메뉴 건너뛰기




Volumn 32, Issue 1, 2007, Pages 45-50

Combination therapy with valproic acid in cancer: Initial clinical approach

Author keywords

[No Author keywords available]

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; AMINOPHYLLINE; AZACITIDINE; CISPLATIN; CYCLOPHOSPHAMIDE; DOXORUBICIN; EPIRUBICIN; FLUOROURACIL; GEMCITABINE; HISTONE DEACETYLASE; HYDRALAZINE; RETINOIC ACID; RNA POLYMERASE; TEMOZOLOMIDE; TRANSCRIPTION FACTOR; VALPROIC ACID;

EID: 34247597896     PISSN: 03778282     EISSN: None     Source Type: Journal    
DOI: 10.1358/dof.2007.032.01.1052960     Document Type: Review
Times cited : (11)

References (38)
  • 1
    • 18244383806 scopus 로고    scopus 로고
    • Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells
    • Gottlicher, M., Minucci, S., Zhu, P. et al. Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells. EMBO J 2001, 20(24): 6969-78.
    • (2001) EMBO J , vol.20 , Issue.24 , pp. 6969-6978
    • Gottlicher, M.1    Minucci, S.2    Zhu, P.3
  • 2
    • 3042576479 scopus 로고    scopus 로고
    • Valproic acid: An old drug newly discovered as inhibitor of histone deacetylases
    • Gottlicher, M. Valproic acid: An old drug newly discovered as inhibitor of histone deacetylases. Ann Hematol 2004, 83(Suppl. 1): S91-2.
    • (2004) Ann Hematol , vol.83 , Issue.SUPPL. 1
    • Gottlicher, M.1
  • 3
    • 0842325787 scopus 로고    scopus 로고
    • Histone deacetylase is a target of valproic acid-mediated cellular differentiation
    • Gurvich, N., Tsygankova, O.M., Meinkoth, J.L., Klein, P.S. Histone deacetylase is a target of valproic acid-mediated cellular differentiation. Cancer Res 2004, 64(3): 1079-86.
    • (2004) Cancer Res , vol.64 , Issue.3 , pp. 1079-1086
    • Gurvich, N.1    Tsygankova, O.M.2    Meinkoth, J.L.3    Klein, P.S.4
  • 4
    • 33745208735 scopus 로고    scopus 로고
    • Epigenetic targets as an approach to cancer therapy and prevention
    • Sorbera, L.A. Epigenetic targets as an approach to cancer therapy and prevention. Drugs Fut 2006, 31(4): 335-44.
    • (2006) Drugs Fut , vol.31 , Issue.4 , pp. 335-344
    • Sorbera, L.A.1
  • 5
    • 30844462355 scopus 로고    scopus 로고
    • The fundamental role of epigenetics in hematopoietic malignancies
    • Galm, O., Herman, J.G., Baylin, S.B. The fundamental role of epigenetics in hematopoietic malignancies. Blood Rev 2006, 20(1): 1-13.
    • (2006) Blood Rev , vol.20 , Issue.1 , pp. 1-13
    • Galm, O.1    Herman, J.G.2    Baylin, S.B.3
  • 6
    • 15944406847 scopus 로고    scopus 로고
    • Valproic acid, in combination with all-trans retinole acid and 5-aza-2′-deoxycytidine, restores expression of silenced RARbeta2 in breast cancer cells
    • Mongan, N.P., Gudas, L.J. Valproic acid, in combination with all-trans retinole acid and 5-aza-2′-deoxycytidine, restores expression of silenced RARbeta2 in breast cancer cells. Mol Cancer Ther 2005, 4(3): 477-86.
    • (2005) Mol Cancer Ther , vol.4 , Issue.3 , pp. 477-486
    • Mongan, N.P.1    Gudas, L.J.2
  • 7
    • 1042267223 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors have a profound antigrowth activity in endometrial cancer cells
    • Takai, N., Desmond, J.C., Kumagai, T. et al. Histone deacetylase inhibitors have a profound antigrowth activity in endometrial cancer cells. Clin Cancer Res 2004, 10(3): 1141-9.
    • (2004) Clin Cancer Res , vol.10 , Issue.3 , pp. 1141-1149
    • Takai, N.1    Desmond, J.C.2    Kumagai, T.3
  • 8
    • 0038675351 scopus 로고    scopus 로고
    • Valproic acid increases the stimulatory effect of estrogens on proliferation of human endometrial adenocarcinoma cells
