Genetic variation in thioredoxin interacting protein (TXNIP) is associated with hypertriglyceridaemia and blood pressure in diabetes mellitus

Diabetic Medicine

Volumn 24, Issue 5, 2007, Pages 498-504

  Van Greevenbroek, M M J ^a,d   Vermeulen, V M M J ^a   Feskens, E J M ^b,c   Evelo, C T ^d   Kruijshoop, M ^a   Hoebee, B ^b   Van Der Kallen, C J H ^a   De Bruin, T W A ^a,e  

^a MAASTRICHT UNIVERSITY   (Netherlands)

^b NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

^c WAGENINGEN UNIVERSITY   (Netherlands)

^d MAASTRICHT UNIVERSITY   (Netherlands)

^e GLAXOSMITHKLINE   (United States)

Author keywords

Diastolic blood pressure; Genetic predisposition; Thioredoxin interacting protein (TXNIP); Triglyceride; Type 2 diabetes mellitus

Indexed keywords

GLUCOSE; THIOREDOXIN; THIOREDOXIN INTERACTING PROTEIN; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

3' UNTRANSLATED REGION; ADULT; ALLELE; ARTICLE; BLOOD PRESSURE; BLOOD PRESSURE MEASUREMENT; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; ENERGY METABOLISM; FEMALE; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; GLUCOSE TOLERANCE; HUMAN; HYPERTRIGLYCERIDEMIA; IMPAIRED GLUCOSE TOLERANCE; LIPID METABOLISM; MAJOR CLINICAL STUDY; MALE; METABOLISM; NON INSULIN DEPENDENT DIABETES MELLITUS; SINGLE NUCLEOTIDE POLYMORPHISM; TRIACYLGLYCEROL BLOOD LEVEL;

AGED; ANIMALS; BLOOD GLUCOSE; BLOOD PRESSURE; CARRIER PROTEINS; DIABETES MELLITUS, TYPE 2; DIABETIC ANGIOPATHIES; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; HYPERTRIGLYCERIDEMIA; MALE; MICE; MIDDLE AGED; POLYMORPHISM, GENETIC; TRIGLYCERIDES;

EID: 34247591001     PISSN: 07423071     EISSN: 14645491     Source Type: Journal    
DOI: 10.1111/j.1464-5491.2007.02109.x     Document Type: Article

References (35)

