Heredity of endothelin secretion: Human twin studies reveal the influence of polymorphism at the chromogranin A locus, a novel determinant of endothelial function

Circulation

Volumn 115, Issue 17, 2007, Pages 2282-2291

  Lillie, Elizabeth O ^a   Mahata, Manjula ^a   Khandrika, Srikrishna ^a   Rao, Fangwen ^a   Bundey, Richard A ^b   Wen, Gen ^a   Chen, Yuqing ^a   Taupenot, Laurent ^a   Smith, Douglas W ^a,b   Mahata, Sushil K ^a,c   Ziegler, Michael G ^a   Cockburn, Myles ^d   Schork, Nicholas J ^b   O'Connor, Daniel T ^a,b,c  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c VA SAN DIEGO HEALTHCARE SYSTEM   (United States)

^d UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

Endothelin; Endothelium; Genetics; Hypertension; Nervous system; Sympathetic; Vasculature

Indexed keywords

CHROMOGRANIN A; CHROMOGRANIN A[116-439]; CHROMOGRANIN A[312-331]; CHROMOGRANIN A[361-372]; CHROMOGRANIN A[439 451]; CHROMOGRANIN A[568 577]; ENDOTHELIN 1; PROTEIN PRECURSOR; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; ENDOTHELIAL DYSFUNCTION; ENDOTHELIUM CELL; FEMALE; GENE EXPRESSION; GENE LINKAGE DISEQUILIBRIUM; GENE LOCUS; HERITABILITY; HETEROZYGOTE; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; MALE; MUTATIONAL ANALYSIS; PLEIOTROPY; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BLOOD LEVEL; PROTEIN SECRETION; SINGLE NUCLEOTIDE POLYMORPHISM; TWINS; UMBILICAL VEIN; VASCULAR ENDOTHELIUM;

ADULT; CHROMOGRANIN A; ENDOTHELIN-1; ENDOTHELIUM, VASCULAR; FEMALE; HAPLOTYPES; HUMANS; HYPERTENSION; MALE; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; PROMOTER REGIONS (GENETICS); SEX FACTORS; SYMPATHETIC NERVOUS SYSTEM; VARIATION (GENETICS);

EID: 34247598427     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.106.648345     Document Type: Article

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