    • Graziani, G., Tentori, L., Portarena, I., Vergati, M., Navarra, P. Valproic acid increases the stimulatory effect of estrogens on proliferation of human endometrial adenocarcinoma cells. Endocrinology 2003, 144(7): 2822-8.
    • (2003) Endocrinology , vol.144 , Issue.7 , pp. 2822-2828
    • Graziani, G.1    Tentori, L.2    Portarena, I.3    Vergati, M.4    Navarra, P.5
  • 9
    • 20144388533 scopus 로고    scopus 로고
    • Valproic acid stimulates proliferation and self-renewal of hematopoietic stem cells
    • Bug, G., Gul, H., Schwarz, K. et al. Valproic acid stimulates proliferation and self-renewal of hematopoietic stem cells. Cancer Res 2005, 65(7): 2537-41.
    • (2005) Cancer Res , vol.65 , Issue.7 , pp. 2537-2541
    • Bug, G.1    Gul, H.2    Schwarz, K.3
  • 10
    • 33745280074 scopus 로고    scopus 로고
    • Synergistic induction of folate receptor beta by all-trans retinole acid and histone deacetylase inhibitors in acute myelogenous leukemia cells: Mechanism and utility in enhancing selective growth inhibition by antifolates
    • Qi, H., Ratnam, M. Synergistic induction of folate receptor beta by all-trans retinole acid and histone deacetylase inhibitors in acute myelogenous leukemia cells: Mechanism and utility in enhancing selective growth inhibition by antifolates. Cancer Res 2006, 66(11): 5875-82.
    • (2006) Cancer Res , vol.66 , Issue.11 , pp. 5875-5882
    • Qi, H.1    Ratnam, M.2
  • 11
    • 0031763892 scopus 로고    scopus 로고
    • Knuepfer, M.M., Hernaiz-Driever, P., Poppenborg, H., Wolff, J.E., Cinatl, J. Valproic acid inhibits proliferation and changes expression of CD44 and CD56 of malignant glioma cells in vitro. Anticancer Res 1998, 18(5A): 3585-90.
    • Knuepfer, M.M., Hernaiz-Driever, P., Poppenborg, H., Wolff, J.E., Cinatl, J. Valproic acid inhibits proliferation and changes expression of CD44 and CD56 of malignant glioma cells in vitro. Anticancer Res 1998, 18(5A): 3585-90.
  • 14
    • 33746883106 scopus 로고    scopus 로고
    • Chronic administration of valproic acid inhibits prostate cancer cell growth in vitro and in vivo
    • Xia, Q., Sung, J., Chowdhury, W. et al. Chronic administration of valproic acid inhibits prostate cancer cell growth in vitro and in vivo. Cancer Res 2006, 66(14): 7237-44.
    • (2006) Cancer Res , vol.66 , Issue.14 , pp. 7237-7244
    • Xia, Q.1    Sung, J.2    Chowdhury, W.3
  • 15
    • 33645071947 scopus 로고    scopus 로고
    • Antineoplastic effects of the DNA methylation inhibitor hydralazine and the histone deacetylase inhibitor valproic acid in cancer cell lines
    • Chavez-Blanco, A., Perez-Plasencia, C., Perez-Cardenas, E. et al. Antineoplastic effects of the DNA methylation inhibitor hydralazine and the histone deacetylase inhibitor valproic acid in cancer cell lines. Cancer Cell Int 2006, 6: 2.
    • (2006) Cancer Cell Int , vol.6 , pp. 2
    • Chavez-Blanco, A.1    Perez-Plasencia, C.2    Perez-Cardenas, E.3
  • 16
    • 26844505068 scopus 로고    scopus 로고
    • Histone acetylation and histone deacetylase activity of magnesium valproate in tumor and peripheral blood of patients with cervical cancer. A phase I study
    • Chavez-Blanco, A., Segura-Pacheco, B., Perez-Cardenas, E. et al. Histone acetylation and histone deacetylase activity of magnesium valproate in tumor and peripheral blood of patients with cervical cancer. A phase I study. Mol Cancer 2005, 4(1): 22.
    • (2005) Mol Cancer , vol.4 , Issue.1 , pp. 22
    • Chavez-Blanco, A.1    Segura-Pacheco, B.2    Perez-Cardenas, E.3
  • 17
    • 25144473548 scopus 로고    scopus 로고
    • A dose-escalating phase I study with valproic acid (VPA) in patients (pts) with advanced cancer
    • Abst 3169