1. Elbein S, Hoffman M, Teng K, Leppert M, Hasstedt S. A genome-wide search for type 2 diabetes susceptibility genes in Utah Caucasians. Diabetes 1999 48 : 1175 1182.
2. Pajukanta P, Nuotio I, Terwilliger JD, Porkka KV, Ylitalo K, Pihlajamaki J, et al. Linkage of familial combined hyperlipidaemia to chromosome 1q21-q23. Nat Genet 1998 18 : 369 373.
3. Buse JB, Polonsky KS, Burant CF. Type 2 diabetes mellitus. In Larsen P, Kronenberg H, Melmed S, Polonsky KS eds. Williams Textbook of Endocrinology. Philidelphia : Saunders 2003 1427 1483.
4. Castellani LW, Weinreb A, Bodnar J, Goto AM, Doolittle M, Mehrabian M, et al. Mapping a gene for combined hyperlipidaemia in a mutant mouse strain. Nat Genet 1998 18 : 374 377.
5. Angelico F, Del Ben M, Conti R, Francioso S, Feole K, Maccioni D, et al. Non-alcoholic fatty liver syndrome: a hepatic consequence of common metabolic diseases. J Gastroenterol Hepatol 2003 18 : 588 594.
6. de Bruin TWA, Georgieva AM, Brouwers MC, Heitink MV, van der Kallen CJ, van Greevenbroek MM. Radiological evidence of nonalcoholic fatty liver disease in familial combined hyperlipidemia. Am J Med 2004 116 : 847 849.
7. Bodnar JS, Chatterjee A, Castellani LW, Ross DA, Ohmen J, Cavalcoli J, et al. Positional cloning of the combined hyperlipidemia gene Hyplip1. Nat Genet 2003 30 : 110 116.
8. Pajukanta P, Lilja H, Sinsheimer J, Cantor RM, Lusis AJ, Gentile M, et al. Familial combined hyperlipidemia is associated with upstream transcription factor 1 (USF1). Nat Genet 2004 36 : 371 376.
9. Coon H, Singh N, Dunn D, Eckfeldt JH, Province MA, Hopkins PN, et al. TXNIP gene not associated with familial combined hyperlipidemia in the NHLBI Family Heart Study. Atherosclerosis 2004 174 : 357 362.
10. van der Vleuten GM, Hijmans A, Kluijtmans LA, Blom HJ, Utalenhoef AF, de Graaf J. Thioredoxin interacting protein in Dutch families with familial combined hyperlipidemia. Am J Med Genet A 2004 130 : 73 75.
11. Salomaa VV, Tuomilehto J, Jauhiainen M, Korhonen HJ, Stengard J, Uusitupa M, et al. Hypertriglyceridemia in different degrees of glucose intolerance in a Finnish population-based study. Diabetes Care 1992 15 : 657 665.
12. Gibson F, Hercberg S, Froguel P. Common polymorphisms in the USF1 gene are not associated with type 2 diabetes in French Caucasians. Diabetes 2005 54 : 3040 3042.
13. Ng MC, Miyake K, So WY, Poon EW, Lam VK, Li JK, et al. The linkage and association of the gene encoding upstream stimulatory factor 1 with type 2 diabetes and metabolic syndrome in the Chinese population. Diabetologia 2005 48 : 2018 2024.
14. Nishiyama A, Matsui M, Iwata S, Hirota K, Masutani H, Nakamura H, et al. Identification of thioredoxin-binding protein-2/vitamin D (3) up-regulated protein 1 as a negative regulator of thioredoxin function and expression. J Biol Chem 1999 274 : 21645 21650.
15. Hotta M, Tashiro F, Ikegami H, Niwa H, Ogihara T, Yodoi J, et al. Pancreatic beta cell-specific expression of thioredoxin, an antioxidative and antiapoptotic protein, prevents autoimmune and streptozotocin-induced diabetes. J Exp Med 1998 188 : 1445 1451.
16. Shalev A, Pise-Masison CA, Radonovich M, Hoffman SC, Hirshberg B, Brady JN, et al. Oligonucleotide microarray analysis of intact human pancreatic islets: identification of glucose-responsive genes and a highly regulated TGFbeta signaling pathway. Endocrinology 2002 143 : 3695 3698.
17. Hui TY, Sheth SS, Diffley JM, Potter DW, Lusis AJ, Attie AD, et al. Mice lacking thioredoxin-interacting protein provide evidence linking cellular redox state to appropriate response to nutritional signals. J Biol Chem 2004 179 : 24387 24393.
18. Kruijshoop M, Feskens EJ, Blaak EE, de Bruin TW. Validation of capillary glucose measurements to detect glucose intolerance or type 2 diabetes mellitus in the general population. Clin Chim Acta 2004 341 : 33 40.
19. van Dam RM, Hoebee B, Seidell JC, Schaap MM, de Bruin TW, Feskens EJ. Common variants in the ATP-sensitive K+ channel genes KCNJ11 (Kir6.2) and ABCC8 (SUR1) in relation to glucose intolerance: population-based studies and meta-analyses. Diabet Med 2005 22 : 590 598.
20. World Health Organization. Definition, diagnosis and classification of diabetes mellitus and its complication. In Report of a WHO Consultation. Part 1 : Diagnosis and Classification of Diabetes Mellitus. WHO Technical Report Series. Geneva : WHO 1999 : 1 59.
21. Keulen ET, Voors-Pette C, de Bruin TW. Familial dyslipidemic hypertension syndrome: familial combined hyperlipidemia, and the role of abdominal fat mass. Am J Hypertens 2001 14 : 357 363.
22. Bonora E, Targher G, Alberiche M, Bonadonna RC, Saggiani F, Zenere MB, et al. Homeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity: studies in subjects with various degrees of glucose tolerance and insulin sensitivity. Diabetes Care 2000 23 : 57 63.
23. Gauderman WJ, Morrison JM. Quanto 1.1: A Computer Program for Power and Sample Size Calculations for Genetic-Epidemiology Studies. 2006. Available at http://hydra.usc.edu/gxe.
24. Minn AH, Hafele C, Shalev A. Thioredoxin-interacting protein is stimulated by glucose through a carbohydrate response element and induces beta cell apoptosis. Endocrinology 2005 146 : 2397 2405.
25. Bruno G, Cavallo-Perin P, Bargero G, Borra M, D'Errico N, Pagano G. Glycaemic control and cardiovascular risk factors in type 2 diabetes: a population-based study. Diabet Med 1998 15 : 304 307.
26. Ostlund RE Jr., Semenkovich CF, Schechtman KB. Quantitative relationship between plasma lipids and glycohemoglobin in type I patients. Longitudinal study of 212 patients. Diabetes Care 1989 12 : 332 336.
27. Sheth SS, Castellani LW, Chari S, Wagg C, Thipphavong CK, Bodnar JS, et al. Thioredoxin-interacting protein deficiency disrupts the fasting-feeding metabolic transition. J Lipid Res 2005 46 : 123 134.
28. Van Greevenbroek MMJ, Vermeulen V, de Bruin TWA. Identification of novel molecular candidates for fatty liver in the hyperlipidemic mouse model, HcB19. J Lipid Res 2004 45 : 1148 1154.
29. Loots GG, Ovcharenko I. rVISTA 2.0: evolutionary analysis of transcription factor binding sites. Nucl Acids Res 2004 32 : W217 W221.
30. Zechel C. The germ cell nuclear factor (GCNF). Mol Reprod Dev 2005 72 : 550 556.
31. Welsh SJ, Bellamy WT, Briehl MM, Powis G. The redox protein thioredoxin-1 (Trx-1) increases hypoxia-inducible factor 1alpha protein expression: Trx-1 overexpression results in increased vascular endothelial growth factor production and enhanced tumor angiogenesis. Cancer Res 2002 62 : 5089 5095.
32. Cha DR, Kang YS, Han SY, Jee YH, Han KH, Han JY, et al. Vascular endothelial growth factor is increased during early stage of diabetic nephropathy in type II diabetic rats. J Endocrinol 2004 183 : 183 94.
33. Asselbergs FW, de Boer RA, Diercks GF, Langeveld B, Tio RA, de Jong PE, et al. Vascular endothelial growth factor: the link between cardiovascular risk factors and microalbuminuria? Int J Cardiol 2004 93 : 211 215.
34. Mogensen CE. Systemic blood pressure and glomerular leakage with particular reference to diabetes and hypertension. J Intern Med 1994 235 : 297 316.
35. Knight EL, Kramer HM, Curhan GC. High-normal blood pressure and microalbuminuria. Am J Kidney Dis 2003 41 : 588 595.