. J Ren Nutr 2004;14:242-7.
19. Shibata K, Kawada T, Iwai K. Simultaneous micro-determination of nicotinamide and its major metabolites N′-methyl-2-pyridone-5-carboxamide and N′-methyl-4-pyridone-3-carboxamide, by high-performance liquid chromatography. J Chromatogr 1988;424:23-8.
20. Anderson ME. Enzymatic and chemical method for the determination of glutathione. In: Dolphin D, Poulson R, Avramovic O, editors. Glutathione: chemical, biochemical and medical aspects, Vol. A. New York: John Wiley and Sons; 1989. p. 339-65.
21. Garibaldi S, Aragna I. Relationship between protein carbonyls, retinol and tocopherols level in human plasma. Biochem Mol Biol Int 1994;34:729-36.
22. Miyata T, Sugiyama S, Saito A, Kurokawa K. Reactive carbonyl compounds related uremic toxicity ("carbonyl stress"). Kidney Int Suppl 2001;78:S25-31.
23. Miyata T, Kurokawa K, Van Ypersele De Strihou C. Relevance of oxidative and carbonyl stress to long-term uremic complications. Kidney Int 2000;58:120-5.
24. Annuk M, Zilmer M, Lind L, Linde T, Fellstrom B. Oxidative stress and endothelial function in chronic renal failure. J Am Soc Nephrol 2001;12:2747-52.
25. Alhamdani MS. Impairment of glutathione biosynthetic pathway in uraemia and dialysis. Nephrol Dial Transplant 2005;20:124-8.
26. Agarwal R, Vasavada N, Sachs NG, Chase S. Oxidative stress and renal injury with intravenous iron in patients with chronic kidney disease. Kidney Int 2004;65:2279-89.
27. Nemeth I, Turi S, Haszon I, Bereczki C. Vitamin E alleviates the oxidative stress of erythropoietin in uremic children on hemodialysis. Pediatr Nephrol 2000;14:13-7.
28. Chen HC, Tsai JC, Tsai JH, Lai YH. Recombinant human erythropoietin enhances superoxide production by FMLP-stimulated polymorphonuclear leukocytes in hemodialysis patients. Kidney Int 1997;52:1390-4.
29. Himmelfarb J, McMenamin E, McMonagle E. Plasma aminothiol oxidation in chronic hemodialysis patients. Kidney Int 2002;61:705-16.
30. Himmelfarb J, McMonagle E, McMenamin E. Plasma protein thiol oxidation and carbonyl formation in chronic renal failure. Kidney Int 2000;58:2571-8.