    • Atmaca, A., Maurer, A., Heinzel, T. et al. A dose-escalating phase I study with valproic acid (VPA) in patients (pts) with advanced cancer. J Clin Oncol 2004, 22(14, Suppl.): Abst 3169.
    • (2004) J Clin Oncol , vol.22 , Issue.14 and SUPPL.
    • Atmaca, A.1    Maurer, A.2    Heinzel, T.3
  • 18
    • 29144526562 scopus 로고    scopus 로고
    • Results of a phase I/II study of the combination of 5-aza-2′-deoxycytidine and valproic acid in patients with acute myeloid leukemia and myelodysplastic syndrome
    • ASCO, May 13-17, Orlando, Abst 6544
    • Garcia-Manero, G., Kantarjian, H., Sanchez-Gonzalez, B. et al. Results of a phase I/II study of the combination of 5-aza-2′-deoxycytidine and valproic acid in patients with acute myeloid leukemia and myelodysplastic syndrome. 41st Annu Meet Am Soc Clin Oncol (ASCO) (May 13-17, Orlando) 2005, Abst 6544.
    • (2005) 41st Annu Meet Am Soc Clin Oncol
    • Garcia-Manero, G.1    Kantarjian, H.2    Sanchez-Gonzalez, B.3
  • 19
    • 33646791942 scopus 로고    scopus 로고
    • Final results of a phase I/II study of the combination of the hypomethylating agent 5-aza-2′-deoxycytidine (DAC) and the histone deacetylase inhibitor valproic acid (VPA) in patients with leukaemia
    • Dec 10-13, Atlanta, Abst 408
    • Garcia-Manero, G., Kantarjian, H., Sanchez-Gonzalez, B. et al. Final results of a phase I/II study of the combination of the hypomethylating agent 5-aza-2′-deoxycytidine (DAC) and the histone deacetylase inhibitor valproic acid (VPA) in patients with leukaemia. Blood [47th Annu Meet Am Soc Hematol (Dec 10-13, Atlanta) 2005] 2005, 106(11): Abst 408.
    • (2005) Blood [47th Annu Meet Am Soc Hematol , vol.106 , Issue.11
    • Garcia-Manero, G.1    Kantarjian, H.2    Sanchez-Gonzalez, B.3
  • 20
    • 22544466164 scopus 로고    scopus 로고
    • Valproic acid and all-trans retinole acid for the treatment of elderly patients with acute myeloid leukaemia
    • Raffoux, E., Chaibi, P., Dombret, H., Degos, L. Valproic acid and all-trans retinole acid for the treatment of elderly patients with acute myeloid leukaemia. Haematologica 2005, 90(7): 986-8.
    • (2005) Haematologica , vol.90 , Issue.7 , pp. 986-988
    • Raffoux, E.1    Chaibi, P.2    Dombret, H.3    Degos, L.4
  • 21
    • 4444309863 scopus 로고    scopus 로고
    • Treatment of myelodysplastic syndromes with valproic acid alone or in combination with all-trans retinoic acid
    • Kuendgen, A., Strupp, C., Aivado, M. et al. Treatment of myelodysplastic syndromes with valproic acid alone or in combination with all-trans retinoic acid. Blood 2004, 104(5): 1266-9.
    • (2004) Blood , vol.104 , Issue.5 , pp. 1266-1269
    • Kuendgen, A.1    Strupp, C.2    Aivado, M.3
  • 22
    • 29144481615 scopus 로고    scopus 로고
    • Results of a phase 2 study of valproic acid alone or in combination with all-trans retinoic acid in 75 patients with myelodysplastic syndrome and relapsed or refractory acute myeloid leukaemia
    • Kuendgen, A., Knipp, S., Fox, F. et al. Results of a phase 2 study of valproic acid alone or in combination with all-trans retinoic acid in 75 patients with myelodysplastic syndrome and relapsed or refractory acute myeloid leukaemia. Ann Hematol 2005, 84(Suppl. 13): 61-6.
    • (2005) Ann Hematol , vol.84 , Issue.SUPPL. 13 , pp. 61-66
    • Kuendgen, A.1    Knipp, S.2    Fox, F.3
  • 23
    • 29744454120 scopus 로고    scopus 로고
    • The histone deacetylase (HDAC) inhibitor valproic acid as monotherapy or in combination with all-trans retinoic acid in patients with acute myeloid leukaemia
