Clinical side effects during aerosol therapy: Cutaneous and ocular effects

Journal of Aerosol Medicine: Deposition, Clearance, and Effects in the Lung

Volumn 20, Issue SUPPL. 1, 2007, Pages

  Geller, David E ^a  

^a NEMOURS CHILDREN S HOSPITAL   (United States)

Author keywords

Aerosol drugs; Facemasks; Inhaled corticosteroids; Side effects

Indexed keywords

BECLOMETASONE DIPROPIONATE; BRONCHODILATING AGENT; BUDESONIDE; CHOLINERGIC RECEPTOR BLOCKING AGENT; CORTICOSTEROID; CROMOGLYCATE DISODIUM; FLUTICASONE; NEDOCROMIL; PLACEBO; PREDNISOLONE; STEROID; TIOTROPIUM BROMIDE; TRIAMCINOLONE ACETATE;

AEROSOL; AGE DISTRIBUTION; ANISOCORIA; ARTICLE; ASTHMA; BRONCHOSPASM; CATARACT; CLINICAL TRIAL; CONJUNCTIVITIS; CUSHINGOID SYNDROME; DOSE RESPONSE; DRUG DELIVERY SYSTEM; DRUG EXPOSURE; EYE TOXICITY; FACE MASK; GLAUCOMA; HUMAN; INTRAOCULAR PRESSURE; LONG TERM CARE; PUPIL; RASH; RISK ASSESSMENT; SIDE EFFECT; SKIN BRUISING; SKIN THINNING; SKIN TOXICITY;

ADMINISTRATION, INHALATION; ADULT; AEROSOLS; AGE FACTORS; CATARACT; CHILD, PRESCHOOL; CORTICOSTERONE; GLAUCOMA; HUMANS; MASKS; RISK; SKIN DISEASES;

EID: 34247576130     PISSN: 08942684     EISSN: None     Source Type: Journal    
DOI: 10.1089/jam.2007.0585     Document Type: Article

References (48)

