Potential role of FDG PET in the setting of diabetic neuro-osteoarthropathy: can it differentiate uncomplicated Charcot's neuroarthropathy from osteomyelitis and soft-tissue infection?

Nuclear Medicine Communications

Volumn 28, Issue 6, 2007, Pages 465-472

  Basu, Sandip ^a   Chryssikos, Timothy ^a   Houseni, Mohamed ^a   Scot Malay, D ^a   Shah, Jagruti ^b   Zhuang, Hongming ^b   Alavi, Abass ^b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b PENN PRESBYTERIAN MEDICAL CENTER   (United States)

Author keywords

Cellulitis; Charcot neuroarthropathy; Diabetic foot; FDG PET; Infection; Osteomyelitis

Indexed keywords

FLUORODEOXYGLUCOSE F 18;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; DIABETIC FOOT; DIAGNOSTIC ACCURACY; DIFFERENTIAL DIAGNOSIS; DRUG UPTAKE; FEMALE; FOLLOW UP; FOOT ULCER; HISTOPATHOLOGY; HUMAN; INTERMETHOD COMPARISON; MAJOR CLINICAL STUDY; MALE; NEUROPATHIC JOINT DISEASE; NUCLEAR MAGNETIC RESONANCE IMAGING; OSTEOMYELITIS; POSITRON EMISSION TOMOGRAPHY; SOFT TISSUE INFECTION; STATISTICAL SIGNIFICANCE; STUDENT T TEST;

ADULT; AGED; ARTHROPATHY, NEUROGENIC; DIABETIC FOOT; DIAGNOSIS, DIFFERENTIAL; FEMALE; FLUORODEOXYGLUCOSE F18; HUMANS; MALE; MIDDLE AGED; OSTEOMYELITIS; POSITRON-EMISSION TOMOGRAPHY; PREDICTIVE VALUE OF TESTS; PROSPECTIVE STUDIES; RADIOPHARMACEUTICALS; SENSITIVITY AND SPECIFICITY; SOFT TISSUE INFECTIONS;

EID: 34247602551     PISSN: 01433636     EISSN: 14735628     Source Type: Journal    
DOI: 10.1097/MNM.0b013e328174447f     Document Type: Article

References (29)