    • Kuendgen, A. et al. The histone deacetylase (HDAC) inhibitor valproic acid as monotherapy or in combination with all-trans retinoic acid in patients with acute myeloid leukaemia. Cancer 2006, 106(1): 112-9.
    • (2006) Cancer , vol.106 , Issue.1 , pp. 112-119
    • Kuendgen, A.1
  • 24
    • 29144484694 scopus 로고    scopus 로고
    • Clinical trial of valproic acid and all-trans retinole acid in patients with poor-risk acute myeloid leukaemia
    • Bug, G., Ritter, M., Wassmann, B. et al. Clinical trial of valproic acid and all-trans retinole acid in patients with poor-risk acute myeloid leukaemia. Cancer 2005, 104(12): 2717-25.
    • (2005) Cancer , vol.104 , Issue.12 , pp. 2717-2725
    • Bug, G.1    Ritter, M.2    Wassmann, B.3
  • 25
    • 20544471661 scopus 로고    scopus 로고
    • Increase in platelet count in older, poor-risk patients with acute myeloid leukemia or myelodysplastic syndrome treated with valproic acid and all-trans retinoic acid
    • Pilatrino, C., Cilloni, D., Messa, E. et al. Increase in platelet count in older, poor-risk patients with acute myeloid leukemia or myelodysplastic syndrome treated with valproic acid and all-trans retinoic acid. Cancer 2005, 104(1): 101-9.
    • (2005) Cancer , vol.104 , Issue.1 , pp. 101-109
    • Pilatrino, C.1    Cilloni, D.2    Messa, E.3
  • 27
    • 34247643726 scopus 로고    scopus 로고
    • Decitabine and valproic acid in treating patients with refractory or relapsed acute myeloid leukemia or previously treated chronic lymphocytic leukemia or small lymphocytic lymphoma (NCT00079378). ClinicalTrials.gov Web site 2006.
    • Decitabine and valproic acid in treating patients with refractory or relapsed acute myeloid leukemia or previously treated chronic lymphocytic leukemia or small lymphocytic lymphoma (NCT00079378). ClinicalTrials.gov Web site 2006.
  • 30
    • 34247624919 scopus 로고    scopus 로고
    • Study on valproic acid, all-trans retinoic acid and their combination in induction and consolidation therapy as well as pegfilgrastim after consolidation therapy in younger patients with newly diagnosed acute myeloid leukemia (NCT00151242). ClinicalTrials.gov Web site 2006.
    • Study on valproic acid, all-trans retinoic acid and their combination in induction and consolidation therapy as well as pegfilgrastim after consolidation therapy in younger patients with newly diagnosed acute myeloid leukemia (NCT00151242). ClinicalTrials.gov Web site 2006.
  • 31
    • 34247637591 scopus 로고    scopus 로고
    • Study on valproic acid in combination with all-trans retinoic acid, standard induction- and consolidation therapy in older patients with newly diagnosed acute myeloid leukemia (NCT00151255). ClinicalTrials.gov Web site 2006.
    • Study on valproic acid in combination with all-trans retinoic acid, standard induction- and consolidation therapy in older patients with newly diagnosed acute myeloid leukemia (NCT00151255). ClinicalTrials.gov Web site 2006.
  • 32
    • 34247605324 scopus 로고    scopus 로고
    • Pharmacokinetic and pharmacodynamic analysis of the histone deacetylase inhibitor, valproic acid in combination with the topoisomerase II inhibitor, epirubicin in solid tumor malignancies
    • Nov 14-18, Philadelphia, Abst B164
    • Munster, P.N., Marchion, D.C., Bicaku, E. et al. Pharmacokinetic and pharmacodynamic analysis of the histone deacetylase inhibitor, valproic acid in combination with the topoisomerase II inhibitor, epirubicin in solid tumor malignancies. 17th AACR-NCI-EORTC Int Conf Mol Targets Cancer Ther (Nov 14-18, Philadelphia) 2005, Abst B164.
    • (2005) 17th AACR-NCI-EORTC Int Conf Mol Targets Cancer Ther
    • Munster, P.N.1    Marchion, D.C.2    Bicaku, E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.