Impairment of glutathione biosynthetic pathway in uraemia and dialysis

Nephrology Dialysis Transplantation

Volumn 20, Issue 1, 2005, Pages 124-128

  Alhamdani, Mohamed Saiel S ^a  

^a MUSTANSIRIYAH UNIVERSITY   (Iraq)

Author keywords

glutamylcysteine synthetase; de novo glutathione; Dialysis; Erythrocyte; Uraemia

Indexed keywords

ANTIOXIDANT; FREE RADICAL; GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE; GLUTATHIONE SYNTHASE; MALONALDEHYDE;

ADULT; AGED; ANALYSIS OF VARIANCE; ARTICLE; BLOOD LEVEL; BLOOD SAMPLING; CHRONIC KIDNEY FAILURE; CONCENTRATION (PARAMETERS); CONTINUOUS AMBULATORY PERITONEAL DIALYSIS; CONTROLLED STUDY; CORRELATION ANALYSIS; DIALYSIS; DOWN REGULATION; ENZYME ACTIVITY; ERYTHROCYTE LEVEL; FEMALE; GLUTATHIONE METABOLISM; HEMODIALYSIS PATIENT; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MALE; METABOLIC DISORDER; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; UREMIA;

ADULT; AGED; BIOLOGICAL MARKERS; CASE-CONTROL STUDIES; FEMALE; GLUTATHIONE; HUMANS; KIDNEY FUNCTION TESTS; MALE; MIDDLE AGED; PROBABILITY; PROGNOSIS; REFERENCE VALUES; RENAL DIALYSIS; RISK ASSESSMENT; SENSITIVITY AND SPECIFICITY; SEVERITY OF ILLNESS INDEX; UREMIA;

EID: 13444250195     PISSN: 09310509     EISSN: None     Source Type: Journal    
DOI: 10.1093/ndt/gfh569     Document Type: Article

References (23)

1. Galli F, Canestrari F, Bellomo G. Pathophysiology of the oxidative stress and its implication in uremia and dialysis. Contrib Nephrol 1999; 127: 1-31
2. Durak I, Akiol O, Basesme E, Cambolat O, Kavutcu M. Reduced erythrocyte defense mechanisms against free radical toxicity in patients with chronic renal failure. Nephron 1994; 66: 76-80
3. Ceballos-Picot J, Witko-Sarsat V, Merad-Boudia M et al. Glutathione antioxidant system as a marker of oxidative stress in chronic renal failure. Free Radic Biol Med 1996; 21: 845-953
4. Costagliola C, Ramano L, Sorice P, Di Benedetto A. Anemia and chronic renal failure: the possible role of the oxidative state of glutathione. Nephron 1989; 52: 11-14
5. Pasaoglu H, Muhtaroglu S, Gunes M, Utas C. The role of the oxidative state of glutathione and glutathione related enzymes in anemia of hemodialysis patients. Clin Biochem 1996; 29: 567-572
6. Schettler V, Wieland E, Methe H, Schuff-Werner P, Muller G. Oxidative stress during dialysis: effect on free radical scavenging enzyme (FRSE) activities and glutathione (GSH) concentration in granulocytes. Nephrol Dial Transplant 1998; 13: 2588-2593
7. Kidd PM. Glutathione: systemic protectant against oxidative and free radical damage. Alt Med Rev 1997; 2: 155-176
8. Griffith OW. Biologic and pharmacologic regulation of mammalian glutathione synthesis. Free Radic Biol Med 1999; 27: 922-935
9. Chao JC, Yuan MD, Chen PY, Chien SW. Vitamin C and E supplements improve the impaired antioxidant status and decrease plasma lipid peroxides in hemodialysis patients small star, filled. J Nutr Biochem 2002; 13: 653-663
10. Richie JP, Jr, Skowronski L, Abraham P, Leutzinger Y. Blood glutathione concentrations in a large-scale human study. Clin Chem 1996; 42: 64-70
11. Beutler E, Gelbart T. Improved assay of the enzymes of glutathione synthesis: gamma-glutamylcysteine synthetase and glutathione synthetase. Clin Chim Acta 1986; 158: 115-123
12. Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by TBA reaction. Anal Biochem 1979; 95: 351-358
13. Murakami K, Kondo T, Ohtsuka Y, Fujiuara Y, Shimada M, Kawakami Y. Impairment of glutathione metabolism in erythrocytes from patients with diabetes mellitus. Metabolism 1989; 38: 753-758
14. Beutler E, Gelbart T, Kondo T, Matsunaga AT. The molecular basis of a case of γ-glutamylcysteine synthetase deficiency. Blood 1999; 94: 2890-2894
15. Griffith OW. Glutathione turnover in human erythrocytes: inhibition by buthionine sulfoximine and incorporation of glycine by exchange. J Biol Chem 1981; 256: 4900-4904
16. Han J, Stamler JS, Li H, Griffith OW. Inhibition of γ-glutamylcysteine synthetase by S-nitrosylation. In: Stamler J, Gross S, Moncada S, Higgs EA, eds. The Biology of Nitric Oxide. Portland Press, London: 1995; 114
17. Kondo T, Higashiyama Y, Goto S et al. Regulation of gamma-glutamylcysteine synthetase expression in response to oxidative stress. Free Radic Res 1999; 31: 325-334
18. Massy ZA, Borderie D, Nguyen-Khoa T, Drüeke TB, Ekindjian OG, Lacour B. Increased plasma S-nitrosothiol levels in chronic haemodialysis patients. Nephrol Dial Transplant 2003; 18: 153-157
19. Suliman ME, Divino Filho GC, Bárány P, Anderstam B, Lindholm B, Bergström J. Effects of methionine loading on plasma and erythrocyte sulphur amino acids and sulph-hydryls before and after co-factor supplementation in haemodialysis patients. Nephrol Dial Transplant 2001; 16: 102-110
20. Kwon YH, Stipanuk MH. Cysteine regulates expression of cysteine dioxygenase and γ-glutamylcysteine synthetase in cultured rat hepatocytes. Am J Physiol Endocrinol Metab 2001; 280: E804-E815
21. Moore W, Wiener HE, Meister A. Inactivation of gamma-glutamylcysteine synthetase, but not of glutamine synthetase, by S-sulfocysteine and S-sulfohomocysteine. J Biol Chem 1987; 262: 16771-16777
22. Kajiyama H, Nojima Y, Mitsuhashi H et al. Elevated levels of serum sulfite in patients with chronic renal failure. J Am Soc Nephrol 2000; 11: 923-927
23. Shih VE, Abroms IF, Johnson JL et al. Sulfite oxidase deficiency. Biochemical and clinical investigations of a hereditary metabolic disorder in sulfur metabolism. N Engl J Med 1977; 297: 1022-1028