1. National Asthma Education and Prevention Program. 1997. Expert Panel Report II: Guidelines for the Diagnosis and Management of Asthma. Publication 97-4051. National Institutes of Health, Bethesda, MD.
2. Sangwan, S., B.K. Gurses, and G.C. Smaldone. 2004. Facemasks and facial deposition of aerosols. Pediatr. Pulmonol. 37:447-152.
3. Bisquerra, R.A., G.H. Botz, and J.L. Nates. 2005. Ipratropium-bromide- induced acute anisocoria in the intensive care setting due to ill-fitting face masks. Respir. Care 50:1662-1664.
4. Iosson, N. 2006. Images in clinical medicine: nebulizer-associated anisocoria. N. Engl. J. Med. 354:e8.
5. Nakagawa, T.A., L. Guerra, and S.A. Storgion. 1993. Aerosolized atropine as an unusual cause of anisocoria in a child with asthma. Pediatr. Emerg. Care 9:153-154.
6. Rho, D.S. 2000. Acute angle-closure glaucoma after albuterol nebulizer treatment. Am. J. Opthalmol. 130: 123-124.
7. Hall, S.K. 1994. Acute angle-closure glaucoma as a complication of beta-agonist and ipratropium bromide therapy in the emergency department. Ann. Emerg. Med. 23:884-887.
8. Watson, W.T., E.P. Shuckett, A.B. Becker, and F.E. Simons. 1994. Effect of nebulized ipratropium bromide on intraocular pressures in children. Chest 105: 1439-1441.
9. Feifel, U., and G. Wellerstein. 2005. Safety and tolerability of tiotropium administered to the eye in healthy male volunteers, simulating inadvertent exposure from an inhaler. Thorax 60(abstract):82-83.
10. Afandi, B., M.S. Toumeh, and H.F. Saadi. 2003. Cushing's syndrome caused by unsupervised use of ocular glucocorticoids. Endocrinol. Pract. 9:526-529.
11. Allen, D.B., L. Bielory, H. Derendorf, R. Dluhy, G.L. Colice, and S.J. Szefler. 2003. Inhaled corticosteroids: Past lessons and future issues. J. Allergy Clin. Immunol. 112:S1-S40.
12. Lipworth, B.J. 1999. Systemic adverse effects of inhaled corticosteroid therapy. Arch. Intern. Med. 159: 941-955.
13. Leone, F.T., J.E. Fish, S.J. Szefler, and S.L. West. 2003. Systematic review of the evidence regarding potential complications of inhaled corticosteroid use in asthma. Chest 124:2329-2340.
14. Capewell, S., S. Reynolds, D. Shuttleworth, C. Edward, and A.Y. Finlay. 1990. Purpura and dermal thinning associated with high dose inhaled corticosteroids. BMJ 300:1548-1551.
15. Haaspasaari, K., O. Rossi, J. Risteli, and A. Oikarinen. 1998. Effects of long-term inhaled corticosteroids on skin collagen synthesis and thickness in asthmatic patients. Eur. Respir. J. 11:139-143.
16. Mak, V.H., R. Melchor, and S.G. Spiro. 1992. Easy bruising as a side effect of inhaled corticosteroids. Eur. Respir. J. 5:1068-1074.
17. Roy, A., C. Leblanc, L. Paquette, H. Ghezzo, J. Côté, A. Cartier, and J.L. Malo. 1996. Skin bruising in asthmatic subjects treated with high doses of inhaled steroids: frequency and association with adrenal function. Eur. Respir. J. 9:226-31.
18. Pauwels, R.A., C.G. Löfdahl, L.A. Laitinen, J.P. Schouten, D.S. Postma, N.B. Pride, and S.V. Ohlsson. 1999. Long-term treatment with inhaled budesonide in persons with mild chronic obstructive pulmonary disease who continue smoking. N. Engl. J. Med. 340: 1948-1953.
19. Agertoft, L., F.E. Larsen, and S. Pedersen. 1998. Posterior subcapsular cataracts, bruises, and hoarseness in children with asthma receiving long-term treatment with inhaled budesonide. Eur. Respir. J. 12:130-135.
20. Jobling, A.I., and R.C. Augusteyn. 2002. What causes steroid cataracts? A review of steroid-induced posterior subcapsular cataracts. Clin. Exp. Optom. 85:61-75.
21. Urban, R.C., and E. Cotlier. 1986. Corticosteroid induced cataracts. Surv. Ophthalmol. 31:102-110.
22. Bhagat, R.G., and H. Chai. 1984. Development of posterior subcapsular cataracts in asthmatic children. Pediatrics 73:626-630.
23. Nootheti, S., and L. Bielory. 2006. Risk of cataracts and glaucoma with inhaled steroid use in children. Compr. Ophthalmol. Update 7:31-39.
24. Carnahan, M.C., and D.A. Goldstein. 2000. Ocular complications of topical, periocular, and systemic corticosteroids. Curr. Opin. Ophthalmol. 11:478-183.
25. Toogood, J.H., A.E. Markov, J. Baskerville, and C. Dyson. 1993. Association of ocular cataracts with inhaled and oral steroid therapy during long-term treatment of asthma. J. Allergy Clin. Immunol. 91:571-579.