1. Clouse ME, Gramm HF, Flood T. Diabetic osteoarthropathy. Clinical and roentgenographic observations in 90 cases. Am J Roentgenol Radium Ther Nucl Med 1974; 121:22-34.
2. Banks AS, McGlamry ED. Charcot foot. J Am Podiatr Med Assoc 1989; 79:213-235.
3. Edmonds ME, Roberts VC, Watkins PJ. Blood flow in the diabetic neuropathic foot. Diabetologia 1982; 22:9-15.
4. Zhuang H, Yu JQ, Alavi A. Applications of fluorodeoxyglucose-PET imaging in the detection of infection and inflammation and other benign disorders. Radiol Clin North Am 2005; 43:121-134.
5. Zhuang H, Alavi A. 18-fluorodeoxyglucose positron emission tomographic imaging in the detection and monitoring of infection and inflammation. Semin Nucl Med 2002; 32:47-59.
6. Temmerman OP, Heyligers IC, Hoekstra OS, Comans EF, Roos JC. Detection of osteomyelitis using FDG and positron emission tomography. J Arthroplasty 2001; 16:243-246.
7. Zhuang H, Duarte PS, Pourdehand M, Shnier D, Alavi A. Exclusion of chronic osteomyelitis with F-18 fluorodeoxyglucose positron emission tomographic imaging. Clin Nucl Med 2000; 25:281-284.
8. Craig JG, Amin MB, Wu K, Eyler WR, van Holsbeeck MT, Bouffard JA, Shirazi K. Osteomyelitis of the diabetic foot: MR imaging-pathologic correlation. Radiology 1997; 203:849-855.
9. Morrison WB, Schweitzer ME, Batte WG, Radack DP, Russel KM. Osteomyelitis of the foot: relative importance of primary and secondary MR imaging signs. Radiology 1998; 207:625-632.
10. Sella JS, Grosser DM. Imaging modalities of the diabetic foot. Clin Podiatr Med Surg 2003; 20:729-740.
11. Schweitzer ME, Morrison WB. MR imaging of the diabetic foot. Radiol Clin North Am 2004; 42:61-71.
12. Grayson ML, Gibbons GW, Balogh K, Levin E, Karchmer A. Probing to bone in infected pedal ulcers: a clinical sign of underlying osteomyelitis in diabetic patients. JAMA 1995; 273:721-723.
13. Sugawara Y, Braun DK, Kison PV, Russo JE, Zasadny KR, Wahl RL. Rapid detection of human infections with fluorine-18 fluorodeoxyglucose and positron emission tomography: preliminary results. Eur J Nucl Med 1998; 25:1238-1243.
14. Lorenzen J, Buchert R, Bohuslavizki KH. Value of FDG PET in patients with fever of unknown origin. Nucl Med Commun 2001; 22:779-783.
15. Guhlmann A, Brecht-Krauss D, Suger G, Glatting G, Kotzerke J, Kinzl L, Reske SN. Chronic osteomyelitis: detection with FDG PET and correlation with histopathologic findings. Radiology 1998; 206:749-754.
16. Guhlmann A, Brecht-Krauss D, Suger G, Glatting G, Kotzerke J, Kinzl L, Reske SN. Fluorine-18-FDG PET and technetium-99m antigranulocyte antibody scintigraphy in chronic osteomyelitis. J Nucl Med 1998; 39:2145-2152.
17. de Winter F, van de Wiele C, Vogelaers D, de Smet K, Verdonk R, Dierckx RA. Fluorine-18 fluorodeoxyglucose-positron emission tomography: a highly accurate imaging modality for the diagnosis of chronic musculoskeletal infections. J Bone Joint Surg Am 2001; 83-A:651-660.
18. Stumpe KD, Dazzi H, Schaffner A, von Schulthess GK. Infection imaging using whole-body FDG-PET. Eur J Nucl Med 2000; 27:822-832.
19. Zhuang H, Duarte PS, Pourdehand M, Shnier D, Alavi A. Exclusion of chronic osteomyelitis with F-18 fluorodeoxyglucose positron emission tomographic imaging. Clin Nucl Med 2000; 25:281-284.
20. Zhuang H, Duarte PS, Pourdehnad M, Maes A, Van Acker F, Shnier D, et al. The promising role of F-18-FDG PET in detecting infected lower limb prosthesis implants. J Nucl Med 2001; 42:44-48.
21. Alavi A, Zhuang H. Finding infection - help from PET. Lancet 2001; 358:1386.
22. Zhuang H, Alavi A. 18-Fluorodeoxyglucose positron emission tomographic imaging in the detection and monitoring of infection and inflammation. Semin Nucl Med 2002; 32:47-59.
23. Jay PR, Michelson JD, Mizel MS, Magid D, Le T. Efficacy of three-phase bone scans in evaluating diabetic foot ulcers. Foot Ankle Int 1999; 20:347-355.
24. Palestro CJ, Torres MA. Radionuclide imaging in orthopedic infections. Semin Nucl Med 1997; 27:334-345.
25. Maurer AH, Millmond SH, Knight LC, Mesgarzadeh M, Siegel JA, Shuman CR, et al. Infection in diabetic osteoarthropathy - Use of indium-labeled leukocytes for diagnosis. Radiology 1986; 161:221-225.
26. Larcos G, Brown ML, Sutton RT. Diagnosis of osteomyelitis of the foot in diabetic-patients - value of In-111 leukocyte scintigraphy. AJR Am J Roentgenol 1991; 157:527-531.
27. Morrison WB, Ledermann HP, Schweitzer ME. MR imaging of inflammatory conditions of the ankle and foot. Magn Res Imag Clin N Am 2001; 9:615-637.
28. Rojas-Burke J. Health officials reacting to infection mishaps. J Nucl Med 1992; 33:13N-14N, 27N.
29. Hopfner S, Krolak C, Kessler S, Tiling R, Brinkbaumer K, Hahn K, Dresel S. Preoperative imaging of Charcot neuroarthropathy in diabetic patients: comparison of ring PET, hybrid PET, and magnetic resonance imaging. Foot Ankle Int 2004; 25:890-895.