Metastability of microtubules induced by competing internal forces

Biophysical Journal

Volumn 92, Issue 9, 2007, Pages 3092-3097

  Hunyadi, Viktória ^a   Jánosi, Imre M ^a  

^a EÖTVÖS LORÁND UNIVERSITY   (Hungary)

Author keywords

[No Author keywords available]

Indexed keywords

DIMER; GUANOSINE TRIPHOSPHATE; TUBULIN;

ARTICLE; CHEMICAL BOND; CONFORMATIONAL TRANSITION; ENERGY BALANCE; ENERGY TRANSFER; HYDROLYSIS; MICROTUBULE; PROTEIN ASSEMBLY;

EID: 34247597863     PISSN: 00063495     EISSN: None     Source Type: Journal    
DOI: 10.1529/biophysj.106.091793     Document Type: Article

References (21)

1. Chrétien, D., and S. D. Fuller. 2000. Microtubules switch occasionally into unfavorable configurations during elongation. J. Mol. Biol. 298:663-676.
2. Wang, H.-W., and E. Nogales. 2005. Nucleotide-dependent bending flexibility of tubulin regulates microtubule assembly. Nature. 435:911-915.
3. Mitchison, T., and M. Kirschner. 1984. Dynamic instability of microtubule growth. Nature. 312:237-242.
4. VanBuren, V., D. J. Odde, and L. Cassimeris. 2002. Estimates of lateral and longitudinal bond energies within the microtubule lattice. Proc. Natl. Acad. Sci. USA. 99:6035-6040.
5. VanBuren, V., L. Cassimeris, and D. J. Odde. 2005. Mechanochemical model of microtubule structure and self-assembly kinetics. Biophys. J. 89:2911-2926.
6. Molodtsov, M. I., E. A. Ermakova, E. E. Shnol, E. L. Grishchuk, J. R. McIntosh, and F. I. Ataullakhanov. 2005. A molecular-mechanical model of the microtubule. Biophys. J. 88:3167-3179.
7. Molodtsov, M. I., E. L. Grishchuk, A. K. Efremov, J. R. McIntosh, and F. I. Ataullakhanov. 2005. Force production by depolymerizing microtubules: a theoretical study. Proc. Natl. Acad. Sci. USA. 102:4353-4358.
8. Hunyadi, V., D. Chrétien, and I. M. Jánosi. 2005. Mechanical stress induced mechanism of microtubule catastrophes. J. Mol. Biol. 348:927-938.
9. Erickson, H. P., and E. T. O'Brien. 1992. Microtubule dynamic instability and GTP hydrolysis. Annu. Rev. Biophys. Biomol. Struct. 21:145-166.
10. Hyman, A. A., S. Salser, D. N. Drechsel, N. Unwin, and T. J. Mitchison. 1992. Role of GTP hydrolysis in microtubule dynamics: information from a slowly hydrolyzable analogue, GMPCPP. Mol. Biol. Cell. 3:1155-1167.
11. Caplow, M., and J. Shanks. 1996. Evidence that a single monolayer tubulin-GTP cap is both necessary and sufficient to stabilize microtubules. Mol. Biol. Cell. 7:663-675.
12. Desai, A., and T. J. Mitchison. 1997. Microtubule polymerization dynamics. Annu. Rev. Cell Dev. Biol. 13:83-117.
13. Jánosi, I. M., D. Chrétien, and H. Flyvbjerg. 2002. Structural microtubule cap: stability, catastrophe, rescue, and third state. Biophys. J. 83:1317-1330.
14. Mitchell, J. B. O., R. A. Laskowski, A. Alex, and J. M. Thornton. 1999. BLEEP - potential of mean force describing protein-ligand interactions: I. Generating potential. J. Comp. Chem. 20:1165-1176.
15. Jiang, L., Y. Gao, F. Mao, Z. Liu, and L. Lai. 2002. Potential of mean force for protein-protein interaction studies. Proteins. 46:190-196.
16. Sept, D., N. A. Baker, and J. A. McCammon. 2003. The physical basis of microtubule structure and stability. Protein Sci. 12:2257-2261.
17. Drabik, P., S. Gusarov, and A. Kovalenko. 2007. Microtubule stability studied by three-dimensional molecular theory of solvation. Biophys. J. 92:394-403.
18. Moon, Y. U., R. A. Curtis, C. O. Anderson, H. W. Blanch, and J. M. Prausnitz. 2000. Protein-protein interactions in aqueous ammonium sulfate solutions. Lysozyme and bovine serum albumin (BSA). J. Solution Chem. 29:699-718.
19. Jánosi, I. M., D. Chrétien, and H. Flyvbjerg. 1998. Modeling elastic properties of microtubule tips and walls. Eur. Biophys. J. 27:501-513.
20. Müller-Reichert, Th., D. Chrétien, F. Severin, and A. A. Hyman. 1998. Structural changes at microtubule ends accompanying GTP hydrolysis: information from a slowly hydrolyzable analogue of GTP, guanylyl (α,β)methylenediphosphonate. Proc. Natl. Acad. Sci. USA. 95:3661-3666.
21. Chrétien, D., I. M. Jánosi, J. C. Taveau, and H. Flyvbjerg. 1999. Microtubule's conformational cap. Cell Struct. Funct. 24:299-303.