26. Simons, F.E., M.P. Persaud, C.A. Gillespie, M. Cheang, and E.P. Shuckett. 1993. Absence of posterior subcapsular cataracts in young patients treated with inhaled glucocorticoids. Lancet 342:776-778.
27. Tinkelman, D.G., C.E. Reed, H.S. Nelson, and K.P. Offord. 1993. Aerosol beclomethasone dipropionate compared with theophylline as primary treatment of chronic, mild to moderately severe asthma in children. Pediatrics 92:64-77.
28. Abuekteish, F., J.N.P. Kirkpatrick, and G. Russell. 1995. Posterior subcapsular cataract and inhaled corticosteroid therapy. Thorax 50:674-676.
29. Childhood Asthma Management Program Research Group. 2000. Long-term effects of budesonide or nedocromil in children with asthma. N. Engl. J. Med. 343:1054-1063.
30. Silverman, M., A.L. Sheffer, P.V. Diaz, and B. Lindberg. 2006. Safety and tolerability of inhaled budesonide in children in the inhaled Steroid Treatment As Regular Therapy (START) trial. Pediatr. Allergy Immunol. 17:14-20.
31. Cumming, R.G., P. Mitchell, and S.R. Leeder. 1997. Use of inhaled corticosteroids and the risk of cataracts. N. Engl. J. Med. 337:8-14.
32. Smeeth, L., M. Boulis, R. Hubbard, and A.E. Fletcher. 2003. A population-based case-control study of cataract and inhaled corticosteroids. Br. J. Opthalmol. 87:1247-1251.
33. Garbe, E., D. Suissa, and J. Delorier. 1998. Association of inhaled corticosteroid use with cataract extraction in elderly patients. JAMA 280:539-543.
34. Pauwels, R.A., S. Pedersen, W.W. Busse, W.C. Tan, Y.Z. Chen, S.V. Ohlsson, A. Ullman, C.J. Lamm, P.M. O'Byrne, and START Investigators Group. 2003. Early intervention with budesonide in mild persistent asthma: a randomized, double-blind trial. Lancet 361: 1071-1076.
35. Sheffer, A.L., M. Silverman, A.J. Woolcock, P.V. Diaz, B. Lindberg, and B. Lindmark. 2005. Long-term safety of once-daily budesonide in patients with early-onset mild persistent asthma: results of the inhaled Steroid Treatment As Regular Therapy (START) study. Ann. Allergy Asthma Immunol. 95:48-54.
36. Cumming, R.G., and P. Mitchell. 1999: Inhaled corticosteroids and cataract: prevalence, prevention, and management. Drug Saf. 20:77-84.
37. Mitchell, P., R.G. Cumming, and D.A. Mackey. 1999. Inhaled corticosteroids, family history, and risk of glaucoma. Ophthalmology 106:2301-2306.
38. Garbe, E., J. LeLorier, J.F. Boivin, and S. Suissa. 1997. Inhaled and nasal glucocorticoids and the risks of ocular hypertension or open angle glaucoma. JAMA 277:722-727.
39. Duh, M.S., A.M. Walker, B. Lindmark, and A.M. Laties. 2000. Association between intraocular pressure and budesonide inhalation therapy in asthmatic patients. Ann. Allergy Asthma Immunol. 85:356-61.
40. Turpeinen, M., O. Kari, and HEICA Study Group. 2001. No changes in intraocular pressure and no posterior subcapsular opacities in children treated for 18 months with budesonide Turbuhaler®. Am. J. Respir. Crit. Care Med. 163:A851.
41. Behbehani, A.H., A.F. Owayed, Z.M. Hijazi, E.A. Eslah, and A.M. Al-Jazzaf. 2005. Cataract and ocular hypertension in children on inhaled corticosteroid therapy. J. Pediatr. Ophthalmol. Strabismus 42:23-27.
42. Geller, D.E., and B. Kesser. 2004. Blowby vs. face mask for nebulized drugs in young children. J. Allergy Clin. Immunol. 113:S32.
43. Amirav, I., I. Balanov, M. Gorenberg, D. Groshar, and A.S. Luder. 2003. Nebuliser hood compared to mask in wheezy infants: aerosol therapy without tears! Arch. Dis. Child. 88:719-723.
44. Bisgaard, H., D. Allen, J. Milanowski, I. Kalev, L. Willits, and P. Davies. 2004. Twelve-month safety and efficacy of fluticasone propionate in children aged 1-3 years with recurrent wheezing. Pediatrics 113:87-94.
45. Szefler, S.J., E. Lyzell, S. Fitzpatrick, and M. Cruz-Rivera. 2004. Safety profile of budesonide inhalation suspension in the pediatric population: worldwide experience. Ann. Allergy Asthma Immunol. 93:83-90.
46. Personal correspondence. Astra Zeneca LP.
47. Berger, W.E., P.Y. Qaqundah, K. Blake, J. Rodriguez-Santana, A.M. Irani, J. Xu, and M. Goldman. 2005. Safety of budesonide inhalation suspension in infants aged six to twelve months with mild to moderate persistent asthma or recurrent wheeze. J. Pediatr. 146:91-95.
48. Jonas, J.B., R. Degenring, U. Vossmerbauemer, and B. Kamppeter. 2005. Frequency of cataract surgery after intravitreal injection of high-dosage triamcinolone acetonide. Eur. J. Ophthalmol. 15:462-464.